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Danio rerio

14 genes annotated in zebrafish

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regulation of defense response

GO:0031347

Any process that modulates the frequency, rate or extent of a defense response.

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Known genes in the process in zebrafish Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "regulation of defense response"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "regulation of defense response" (in gray)

Name	Description	Probability	Func Analog Organism
ef1a	elongation factor 1-alpha	0.705
pdcd2	programmed cell death 2	0.456
chuk	conserved helix-loop-helix ubiquitous kinase	0.301	Fly
mpx	myeloid-specific peroxidase	0.218
cyt1	type I cytokeratin, enveloping layer	0.215
nfkbiaa	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha a	0.185	Mouse Fly
epas1b	endothelial PAS domain protein 1b	0.181
cp	ceruloplasmin	0.180
mmp9	matrix metalloproteinase 9	0.167
ripk2	receptor-interacting serine-threonine kinase 2	0.141
spi1	spleen focus forming virus (SFFV) proviral integration oncogene spi1	0.138
nod1	nucleotide-binding oligomerization domain containing 1	0.112
pcsk2	proprotein convertase subtilisin/kexin type 2	0.106
nanos3	nanos homolog 3	0.100
LOC557072	caspase recruitment domain-containing protein 11-like	0.100
ip6k2	inositol hexaphosphate kinase 2	0.099
lpp	LIM domain containing preferred translocation partner in lipoma	0.098
pglyrp5	peptidoglycan recognition protein 5	0.098
tlr9	toll-like receptor 9	0.096
rbp4	retinol binding protein 4, plasma	0.094
stc1l	stanniocalcin 1, like	0.090
tnfa	tumor necrosis factor a (TNF superfamily, member 2)	0.089	Mouse Rat
adrb2a	adrenergic receptor, beta 2a	0.081
tagln2	transgelin 2	0.080
fgfr3	fibroblast growth factor receptor 3	0.078	Fly
fabp11a	fatty acid binding protein 11a	0.072	Mouse
epor	erythropoietin receptor	0.071
il8	interleukin 8	0.068
igf1ra	insulin-like growth factor 1a receptor	0.066
fn1	fibronectin 1	0.062
cry1a	cryptochrome 1a	0.062
gngt1	guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1	0.061
pcsk9	proprotein convertase subtilisin/kexin type 9	0.061
axin2	axin 2 (conductin, axil)	0.060
tlr21	toll-like receptor 21	0.056
tgm2b	transglutaminase 2b	0.056
mcoln1	mucolipin 1	0.055
cebpb	CCAAT/enhancer binding protein (C/EBP), beta	0.054
sh3gl1b	SH3-domain GRB2-like 1b	0.054
pycard	PYD and CARD domain containing	0.052	Human Mouse
rhag	Rhesus blood group-associated glycoprotein	0.052
atf3	activating transcription factor 3	0.050
efnb3b	ephrin B3b	0.050
ctsl1a	cathepsin L, 1 a	0.048
rhcgb	Rhesus blood group, C glycoprotein b	0.043
smc1al	structural maintenance of chromosomes 1A, like	0.043
gcm2	glial cells missing homolog 2 (Drosophila)	0.042
alp	alkaline phosphatase	0.041
bhmt	betaine-homocysteine methyltransferase	0.041
cps1	carbamoyl-phosphate synthase 1, mitochondrial	0.040
lyz	lysozyme	0.037
mtp	microsomal triglyceride transfer protein	0.037
foxi3b	forkhead box I3b	0.036
ctsba	cathepsin B, a	0.035
LOC100000934	hypothetical protein LOC100000934	0.034
avpl	arginine vasopressin-like	0.034
mmp13a	matrix metalloproteinase 13a	0.034	Zebrafish
il6r	interleukin 6 receptor	0.033
tnfb	tumor necrosis factor b (TNF superfamily, member 2)	0.032	Mouse Rat
ptger2a	prostaglandin E receptor 2a (subtype EP2)	0.032
