IMP

Process View

Mus musculus

3 genes annotated in mouse

Multi-species View

neutrophil differentiation

GO:0030223

The process in which a myeloid precursor cell acquires the specialized features of a neutrophil.

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Known genes in the process in mouse Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "neutrophil differentiation"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "neutrophil differentiation" (in gray)

Name	Description	Probability	Func Analog Organism
Igh	immunoglobulin heavy chain complex	0.935
Ikzf1	IKAROS family zinc finger 1	0.900
Nfkb2	nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100	0.849
Btk	Bruton agammaglobulinemia tyrosine kinase	0.766
Pbx1	pre B-cell leukemia transcription factor 1	0.716
Runx1	runt related transcription factor 1	0.621
Foxp3	forkhead box P3	0.620
Card11	caspase recruitment domain family, member 11	0.597
Cd79a	CD79A antigen (immunoglobulin-associated alpha)	0.592
Cd19	CD19 antigen	0.475
Bcl11a	B-cell CLL/lymphoma 11A (zinc finger protein)	0.369
Map3k14	mitogen-activated protein kinase kinase kinase 14	0.358
Bcl2l11	BCL2-like 11 (apoptosis facilitator)	0.343
Blnk	B-cell linker	0.306
Il2rg	interleukin 2 receptor, gamma chain	0.244
Trp53	transformation related protein 53	0.242
Shc1	src homology 2 domain-containing transforming protein C1	0.220
Tcf3	transcription factor 3	0.207
Tcf7	transcription factor 7, T-cell specific	0.187
Plcg2	phospholipase C, gamma 2	0.165
Grb2	growth factor receptor bound protein 2	0.157
Tnfsf14	tumor necrosis factor (ligand) superfamily, member 14	0.154
Sfpi1	SFFV proviral integration 1	0.133	Zebrafish
Tnf	tumor necrosis factor	0.131
Ptpn6	protein tyrosine phosphatase, non-receptor type 6	0.125
Dok1	docking protein 1	0.123
Il4	interleukin 4	0.118
Shh	sonic hedgehog	0.114
Pik3cd	phosphatidylinositol 3-kinase catalytic delta polypeptide	0.113
Hoxa9	homeobox A9	0.107
Msx1	homeobox, msh-like 1	0.094
Rag1	recombination activating gene 1	0.092
Dok3	docking protein 3	0.083
Parvg	parvin, gamma	0.082
Ltb	lymphotoxin B	0.081
Sykb	spleen tyrosine kinase	0.079
Lta	lymphotoxin A	0.079
Lat	linker for activation of T cells	0.078
Gli3	GLI-Kruppel family member GLI3	0.072
Irf4	interferon regulatory factor 4	0.068
Tcra	T-cell receptor alpha chain	0.062
Fgr	Gardner-Rasheed feline sarcoma viral (Fgr) oncogene homolog	0.060
P2rx7	purinergic receptor P2X, ligand-gated ion channel, 7	0.057
Pstpip1	proline-serine-threonine phosphatase-interacting protein 1	0.056
Tnfrsf13c	tumor necrosis factor receptor superfamily, member 13c	0.053
Lyz2	lysozyme 2	0.053
Ptprc	protein tyrosine phosphatase, receptor type, C	0.053
Lyn	Yamaguchi sarcoma viral (v-yes-1) oncogene homolog	0.051
Inpp5d	inositol polyphosphate-5-phosphatase D	0.048
Cbl	Casitas B-lineage lymphoma	0.047
Flt3	FMS-like tyrosine kinase 3	0.046
Dok2	docking protein 2	0.041
Cd22	CD22 antigen	0.039
Cxcr2	chemokine (C-X-C motif) receptor 2	0.039
Axin2	axin2	0.037
Ncf1	neutrophil cytosolic factor 1	0.037
Irf8	interferon regulatory factor 8	0.037
Hoxb4	homeobox B4	0.035
Zeb1	zinc finger E-box binding homeobox 1	0.035
Meis2	Meis homeobox 2	0.035
Rag2	recombination activating gene 2	0.034
Fcgr2b	Fc receptor, IgG, low affinity IIb	0.033
Hoxa2	homeobox A2	0.033
Hoxa5	homeobox A5	0.031
Fgfr2	fibroblast growth factor receptor 2	0.031
St6galnac3	ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3	0.030
Prkcd	protein kinase C, delta	0.029
Foxn1	forkhead box N1	0.029
Vav1	vav 1 oncogene	0.028
Prf1	perforin 1 (pore forming protein)	0.028
Fmnl1	formin-like 1	0.028
Hes1	hairy and enhancer of split 1 (Drosophila)	0.027
