IMP
Process View
trigeminal nerve development
The process whose specific outcome is the progression of the trigeminal nerve over time, from its formation to the mature structure. The trigeminal nerve is composed of three large branches. They are the ophthalmic (V1, sensory), maxillary (V2, sensory) and mandibular (V3, motor and sensory) branches. The sensory ophthalmic branch travels through the superior orbital fissure and passes through the orbit to reach the skin of the forehead and top of the head. The maxillary nerve contains sensory branches that reach the pterygopalatine fossa via the inferior orbital fissure (face, cheek and upper teeth) and pterygopalatine canal (soft and hard palate, nasal cavity and pharynx). The motor part of the mandibular branch is distributed to the muscles of mastication, the mylohyoid muscle and the anterior belly of the digastric. The mandibular nerve also innervates the tensor veli palatini and tensor tympani muscles. The sensory part of the mandibular nerve is composed of branches that carry general sensory information from the mucous membranes of the mouth and cheek, anterior two-thirds of the tongue, lower teeth, skin of the lower jaw, side of the head and scalp and meninges of the anterior and middle cranial fossae.
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In addition to gene-name show these genes:
Click on a gene's description to view its network relationships with genes known to be involved in "trigeminal nerve development"
| Name | Description | Probability | Func Analog Organism | |
|---|---|---|---|---|
| Otx2 | orthodenticle homolog 2 (Drosophila) | 0.999 | ||
| Pax6 | paired box gene 6 | 0.993 | ||
| Sema6a | sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A | 0.991 | Mouse | |
| Ntrk2 | neurotrophic tyrosine kinase, receptor, type 2 | 0.976 | ||
| Gli3 | GLI-Kruppel family member GLI3 | 0.972 | ||
| Pax2 | paired box gene 2 | 0.969 | ||
| Sox2 | SRY-box containing gene 2 | 0.928 | ||
| Ret | ret proto-oncogene | 0.907 | ||
| Emx2 | empty spiracles homolog 2 (Drosophila) | 0.906 | ||
| Arhgef11 | Rho guanine nucleotide exchange factor (GEF) 11 | 0.900 | ||
| Pax3 | paired box gene 3 | 0.897 | ||
| Eya1 | eyes absent 1 homolog (Drosophila) | 0.717 | ||
| Insm1 | insulinoma-associated 1 | 0.696 | ||
| Phox2b | paired-like homeobox 2b | 0.669 | Mouse | |
| Lhx1 | LIM homeobox protein 1 | 0.668 | Mouse | |
| Emx1 | empty spiracles homolog 1 (Drosophila) | 0.651 | ||
| Gfra1 | glial cell line derived neurotrophic factor family receptor alpha 1 | 0.604 | ||
| Shh | sonic hedgehog | 0.562 | ||
| Ednra | endothelin receptor type A | 0.528 | ||
| Msx1 | homeobox, msh-like 1 | 0.515 | ||
| Hes5 | hairy and enhancer of split 5 (Drosophila) | 0.455 | ||
| Chd7 | chromodomain helicase DNA binding protein 7 | 0.431 | ||
| Msx2 | homeobox, msh-like 2 | 0.421 | ||
| Gbx2 | gastrulation brain homeobox 2 | 0.415 | ||
| Erbb3 | v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) | 0.375 | ||
| Dlx5 | distal-less homeobox 5 | 0.359 | ||