msi1	musashi homolog 1 (Drosophila)	0.032
ptger4b	prostaglandin E receptor 4 (subtype EP4) b	0.032	Human Mouse
psmc5	proteasome (prosome, macropain) 26S subunit, ATPase, 5	0.032
vasa	vasa homolog	0.031
plg	plasminogen	0.031
copg2	coatomer protein complex, subunit gamma 2	0.031
si:dkey-76b14.4	si:dkey-76b14.4	0.031
caspa	caspase a	0.030
ptgs1	prostaglandin-endoperoxide synthase 1	0.029
zgc:171802	zgc:171802	0.029
junb	jun B proto-oncogene	0.029
il1b	interleukin 1, beta and interleukin 1, beta	0.028	Mouse
pglyrp6	peptidoglycan recognition protein 6	0.028
oprk1	opioid receptor, kappa 1	0.028
rel	v-rel reticuloendotheliosis viral oncogene homolog	0.027
tlr4bb	toll-like receptor 4b, duplicate b	0.027	Human Mouse
arrb2b	arrestin, beta 2b	0.027	Human Mouse Fly
sp2	sp2 transcription factor	0.026
setd7	SET domain containing (lysine methyltransferase) 7	0.025
c1qb	complement component 1, q subcomponent, B chain	0.025
spry4	sprouty (Drosophila) homolog 4	0.025
serpinb1	serpin peptidase inhibitor, clade B (ovalbumin), member 1	0.024
tbx1	T-box 1	0.024
rpl37	ribosomal protein L37	0.024
npy7r	neuropeptide Y receptor Y7	0.024
hmgcrb	3-hydroxy-3-methylglutaryl-Coenzyme A reductase b	0.024
nfkbiab	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha b	0.024	Mouse Fly
fn1b	fibronectin 1b	0.024
cd40lg	CD40 ligand	0.023
zgc:123282	zgc:123282	0.023
dab1a	disabled homolog 1a (Drosophila)	0.023
bhlhe40	basic helix-loop-helix family, member e40	0.022
prkcz	protein kinase C, zeta	0.022
si:ch211-195h23.3	si:ch211-195h23.3	0.022
bmp2b	bone morphogenetic protein 2b	0.022
si:ch1073-351m12.1	si:ch1073-351m12.1	0.022
gata5	GATA-binding protein 5	0.022
LOC566708	FL cytokine receptor-like	0.022
wls	wntless homolog (Drosophila)	0.022
tlr18	toll-like receptor 18	0.022
mapk8b	mitogen-activated protein kinase 8b	0.021
ascl1a	achaete-scute complex-like 1a (Drosophila)	0.021
foxi2	forkhead box I2	0.021
LOC799612	prolactin 2	0.021
vwf	von Willebrand factor	0.021
otul	OTU like protein	0.021
si:ch211-140f21.1	si:ch211-140f21.1	0.020
foxi3a	forkhead box I3a	0.020
ighm	immunoglobulin heavy constant mu and immunoglobulin heavy constant mu	0.020
cdh1	cadherin 1, epithelial	0.020
tmem88a	transmembrane protein 88 a	0.019
aldob	aldolase b, fructose-bisphosphate	0.019
spry2	sprouty homolog 2	0.019
tirap	toll-interleukin 1 receptor (TIR) domain containing adaptor protein	0.019
card14	caspase recruitment domain family, member 14	0.019
esama	endothelial cell adhesion molecule a	0.019
ppp2r5ea	protein phosphatase 2, regulatory subunit B', epsilon isoform a	0.019
irf11	interferon regulatory factor 11	0.019
dvl3	dishevelled, dsh homolog 3 (Drosophila)	0.019
adra2a	adrenergic, alpha-2A-, receptor	0.019	Worm
defbl3	defensin, beta-like 3	0.018
spi1l	spleen focus forming virus (SFFV) proviral integration oncogene spi1 like	0.018
kif5bb	kinesin family member 5B, b	0.018
nr3c2	nuclear receptor subfamily 3, group C, member 2	0.018
dab1b	disabled homolog 1b (Drosophila)	0.018
c1qc	complement component 1, q subcomponent, C chain	0.018
tbx18	T-box 18	0.018
fabp1a	fatty acid binding protein 1a, liver	0.018
pdpk1a	3-phosphoinositide dependent protein kinase-1a	0.018
tef	thyrotroph embryonic factor	0.017
adora2aa	adenosine A2a receptor a	0.017	Mouse
yes1	v-yes-1 Yamaguchi sarcoma viral oncogene homolog 1	0.017
ets1a	v-ets erythroblastosis virus E26 oncogene homolog 1a	0.017
