IMP

Process View

Danio rerio

8 genes annotated in zebrafish

retinal pigment epithelium development

The progression of the retinal pigment epithelium over time, from its initial formation to the mature structure. The retinal pigment epithelium is the melanin-containing layer of cells between the retina and the choroid that absorbs scattered and reflected light and removes waste products produced by the photoreceptor cells.

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Known genes in the process in zebrafish Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "retinal pigment epithelium development"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "retinal pigment epithelium development" (in gray)

Name	Description	Probability	Func Analog Organism
atp6v0ca	ATPase, H+ transporting, lysosomal, V0 subunit c, a	0.928
otx2	orthodenticle homolog 2	0.703
atp6v1e1b	ATPase, H+ transporting, lysosomal, V1 subunit E isoform 1b	0.669
tbx2b	T-box 2b	0.556
pax6b	paired box gene 6b	0.540
pax6a	paired box gene 6a	0.520
atp6v0d1	ATPase, H+ transporting, V0 subunit D isoform 1	0.504
fgf8a	fibroblast growth factor 8 a	0.495
six3b	sine oculis homeobox homolog 3b	0.469
atp6ap1	ATPase, H+ transporting, lysosomal accessory protein 1	0.451
pax8	paired box gene 8	0.371
tcf7l2	transcription factor 7-like 2 (T-cell specific, HMG-box)	0.350
shha	sonic hedgehog a	0.317
slc45a2	solute carrier family 45, member 2	0.312
prdm1a	PR domain containing 1a, with ZNF domain	0.287
raraa	retinoic acid receptor, alpha a	0.260
neurog1	neurogenin 1	0.213
ptch1	patched 1	0.213
atp6v1h	ATPase, H+ transporting, lysosomal, V1 subunit H	0.213
rarab	retinoic acid receptor, alpha b	0.202
foxd3	forkhead box D3	0.177
rx3	retinal homeobox gene 3	0.176
sox2	SRY-box containing gene 2	0.171
ptch2	patched 2	0.171
wnt8b	wingless-type MMTV integration site family, member 8b	0.165
ephb3a	eph receptor B3a	0.124
zic2a	zic family member 2 (odd-paired homolog, Drosophila), a	0.124
tfap2a	transcription factor AP-2 alpha	0.119
cdh2	cadherin 2, neuronal	0.109
gbx2	gastrulation brain homeo box 2	0.108
nkx2.1a	NK2 homeobox 1a	0.104
ndr2	nodal-related 2	0.098
foxi1	forkhead box I1	0.096
mitfa	microphthalmia-associated transcription factor a	0.089
atp6ap2	ATPase, H+ transporting, lysosomal accessory protein 2	0.084
cdipt	CDP-diacylglycerol--inositol 3-phosphatidyltransferase (phosphatidylinositol synthase)	0.083
crb2a	crumbs homolog 2a	0.082
otx1b	orthodenticle homolog 1b	0.079
msxe	muscle segment homeobox E	0.074
dla	deltaA	0.073
rx2	retinal homeobox gene 2	0.072
atp6v1f	ATPase, H+ transporting, V1 subunit F	0.067
chd	chordin	0.066
wnt1	wingless-type MMTV integration site family, member 1	0.062
dbx1a	developing brain homeobox 1a	0.060
rx1	retinal homeobox gene 1	0.059
fezf2	FEZ family zinc finger 2	0.059
nr2e3	nuclear receptor subfamily 2, group E, member 3	0.058
ntla	no tail a	0.056
zgc:100919	zgc:100919	0.055
flh	floating head	0.053
atp6v1ba	ATPase, H+ transporting, lysosomal, V1 subunit B, member a	0.053
aanat2	arylalkylamine N-acetyltransferase	0.053
mdkb	midkine-related growth factor b	0.053
her8a	hairy-related 8a	0.050
ncor1	nuclear receptor co-repressor 1	0.046
tp53	tumor protein p53	0.046
dmbx1a	diencephalon/mesencephalon homeobox 1a	0.043
csf1ra	colony stimulating factor 1 receptor, a	0.042
dlx2a	distal-less homeobox gene 2a	0.042
foxa2	forkhead box A2	0.042
