IMP
Process View
transforming growth factor beta receptor signaling pathway involved in primitive streak formation
A series of molecular signals initiated by the binding of an extracellular ligand to a transforming growth factor beta receptor on the surface of a target cell, which contributes to the formation of the primitive streak.
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Click on a gene's description to view its network relationships with genes known to be involved in "transforming growth factor beta receptor signaling pathway involved in primitive streak formation"
| Name | Description | Probability | Func Analog Organism | |
|---|---|---|---|---|
| Bmp4 | bone morphogenetic protein 4 | 0.994 | ||
| Pdgfra | platelet derived growth factor receptor, alpha polypeptide | 0.979 | ||
| Gli3 | GLI-Kruppel family member GLI3 | 0.975 | ||
| Shh | sonic hedgehog | 0.964 | ||
| Foxc1 | forkhead box C1 | 0.947 | ||
| Fgfr2 | fibroblast growth factor receptor 2 | 0.946 | ||
| Msx1 | homeobox, msh-like 1 | 0.946 | ||
| Ror2 | receptor tyrosine kinase-like orphan receptor 2 | 0.946 | ||
| Hand1 | heart and neural crest derivatives expressed transcript 1 | 0.894 | ||
| Bmp7 | bone morphogenetic protein 7 | 0.854 | Mouse | |
| Gli2 | GLI-Kruppel family member GLI2 | 0.842 | ||
| Fgfr3 | fibroblast growth factor receptor 3 | 0.839 | ||
| Smo | smoothened homolog (Drosophila) | 0.795 | ||
| Gdf5 | growth differentiation factor 5 | 0.792 | Mouse | |
| Mn1 | meningioma 1 | 0.670 | ||
| Ednra | endothelin receptor type A | 0.623 | ||
| Msx2 | homeobox, msh-like 2 | 0.584 | ||
| Prrx1 | paired related homeobox 1 | 0.569 | ||
| Hoxd13 | homeobox D13 | 0.564 | ||
| Ptch1 | patched homolog 1 | 0.548 | ||
| Tbx15 | T-box 15 | 0.528 | ||
| Rspo2 | R-spondin 2 homolog (Xenopus laevis) | 0.478 | ||
| Gdf6 | growth differentiation factor 6 | 0.442 | Mouse | |
| Zeb1 | zinc finger E-box binding homeobox 1 | 0.435 | ||
| Pax2 | paired box gene 2 | 0.406 | ||
| Sox9 | SRY-box containing gene 9 | 0.341 | ||
| Alx1 | ALX homeobox 1 | 0.310 | ||
| Bmper | BMP-binding endothelial regulator | 0.289 | ||
| Gas1 | growth arrest specific 1 | 0.276 | ||
| Foxc2 | forkhead box C2 | 0.262 | ||
| Alx4 | aristaless-like homeobox 4 | 0.245 | ||
| Hand2 | heart and neural crest derivatives expressed transcript 2 | 0.240 | ||
| Hoxa13 | homeobox A13 | 0.218 | ||
| Foxh1 | forkhead box H1 | 0.203 | ||
| Bmp2 | bone morphogenetic protein 2 | 0.200 | ||
| Tgfb2 | transforming growth factor, beta 2 | 0.183 | ||
| Otx2 | orthodenticle homolog 2 (Drosophila) | 0.182 | ||
| Gsc | goosecoid homeobox | 0.173 | ||
| Runx2 | runt related transcription factor 2 | 0.164 | ||
| Pthlh | parathyroid hormone-like peptide | 0.135 | ||
| Dlx5 | distal-less homeobox 5 | 0.124 | ||
| Fgfr1 | fibroblast growth factor receptor 1 | 0.119 | ||
