IMP

Process View

Mus musculus

24 genes annotated in mouse

Multi-species View

cholesterol efflux

GO:0033344

The directed movement of cholesterol, cholest-5-en-3-beta-ol, out of a cell or organelle.

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Known genes in the process in mouse Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "cholesterol efflux"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "cholesterol efflux" (in gray)

Name	Description	Probability	Func Analog Organism
Apoe	apolipoprotein E	0.997
Abca1	ATP-binding cassette, sub-family A (ABC1), member 1	0.988
Npc1	Niemann Pick type C1	0.975
Apoa1	apolipoprotein A-I	0.943
Pten	phosphatase and tensin homolog	0.887
Cebpa	CCAAT/enhancer binding protein (C/EBP), alpha	0.879
Traf6	TNF receptor-associated factor 6	0.874
Kiss1	KiSS-1 metastasis-suppressor	0.437
Lrp1	low density lipoprotein receptor-related protein 1	0.396
Ldlr	low density lipoprotein receptor	0.313
Abcg5	ATP-binding cassette, sub-family G (WHITE), member 5	0.250
Fgfr2	fibroblast growth factor receptor 2	0.239
Ghr	growth hormone receptor	0.235
Abcg8	ATP-binding cassette, sub-family G (WHITE), member 8	0.216
Tbx3	T-box 3	0.209
Abcg1	ATP-binding cassette, sub-family G (WHITE), member 1	0.190
Nfkb1	nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p105	0.178
Rdh8	retinol dehydrogenase 8	0.170
Relb	avian reticuloendotheliosis viral (v-rel) oncogene related B	0.160
Myd88	myeloid differentiation primary response gene 88	0.151
Hnf4a	hepatic nuclear factor 4, alpha	0.149
Apob	apolipoprotein B	0.146
Gpr116	G protein-coupled receptor 116	0.132
Rela	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	0.127
Plg	plasminogen	0.108
Mapk8ip1	mitogen-activated protein kinase 8 interacting protein 1	0.099
Nr0b2	nuclear receptor subfamily 0, group B, member 2	0.083
Cav1	caveolin 1, caveolae protein	0.082
C3	complement component 3	0.081
Serpinf2	serine (or cysteine) peptidase inhibitor, clade F, member 2	0.080
Pparg	peroxisome proliferator activated receptor gamma	0.074
Aldob	aldolase B, fructose-bisphosphate	0.072
Nr5a1	nuclear receptor subfamily 5, group A, member 1	0.072
Lyz2	lysozyme 2	0.069
Foxa2	forkhead box A2	0.066
Nr1h3	nuclear receptor subfamily 1, group H, member 3	0.060
Clock	circadian locomotor output cycles kaput	0.059
Zeb1	zinc finger E-box binding homeobox 1	0.055
Pick1	protein interacting with C kinase 1	0.055
Apoa2	apolipoprotein A-II	0.053
Ndst1	N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1	0.052
Fgg	fibrinogen gamma chain	0.050
Cfh	complement component factor h	0.049
Cebpb	CCAAT/enhancer binding protein (C/EBP), beta	0.048
Slc2a4	solute carrier family 2 (facilitated glucose transporter), member 4	0.048
Atp4a	ATPase, H+/K+ exchanging, gastric, alpha polypeptide	0.048
Klf15	Kruppel-like factor 15	0.047
Lrp6	low density lipoprotein receptor-related protein 6	0.046	Mouse
Peli2	pellino 2	0.046
Lpl	lipoprotein lipase	0.045
Pltp	phospholipid transfer protein	0.044
Apoc3	apolipoprotein C-III	0.042
Fgfr3	fibroblast growth factor receptor 3	0.042
Fabp2	fatty acid binding protein 2, intestinal	0.040
Stat3	signal transducer and activator of transcription 3	0.040
Ihh	Indian hedgehog	0.040	Mouse
Pzp	pregnancy zone protein	0.040