| Gfra2 | glial cell line derived neurotrophic factor family receptor alpha 2 | 0.308 | ||
| Gdnf | glial cell line derived neurotrophic factor | 0.285 | ||
| Ror1 | receptor tyrosine kinase-like orphan receptor 1 | 0.244 | ||
| Lhx9 | LIM homeobox protein 9 | 0.243 | Mouse | |
| Tcfap2a | transcription factor AP-2, alpha | 0.234 | ||
| Tbx10 | T-box 10 | 0.226 | ||
| Sox10 | SRY-box containing gene 10 | 0.225 | ||
| Bdnf | brain derived neurotrophic factor | 0.223 | ||
| Six1 | sine oculis-related homeobox 1 homolog (Drosophila) | 0.215 | ||
| Bmp7 | bone morphogenetic protein 7 | 0.201 | ||
| Tcfap2c | transcription factor AP-2, gamma | 0.198 | Mouse | |
| Wnt7b | wingless-related MMTV integration site 7B | 0.196 | ||
| Sall3 | sal-like 3 (Drosophila) | 0.191 | ||
| Fgf8 | fibroblast growth factor 8 | 0.190 | ||
| Nrp2 | neuropilin 2 | 0.178 | ||
| Nrtn | neurturin | 0.169 | ||
| Ngfr | nerve growth factor receptor (TNFR superfamily, member 16) | 0.161 | ||
| Ebf3 | early B-cell factor 3 | 0.160 | ||
| Sox3 | SRY-box containing gene 3 | 0.157 | ||
| Ascl1 | achaete-scute complex homolog 1 (Drosophila) | 0.154 | ||
| Nog | noggin | 0.151 | ||
| Sema3f | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F | 0.145 | ||
| Hoxd13 | homeobox D13 | 0.143 | ||
| Hoxb1 | homeobox B1 | 0.138 | ||
| Nr5a1 | nuclear receptor subfamily 5, group A, member 1 | 0.133 | ||
| Tlx3 | T-cell leukemia, homeobox 3 | 0.130 | ||
| Nr2e1 | nuclear receptor subfamily 2, group E, member 1 | 0.126 | ||
| Chrd | chordin | 0.126 | ||
| Nrg1 | neuregulin 1 | 0.123 | ||
| Epha4 | Eph receptor A4 | 0.114 | ||
| Fgfr2 | fibroblast growth factor receptor 2 | 0.109 | ||
| Foxg1 | forkhead box G1 | 0.107 | ||
| Sall4 | sal-like 4 (Drosophila) | 0.106 | ||
| Maf | avian musculoaponeurotic fibrosarcoma (v-maf) AS42 oncogene homolog | 0.106 | ||
| Sdc3 | syndecan 3 | 0.094 | ||
| Zic2 | zinc finger protein of the cerebellum 2 | 0.089 | ||
| Ldb2 | LIM domain binding 2 | 0.087 | ||
| Atoh7 | atonal homolog 7 (Drosophila) | 0.087 | ||
| Sox11 | SRY-box containing gene 11 | 0.085 | ||
| Alx4 | aristaless-like homeobox 4 | 0.080 | ||
| Foxc1 | forkhead box C1 | 0.078 | ||
| Wnt6 | wingless-related MMTV integration site 6 | 0.075 | ||
| Msi1 | Musashi homolog 1(Drosophila) | 0.070 | ||
| Irx4 | Iroquois related homeobox 4 (Drosophila) | 0.069 | ||
| Flt1 | FMS-like tyrosine kinase 1 | 0.069 | ||
| Nanog | Nanog homeobox | 0.067 | ||
| Tbx15 | T-box 15 | 0.064 | ||
| Arhgef12 | Rho guanine nucleotide exchange factor (GEF) 12 | 0.064 | ||
| Fgf3 | fibroblast growth factor 3 | 0.063 | ||
| Wt1 | Wilms tumor 1 homolog | 0.062 | ||
| Six4 | sine oculis-related homeobox 4 homolog (Drosophila) | 0.061 | ||
| Lama5 | laminin, alpha 5 | 0.061 | ||
| Igdcc3 | immunoglobulin superfamily, DCC subclass, member 3 | 0.059 | ||
| Hand1 | heart and neural crest derivatives expressed transcript 1 | 0.058 | ||
| Fgf18 | fibroblast growth factor 18 | 0.056 | ||
| Plxna4 | plexin A4 | 0.055 | ||
| Cdk5r1 | cyclin-dependent kinase 5, regulatory subunit 1 (p35) | 0.055 | ||
