IMP

Process View

Mus musculus

14 genes annotated in mouse

Multi-species View

negative regulation of notch signaling pathway

GO:0045746

Any process that stops, prevents, or reduces the frequency, rate or extent of the Notch signaling pathway.

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Known genes in the process in mouse Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "negative regulation of notch signaling pathway"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "negative regulation of notch signaling pathway" (in gray)

Name	Description	Probability	Func Analog Organism
Vangl2	vang-like 2 (van gogh, Drosophila)	0.991
Notch1	Notch gene homolog 1 (Drosophila)	0.939
Hand2	heart and neural crest derivatives expressed transcript 2	0.636
Dll1	delta-like 1 (Drosophila)	0.491	Mouse
Rb1	retinoblastoma 1	0.469
Msx1	homeobox, msh-like 1	0.462
Gsc	goosecoid homeobox	0.429
Dvl2	dishevelled 2, dsh homolog (Drosophila)	0.393	Fly
Bmp7	bone morphogenetic protein 7	0.385
Psen1	presenilin 1	0.370
Shh	sonic hedgehog	0.357
Zeb1	zinc finger E-box binding homeobox 1	0.323
Cd79a	CD79A antigen (immunoglobulin-associated alpha)	0.304
Cyld	cylindromatosis (turban tumor syndrome)	0.291
Eya1	eyes absent 1 homolog (Drosophila)	0.290
Prrx1	paired related homeobox 1	0.244
Ptk7	PTK7 protein tyrosine kinase 7	0.240
Hand1	heart and neural crest derivatives expressed transcript 1	0.240
Efnb2	ephrin B2	0.239
Rbpj	recombination signal binding protein for immunoglobulin kappa J region	0.230
Foxc1	forkhead box C1	0.209
Tbx1	T-box 1	0.207
Cdkn1b	cyclin-dependent kinase inhibitor 1B	0.201
Hes1	hairy and enhancer of split 1 (Drosophila)	0.186
Sox2	SRY-box containing gene 2	0.149
Gata4	GATA binding protein 4	0.147
Rxra	retinoid X receptor alpha	0.146
Foxc2	forkhead box C2	0.135
Raver2	ribonucleoprotein, PTB-binding 2	0.117
Vangl1	vang-like 1 (van gogh, Drosophila)	0.115
Dlx2	distal-less homeobox 2	0.109
Hey1	hairy/enhancer-of-split related with YRPW motif 1	0.109	Human Mouse
Arrb1	arrestin, beta 1	0.109	Fly
Dvl1	dishevelled, dsh homolog 1 (Drosophila)	0.105	Fly
Arrb2	arrestin, beta 2	0.099	Fly
Ednra	endothelin receptor type A	0.089
Notch3	Notch gene homolog 3 (Drosophila)	0.087
Cd19	CD19 antigen	0.082
Msx2	homeobox, msh-like 2	0.077
Cd22	CD22 antigen	0.074
Dlx6	distal-less homeobox 6	0.074	Mouse
Dlx5	distal-less homeobox 5	0.072	Mouse
Igh	immunoglobulin heavy chain complex	0.071
Jag1	jagged 1	0.070	Mouse Fly
Ror2	receptor tyrosine kinase-like orphan receptor 2	0.070
Six1	sine oculis-related homeobox 1 homolog (Drosophila)	0.069
Hey2	hairy/enhancer-of-split related with YRPW motif 2	0.068
Notch2	Notch gene homolog 2 (Drosophila)	0.067
Pdgfra	platelet derived growth factor receptor, alpha polypeptide	0.067
Tnfrsf19	tumor necrosis factor receptor superfamily, member 19	0.062
Vav2	vav 2 oncogene	0.059	Worm
Pik3cd	phosphatidylinositol 3-kinase catalytic delta polypeptide	0.058
Chd7	chromodomain helicase DNA binding protein 7	0.057
Fgfr1	fibroblast growth factor receptor 1	0.056
Sp6	trans-acting transcription factor 6	0.054
Nrarp	Notch-regulated ankyrin repeat protein	0.053
Tbx2	T-box 2	0.050
Edar	ectodysplasin-A receptor	0.049
Pou2af1	POU domain, class 2, associating factor 1	0.045
Dlx1	distal-less homeobox 1	0.044
Rela	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	0.043
Braf	Braf transforming gene	0.041
Tgfb2	transforming growth factor, beta 2	0.040
Sox18	SRY-box containing gene 18	0.040
Jag2	jagged 2	0.040	Mouse Fly
Pax2	paired box gene 2	0.039
Pax3	paired box gene 3	0.039
Pbx1	pre B-cell leukemia transcription factor 1	0.038
Rspo2	R-spondin 2 homolog (Xenopus laevis)	0.038
Sykb	spleen tyrosine kinase	0.038
Tgfbr2	transforming growth factor, beta receptor II	0.038
Nfkb2	nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100	0.036
Eng	endoglin	0.034
Hes5	hairy and enhancer of split 5 (Drosophila)	0.034
Gdf6	growth differentiation factor 6	0.032	Mouse