trim3a	tripartite motif-containing 3a	0.017
rbpja	recombination signal binding protein for immunoglobulin kappa J region a	0.017
valopa	vertebrate ancient long opsin a	0.017
ca15a	carbonic anhydrase XV a	0.017
nrp2b	neuropilin 2b	0.017
igf1rb	insulin-like growth factor 1b receptor	0.017
hgfa	hepatocyte growth factor a	0.017
nitr4a	novel immune-type receptor 4a	0.017
itih2	inter-alpha (globulin) inhibitor H2	0.017
zgc:112161	zgc:112161	0.017
pcsk1	proprotein convertase subtilisin/kexin type 1	0.016
LOC567678	avidin-like	0.016
prom1b	prominin 1 b	0.016
cd40	CD40 antigen	0.016
ctssb.2	cathepsin S, b.2	0.016	Mouse
huwe1	HECT, UBA and WWE domain containing 1	0.016
traf6	TNF receptor-associated factor 6	0.016
shbg	sex hormone binding globulin	0.016
ikbkg	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma	0.016
sox7	SRY-box containing gene 7	0.016
nos2a	nitric oxide synthase 2a, inducible	0.016
hcrt	hypocretin (orexin) neuropeptide precursor	0.016
pnrc2	proline-rich nuclear receptor coactivator 2	0.016
polb	polymerase (DNA directed), beta	0.016
irak4	interleukin-1 receptor-associated kinase 4	0.016
rorca	RAR-related orphan receptor C a	0.016
ecscr	endothelial cell-specific chemotaxis regulator	0.016
ccr6a	chemokine (C-C motif) receptor 6a	0.016
tnfsf10l	tumor necrosis factor (ligand) superfamily, member 10 like	0.015
cd63	Cd63 antigen	0.015
si:ch211-9d9.3	si:ch211-9d9.3	0.015
oclna	occludin a	0.015
il10	interleukin 10	0.015
zgc:111821	zgc:111821	0.015
pias4b	protein inhibitor of activated STAT, 4b	0.015	Zebrafish
copa	coatomer protein complex, subunit alpha	0.015
elovl1a	elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 1a	0.015
adipor1b	adiponectin receptor 1b	0.015
si:ch211-212m21.5	si:ch211-212m21.5	0.015	Human
cldni	claudin i	0.015
LOC100001239	interferon-induced protein with tetratricopeptide repeats 5-like	0.015
LOC562403	hypothetical LOC562403	0.014
LOC100332193	growth hormone secretagogue receptor type 1-like	0.014
angptl2	angiopoietin-like 2	0.014
c3c	complement component c3c	0.014
camk2g2	calcium/calmodulin-dependent protein kinase (CaM kinase) II gamma 2	0.014
myh11a	myosin, heavy polypeptide 11, smooth muscle a	0.014
kop	askopos	0.014
si:ch211-14k19.8	si:ch211-14k19.8	0.014
crhbp	corticotropin releasing hormone binding protein	0.014
rhbg	Rhesus blood group, B glycoprotein	0.014
slc25a14	solute carrier family 25 (mitochondrial carrier, brain), member 14	0.014
sgpl1	sphingosine-1-phosphate lyase 1	0.014
limk1	LIM domain kinase 1	0.014
prkar1aa	protein kinase, cAMP-dependent, regulatory, type I, alpha (tissue specific extinguisher 1) a	0.014
rhogb	ras homolog gene family, member Gb	0.014
tlr3	toll-like receptor 3	0.014	Human Fly
rrm2b	ribonucleotide reductase M2 b	0.014
LOC555504	novel protocadherin protein	0.013
crfa31.2	IL-4RA-like protein 2	0.013
myhz2	myosin, heavy polypeptide 2, fast muscle specific	0.013
zgc:55891	zgc:55891	0.013
LOC793458	peptide Y-like	0.013
rbm22	RNA binding motif protein 22	0.013
ptgs2a	prostaglandin-endoperoxide synthase 2a	0.013	Mouse Rat
atp6v1ba	ATPase, H+ transporting, lysosomal, V1 subunit B, member a	0.013
c1qa	complement component 1, q subcomponent, A chain	0.013
elk4	ELK4, ETS-domain protein	0.013
cecr1a	cat eye syndrome chromosome region, candidate 1a	0.013
flt1	fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)	0.013