| Foxd1 | forkhead box D1 | 0.054 | ||
| Col9a2 | collagen, type IX, alpha 2 | 0.049 | ||
| Fscn1 | fascin homolog 1, actin bundling protein (Strongylocentrotus purpuratus) | 0.049 | ||
| Ntf3 | neurotrophin 3 | 0.048 | ||
| Isl1 | ISL1 transcription factor, LIM/homeodomain | 0.047 | ||
| Odz2 | odd Oz/ten-m homolog 2 (Drosophila) | 0.047 | ||
| Mycn | v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian) | 0.046 | ||
| Fzd2 | frizzled homolog 2 (Drosophila) | 0.045 | ||
| Dlx1 | distal-less homeobox 1 | 0.045 | ||
| Hoxa11 | homeobox A11 | 0.044 | ||
| Otx1 | orthodenticle homolog 1 (Drosophila) | 0.044 | ||
| Clip2 | CAP-GLY domain containing linker protein 2 | 0.043 | ||
| Prokr2 | prokineticin receptor 2 | 0.043 | ||
| Pitx2 | paired-like homeodomain transcription factor 2 | 0.042 | ||
| Erbb2 | v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) | 0.041 | ||
| Ptch2 | patched homolog 2 | 0.040 | ||
| En1 | engrailed 1 | 0.040 | ||
| Pbx1 | pre B-cell leukemia transcription factor 1 | 0.040 | ||
| Pou3f2 | POU domain, class 3, transcription factor 2 | 0.040 | Mouse | |
| Gjb5 | gap junction protein, beta 5 | 0.040 | ||
| Prrx1 | paired related homeobox 1 | 0.039 | Mouse | |
| Phox2a | paired-like homeobox 2a | 0.039 | Mouse | |
| Mab21l2 | mab-21-like 2 (C. elegans) | 0.038 | ||
| Sema5b | sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5B | 0.038 | ||
| Tcfcp2l1 | transcription factor CP2-like 1 | 0.037 | ||
| Pou4f2 | POU domain, class 4, transcription factor 2 | 0.036 | Mouse | |
| Hoxa1 | homeobox A1 | 0.035 | ||
| Hand2 | heart and neural crest derivatives expressed transcript 2 | 0.035 | ||
| Six3 | sine oculis-related homeobox 3 homolog (Drosophila) | 0.035 | ||
| Lmx1b | LIM homeobox transcription factor 1 beta | 0.034 | Mouse | |
| Osr1 | odd-skipped related 1 (Drosophila) | 0.033 | ||
| Fzd1 | frizzled homolog 1 (Drosophila) | 0.033 | ||
| Lama1 | laminin, alpha 1 | 0.032 | ||
| Tbx1 | T-box 1 | 0.032 | ||
| Neurog2 | neurogenin 2 | 0.032 | ||
| Magel2 | melanoma antigen, family L, 2 | 0.030 | ||
| Htr7 | 5-hydroxytryptamine (serotonin) receptor 7 | 0.029 | ||
| Hoxd11 | homeobox D11 | 0.028 | ||
| Col9a1 | collagen, type IX, alpha 1 | 0.028 | ||
| Zic4 | zinc finger protein of the cerebellum 4 | 0.028 | ||
| Fgf17 | fibroblast growth factor 17 | 0.027 | ||
| Gpr27 | G protein-coupled receptor 27 | 0.027 | ||
| Fgf10 | fibroblast growth factor 10 | 0.027 | ||
| Cacng4 | calcium channel, voltage-dependent, gamma subunit 4 | 0.026 | ||
| Uncx | UNC homeobox | 0.026 | ||
| Mmp24 | matrix metallopeptidase 24 | 0.026 | ||
| Dock4 | dedicator of cytokinesis 4 | 0.026 | ||
| Fjx1 | four jointed box 1 (Drosophila) | 0.025 | ||
| Pde6b | phosphodiesterase 6B, cGMP, rod receptor, beta polypeptide | 0.025 | ||
| Prox1 | prospero-related homeobox 1 | 0.025 | ||
| Sox21 | SRY-box containing gene 21 | 0.024 | ||
| Bcl2 | B-cell leukemia/lymphoma 2 | 0.023 | ||
| Grb10 | growth factor receptor bound protein 10 | 0.022 | ||
| Plxnb3 | plexin B3 | 0.022 | Mouse | |
