IMP

Process View

Mus musculus

4 genes annotated in mouse

negative regulation of cholesterol efflux

Any process that decreases the frequency, rate or extent of cholesterol efflux. Cholesterol efflux is the directed movement of cholesterol, cholest-5-en-3-beta-ol, out of a cell or organelle.

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Known genes in the process in mouse Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "negative regulation of cholesterol efflux"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "negative regulation of cholesterol efflux" (in gray)

Name	Description	Probability	Func Analog Organism
Fgfr2	fibroblast growth factor receptor 2	0.963
Ctnnb1	catenin (cadherin associated protein), beta 1	0.590
Myd88	myeloid differentiation primary response gene 88	0.495
Mapk8ip1	mitogen-activated protein kinase 8 interacting protein 1	0.111
Cebpa	CCAAT/enhancer binding protein (C/EBP), alpha	0.091
Lrp2	low density lipoprotein receptor-related protein 2	0.091	Mouse
Nos3	nitric oxide synthase 3, endothelial cell	0.087
Npc1	Niemann Pick type C1	0.087
Ldlr	low density lipoprotein receptor	0.087
Axin1	axin 1	0.074
Abca1	ATP-binding cassette, sub-family A (ABC1), member 1	0.071
Otx2	orthodenticle homolog 2 (Drosophila)	0.070
Ybx2	Y box protein 2	0.063
Gli3	GLI-Kruppel family member GLI3	0.061
Pparg	peroxisome proliferator activated receptor gamma	0.058
Lepr	leptin receptor	0.054
Pitx2	paired-like homeodomain transcription factor 2	0.050
Tex19.1	testis expressed gene 19.1	0.047
Ar	androgen receptor	0.046
Col4a3	collagen, type IV, alpha 3	0.043
Crb3	crumbs homolog 3 (Drosophila)	0.041
Tbx3	T-box 3	0.041
Vangl2	vang-like 2 (van gogh, Drosophila)	0.038
Nodal	nodal	0.037
Nr5a1	nuclear receptor subfamily 5, group A, member 1	0.036
Fgfr3	fibroblast growth factor receptor 3	0.035
Klf15	Kruppel-like factor 15	0.035
Pltp	phospholipid transfer protein	0.034
Lep	leptin	0.034
Pla2g10	phospholipase A2, group X	0.033
Ndst1	N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1	0.033
Sall4	sal-like 4 (Drosophila)	0.032
Sertad2	SERTA domain containing 2	0.030
Mertk	c-mer proto-oncogene tyrosine kinase	0.030
Amhr2	anti-Mullerian hormone type 2 receptor	0.028
Fgf4	fibroblast growth factor 4	0.028
Notch2	Notch gene homolog 2 (Drosophila)	0.027
Srcrb4d	scavenger receptor cysteine rich domain containing, group B (4 domains)	0.027
Tff1	trefoil factor 1	0.027
Scd1	stearoyl-Coenzyme A desaturase 1	0.026
Cdh16	cadherin 16	0.026
Fgf9	fibroblast growth factor 9	0.025
Ihh	Indian hedgehog	0.025	Mouse
Atp4a	ATPase, H+/K+ exchanging, gastric, alpha polypeptide	0.025
Col4a4	collagen, type IV, alpha 4	0.024
Gsk3b	glycogen synthase kinase 3 beta	0.024
Srf	serum response factor	0.024
Clcnka	chloride channel Ka	0.024
Apln	apelin	0.024
T	brachyury	0.024
Pthlh	parathyroid hormone-like peptide	0.023
Pomc	pro-opiomelanocortin-alpha	0.023
Sox13	SRY-box containing gene 13	0.023
Smpd3	sphingomyelin phosphodiesterase 3, neutral	0.023
Nr0b1	nuclear receptor subfamily 0, group B, member 1	0.023
Slc22a2	solute carrier family 22 (organic cation transporter), member 2	0.023
Hes1	hairy and enhancer of split 1 (Drosophila)	0.023
Clps	colipase, pancreatic	0.023