ptges	prostaglandin E synthase	0.013
fcer1g	Fc receptor, IgE, high affinity I, gamma polypeptide	0.013
serpinf2	serine (or cysteine) peptidase inhibitor, clade F, member 2	0.013
cdkn1c	cyclin-dependent kinase inhibitor 1C (p57, Kip2)	0.013
st8sia6	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 6	0.013
nr3c1	nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)	0.013
atp2b1b	ATPase, Ca++ transporting, plasma membrane 1b	0.013
unc5c	unc-5 homolog C (C. elegans)	0.013
emx3	empty spiracles homeobox 3	0.013
sarm1	sterile alpha and TIR motif containing 1	0.012
wasb	Wiskott-Aldrich syndrome (eczema-thrombocytopenia) b	0.012
vtg6	vitellogenin 6	0.012
hspb6	heat shock protein, alpha-crystallin-related, b6	0.012
tlr2	toll-like receptor 2	0.012	Mouse
anxa13	annexin A13	0.012
slc2a1b	solute carrier family 2 (facilitated glucose transporter), member 1b	0.012
msna	moesin a	0.012
fgg	fibrinogen, gamma polypeptide	0.012
atoh1b	atonal homolog 1b	0.012
LOC557722	similar to transient receptor potential cation channel, subfamily M, member 5	0.012
nitr13	novel immune-type receptor 13	0.012
LOC567441	interferon-induced protein with tetratricopeptide repeats 5-like	0.012
cry3	cryptochrome 3	0.012
per3	period homolog 3 (Drosophila)	0.012
tlr20a	toll-like receptor 20a	0.012
ifng1-2	interferon, gamma 1-2	0.011
stat3	signal transduction and activation of transcription 3	0.011
pknox1.2	pbx/knotted 1 homeobox 1.2	0.011
rcn1	reticulocalbin 1, EF-hand calcium binding domain	0.011
vcp	valosin containing protein	0.011
cebpa	CCAAT/enhancer binding protein (C/EBP), alpha	0.011
spns2	spinster homolog 2 (Drosophila)	0.011
org	oogenesis-related gene	0.011
sdprb	serum deprivation response b	0.011
eya2	eyes absent homolog 2 (Drosophila)	0.011
coro1a	coronin, actin binding protein, 1A	0.011
cnr1	cannabinoid receptor 1	0.011	Rat
zgc:152778	zgc:152778	0.011
slc13a3	solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 3	0.011
fxr2	fragile X mental retardation, autosomal homolog 2	0.011
tnfsf10l2	tumor necrosis factor (ligand) superfamily, member 10 like 2	0.011
otc	ornithine carbamoyltransferase	0.011
rap1b	RAS related protein 1b	0.011
si:dkey-8l13.4	si:dkey-8l13.4	0.011
il22	interleukin 22	0.011
si:ch211-284e13.2	si:ch211-284e13.2	0.011
slc12a10.1	solute carrier family 12 (sodium/potassium/chloride transporters), member 10.1	0.011
socs3a	suppressor of cytokine signaling 3a	0.011	Zebrafish Mouse
acvrl1	activin A receptor type II-like 1	0.011	Fly
dnmt4	DNA (cytosine-5-)-methyltransferase 4	0.011
si:dkey-12o15.1	si:dkey-12o15.1	0.011
sult2st1	sulfotransferase family 2, cytosolic sulfotransferase 1	0.011
copz2	zeta2-cop	0.011
hif1ab	hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) b	0.011
ldhbb	lactate dehydrogenase Bb	0.011
sema3aa	semaphorin 3aa	0.011
robo4	roundabout homolog 4	0.010
itga2b	integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41B)	0.010
slc9a1	solute carrier family 9 (sodium/hydrogen exchanger), member 1	0.010
anxa2a	annexin A2a	0.010
tbx21	T-box 21	0.010
ppardb	peroxisome proliferator-activated receptor delta b	0.010	Rat
h1m	linker histone H1M	0.010
zgc:64042	zgc:64042	0.010
clic2	chloride intracellular channel 2	0.010
nitr8	novel immune-type receptor 8	0.010
perp	PERP, TP53 apoptosis effector	0.010
zgc:136878	zgc:136878	0.010
mdm2	transformed 3T3 cell double minute 2 homolog (mouse)	0.010