Slc12a6	solute carrier family 12, member 6	0.040
Mertk	c-mer proto-oncogene tyrosine kinase	0.040
Ar	androgen receptor	0.040
Lrp5	low density lipoprotein receptor-related protein 5	0.039	Mouse
Dhcr7	7-dehydrocholesterol reductase	0.038
Aqp8	aquaporin 8	0.038
Hoxd10	homeobox D10	0.036
Fbp2	fructose bisphosphatase 2	0.035
Hgd	homogentisate 1, 2-dioxygenase	0.034
Slc22a1	solute carrier family 22 (organic cation transporter), member 1	0.034
Lgals2	lectin, galactose-binding, soluble 2	0.034
Ahsg	alpha-2-HS-glycoprotein	0.033
Cdhr5	cadherin-related family member 5	0.033
Hpd	4-hydroxyphenylpyruvic acid dioxygenase	0.033
Slc22a2	solute carrier family 22 (organic cation transporter), member 2	0.033
Amhr2	anti-Mullerian hormone type 2 receptor	0.032
Irak4	interleukin-1 receptor-associated kinase 4	0.032
Arntl	aryl hydrocarbon receptor nuclear translocator-like	0.031
Ctrb1	chymotrypsinogen B1	0.031
Mogat2	monoacylglycerol O-acyltransferase 2	0.031
Ctnnb1	catenin (cadherin associated protein), beta 1	0.030
Spp2	secreted phosphoprotein 2	0.030
Pcyt1a	phosphate cytidylyltransferase 1, choline, alpha isoform	0.030
Slc7a9	solute carrier family 7 (cationic amino acid transporter, y+ system), member 9	0.030
Gsk3b	glycogen synthase kinase 3 beta	0.029
Hand1	heart and neural crest derivatives expressed transcript 1	0.029
Hgfac	hepatocyte growth factor activator	0.029
Col4a4	collagen, type IV, alpha 4	0.029
Otx2	orthodenticle homolog 2 (Drosophila)	0.029
Slc4a1	solute carrier family 4 (anion exchanger), member 1	0.028
Notch2	Notch gene homolog 2 (Drosophila)	0.028
Hpx	hemopexin	0.027
Gnrh1	gonadotropin releasing hormone 1	0.027
Srf	serum response factor	0.027
Lrp2	low density lipoprotein receptor-related protein 2	0.026	Mouse
Ambp	alpha 1 microglobulin/bikunin	0.026
Timd2	T-cell immunoglobulin and mucin domain containing 2	0.026
Fgb	fibrinogen beta chain	0.026
Gli3	GLI-Kruppel family member GLI3	0.026
Cfi	complement component factor i	0.025
Rab11a	RAB11a, member RAS oncogene family	0.025
Aspdh	aspartate dehydrogenase domain containing	0.025
Gata4	GATA binding protein 4	0.024
Mapk8ip2	mitogen-activated protein kinase 8 interacting protein 2	0.023
Serpinc1	serine (or cysteine) peptidase inhibitor, clade C (antithrombin), member 1	0.023
Cubn	cubilin (intrinsic factor-cobalamin receptor)	0.023
Clstn1	calsyntenin 1	0.023
Apoc4	apolipoprotein C-IV	0.022
Pklr	pyruvate kinase liver and red blood cell	0.022
Inca1	inhibitor of CDK, cyclin A1 interacting protein 1	0.022
Slc27a5	solute carrier family 27 (fatty acid transporter), member 5	0.022
Pla2g12b	phospholipase A2, group XIIB	0.022
Nos3	nitric oxide synthase 3, endothelial cell	0.022
Bmp4	bone morphogenetic protein 4	0.021
D19Wsu162e	DNA segment, Chr 19, Wayne State University 162, expressed	0.021
Mybpc3	myosin binding protein C, cardiac	0.021
Rab17	RAB17, member RAS oncogene family	0.021
Golt1a	golgi transport 1 homolog A (S. cerevisiae)	0.021
Aqp7	aquaporin 7	0.021
Pax2	paired box gene 2	0.020
Anpep	alanyl (membrane) aminopeptidase	0.020
Proc	protein C	0.020
Tlr4	toll-like receptor 4	0.020
Smagp	small cell adhesion glycoprotein	0.020
Il1r1	interleukin 1 receptor, type I	0.020
1300017J02Rik	RIKEN cDNA 1300017J02 gene	0.020