| Cdon | cell adhesion molecule-related/down-regulated by oncogenes | 0.108 | ||
| Fgf8 | fibroblast growth factor 8 | 0.098 | ||
| Gpc3 | glypican 3 | 0.092 | ||
| Wnt3a | wingless-related MMTV integration site 3A | 0.091 | ||
| Lrp6 | low density lipoprotein receptor-related protein 6 | 0.077 | ||
| Smad6 | MAD homolog 6 (Drosophila) | 0.075 | ||
| Pitx2 | paired-like homeodomain transcription factor 2 | 0.072 | ||
| Ybx2 | Y box protein 2 | 0.061 | ||
| Prrx2 | paired related homeobox 2 | 0.061 | ||
| Apob | apolipoprotein B | 0.058 | ||
| Col2a1 | collagen, type II, alpha 1 | 0.058 | ||
| Tbx3 | T-box 3 | 0.057 | ||
| Meox2 | mesenchyme homeobox 2 | 0.057 | ||
| Lhx1 | LIM homeobox protein 1 | 0.052 | ||
| Phex | phosphate regulating gene with homologies to endopeptidases on the X chromosome (hypophosphatemia, vitamin D resistant rickets) | 0.052 | ||
| Lrp2 | low density lipoprotein receptor-related protein 2 | 0.051 | ||
| Fmn1 | formin 1 | 0.047 | ||
| Npr2 | natriuretic peptide receptor 2 | 0.045 | ||
| Dkk1 | dickkopf homolog 1 (Xenopus laevis) | 0.045 | ||
| Ihh | Indian hedgehog | 0.043 | ||
| Cldn6 | claudin 6 | 0.042 | ||
| Gdf3 | growth differentiation factor 3 | 0.041 | ||
| Foxf1a | forkhead box F1a | 0.041 | ||
| She | src homology 2 domain-containing transforming protein E | 0.040 | ||
| Apc | adenomatosis polyposis coli | 0.040 | ||
| Alx3 | aristaless-like homeobox 3 | 0.040 | ||
| Gdf1 | growth differentiation factor 1 | 0.039 | ||
| Rarg | retinoic acid receptor, gamma | 0.038 | ||
| Hoxa11 | homeobox A11 | 0.035 | ||
| Chrd | chordin | 0.033 | ||
| Irs3 | insulin receptor substrate 3 | 0.032 | ||
| Mecom | MDS1 and EVI1 complex locus | 0.032 | ||
| Pax9 | paired box gene 9 | 0.032 | ||
| Tbx1 | T-box 1 | 0.031 | ||
| Itga3 | integrin alpha 3 | 0.031 | ||
| Bmpr1b | bone morphogenetic protein receptor, type 1B | 0.030 | ||
| Wnt5a | wingless-related MMTV integration site 5A | 0.029 | ||
| Osta | organic solute transporter alpha | 0.029 | ||
| Slc22a6 | solute carrier family 22 (organic anion transporter), member 6 | 0.028 | ||
| Gja3 | gap junction protein, alpha 3 | 0.028 | ||
| Cilp2 | cartilage intermediate layer protein 2 | 0.027 | ||
| Hoxd11 | homeobox D11 | 0.027 | ||
| Gli1 | GLI-Kruppel family member GLI1 | 0.027 | ||
| Prl3d1 | prolactin family 3, subfamily d, member 1 | 0.026 | ||
| Lmx1b | LIM homeobox transcription factor 1 beta | 0.025 | ||
| Fut7 | fucosyltransferase 7 | 0.025 | ||
| Btbd17 | BTB (POZ) domain containing 17 | 0.025 | ||
| Gata6 | GATA binding protein 6 | 0.024 | ||
| Hoxb3 | homeobox B3 | 0.024 | ||
| Npr3 | natriuretic peptide receptor 3 | 0.024 | ||
| Gabrr1 | gamma-aminobutyric acid (GABA) C receptor, subunit rho 1 | 0.024 | ||
| Col13a1 | collagen, type XIII, alpha 1 | 0.023 | ||
