IMP

Process View

Mus musculus

1 genes annotated in mouse

roof plate formation

The formation of a single row of glia at the dorsal midline of the developing neural tube. This region provides inductive signals for the specification of neuronal cell types and of the specification of neural crest cells. The cells comprising the roof plate are the precursors to radial glial cells.

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Known genes in the process in mouse Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "roof plate formation"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "roof plate formation" (in gray)

Name	Description	Probability	Func Analog Organism
Bmp4	bone morphogenetic protein 4	1.000
Shh	sonic hedgehog	0.999
Foxc1	forkhead box C1	0.998
Fgfr2	fibroblast growth factor receptor 2	0.998
Pdgfra	platelet derived growth factor receptor, alpha polypeptide	0.994
Gli3	GLI-Kruppel family member GLI3	0.994
Msx1	homeobox, msh-like 1	0.990
Prrx1	paired related homeobox 1	0.973
Smo	smoothened homolog (Drosophila)	0.970
Rspo2	R-spondin 2 homolog (Xenopus laevis)	0.937
Hand1	heart and neural crest derivatives expressed transcript 1	0.933
Fgfr3	fibroblast growth factor receptor 3	0.918
Otx2	orthodenticle homolog 2 (Drosophila)	0.909
Ror2	receptor tyrosine kinase-like orphan receptor 2	0.907
Fgfr1	fibroblast growth factor receptor 1	0.886
Pitx2	paired-like homeodomain transcription factor 2	0.883
Msx2	homeobox, msh-like 2	0.872
Fgf8	fibroblast growth factor 8	0.869
Tbx1	T-box 1	0.867
Foxc2	forkhead box C2	0.866
Bmp7	bone morphogenetic protein 7	0.838	Mouse
Pax2	paired box gene 2	0.835
Sox9	SRY-box containing gene 9	0.817
Hand2	heart and neural crest derivatives expressed transcript 2	0.770
Zeb1	zinc finger E-box binding homeobox 1	0.722
Eya1	eyes absent 1 homolog (Drosophila)	0.703
Gli2	GLI-Kruppel family member GLI2	0.668
Tgfb2	transforming growth factor, beta 2	0.652
Pax3	paired box gene 3	0.584
Tcfap2a	transcription factor AP-2, alpha	0.568
Six1	sine oculis-related homeobox 1 homolog (Drosophila)	0.551
Foxh1	forkhead box H1	0.500
Ptch1	patched homolog 1	0.497
Gdf6	growth differentiation factor 6	0.471	Mouse
Tbx15	T-box 15	0.468
Dlx5	distal-less homeobox 5	0.432
Prrx2	paired related homeobox 2	0.325
Disp1	dispatched homolog 1 (Drosophila)	0.323
Alx4	aristaless-like homeobox 4	0.299
Bmp2	bone morphogenetic protein 2	0.283
Meox2	mesenchyme homeobox 2	0.279
Runx2	runt related transcription factor 2	0.259
Alx1	ALX homeobox 1	0.250
Gsc	goosecoid homeobox	0.245
Hoxd13	homeobox D13	0.218
Apc	adenomatosis polyposis coli	0.198
Lhx1	LIM homeobox protein 1	0.187
Gas1	growth arrest specific 1	0.179
Gdf5	growth differentiation factor 5	0.179	Mouse
Ednra	endothelin receptor type A	0.159
Rarg	retinoic acid receptor, gamma	0.147
Rarb	retinoic acid receptor, beta	0.143
Gdf7	growth differentiation factor 7	0.128
Chrd	chordin	0.126
Lrp6	low density lipoprotein receptor-related protein 6	0.125
Bmp5	bone morphogenetic protein 5	0.111	Mouse
Zic3	zinc finger protein of the cerebellum 3	0.110
Gdf1	growth differentiation factor 1	0.090