Gdf5	growth differentiation factor 5	0.030	Mouse
Disp1	dispatched homolog 1 (Drosophila)	0.028
Arhgap31	Rho GTPase activating protein 31	0.027
Fgf8	fibroblast growth factor 8	0.027
Bmp4	bone morphogenetic protein 4	0.026
Wnt3a	wingless-related MMTV integration site 3A	0.025
Dvl3	dishevelled 3, dsh homolog (Drosophila)	0.025	Fly
She	src homology 2 domain-containing transforming protein E	0.024
Otx2	orthodenticle homolog 2 (Drosophila)	0.024
Mn1	meningioma 1	0.023
Foxg1	forkhead box G1	0.023
Cdkn2d	cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4)	0.023	Mouse
Hoxa2	homeobox A2	0.022
T	brachyury	0.022
Hdac1	histone deacetylase 1	0.022	Worm
Lama5	laminin, alpha 5	0.020
Efs	embryonal Fyn-associated substrate	0.020
Hdac2	histone deacetylase 2	0.019	Worm
Padi3	peptidyl arginine deiminase, type III	0.019
Aicda	activation-induced cytidine deaminase	0.019
Ptpn6	protein tyrosine phosphatase, non-receptor type 6	0.019
Btbd17	BTB (POZ) domain containing 17	0.019
Pten	phosphatase and tensin homolog	0.019
Apc	adenomatosis polyposis coli	0.018
Lfng	LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase	0.018
Cdkn2c	cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)	0.018	Mouse
Fgfr2	fibroblast growth factor receptor 2	0.018
Efna2	ephrin A2	0.018
Ascl1	achaete-scute complex homolog 1 (Drosophila)	0.018
Eda	ectodysplasin-A	0.017
Ptpn14	protein tyrosine phosphatase, non-receptor type 14	0.017
Bmper	BMP-binding endothelial regulator	0.017
Emid2	EMI domain containing 2	0.017
Cd40	CD40 antigen	0.017
Eps15	epidermal growth factor receptor pathway substrate 15	0.017
Traf6	TNF receptor-associated factor 6	0.016
Podxl	podocalyxin-like	0.016
Hoxa1	homeobox A1	0.016
Neurl1a	neuralized homolog 1A (Drosophila)	0.015
Vav3	vav 3 oncogene	0.015	Worm
Ceacam16	carcinoembryonic antigen-related cell adhesion molecule 16	0.015
Ephb2	Eph receptor B2	0.015
Bmp2	bone morphogenetic protein 2	0.015
Dnm1	dynamin 1	0.015
Cnih2	cornichon homolog 2 (Drosophila)	0.015
Acvr1	activin A receptor, type 1	0.014
Emx1	empty spiracles homolog 1 (Drosophila)	0.014
Wnk2	WNK lysine deficient protein kinase 2	0.014
Dsg4	desmoglein 4	0.014
Tcrb	T-cell receptor beta chain	0.014
Ptpn22	protein tyrosine phosphatase, non-receptor type 22 (lymphoid)	0.014
Smo	smoothened homolog (Drosophila)	0.013	Fly
Pax9	paired box gene 9	0.013
Lrp6	low density lipoprotein receptor-related protein 6	0.013
Pou3f1	POU domain, class 3, transcription factor 1	0.013
Nog	noggin	0.013
Smad6	MAD homolog 6 (Drosophila)	0.013
Foxo1	forkhead box O1	0.013
Esam	endothelial cell-specific adhesion molecule	0.013
Acvrl1	activin A receptor, type II-like 1	0.012
Nkd2	naked cuticle 2 homolog (Drosophila)	0.012
Slc6a2	solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2	0.012
Tmem64	transmembrane protein 64	0.012
Bmpr2	bone morphogenic protein receptor, type II (serine/threonine kinase)	0.012
Plxna3	plexin A3	0.012
Tbx18	T-box18	0.012
Nkx2-3	NK2 transcription factor related, locus 3 (Drosophila)	0.012
Vav1	vav 1 oncogene	0.012	Worm
Tnfrsf13c	tumor necrosis factor receptor superfamily, member 13c	0.012
Irs3	insulin receptor substrate 3	0.012
Foxf2	forkhead box F2	0.012
Itga3	integrin alpha 3	0.012
Ybx2	Y box protein 2	0.011
Shank3	SH3/ankyrin domain gene 3	0.011
Nf1	neurofibromatosis 1	0.011
Cilp2	cartilage intermediate layer protein 2	0.011
Prkcd	protein kinase C, delta	0.011
Gja3	gap junction protein, alpha 3	0.011
Mib1	mindbomb homolog 1 (Drosophila)	0.011
Aldh1a2	aldehyde dehydrogenase family 1, subfamily A2	0.011
Trim3	tripartite motif-containing 3	0.011
Chrd	chordin	0.010
Kcnu1	potassium channel, subfamily U, member 1	0.010
Nkx2-5	NK2 transcription factor related, locus 5 (Drosophila)	0.010
Tcrd	T-cell receptor delta chain	0.010
Cd79b	CD79B antigen	0.010
Mta1	metastasis associated 1	0.010
Lef1	lymphoid enhancer binding factor 1	0.010
Myt1l	myelin transcription factor 1-like	0.010
Tsc1	tuberous sclerosis 1	0.010
Gata6	GATA binding protein 6	0.010