Pick1	protein interacting with C kinase 1	0.022
Pkd1	polycystic kidney disease 1 homolog	0.022
Bmp4	bone morphogenetic protein 4	0.022
Lgals2	lectin, galactose-binding, soluble 2	0.022
Slc12a1	solute carrier family 12, member 1	0.021
Chrna7	cholinergic receptor, nicotinic, alpha polypeptide 7	0.021
Foxa2	forkhead box A2	0.020
C3	complement component 3	0.020
Cyp27b1	cytochrome P450, family 27, subfamily b, polypeptide 1	0.020
Traf6	TNF receptor-associated factor 6	0.020
Pten	phosphatase and tensin homolog	0.020
Hand1	heart and neural crest derivatives expressed transcript 1	0.020
Emx2	empty spiracles homolog 2 (Drosophila)	0.020
Runx2	runt related transcription factor 2	0.020
Kcnq1	potassium voltage-gated channel, subfamily Q, member 1	0.020
Slc6a20b	solute carrier family 6 (neurotransmitter transporter), member 20B	0.020
Pitx1	paired-like homeodomain transcription factor 1	0.020
Agtr2	angiotensin II receptor, type 2	0.020
Cubn	cubilin (intrinsic factor-cobalamin receptor)	0.019
Shh	sonic hedgehog	0.019
Kl	klotho	0.019
En1	engrailed 1	0.019
Pofut1	protein O-fucosyltransferase 1	0.018
Peli2	pellino 2	0.018
Cebpb	CCAAT/enhancer binding protein (C/EBP), beta	0.018
Otog	otogelin	0.018
Ppef2	protein phosphatase, EF hand calcium-binding domain 2	0.018
Scarb1	scavenger receptor class B, member 1	0.018
Vdr	vitamin D receptor	0.018
Aqp7	aquaporin 7	0.018
Zp3	zona pellucida glycoprotein 3	0.018
Lpin1	lipin 1	0.018
Drd4	dopamine receptor D4	0.018
Clstn1	calsyntenin 1	0.017
Gsg1	germ cell-specific gene 1	0.017
Kcnk7	potassium channel, subfamily K, member 7	0.017
Agtr1a	angiotensin II receptor, type 1a	0.017
Slc34a1	solute carrier family 34 (sodium phosphate), member 1	0.017
Amh	anti-Mullerian hormone	0.016
App	amyloid beta (A4) precursor protein	0.016
Ggnbp1	gametogenetin binding protein 1	0.016
Zp2	zona pellucida glycoprotein 2	0.016
Ift88	intraflagellar transport 88 homolog (Chlamydomonas)	0.016
Syngr4	synaptogyrin 4	0.016
Fbp2	fructose bisphosphatase 2	0.016
Scin	scinderin	0.016
Ror2	receptor tyrosine kinase-like orphan receptor 2	0.016
Zbtb16	zinc finger and BTB domain containing 16	0.016
Smagp	small cell adhesion glycoprotein	0.016
Stc2	stanniocalcin 2	0.015
Dhcr7	7-dehydrocholesterol reductase	0.015
Agrp	agouti related protein	0.015
Abhd5	abhydrolase domain containing 5	0.015
Ceacam2	carcinoembryonic antigen-related cell adhesion molecule 2	0.015
Tcf21	transcription factor 21	0.015
Itga3	integrin alpha 3	0.015
Uts2r	urotensin 2 receptor	0.015
Wap	whey acidic protein	0.015
Pak4	p21 protein (Cdc42/Rac)-activated kinase 4	0.015
Slc7a9	solute carrier family 7 (cationic amino acid transporter, y+ system), member 9	0.015
Sqle	squalene epoxidase	0.014
Ltbr	lymphotoxin B receptor	0.014
Bmp7	bone morphogenetic protein 7	0.014
Ghr	growth hormone receptor	0.014
Crtc3	CREB regulated transcription coactivator 3	0.014
Wt1	Wilms tumor 1 homolog	0.014
Cela1	chymotrypsin-like elastase family, member 1	0.014
Nrtn	neurturin	0.014
Cav1	caveolin 1, caveolae protein	0.013
Capn9	calpain 9	0.013
Fabp2	fatty acid binding protein 2, intestinal	0.013
Rapsn	receptor-associated protein of the synapse	0.013
Slc12a3	solute carrier family 12, member 3	0.013
Lef1	lymphoid enhancer binding factor 1	0.013