Phex	phosphate regulating gene with homologies to endopeptidases on the X chromosome (hypophosphatemia, vitamin D resistant rickets)	0.085
Gata4	GATA binding protein 4	0.085
Ctnnb1	catenin (cadherin associated protein), beta 1	0.082
Hoxa13	homeobox A13	0.068
Rhox6	reproductive homeobox 6	0.068
Pbx1	pre B-cell leukemia transcription factor 1	0.066
Gdf3	growth differentiation factor 3	0.065
Smad6	MAD homolog 6 (Drosophila)	0.062
Cdon	cell adhesion molecule-related/down-regulated by oncogenes	0.061
Pcsk5	proprotein convertase subtilisin/kexin type 5	0.060
Irs3	insulin receptor substrate 3	0.058
Lrp2	low density lipoprotein receptor-related protein 2	0.058
Dkk1	dickkopf homolog 1 (Xenopus laevis)	0.058
Vangl2	vang-like 2 (van gogh, Drosophila)	0.057
Fmn1	formin 1	0.051
Ern2	endoplasmic reticulum (ER) to nucleus signalling 2	0.051
Tdgf1	teratocarcinoma-derived growth factor 1	0.051
Tbx3	T-box 3	0.050
Jag1	jagged 1	0.049
Wnt3a	wingless-related MMTV integration site 3A	0.048
Acvr1	activin A receptor, type 1	0.047
Brs3	bombesin-like receptor 3	0.047
Nog	noggin	0.046
Gdf9	growth differentiation factor 9	0.046
Fgf15	fibroblast growth factor 15	0.043
Trp63	transformation related protein 63	0.042
Pth1r	parathyroid hormone 1 receptor	0.040
Tcf21	transcription factor 21	0.039
Gpc3	glypican 3	0.039
Wt1	Wilms tumor 1 homolog	0.038
Cldn6	claudin 6	0.034
Hoxa11	homeobox A11	0.032
Tcf7l1	transcription factor 7-like 1 (T-cell specific, HMG box)	0.032
Wnt5a	wingless-related MMTV integration site 5A	0.032
Hoxa1	homeobox A1	0.031
Foxa2	forkhead box A2	0.029
Bmpr1a	bone morphogenetic protein receptor, type 1A	0.029
Mecom	MDS1 and EVI1 complex locus	0.028
Ppap2b	phosphatidic acid phosphatase type 2B	0.028
Fpr-rs4	formyl peptide receptor, related sequence 4	0.028
She	src homology 2 domain-containing transforming protein E	0.027
Gata6	GATA binding protein 6	0.026
Osta	organic solute transporter alpha	0.026
Pax9	paired box gene 9	0.026
Tgfbr2	transforming growth factor, beta receptor II	0.025
Mycn	v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)	0.025
Slc22a6	solute carrier family 22 (organic anion transporter), member 6	0.025
Mks1	Meckel syndrome, type 1	0.025
Ihh	Indian hedgehog	0.024
Dnahc5	dynein, axonemal, heavy chain 5	0.024
Isl1	ISL1 transcription factor, LIM/homeodomain	0.024
Wnt3	wingless-related MMTV integration site 3	0.023
Aldh1a2	aldehyde dehydrogenase family 1, subfamily A2	0.023
Gbx2	gastrulation brain homeobox 2	0.023
Ifna2	interferon alpha 2	0.022
Smad3	MAD homolog 3 (Drosophila)	0.022
Pip	prolactin induced protein	0.022
Cfc1	cripto, FRL-1, cryptic family 1	0.021
Itga3	integrin alpha 3	0.021
Nkx2-5	NK2 transcription factor related, locus 5 (Drosophila)	0.021
Emx2	empty spiracles homolog 2 (Drosophila)	0.020
Mn1	meningioma 1	0.020
Foxf2	forkhead box F2	0.019
Smad4	MAD homolog 4 (Drosophila)	0.019
Otx1	orthodenticle homolog 1 (Drosophila)	0.019
Fgfrl1	fibroblast growth factor receptor-like 1	0.019
Hoxb3	homeobox B3	0.019
Tbx2	T-box 2	0.019
Mesp1	mesoderm posterior 1	0.019
Alx3	aristaless-like homeobox 3	0.019
