IMP

Process View

Mus musculus

6 genes annotated in mouse

noradrenergic neuron differentiation

The process in which a relatively unspecialized cell acquires specialized features of an noradrenergic neuron, a neuron that secretes noradrenaline.

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Known genes in the process in mouse Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "noradrenergic neuron differentiation"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "noradrenergic neuron differentiation" (in gray)

Name	Description	Probability	Func Analog Organism
Shh	sonic hedgehog	1.000
Gli3	GLI-Kruppel family member GLI3	1.000
Isl1	ISL1 transcription factor, LIM/homeodomain	1.000
Fgfr2	fibroblast growth factor receptor 2	1.000
Otx2	orthodenticle homolog 2 (Drosophila)	0.999
Pax3	paired box gene 3	0.999
Bmp4	bone morphogenetic protein 4	0.999
Sox9	SRY-box containing gene 9	0.999	Mouse
Six1	sine oculis-related homeobox 1 homolog (Drosophila)	0.999
Msx1	homeobox, msh-like 1	0.999
Fgf8	fibroblast growth factor 8	0.998
Eya1	eyes absent 1 homolog (Drosophila)	0.998
Tcfap2a	transcription factor AP-2, alpha	0.998
Prrx1	paired related homeobox 1	0.998	Mouse
Hand2	heart and neural crest derivatives expressed transcript 2	0.997
Hand1	heart and neural crest derivatives expressed transcript 1	0.996
Foxc1	forkhead box C1	0.991
Tgfb2	transforming growth factor, beta 2	0.991
Prrx2	paired related homeobox 2	0.982	Mouse
Dlx5	distal-less homeobox 5	0.980
Pitx2	paired-like homeodomain transcription factor 2	0.971
Pax6	paired box gene 6	0.971
Chrd	chordin	0.958
Bmp7	bone morphogenetic protein 7	0.957
Fgfr1	fibroblast growth factor receptor 1	0.955
Sox2	SRY-box containing gene 2	0.955	Mouse
Ret	ret proto-oncogene	0.943
Foxc2	forkhead box C2	0.938
Tbx1	T-box 1	0.919
Ednra	endothelin receptor type A	0.909
Phox2b	paired-like homeobox 2b	0.908
Alx4	aristaless-like homeobox 4	0.905
Smo	smoothened homolog (Drosophila)	0.898
Gbx2	gastrulation brain homeobox 2	0.895
Pdgfra	platelet derived growth factor receptor, alpha polypeptide	0.864
Pax2	paired box gene 2	0.823
Gli2	GLI-Kruppel family member GLI2	0.786
Ror2	receptor tyrosine kinase-like orphan receptor 2	0.775
Fgf10	fibroblast growth factor 10	0.739
Ntf3	neurotrophin 3	0.728
Gsc	goosecoid homeobox	0.667
Rarb	retinoic acid receptor, beta	0.646
Rspo2	R-spondin 2 homolog (Xenopus laevis)	0.638
Sox11	SRY-box containing gene 11	0.584
Ascl1	achaete-scute complex homolog 1 (Drosophila)	0.553
Nkx2-5	NK2 transcription factor related, locus 5 (Drosophila)	0.545
Zeb1	zinc finger E-box binding homeobox 1	0.544
Hes1	hairy and enhancer of split 1 (Drosophila)	0.525
Msx2	homeobox, msh-like 2	0.523
Erbb3	v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)	0.451
Jag1	jagged 1	0.439
Meox2	mesenchyme homeobox 2	0.402
Foxg1	forkhead box G1	0.392
Chd7	chromodomain helicase DNA binding protein 7	0.391
Sox4	SRY-box containing gene 4	0.386
Nog	noggin	0.382