| Wnt6 | wingless-related MMTV integration site 6 | 0.023 | ||
| Fgfrl1 | fibroblast growth factor receptor-like 1 | 0.022 | ||
| Kif3a | kinesin family member 3A | 0.022 | ||
| Tbx2 | T-box 2 | 0.022 | ||
| Zg16 | zymogen granule protein 16 | 0.022 | ||
| Dpep1 | dipeptidase 1 (renal) | 0.022 | ||
| Ctnnb1 | catenin (cadherin associated protein), beta 1 | 0.022 | ||
| Mks1 | Meckel syndrome, type 1 | 0.022 | ||
| Fgf18 | fibroblast growth factor 18 | 0.022 | ||
| Sox17 | SRY-box containing gene 17 | 0.021 | ||
| Pcsk5 | proprotein convertase subtilisin/kexin type 5 | 0.021 | ||
| Itga8 | integrin alpha 8 | 0.021 | ||
| Foxf2 | forkhead box F2 | 0.021 | ||
| Aym1 | activator of yeast meiotic promoters 1 | 0.020 | ||
| Moxd2 | monooxygenase, DBH-like 2 | 0.020 | ||
| Eya1 | eyes absent 1 homolog (Drosophila) | 0.020 | ||
| Gata5 | GATA binding protein 5 | 0.020 | ||
| Krt72-ps | keratin 72, pseudogene | 0.020 | ||
| Col4a3 | collagen, type IV, alpha 3 | 0.020 | ||
| Degs2 | degenerative spermatocyte homolog 2 (Drosophila), lipid desaturase | 0.020 | ||
| Ptprb | protein tyrosine phosphatase, receptor type, B | 0.019 | ||
| Gata4 | GATA binding protein 4 | 0.019 | ||
| Igll1 | immunoglobulin lambda-like polypeptide 1 | 0.018 | ||
| Chrdl2 | chordin-like 2 | 0.018 | ||
| Zfp503 | zinc finger protein 503 | 0.018 | ||
| Rarb | retinoic acid receptor, beta | 0.018 | ||
| Ifna2 | interferon alpha 2 | 0.018 | ||
| Sox7 | SRY-box containing gene 7 | 0.017 | ||
| Lef1 | lymphoid enhancer binding factor 1 | 0.017 | ||
| Pnliprp2 | pancreatic lipase-related protein 2 | 0.017 | ||
| Chrna6 | cholinergic receptor, nicotinic, alpha polypeptide 6 | 0.016 | ||
| Tdgf1 | teratocarcinoma-derived growth factor 1 | 0.016 | ||
| Esx1 | extraembryonic, spermatogenesis, homeobox 1 | 0.016 | ||
| Kremen2 | kringle containing transmembrane protein 2 | 0.016 | ||
| Fgf15 | fibroblast growth factor 15 | 0.016 | ||
| Sel1l2 | sel-1 suppressor of lin-12-like 2 (C. elegans) | 0.016 | ||
| Hsd11b2 | hydroxysteroid 11-beta dehydrogenase 2 | 0.016 | ||
| Adra2b | adrenergic receptor, alpha 2b | 0.016 | ||
| Gm10244 | predicted gene 10244 | 0.015 | ||
| Wt1 | Wilms tumor 1 homolog | 0.015 | ||
| Edn3 | endothelin 3 | 0.015 | ||
| Mpl | myeloproliferative leukemia virus oncogene | 0.015 | ||
| Rhox6 | reproductive homeobox 6 | 0.015 | ||
| Prop1 | paired like homeodomain factor 1 | 0.015 | ||
| Nr6a1 | nuclear receptor subfamily 6, group A, member 1 | 0.015 | ||
| Barx1 | BarH-like homeobox 1 | 0.015 | ||
| Il13 | interleukin 13 | 0.014 | ||
| Wnt8a | wingless-related MMTV integration site 8A | 0.014 | ||
| Col14a1 | collagen, type XIV, alpha 1 | 0.014 | ||
| Wnt3 | wingless-related MMTV integration site 3 | 0.014 | ||
| Hoxb9 | homeobox B9 | 0.014 | ||
| Efna4 | ephrin A4 | 0.014 | ||
