IMP

Process View

Mus musculus

13 genes annotated in mouse

autophagic vacuole assembly

The formation of a double membrane-bounded structure, the autophagosome, that occurs when a specialized membrane sac, called the isolation membrane, starts to enclose a portion of the cytoplasm.

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Known genes in the process in mouse Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "autophagic vacuole assembly"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "autophagic vacuole assembly" (in gray)

Name	Description	Probability
Notch2	Notch gene homolog 2 (Drosophila)	0.979
Atg12	autophagy-related 12 (yeast)	0.959
Ulk1	Unc-51 like kinase 1 (C. elegans)	0.892
Ncstn	nicastrin	0.768
Mtor	mechanistic target of rapamycin (serine/threonine kinase)	0.747
Grb10	growth factor receptor bound protein 10	0.744
Atg3	autophagy-related 3 (yeast)	0.724
Atg13	ATG13 autophagy related 13 homolog (S. cerevisiae)	0.682
Gnas	GNAS (guanine nucleotide binding protein, alpha stimulating) complex locus	0.573
Sqstm1	sequestosome 1	0.525
Aph1a	anterior pharynx defective 1a homolog (C. elegans)	0.418
Igf2r	insulin-like growth factor 2 receptor	0.309
Notch1	Notch gene homolog 1 (Drosophila)	0.293
Atg7	autophagy-related 7 (yeast)	0.248
Sesn2	sestrin 2	0.231
Trp53inp2	transformation related protein 53 inducible nuclear protein 2	0.215
Wbp2	WW domain binding protein 2	0.163
App	amyloid beta (A4) precursor protein	0.149
Ift57	intraflagellar transport 57 homolog (Chlamydomonas)	0.121
Atp6v1a	ATPase, H+ transporting, lysosomal V1 subunit A	0.117
Pld3	phospholipase D family, member 3	0.116
Igf2	insulin-like growth factor 2	0.100
Ctsb	cathepsin B	0.099
Kif3a	kinesin family member 3A	0.097
Atg2a	ATG2 autophagy related 2 homolog A (S. cerevisiae)	0.091
Pef1	penta-EF hand domain containing 1	0.085
Mks1	Meckel syndrome, type 1	0.084
Crim1	cysteine rich transmembrane BMP regulator 1 (chordin like)	0.077
Atp6v0b	ATPase, H+ transporting, lysosomal V0 subunit B	0.076
Agtr1a	angiotensin II receptor, type 1a	0.072
Glis2	GLIS family zinc finger 2	0.072
Irs2	insulin receptor substrate 2	0.071
Irs1	insulin receptor substrate 1	0.065
Erlin2	ER lipid raft associated 2	0.062
Bsg	basigin	0.057
Psap	prosaposin	0.056
Rb1cc1	RB1-inducible coiled-coil 1	0.051
Cdkn1b	cyclin-dependent kinase inhibitor 1B	0.051
D19Wsu162e	DNA segment, Chr 19, Wayne State University 162, expressed	0.050
Tecr	trans-2,3-enoyl-CoA reductase	0.047
Sirt2	sirtuin 2 (silent mating type information regulation 2, homolog) 2 (S. cerevisiae)	0.046
Vamp4	vesicle-associated membrane protein 4	0.044
Pparg	peroxisome proliferator activated receptor gamma	0.042
Abtb1	ankyrin repeat and BTB (POZ) domain containing 1	0.039
Atg5	autophagy-related 5 (yeast)	0.035
Mapre3	microtubule-associated protein, RP/EB family, member 3	0.035
Gabarap	gamma-aminobutyric acid receptor associated protein	0.033
Mib1	mindbomb homolog 1 (Drosophila)	0.033
Gsk3b	glycogen synthase kinase 3 beta	0.032
Grina	glutamate receptor, ionotropic, N-methyl D-aspartate-associated protein 1 (glutamate binding)	0.031
Mapkap1	mitogen-activated protein kinase associated protein 1	0.028
Sik3	SIK family kinase 3	0.028
Rnf167	ring finger protein 167	0.028
Lepr	leptin receptor	0.027
Ubl7	ubiquitin-like 7 (bone marrow stromal cell-derived)	0.027
Atg10	autophagy-related 10 (yeast)	0.027
Atp6v0d1	ATPase, H+ transporting, lysosomal V0 subunit D1	0.026
Rnf103	ring finger protein 103	0.026
Ift81	intraflagellar transport 81 homolog (Chlamydomonas)	0.026
Mark4	MAP/microtubule affinity-regulating kinase 4	0.026
Ace	angiotensin I converting enzyme (peptidyl-dipeptidase A) 1	0.026
Pex5	peroxisomal biogenesis factor 5	0.026
Aes	amino-terminal enhancer of split	0.025
Ptpn9	protein tyrosine phosphatase, non-receptor type 9	0.025