Emx1	empty spiracles homolog 1 (Drosophila)	0.363
Pitx1	paired-like homeodomain transcription factor 1	0.354
Six4	sine oculis-related homeobox 4 homolog (Drosophila)	0.336
Runx2	runt related transcription factor 2	0.322
Gfra1	glial cell line derived neurotrophic factor family receptor alpha 1	0.318
Alx3	aristaless-like homeobox 3	0.308
Ptpn11	protein tyrosine phosphatase, non-receptor type 11	0.282
Pbx1	pre B-cell leukemia transcription factor 1	0.272
Hoxa1	homeobox A1	0.270
Fgfr3	fibroblast growth factor receptor 3	0.267
Bmp2	bone morphogenetic protein 2	0.230
Alx1	ALX homeobox 1	0.222
Fgf3	fibroblast growth factor 3	0.222
Lmx1b	LIM homeobox transcription factor 1 beta	0.221
Gata4	GATA binding protein 4	0.216
Hes5	hairy and enhancer of split 5 (Drosophila)	0.207
Gdnf	glial cell line derived neurotrophic factor	0.195
Neurod1	neurogenic differentiation 1	0.188
Mycn	v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)	0.183
Neurog2	neurogenin 2	0.165
Lhx3	LIM homeobox protein 3	0.161
Rarg	retinoic acid receptor, gamma	0.134
Vegfa	vascular endothelial growth factor A	0.120
Acvr1	activin A receptor, type 1	0.120
Foxi3	forkhead box I3	0.113
Hoxa2	homeobox A2	0.109
Nrg1	neuregulin 1	0.101
She	src homology 2 domain-containing transforming protein E	0.098
Dlx2	distal-less homeobox 2	0.093
Efnb2	ephrin B2	0.091
Vangl2	vang-like 2 (van gogh, Drosophila)	0.088
Pou5f1	POU domain, class 5, transcription factor 1	0.088
Nkx2-2	NK2 transcription factor related, locus 2 (Drosophila)	0.081
Ednrb	endothelin receptor type B	0.080
Ntrk2	neurotrophic tyrosine kinase, receptor, type 2	0.078
Tbx15	T-box 15	0.078
Nkx6-1	NK6 homeobox 1	0.078
Hoxd13	homeobox D13	0.075
Cldn5	claudin 5	0.071
Ptprb	protein tyrosine phosphatase, receptor type, B	0.071
Sall3	sal-like 3 (Drosophila)	0.070
Nrtn	neurturin	0.069
Sall4	sal-like 4 (Drosophila)	0.068
Dlx6	distal-less homeobox 6	0.067
Bdnf	brain derived neurotrophic factor	0.067
Sox18	SRY-box containing gene 18	0.065	Mouse
Phox2a	paired-like homeobox 2a	0.065
Col2a1	collagen, type II, alpha 1	0.063
Ctnnb1	catenin (cadherin associated protein), beta 1	0.060
Nos3	nitric oxide synthase 3, endothelial cell	0.060
Smad6	MAD homolog 6 (Drosophila)	0.059
Nf1	neurofibromatosis 1	0.057
Sox7	SRY-box containing gene 7	0.057	Mouse
Twist2	twist homolog 2 (Drosophila)	0.056
Otx1	orthodenticle homolog 1 (Drosophila)	0.054
Erbb2	v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)	0.051
Sox17	SRY-box containing gene 17	0.051	Mouse
Aldh1a2	aldehyde dehydrogenase family 1, subfamily A2	0.050
Sox10	SRY-box containing gene 10	0.047	Mouse
Tie1	tyrosine kinase with immunoglobulin-like and EGF-like domains 1	0.046
Emx2	empty spiracles homolog 2 (Drosophila)	0.045
Gas1	growth arrest specific 1	0.041
Rara	retinoic acid receptor, alpha	0.041
Lef1	lymphoid enhancer binding factor 1	0.040
Wnt3a	wingless-related MMTV integration site 3A	0.038
Itgb1	integrin beta 1 (fibronectin receptor beta)	0.036