| Klk4 | kallikrein related-peptidase 4 (prostase, enamel matrix, prostate) | 0.014 | ||
| Ptpn14 | protein tyrosine phosphatase, non-receptor type 14 | 0.014 | ||
| Adra1a | adrenergic receptor, alpha 1a | 0.013 | ||
| Emid2 | EMI domain containing 2 | 0.013 | ||
| Tgfbr3 | transforming growth factor, beta receptor III | 0.013 | ||
| Cnga3 | cyclic nucleotide gated channel alpha 3 | 0.013 | ||
| Otx1 | orthodenticle homolog 1 (Drosophila) | 0.013 | ||
| Six1 | sine oculis-related homeobox 1 homolog (Drosophila) | 0.013 | ||
| Nr5a1 | nuclear receptor subfamily 5, group A, member 1 | 0.013 | ||
| Cdx2 | caudal type homeobox 2 | 0.013 | ||
| Bdkrb2 | bradykinin receptor, beta 2 | 0.013 | ||
| Tcf7l1 | transcription factor 7-like 1 (T-cell specific, HMG box) | 0.013 | ||
| Pax4 | paired box gene 4 | 0.013 | ||
| Hoxb6 | homeobox B6 | 0.013 | ||
| Nog | noggin | 0.013 | ||
| Pax3 | paired box gene 3 | 0.012 | ||
| Abca17 | ATP-binding cassette, sub-family A (ABC1), member 17 | 0.012 | ||
| Fgf9 | fibroblast growth factor 9 | 0.012 | ||
| Gzmf | granzyme F | 0.012 | ||
| Kcnj5 | potassium inwardly-rectifying channel, subfamily J, member 5 | 0.012 | ||
| Gip | gastric inhibitory polypeptide | 0.012 | ||
| Clcnka | chloride channel Ka | 0.012 | ||
| Mylk | myosin, light polypeptide kinase | 0.012 | ||
| Rem1 | rad and gem related GTP binding protein 1 | 0.012 | ||
| Slc5a11 | solute carrier family 5 (sodium/glucose cotransporter), member 11 | 0.011 | ||
| Fzd7 | frizzled homolog 7 (Drosophila) | 0.011 | ||
| Capn9 | calpain 9 | 0.011 | ||
| Gdf9 | growth differentiation factor 9 | 0.011 | ||
| Tecta | tectorin alpha | 0.011 | ||
| Csf2 | colony stimulating factor 2 (granulocyte-macrophage) | 0.011 | ||
| Sfrp2 | secreted frizzled-related protein 2 | 0.011 | ||
| Wnt10b | wingless related MMTV integration site 10b | 0.011 | ||
| Smad3 | MAD homolog 3 (Drosophila) | 0.011 | ||
| Smad4 | MAD homolog 4 (Drosophila) | 0.011 | ||
| Bmpr1a | bone morphogenetic protein receptor, type 1A | 0.011 | ||
| Tek | endothelial-specific receptor tyrosine kinase | 0.011 | ||
| Pcsk6 | proprotein convertase subtilisin/kexin type 6 | 0.011 | ||
| Dmrt1 | doublesex and mab-3 related transcription factor 1 | 0.010 | ||
| Angpt1 | angiopoietin 1 | 0.010 | ||
| Ern2 | endoplasmic reticulum (ER) to nucleus signalling 2 | 0.010 | ||
| Clic3 | chloride intracellular channel 3 | 0.010 | ||
| Tsx | testis specific X-linked gene | 0.010 | ||
| Ccdc85c | coiled-coil domain containing 85C | 0.010 | ||
| Gast | gastrin | 0.010 | ||
| T | brachyury | 0.010 | ||
| Cdkn1c | cyclin-dependent kinase inhibitor 1C (P57) | 0.010 | ||
| Rdh16 | retinol dehydrogenase 16 | 0.010 | ||
| Wnt11 | wingless-related MMTV integration site 11 | 0.010 | ||
| Psma7 | proteasome (prosome, macropain) subunit, alpha type 7 | 0.010 | ||
| Hoxa9 | homeobox A9 | 0.010 |