Grb7	growth factor receptor bound protein 7	0.013
Slc30a3	solute carrier family 30 (zinc transporter), member 3	0.013
Irak4	interleukin-1 receptor-associated kinase 4	0.012
Folr1	folate receptor 1 (adult)	0.012
Pigt	phosphatidylinositol glycan anchor biosynthesis, class T	0.012
Mks1	Meckel syndrome, type 1	0.012
Galnt3	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 3	0.012
Otp	orthopedia homolog (Drosophila)	0.012
Kif7	kinesin family member 7	0.012
Chd7	chromodomain helicase DNA binding protein 7	0.012
Lrp6	low density lipoprotein receptor-related protein 6	0.012	Mouse
1810021B22Rik	RIKEN cDNA 1810021B22 gene	0.012
Sox3	SRY-box containing gene 3	0.012
Slc22a12	solute carrier family 22 (organic anion/cation transporter), member 12	0.012
Elf3	E74-like factor 3	0.012
H6pd	hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase)	0.012
Mas1	MAS1 oncogene	0.012
Cyp11a1	cytochrome P450, family 11, subfamily a, polypeptide 1	0.012
Ltk	leukocyte tyrosine kinase	0.012
Mesdc2	mesoderm development candidate 2	0.012
Man1b1	mannosidase, alpha, class 1B, member 1	0.012
Wdr19	WD repeat domain 19	0.011
Gdf9	growth differentiation factor 9	0.011
Krtap5-1	keratin associated protein 5-1	0.011
Cacna1s	calcium channel, voltage-dependent, L type, alpha 1S subunit	0.011
Tex19.2	testis expressed gene 19.2	0.011
Lyz2	lysozyme 2	0.011
Stat3	signal transducer and activator of transcription 3	0.011
Mesp2	mesoderm posterior 2	0.011
Dhcr24	24-dehydrocholesterol reductase	0.011
Cilp2	cartilage intermediate layer protein 2	0.011
Rsph1	radial spoke head 1 homolog (Chlamydomonas)	0.011
Slc3a1	solute carrier family 3, member 1	0.011
Sct	secretin	0.011
Olfr15	olfactory receptor 15	0.011
Rab17	RAB17, member RAS oncogene family	0.011
Fam83h	family with sequence similarity 83, member H	0.011
Fads2	fatty acid desaturase 2	0.011
Llgl2	lethal giant larvae homolog 2 (Drosophila)	0.011
D19Wsu162e	DNA segment, Chr 19, Wayne State University 162, expressed	0.011
Akr1c21	aldo-keto reductase family 1, member C21	0.011
Tsks	testis-specific serine kinase substrate	0.011
Otx1	orthodenticle homolog 1 (Drosophila)	0.011
Phlda2	pleckstrin homology-like domain, family A, member 2	0.011
Hr	hairless	0.011
Crh	corticotropin releasing hormone	0.011
Aqp8	aquaporin 8	0.011
Rs1	retinoschisis (X-linked, juvenile) 1 (human)	0.011
Pmel	premelanosome protein	0.011
Zan	zonadhesin	0.010
Cdh1	cadherin 1	0.010
Pla2g1b	phospholipase A2, group IB, pancreas	0.010	Mouse
Mgmt	O-6-methylguanine-DNA methyltransferase	0.010
Anpep	alanyl (membrane) aminopeptidase	0.010
Fgf8	fibroblast growth factor 8	0.010
Tmprss2	transmembrane protease, serine 2	0.010
Gnat2	guanine nucleotide binding protein, alpha transducing 2	0.010
Nr6a1	nuclear receptor subfamily 6, group A, member 1	0.010
Jup	junction plakoglobin	0.010
Lefty1	left right determination factor 1	0.010
Srp54b	signal recognition particle 54B	0.010
Mep1a	meprin 1 alpha	0.010
Nr0b2	nuclear receptor subfamily 0, group B, member 2	0.010
Slc5a11	solute carrier family 5 (sodium/glucose cotransporter), member 11	0.010
Gh	growth hormone	0.010
P2rx1	purinergic receptor P2X, ligand-gated ion channel, 1	0.010
Miox	myo-inositol oxygenase	0.010
Rhod	ras homolog gene family, member D	0.010