Ptch1	patched homolog 1	0.036
Kdr	kinase insert domain protein receptor	0.036
Sox3	SRY-box containing gene 3	0.036	Mouse
Nkx2-3	NK2 transcription factor related, locus 3 (Drosophila)	0.035
Eng	endoglin	0.035
Pax9	paired box gene 9	0.035
Fgf4	fibroblast growth factor 4	0.033
Bcl6b	B-cell CLL/lymphoma 6, member B	0.033
Atoh7	atonal homolog 7 (Drosophila)	0.033
Tcfap2c	transcription factor AP-2, gamma	0.032
Tbx3	T-box 3	0.032
Mn1	meningioma 1	0.032
Emcn	endomucin	0.031
Trp63	transformation related protein 63	0.031
Dlx1	distal-less homeobox 1	0.030
Insm1	insulinoma-associated 1	0.029
Ebf3	early B-cell factor 3	0.029
Six3	sine oculis-related homeobox 3 homolog (Drosophila)	0.028
Nkx3-2	NK3 homeobox 2	0.028
Aplnr	apelin receptor	0.027
Lmx1a	LIM homeobox transcription factor 1 alpha	0.026
Onecut1	one cut domain, family member 1	0.026
Hesx1	homeobox gene expressed in ES cells	0.026
Pkd1	polycystic kidney disease 1 homolog	0.025
Hoxb13	homeobox B13	0.024
Tcf15	transcription factor 15	0.024
Hey2	hairy/enhancer-of-split related with YRPW motif 2	0.024
Lhx5	LIM homeobox protein 5	0.024
En1	engrailed 1	0.024
Hoxa3	homeobox A3	0.020
En2	engrailed 2	0.020
Gja4	gap junction protein, alpha 4	0.019
Foxd2	forkhead box D2	0.018
Hspg2	perlecan (heparan sulfate proteoglycan 2)	0.018
Neurog3	neurogenin 3	0.018
Btbd17	BTB (POZ) domain containing 17	0.017
Lhx1	LIM homeobox protein 1	0.017
Pou3f3	POU domain, class 3, transcription factor 3	0.017
Tbx2	T-box 2	0.017
Mesp1	mesoderm posterior 1	0.017
Pou3f1	POU domain, class 3, transcription factor 1	0.016
Dkk1	dickkopf homolog 1 (Xenopus laevis)	0.016
Arx	aristaless related homeobox	0.016
Bmper	BMP-binding endothelial regulator	0.016
Fgf17	fibroblast growth factor 17	0.015
Gata6	GATA binding protein 6	0.015
Esam	endothelial cell-specific adhesion molecule	0.015
Hoxd11	homeobox D11	0.015
Tek	endothelial-specific receptor tyrosine kinase	0.014
Igdcc3	immunoglobulin superfamily, DCC subclass, member 3	0.014
Bmp5	bone morphogenetic protein 5	0.014
Tbx10	T-box 10	0.014
Rasip1	Ras interacting protein 1	0.014
Hoxb1	homeobox B1	0.014
Esrrb	estrogen related receptor, beta	0.013
Twist1	twist homolog 1 (Drosophila)	0.013
Sox1	SRY-box containing gene 1	0.013
Dusp9	dual specificity phosphatase 9	0.013
Wnt5a	wingless-related MMTV integration site 5A	0.013
Edar	ectodysplasin-A receptor	0.013
Gh	growth hormone	0.013
Lrp6	low density lipoprotein receptor-related protein 6	0.012
Pthlh	parathyroid hormone-like peptide	0.012
Foxd1	forkhead box D1	0.012
Cdh5	cadherin 5	0.012
Rxra	retinoid X receptor alpha	0.012
Tcf21	transcription factor 21	0.012
Zic3	zinc finger protein of the cerebellum 3	0.012
Lbx1	ladybird homeobox homolog 1 (Drosophila)	0.012
Ngfr	nerve growth factor receptor (TNFR superfamily, member 16)	0.011
Flt1	FMS-like tyrosine kinase 1	0.011
Col11a1	collagen, type XI, alpha 1	0.011
Htr4	5 hydroxytryptamine (serotonin) receptor 4	0.010
Bnc1	basonuclin 1	0.010