ift88	intraflagellar transport 88 homolog	0.041
irx1b	iroquois homeobox protein 1, b	0.041
six3a	sine oculis homeobox homolog 3a	0.039
sox9b	SRY-box containing gene 9b	0.039
cyp26c1	cytochrome P450, family 26, subfamily C, polypeptide 1	0.038
zic1	zic family member 1 (odd-paired homolog, Drosophila)	0.037
rho	rhodopsin	0.037
irx7	iroquois homeobox protein 7	0.034
lratb	lecithin retinol acyltransferase b (phosphatidylcholine--retinol O-acyltransferase b)	0.034
otx5	orthodenticle homolog 5	0.034	Zebrafish
sox9a	SRY-box containing gene 9a	0.032
pmela	premelanosome protein a	0.030
mpp5a	membrane protein, palmitoylated 5a (MAGUK p55 subfamily member 5a)	0.029
sox19b	SRY-box containing gene 19b	0.029
crx	cone-rod homeobox	0.029	Zebrafish
wnt4a	wingless-type MMTV integration site family, member 4a	0.029
tcf7l1a	transcription factor 7-like 1a (T-cell specific, HMG-box)	0.028
mab21l2	mab-21-like 2	0.028
lrrc6	leucine rich repeat containing 6	0.028
smo	smoothened homolog (Drosophila)	0.026
sox3	SRY-box containing gene 3	0.025
boc	brother of CDO	0.025
atoh7	atonal homolog 7	0.025
cdx4	caudal type homeo box transcription factor 4	0.024
sox10	SRY-box containing gene 10	0.023
pde6c	phosphodiesterase 6C, cGMP-specific, cone, alpha prime	0.022
eng2b	engrailed 2b	0.021
nr2e1	nuclear receptor subfamily 2, group E, member 1	0.021
epb41l5	erythrocyte membrane protein band 4.1 like 5	0.020
her5	hairy-related 5	0.020
gli1	GLI-Kruppel family member 1	0.020
fzd10	frizzled homolog 10	0.020
znf503	zinc finger protein 503	0.019
tfec	transcription factor EC	0.019
sp7	Sp7 transcription factor	0.018
st8sia4	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4	0.018
ptpro	protein tyrosine phosphatase, receptor type, O	0.018
hdac1	histone deacetylase 1	0.018
dctn1a	dynactin 1a	0.018
gc3	guanylyl cyclase 3	0.018
kita	kit receptor a	0.017
pou5f1	POU domain, class 5, transcription factor 1	0.017
tyrp1b	tyrosinase-related protein 1b	0.017
fgf3	fibroblast growth factor 3	0.017
neurod4	neurogenic differentiation 4	0.016
slc24a5	solute carrier family 24, member 5	0.016
extl3	exostoses (multiple)-like 3	0.016
dlx3b	distal-less homeobox gene 3b	0.015
mll	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila)	0.015
barhl2	BarH-like 2	0.015
otx1a	orthodenticle homolog 1a	0.015
pbx4	pre-B-cell leukemia transcription factor 4	0.015
ascl1a	achaete-scute complex-like 1a (Drosophila)	0.015
pax5	paired box gene 5	0.015
dbx1b	developing brain homeobox 1b	0.015
lhx5	LIM homeobox 5	0.015
emx3	empty spiracles homeobox 3	0.014
cyfip2	cytoplasmic FMR1 interacting protein 2	0.014
nkx1.2la	NK1 transcription factor related 2-like,a	0.014
rnaseka	ribonuclease, RNase K a	0.014
sim2	single-minded homolog 2 (Drosophila)	0.013
eng2a	engrailed 2a	0.013
tyr	tyrosinase	0.013
med12	mediator of RNA polymerase II transcription, subunit 12 homolog	0.013
olig3	oligodendrocyte transcription factor 3	0.013
ptf1a	pancreas specific transcription factor, 1a	0.013
shhb	sonic hedgehog b	0.013
pcdh19	protocadherin 19	0.013
isl1	islet1	0.012
pax2a	paired box gene 2a	0.012	Mouse
smarca4	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4	0.012
sfrp5	secreted frizzled-related protein 5	0.012
sec13	SEC13 homolog (S. cerevisiae)	0.012
adra2a	adrenergic, alpha-2A-, receptor	0.012
snai1b	snail homolog 1b (Drosophila)	0.011
chm	choroideremia	0.011
her3	hairy-related 3	0.011
vox	ventral homeobox	0.011