| Dkk1 | dickkopf homolog 1 (Xenopus laevis) | 0.022 | ||
| Sox1 | SRY-box containing gene 1 | 0.022 | ||
| Plxna1 | plexin A1 | 0.022 | Mouse | |
| Artn | artemin | 0.022 | ||
| Isl2 | insulin related protein 2 (islet 2) | 0.022 | Mouse | |
| Tcfap2b | transcription factor AP-2 beta | 0.021 | Mouse | |
| Hspg2 | perlecan (heparan sulfate proteoglycan 2) | 0.021 | ||
| Foxp2 | forkhead box P2 | 0.021 | ||
| Matn4 | matrilin 4 | 0.021 | ||
| Chrnb2 | cholinergic receptor, nicotinic, beta polypeptide 2 (neuronal) | 0.021 | ||
| Rax | retina and anterior neural fold homeobox | 0.020 | ||
| Arid3a | AT rich interactive domain 3A (BRIGHT-like) | 0.020 | ||
| Onecut2 | one cut domain, family member 2 | 0.020 | ||
| Gdf11 | growth differentiation factor 11 | 0.020 | ||
| Epha3 | Eph receptor A3 | 0.019 | ||
| Igfbpl1 | insulin-like growth factor binding protein-like 1 | 0.019 | ||
| Gfra3 | glial cell line derived neurotrophic factor family receptor alpha 3 | 0.019 | ||
| Mdfi | MyoD family inhibitor | 0.019 | ||
| Rarg | retinoic acid receptor, gamma | 0.019 | ||
| Ncs1 | neuronal calcium sensor 1 | 0.019 | ||
| Pde1b | phosphodiesterase 1B, Ca2+-calmodulin dependent | 0.019 | ||
| Msx3 | homeobox, msh-like 3 | 0.019 | ||
| Tulp1 | tubby like protein 1 | 0.018 | ||
| Nes | nestin | 0.018 | ||
| Cdk5r2 | cyclin-dependent kinase 5, regulatory subunit 2 (p39) | 0.018 | ||
| Cntn2 | contactin 2 | 0.018 | ||
| Fgf15 | fibroblast growth factor 15 | 0.018 | ||
| Epha8 | Eph receptor A8 | 0.018 | ||
| Foxd2 | forkhead box D2 | 0.017 | ||
| Col2a1 | collagen, type II, alpha 1 | 0.017 | ||
| Nppc | natriuretic peptide type C | 0.017 | ||
| Peg10 | paternally expressed 10 | 0.017 | ||
| Vangl2 | vang-like 2 (van gogh, Drosophila) | 0.017 | ||
| Evx1 | even skipped homeotic gene 1 homolog | 0.017 | ||
| Hmx3 | H6 homeobox 3 | 0.017 | ||
| Esrrb | estrogen related receptor, beta | 0.017 | ||
| Atp2b2 | ATPase, Ca++ transporting, plasma membrane 2 | 0.017 | ||
| Grin2d | glutamate receptor, ionotropic, NMDA2D (epsilon 4) | 0.016 | ||
| Cdh13 | cadherin 13 | 0.016 | ||
| Foxh1 | forkhead box H1 | 0.016 | ||
| Kcne1l | potassium voltage-gated channel, Isk-related family, member 1-like, pseudogene | 0.016 | ||
| Nhlh1 | nescient helix loop helix 1 | 0.016 | ||
| Gli2 | GLI-Kruppel family member GLI2 | 0.016 | ||
| Oprd1 | opioid receptor, delta 1 | 0.016 | ||
| S1pr3 | sphingosine-1-phosphate receptor 3 | 0.016 | ||
| Zic1 | zinc finger protein of the cerebellum 1 | 0.015 | ||
| Ddr2 | discoidin domain receptor family, member 2 | 0.015 | ||
| Tead3 | TEA domain family member 3 | 0.015 | ||
| Bmpr1b | bone morphogenetic protein receptor, type 1B | 0.015 | ||
| Dcc | deleted in colorectal carcinoma | 0.015 | ||
| Nr2f1 | nuclear receptor subfamily 2, group F, member 1 | 0.014 | ||
| Neurod2 | neurogenic differentiation 2 | 0.014 | ||
| Sall1 | sal-like 1 (Drosophila) | 0.014 | ||
| Dlx3 | distal-less homeobox 3 | 0.014 | Zebrafish | |
| Pou3f1 | POU domain, class 3, transcription factor 1 | 0.014 | Mouse | |