Igfbp1	insulin-like growth factor binding protein 1	0.020
Oxt	oxytocin	0.019
Cel	carboxyl ester lipase	0.019
Pofut1	protein O-fucosyltransferase 1	0.019
Pkd1	polycystic kidney disease 1 homolog	0.019
Lepr	leptin receptor	0.019
P2rx1	purinergic receptor P2X, ligand-gated ion channel, 1	0.019
Fabp4	fatty acid binding protein 4, adipocyte	0.019
Alpi	alkaline phosphatase, intestinal	0.019
Vangl2	vang-like 2 (van gogh, Drosophila)	0.018
Gns	glucosamine (N-acetyl)-6-sulfatase	0.018
Pdzk1	PDZ domain containing 1	0.018
Apom	apolipoprotein M	0.018
Gulo	gulonolactone (L-) oxidase	0.018
Abca3	ATP-binding cassette, sub-family A (ABC1), member 3	0.018	Mouse
Sertad2	SERTA domain containing 2	0.018
Lcat	lecithin cholesterol acyltransferase	0.018
F2	coagulation factor II	0.018
Spink4	serine peptidase inhibitor, Kazal type 4	0.017
H6pd	hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase)	0.017
Slc3a1	solute carrier family 3, member 1	0.017
C8g	complement component 8, gamma polypeptide	0.017
Scd1	stearoyl-Coenzyme A desaturase 1	0.017
Rxra	retinoid X receptor alpha	0.017
Mesdc2	mesoderm development candidate 2	0.017
Soat2	sterol O-acyltransferase 2	0.017
Gm13290	predicted gene 13290	0.017
Fgf4	fibroblast growth factor 4	0.017
App	amyloid beta (A4) precursor protein	0.017
Cyp2c70	cytochrome P450, family 2, subfamily c, polypeptide 70	0.017
Angptl4	angiopoietin-like 4	0.017
Slc6a4	solute carrier family 6 (neurotransmitter transporter, serotonin), member 4	0.017
Foxa3	forkhead box A3	0.016
Foxo3	forkhead box O3	0.016
Bsnd	Bartter syndrome, infantile, with sensorineural deafness (Barttin)	0.016
Mcl1	myeloid cell leukemia sequence 1	0.016
Clps	colipase, pancreatic	0.016
Sct	secretin	0.016
Prlr	prolactin receptor	0.015
Cps1	carbamoyl-phosphate synthetase 1	0.015
Scd2	stearoyl-Coenzyme A desaturase 2	0.015
Mt1	metallothionein 1	0.015
Mt2	metallothionein 2	0.015
C9	complement component 9	0.015
Pthlh	parathyroid hormone-like peptide	0.015
Hsd17b2	hydroxysteroid (17-beta) dehydrogenase 2	0.015
Gcgr	glucagon receptor	0.015
Serpina10	serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10	0.015
Slc25a47	solute carrier family 25, member 47	0.015
Lamp1	lysosomal-associated membrane protein 1	0.014
Grb7	growth factor receptor bound protein 7	0.014
S100g	S100 calcium binding protein G	0.014
Rgs9bp	regulator of G-protein signalling 9 binding protein	0.014
Slc2a2	solute carrier family 2 (facilitated glucose transporter), member 2	0.014
Dhcr24	24-dehydrocholesterol reductase	0.014
Spink3	serine peptidase inhibitor, Kazal type 3	0.014
Mep1a	meprin 1 alpha	0.014
Ppara	peroxisome proliferator activated receptor alpha	0.014
Kcnk7	potassium channel, subfamily K, member 7	0.014
G6pc	glucose-6-phosphatase, catalytic	0.014
Fga	fibrinogen alpha chain	0.014
Rs1	retinoschisis (X-linked, juvenile) 1 (human)	0.014
Atp13a2	ATPase type 13A2	0.014
Krtap5-1	keratin associated protein 5-1	0.014
Nr1h2	nuclear receptor subfamily 1, group H, member 2	0.014
Ppargc1a	peroxisome proliferative activated receptor, gamma, coactivator 1 alpha	0.014
Abcc2	ATP-binding cassette, sub-family C (CFTR/MRP), member 2	0.014
Sntg2	syntrophin, gamma 2	0.014
Lpin1	lipin 1	0.013
Agtr1a	angiotensin II receptor, type 1a	0.013