Mapk9	mitogen-activated protein kinase 9	0.025
Vps35	vacuolar protein sorting 35	0.024
Cript	cysteine-rich PDZ-binding protein	0.024
Bet1	blocked early in transport 1 homolog (S. cerevisiae)	0.023
Uso1	USO1 homolog, vesicle docking protein (yeast)	0.023
Agtr2	angiotensin II receptor, type 2	0.022
Cav1	caveolin 1, caveolae protein	0.022
Pnpla2	patatin-like phospholipase domain containing 2	0.022
Wbp1	WW domain binding protein 1	0.022
Mlst8	MTOR associated protein, LST8 homolog (S. cerevisiae)	0.022
Eif2ak1	eukaryotic translation initiation factor 2 alpha kinase 1	0.021
Rbl2	retinoblastoma-like 2	0.021
Foxg1	forkhead box G1	0.021
Syvn1	synovial apoptosis inhibitor 1, synoviolin	0.020
Chmp1b	chromatin modifying protein 1B	0.019
Dll1	delta-like 1 (Drosophila)	0.018
Ubap1	ubiquitin-associated protein 1	0.018
Lfng	LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase	0.017
Ppp3ca	protein phosphatase 3, catalytic subunit, alpha isoform	0.017
Gabarapl1	gamma-aminobutyric acid (GABA) A receptor-associated protein-like 1	0.017
2510006D16Rik	RIKEN cDNA 2510006D16 gene	0.017
Dgcr2	DiGeorge syndrome critical region gene 2	0.017
Lamp2	lysosomal-associated membrane protein 2	0.017
Dctn1	dynactin 1	0.016
Lrp6	low density lipoprotein receptor-related protein 6	0.016
Slc25a10	solute carrier family 25 (mitochondrial carrier, dicarboxylate transporter), member 10	0.016
Asb8	ankyrin repeat and SOCS box-containing 8	0.016
Ap2b1	adaptor-related protein complex 2, beta 1 subunit	0.016
Ypel3	yippee-like 3 (Drosophila)	0.015
Zfp40	zinc finger protein 40	0.015
Rab33b	RAB33B, member of RAS oncogene family	0.015
Dcaf11	DDB1 and CUL4 associated factor 11	0.015
Dnajb9	DnaJ (Hsp40) homolog, subfamily B, member 9	0.014
Psenen	presenilin enhancer 2 homolog (C. elegans)	0.014
Pex19	peroxisomal biogenesis factor 19	0.014
Lipe	lipase, hormone sensitive	0.014
Narf	nuclear prelamin A recognition factor	0.014
H47	histocompatibility 47	0.013
Bre	brain and reproductive organ-expressed protein	0.013
Mlx	MAX-like protein X	0.013
Dlg4	discs, large homolog 4 (Drosophila)	0.013
Smpd2	sphingomyelin phosphodiesterase 2, neutral	0.013
Ghr	growth hormone receptor	0.013
Fam134a	family with sequence similarity 134, member A	0.013
Bsdc1	BSD domain containing 1	0.013
Foxo1	forkhead box O1	0.013
Smpd1	sphingomyelin phosphodiesterase 1, acid lysosomal	0.013
Ddx3x	DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 3, X-linked	0.013
Pi4k2a	phosphatidylinositol 4-kinase type 2 alpha	0.012
Lpin1	lipin 1	0.012
Slc25a44	solute carrier family 25, member 44	0.012
Mlf2	myeloid leukemia factor 2	0.012
Epn1	epsin 1	0.012
Ube2h	ubiquitin-conjugating enzyme E2H	0.012
Mdm2	transformed mouse 3T3 cell double minute 2	0.012
Hipk1	homeodomain interacting protein kinase 1	0.011
Syap1	synapse associated protein 1	0.011
Hs6st1	heparan sulfate 6-O-sulfotransferase 1	0.011
Atg16l1	autophagy-related 16-like 1 (yeast)	0.011
Pcsk7	proprotein convertase subtilisin/kexin type 7	0.011
Nr1h2	nuclear receptor subfamily 1, group H, member 2	0.011
1500003O03Rik	RIKEN cDNA 1500003O03 gene	0.011
Dhdds	dehydrodolichyl diphosphate synthase	0.011
Tcfcp2	transcription factor CP2	0.011
Cftr	cystic fibrosis transmembrane conductance regulator homolog	0.011
C78339	expressed sequence C78339	0.011
Sgta	small glutamine-rich tetratricopeptide repeat (TPR)-containing, alpha	0.011
Oaz2-ps	ornithine decarboxylase antizyme 2, pseudogene	0.011
Mgrn1	mahogunin, ring finger 1	0.011
Apeh	acylpeptide hydrolase	0.011
Atp6v0a1	ATPase, H+ transporting, lysosomal V0 subunit A1	0.011
Rab5b	RAB5B, member RAS oncogene family	0.011
Meox2	mesenchyme homeobox 2	0.010
Por	P450 (cytochrome) oxidoreductase	0.010
Pdpk1	3-phosphoinositide dependent protein kinase 1	0.010
2310035K24Rik	RIKEN cDNA 2310035K24 gene	0.010
Rab7	RAB7, member RAS oncogene family	0.010