| Kcna6 | potassium voltage-gated channel, shaker-related, subfamily, member 6 | 0.014 | ||
| A2m | alpha-2-macroglobulin | 0.014 | ||
| Itm2c | integral membrane protein 2C | 0.014 | ||
| Zfhx4 | zinc finger homeodomain 4 | 0.014 | ||
| Pou3f3 | POU domain, class 3, transcription factor 3 | 0.014 | Mouse | |
| Srgap1 | SLIT-ROBO Rho GTPase activating protein 1 | 0.014 | ||
| Neurog1 | neurogenin 1 | 0.014 | ||
| S1pr2 | sphingosine-1-phosphate receptor 2 | 0.014 | ||
| Hapln1 | hyaluronan and proteoglycan link protein 1 | 0.013 | ||
| Hes3 | hairy and enhancer of split 3 (Drosophila) | 0.013 | ||
| Gli1 | GLI-Kruppel family member GLI1 | 0.013 | Zebrafish | |
| Cyp26a1 | cytochrome P450, family 26, subfamily a, polypeptide 1 | 0.013 | ||
| Gad2 | glutamic acid decarboxylase 2 | 0.013 | ||
| Sim2 | single-minded homolog 2 (Drosophila) | 0.013 | ||
| Neurod1 | neurogenic differentiation 1 | 0.013 | ||
| Wnt9b | wingless-type MMTV integration site 9B | 0.013 | ||
| Plxna2 | plexin A2 | 0.012 | Mouse | |
| Hmx1 | H6 homeobox 1 | 0.012 | ||
| Plxna3 | plexin A3 | 0.012 | ||
| Olig2 | oligodendrocyte transcription factor 2 | 0.012 | ||
| Cbln1 | cerebellin 1 precursor protein | 0.012 | ||
| Apc2 | adenomatosis polyposis coli 2 | 0.012 | ||
| BC024139 | cDNA sequence BC024139 | 0.012 | ||
| Gnaq | guanine nucleotide binding protein, alpha q polypeptide | 0.012 | ||
| Kcnj10 | potassium inwardly-rectifying channel, subfamily J, member 10 | 0.012 | ||
| Aif1l | allograft inflammatory factor 1-like | 0.012 | ||
| Axin2 | axin2 | 0.012 | ||
| St8sia2 | ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2 | 0.012 | ||
| T | brachyury | 0.012 | ||
| Cacng7 | calcium channel, voltage-dependent, gamma subunit 7 | 0.012 | ||
| Ntf5 | neurotrophin 5 | 0.012 | ||
| Ptprn2 | protein tyrosine phosphatase, receptor type, N polypeptide 2 | 0.012 | ||
| Adam11 | a disintegrin and metallopeptidase domain 11 | 0.011 | ||
| Cdh3 | cadherin 3 | 0.011 | ||
| Sema3a | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | 0.011 | ||
| Cbx2 | chromobox homolog 2 (Drosophila Pc class) | 0.011 | ||
| Igf2bp1 | insulin-like growth factor 2 mRNA binding protein 1 | 0.011 | ||
| Btbd3 | BTB (POZ) domain containing 3 | 0.011 | ||
| Sirpa | signal-regulatory protein alpha | 0.011 | ||
| Sebox | SEBOX homeobox | 0.011 | ||
| Fzd10 | frizzled homolog 10 (Drosophila) | 0.011 | ||
| Barhl1 | BarH-like 1 (Drosophila) | 0.011 | ||
| Nodal | nodal | 0.011 | ||
| Fev | FEV (ETS oncogene family) | 0.011 | ||
| Ednrb | endothelin receptor type B | 0.011 | ||
| Drd4 | dopamine receptor D4 | 0.011 | ||
| Elavl3 | ELAV (embryonic lethal, abnormal vision, Drosophila)-like 3 (Hu antigen C) | 0.011 | ||
| Sh2b2 | SH2B adaptor protein 2 | 0.011 | ||
| Lbx1 | ladybird homeobox homolog 1 (Drosophila) | 0.010 | ||
| Tlx2 | T-cell leukemia, homeobox 2 | 0.010 | ||
| Dpf1 | D4, zinc and double PHD fingers family 1 | 0.010 | ||
| Fgfr3 | fibroblast growth factor receptor 3 | 0.010 | ||
| Bmp5 | bone morphogenetic protein 5 | 0.010 | ||
| Tmprss5 | transmembrane protease, serine 5 (spinesin) | 0.010 |