Cry1	cryptochrome 1 (photolyase-like)	0.013
Apoa4	apolipoprotein A-IV	0.013	Mouse
Tsks	testis-specific serine kinase substrate	0.013
Hpn	hepsin	0.013
Crtc3	CREB regulated transcription coactivator 3	0.013
Slc6a20b	solute carrier family 6 (neurotransmitter transporter), member 20B	0.013
Rragc	Ras-related GTP binding C	0.013
Foxd2	forkhead box D2	0.013
Mfsd7c	major facilitator superfamily domain containing 7C	0.013
Myom2	myomesin 2	0.013
Sox13	SRY-box containing gene 13	0.013
Plin2	perilipin 2	0.013
Cyp2d26	cytochrome P450, family 2, subfamily d, polypeptide 26	0.013
Nr0b1	nuclear receptor subfamily 0, group B, member 1	0.013
Asah1	N-acylsphingosine amidohydrolase 1	0.013
Scarb1	scavenger receptor class B, member 1	0.013
Sycn	syncollin	0.012
Ifngr1	interferon gamma receptor 1	0.012
Igfals	insulin-like growth factor binding protein, acid labile subunit	0.012
T	brachyury	0.012
Fcgrt	Fc receptor, IgG, alpha chain transporter	0.012
Art5	ADP-ribosyltransferase 5	0.012
Cldn2	claudin 2	0.012
Ttr	transthyretin	0.012
Arrb1	arrestin, beta 1	0.012
Crb3	crumbs homolog 3 (Drosophila)	0.012
Gjb2	gap junction protein, beta 2	0.012
Cstb	cystatin B	0.012
F12	coagulation factor XII (Hageman factor)	0.012
Sqle	squalene epoxidase	0.012
Abcb11	ATP-binding cassette, sub-family B (MDR/TAP), member 11	0.012
Slc22a7	solute carrier family 22 (organic anion transporter), member 7	0.012
Tff3	trefoil factor 3, intestinal	0.011
Apoa5	apolipoprotein A-V	0.011	Mouse
Runx2	runt related transcription factor 2	0.011
Eml3	echinoderm microtubule associated protein like 3	0.011
Slc6a13	solute carrier family 6 (neurotransmitter transporter, GABA), member 13	0.011
Slc17a1	solute carrier family 17 (sodium phosphate), member 1	0.011
Cdh16	cadherin 16	0.011
Alppl2	alkaline phosphatase, placental-like 2	0.011
Sdsl	serine dehydratase-like	0.011
Irs2	insulin receptor substrate 2	0.011
Itih4	inter alpha-trypsin inhibitor, heavy chain 4	0.011
Plekha5	pleckstrin homology domain containing, family A member 5	0.011
Klk1b9	kallikrein 1-related peptidase b9	0.011
Guca2b	guanylate cyclase activator 2b (retina)	0.011
Pvrl2	poliovirus receptor-related 2	0.011
Cela1	chymotrypsin-like elastase family, member 1	0.011
Vwce	von Willebrand factor C and EGF domains	0.011
Hsd11b1	hydroxysteroid 11-beta dehydrogenase 1	0.011
Ceacam2	carcinoembryonic antigen-related cell adhesion molecule 2	0.011
Aes	amino-terminal enhancer of split	0.011
Rnpc3	RNA-binding region (RNP1, RRM) containing 3	0.011
Cox8c	cytochrome c oxidase, subunit VIIIc	0.011
Nfib	nuclear factor I/B	0.011
Tmprss2	transmembrane protease, serine 2	0.010
Ift88	intraflagellar transport 88 homolog (Chlamydomonas)	0.010
Cela2a	chymotrypsin-like elastase family, member 2A	0.010
Zp2	zona pellucida glycoprotein 2	0.010
Pcnxl3	pecanex-like 3 (Drosophila)	0.010
Cd36	CD36 antigen	0.010	Mouse
Lgals4	lectin, galactose binding, soluble 4	0.010
Igf1	insulin-like growth factor 1	0.010
Abcc6	ATP-binding cassette, sub-family C (CFTR/MRP), member 6	0.010
Mvd	mevalonate (diphospho) decarboxylase	0.010
Gstm3	glutathione S-transferase, mu 3	0.010
Apof	apolipoprotein F	0.010
Mylip	myosin regulatory light chain interacting protein	0.010
Apoh	apolipoprotein H	0.010