Icos	inducible T-cell co-stimulator	0.027
Foxd2	forkhead box D2	0.027
Dclre1c	DNA cross-link repair 1C, PSO2 homolog (S. cerevisiae)	0.027
Hoxb3	homeobox B3	0.026
Jak3	Janus kinase 3	0.026
Otx2	orthodenticle homolog 2 (Drosophila)	0.025
Lyl1	lymphoblastomic leukemia 1	0.025
Rgs14	regulator of G-protein signaling 14	0.025
Ttc7	tetratricopeptide repeat domain 7	0.025
Mcl1	myeloid cell leukemia sequence 1	0.024
Cxcr5	chemokine (C-X-C motif) receptor 5	0.023
Tnfrsf1a	tumor necrosis factor receptor superfamily, member 1a	0.022
Gab2	growth factor receptor bound protein 2-associated protein 2	0.022
Rac2	RAS-related C3 botulinum substrate 2	0.021
Pou2af1	POU domain, class 2, associating factor 1	0.021
Emx1	empty spiracles homolog 1 (Drosophila)	0.020
Itsn1	intersectin 1 (SH3 domain protein 1A)	0.020
Nfe2	nuclear factor, erythroid derived 2	0.020
Tnfrsf13b	tumor necrosis factor receptor superfamily, member 13b	0.020
Itgal	integrin alpha L	0.019
Gata1	GATA binding protein 1	0.019
Il27ra	interleukin 27 receptor, alpha	0.019
Bmp7	bone morphogenetic protein 7	0.019
Cd33	CD33 antigen	0.019
Hmha1	histocompatibility (minor) HA-1	0.017
Gab1	growth factor receptor bound protein 2-associated protein 1	0.017
Rarb	retinoic acid receptor, beta	0.017
Kit	kit oncogene	0.017
Ptpn22	protein tyrosine phosphatase, non-receptor type 22 (lymphoid)	0.017
Cx3cr1	chemokine (C-X3-C) receptor 1	0.017
Abl1	c-abl oncogene 1, non-receptor tyrosine kinase	0.017
Cd79b	CD79B antigen	0.016
Gata3	GATA binding protein 3	0.016
Epor	erythropoietin receptor	0.016
Nck2	non-catalytic region of tyrosine kinase adaptor protein 2	0.016
Ifitm6	interferon induced transmembrane protein 6	0.016
Gli2	GLI-Kruppel family member GLI2	0.015
Cxcr4	chemokine (C-X-C motif) receptor 4	0.015
Itga4	integrin alpha 4	0.015
Eya1	eyes absent 1 homolog (Drosophila)	0.015
Six4	sine oculis-related homeobox 4 homolog (Drosophila)	0.015
Bcl2	B-cell leukemia/lymphoma 2	0.015
Hoxb6	homeobox B6	0.014
Arid3a	AT rich interactive domain 3A (BRIGHT-like)	0.014
Cdon	cell adhesion molecule-related/down-regulated by oncogenes	0.014
Tox	thymocyte selection-associated high mobility group box	0.014
Ikzf3	IKAROS family zinc finger 3	0.014	Mouse
Il10ra	interleukin 10 receptor, alpha	0.013
Pou2f2	POU domain, class 2, transcription factor 2	0.013
Ebi3	Epstein-Barr virus induced gene 3	0.013
Nfam1	Nfat activating molecule with ITAM motif 1	0.013
Ryr3	ryanodine receptor 3	0.013
Siae	sialic acid acetylesterase	0.013
Gimap1	GTPase, IMAP family member 1	0.013
Hoxa10	homeobox A10	0.013
Csf3r	colony stimulating factor 3 receptor (granulocyte)	0.012	Zebrafish
Atxn1	ataxin 1	0.012
Cd300ld	CD300 molecule-like family member d	0.012
Mmp8	matrix metallopeptidase 8	0.012
Pbx3	pre B-cell leukemia transcription factor 3	0.012
Cd37	CD37 antigen	0.012
Cebpa	CCAAT/enhancer binding protein (C/EBP), alpha	0.012
Itgam	integrin alpha M	0.012
Cd40	CD40 antigen	0.012
Gnaq	guanine nucleotide binding protein, alpha q polypeptide	0.012
Cd300a	CD300A antigen	0.011
Ltf	lactotransferrin	0.011
Il7	interleukin 7	0.011
Spn	sialophorin	0.011
Myb	myeloblastosis oncogene	0.011
Nckap1l	NCK associated protein 1 like	0.011
Myo1f	myosin IF	0.011
Gna15	guanine nucleotide binding protein, alpha 15	0.011
Mmp9	matrix metallopeptidase 9	0.011
Tnfaip8l2	tumor necrosis factor, alpha-induced protein 8-like 2	0.010
Ets1	E26 avian leukemia oncogene 1, 5' domain	0.010
Egr3	early growth response 3	0.010
Tnfaip3	tumor necrosis factor, alpha-induced protein 3	0.010
Drd4	dopamine receptor D4	0.010
Zap70	zeta-chain (TCR) associated protein kinase	0.010
Tbx3	T-box 3	0.010