Vegfa	vascular endothelial growth factor A	0.019
Itgb1	integrin beta 1 (fibronectin receptor beta)	0.019
Il13	interleukin 13	0.018
Hoxa2	homeobox A2	0.018
Nr5a1	nuclear receptor subfamily 5, group A, member 1	0.018
Dppa3	developmental pluripotency-associated 3	0.018
Ovol2	ovo-like 2 (Drosophila)	0.018
Npr2	natriuretic peptide receptor 2	0.017
Six4	sine oculis-related homeobox 4 homolog (Drosophila)	0.017
En1	engrailed 1	0.017
Sox7	SRY-box containing gene 7	0.017
Klk4	kallikrein related-peptidase 4 (prostase, enamel matrix, prostate)	0.017
Npr3	natriuretic peptide receptor 3	0.017
Hoxd11	homeobox D11	0.016
Tgfbr3	transforming growth factor, beta receptor III	0.016
Hesx1	homeobox gene expressed in ES cells	0.016
Itga8	integrin alpha 8	0.016
Sall4	sal-like 4 (Drosophila)	0.016
Cnga3	cyclic nucleotide gated channel alpha 3	0.016
Trap1a	tumor rejection antigen P1A	0.016
Zfp503	zinc finger protein 503	0.015
Sox17	SRY-box containing gene 17	0.015
Yap1	yes-associated protein 1	0.015
Bmpr1b	bone morphogenetic protein receptor, type 1B	0.015
Eomes	eomesodermin homolog (Xenopus laevis)	0.015
Gabrr1	gamma-aminobutyric acid (GABA) C receptor, subunit rho 1	0.015
Gja1	gap junction protein, alpha 1	0.015
Foxf1a	forkhead box F1a	0.014
Hoxa9	homeobox A9	0.014
Edn3	endothelin 3	0.014
Pax8	paired box gene 8	0.014
Lmx1b	LIM homeobox transcription factor 1 beta	0.014
Bdkrb2	bradykinin receptor, beta 2	0.013
Hoxa10	homeobox A10	0.013
Col4a3	collagen, type IV, alpha 3	0.013
Pik3c2g	phosphatidylinositol 3-kinase, C2 domain containing, gamma polypeptide	0.013
Ybx2	Y box protein 2	0.013
Gata5	GATA binding protein 5	0.013
Acvr2b	activin receptor IIB	0.013
Bmper	BMP-binding endothelial regulator	0.013
Tmprss2	transmembrane protease, serine 2	0.012
Lef1	lymphoid enhancer binding factor 1	0.012
Crxos1	Crx opposite strand transcript 1	0.012
Col13a1	collagen, type XIII, alpha 1	0.012
Efnb2	ephrin B2	0.012
Npy6r	neuropeptide Y receptor Y6	0.012
Mst1r	macrophage stimulating 1 receptor (c-met-related tyrosine kinase)	0.012
Mep1a	meprin 1 alpha	0.012
Gli1	GLI-Kruppel family member GLI1	0.012
Evx1	even skipped homeotic gene 1 homolog	0.012
Irs1	insulin receptor substrate 1	0.011
Ntf3	neurotrophin 3	0.011
Slc7a9	solute carrier family 7 (cationic amino acid transporter, y+ system), member 9	0.011
Ccdc85c	coiled-coil domain containing 85C	0.011
Acsm2	acyl-CoA synthetase medium-chain family member 2	0.011
Fgf9	fibroblast growth factor 9	0.011
Fabp9	fatty acid binding protein 9, testis	0.011
Btc	betacellulin, epidermal growth factor family member	0.011
Pcsk6	proprotein convertase subtilisin/kexin type 6	0.011
Rara	retinoic acid receptor, alpha	0.011
Gja3	gap junction protein, alpha 3	0.011
Cer1	cerberus 1 homolog (Xenopus laevis)	0.010
Sim1	single-minded homolog 1 (Drosophila)	0.010
Gm711	predicted gene 711	0.010
Gm4980	predicted gene 4980	0.010
Fuz	fuzzy homolog (Drosophila)	0.010
Cdx2	caudal type homeobox 2	0.010
Bmp6	bone morphogenetic protein 6	0.010	Mouse
Olfr49	olfactory receptor 49	0.010
Cd1d2	CD1d2 antigen	0.010
Hoxb6	homeobox B6	0.010