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Process View

Danio rerio

9 genes annotated in zebrafish

lymphocyte differentiation

The process in which a relatively unspecialized precursor cell acquires specialized features of a lymphocyte. A lymphocyte is a leukocyte commonly found in the blood and lymph that has the characteristics of a large nucleus, a neutral staining cytoplasm, and prominent heterochromatin.

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Known genes in the process in zebrafish Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "lymphocyte differentiation"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "lymphocyte differentiation" (in gray)

Name	Description	Probability	Func Analog Organism
cmyb	transcription factor cmyb	0.964	Human Mouse
ikzf1	IKAROS family zinc finger 1 (Ikaros)	0.719
bmp2b	bone morphogenetic protein 2b	0.664
rag1	recombination activating gene 1	0.519	Mouse
tp53	tumor protein p53	0.495	Mouse
tcf7	transcription factor 7 (T-cell specific, HMG-box)	0.445	Mouse
cdx4	caudal type homeo box transcription factor 4	0.412
bcl2	B-cell leukemia/lymphoma 2	0.394	Mouse
lcp1	lymphocyte cytosolic plastin 1	0.358
trim33	tripartite motif-containing 33	0.329
runx3	runt-related transcription factor 3	0.317
rspo3	R-spondin 3 homolog (Xenopus laevis)	0.293
bmper	BMP binding endothelial regulator	0.289
il7r	interleukin 7 receptor	0.286
flh	floating head	0.259
slc30a7	solute carrier family 30 (zinc transporter), member 7	0.231
ccnd1	cyclin D1	0.225
gata1a	GATA binding protein 1a	0.224
chd	chordin	0.203
lef1	lymphocyte enhancer binding factor 1	0.200	Mouse
tbx1	T-box 1	0.195
cobl	cordon-bleu homolog (mouse)	0.192
ptger4a	prostaglandin E receptor 4 (subtype EP4) a	0.188
spns2	spinster homolog 2 (Drosophila)	0.185
wnt8a	wingless-type MMTV integration site family, member 8a	0.184
dlc	deltaC	0.173
runx1	runt-related transcription factor 1	0.171
nrp2b	neuropilin 2b	0.166
hoxa2b	homeo box A2b	0.158
zgc:64115	zgc:64115	0.152
runx2a	runt-related transcription factor 2a	0.149	Mouse
coro1a	coronin, actin binding protein, 1A	0.136
fgf3	fibroblast growth factor 3	0.134
fzd5	frizzled homolog 5	0.124	Mouse
kita	kit receptor a	0.120	Mouse
anxa11a	annexin A11a	0.119
smoc2	secreted modular calcium binding protein 2	0.114
fgf4	fibroblast growth factor 4	0.112
mmp9	matrix metalloproteinase 9	0.111
rad21	RAD21 homolog (S. pombe)	0.100
id1	inhibitor of DNA binding 1	0.095
ets1a	v-ets erythroblastosis virus E26 oncogene homolog 1a	0.095
egr2b	early growth response 2b	0.095
rest	RE1-silencing transcription factor	0.082
cd247l	CD247 antigen like	0.082
ncor1	nuclear receptor co-repressor 1	0.081	Mouse
tgfb3	transforming growth factor, beta 3	0.078
rpl23a	ribosomal protein L23a	0.077
dnmt4	DNA (cytosine-5-)-methyltransferase 4	0.076
pdlim3a	PDZ and LIM domain 3a	0.075
shhb	sonic hedgehog b	0.072	Mouse
tal1	T-cell acute lymphocytic leukemia 1	0.071
pax5	paired box gene 5	0.070
elk4	ELK4, ETS-domain protein	0.070
jag1b	jagged 1b	0.069
dld	deltaD	0.067
plcb3	phospholipase C, beta 3 (phosphatidylinositol-specific)	0.065
pcdh18b	protocadherin 18b	0.056
lfng	lunatic fringe homolog	0.055
rag2	recombination activating gene 2	0.055	Mouse
krt5	keratin 5	0.055
fzd8a	frizzled homolog 8a	0.054	Mouse
dntt	deoxynucleotidyltransferase, terminal	0.054
gsc	goosecoid	0.053
tp63	tumor protein p63	0.051
lmx1b.1	LIM homeobox transcription factor 1, beta 1	0.051
nme2b.1	non-metastatic cells 2b.1, protein (NM23B) expressed in	0.049
jak3	Janus kinase 3 (a protein tyrosine kinase, leukocyte)	0.047
cxcr4b	chemokine (C-X-C motif), receptor 4b	0.044
gfi1.1	growth factor independent 1.1	0.043
mcm5	MCM5 minichromosome maintenance deficient 5 (S. cerevisiae)	0.043
myca	myelocytomatosis oncogene a	0.043
znf703	zinc finger protein 703	0.042
tfe3a	transcription factor binding to IGHM enhancer 3a	0.042
tbx2b	T-box 2b	0.041
wasb	Wiskott-Aldrich syndrome (eczema-thrombocytopenia) b	0.039
alk	anaplastic lymphoma kinase (Ki-1)	0.036
sfrp5	secreted frizzled-related protein 5	0.036
eomesb	eomesodermin homolog b	0.033	Human Mouse
rarga	retinoic acid receptor gamma a	0.032
erbb3b	v-erb-b2 erythroblastic leukemia viral oncogene homolog 3b	0.031
pdcd2	programmed cell death 2	0.030
gata3	GATA-binding protein 3	0.029	Mouse
msxb	muscle segment homeobox B	0.028
baxa	bcl2-associated X protein, a	0.028	Mouse
pwp2h	PWP2 periodic tryptophan protein homolog (yeast)	0.028
rpl7a	ribosomal protein L7a	0.027
mitfa	microphthalmia-associated transcription factor a	0.027
tfec	transcription factor EC	0.027
rhoab	ras homolog gene family, member Ab	0.026
crip2	cysteine-rich protein 2	0.026
ighm	immunoglobulin heavy constant mu and immunoglobulin heavy constant mu	0.026
hlxb9la	homeo box HB9 like a	0.026
fn1	fibronectin 1	0.024
dusp6	dual specificity phosphatase 6	0.024
cdkn1c	cyclin-dependent kinase inhibitor 1C (p57, Kip2)	0.024
zgc:123327	zgc:123327	0.024
zbtb4	zinc finger and BTB domain containing 4	0.024
mll	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila)	0.024
capns1b	calpain, small subunit 1 b	0.024
lft1	lefty1	0.024
npnt	nephronectin	0.023
cav1	caveolin 1	0.023
wnt1	wingless-type MMTV integration site family, member 1	0.023	Mouse
six4b	sine oculis homeobox homolog 4b	0.022
cdx1b	caudal type homeobox 1 b	0.021
klf4	Kruppel-like factor 4	0.021
wnt10a	wingless-type MMTV integration site family, member 10a	0.021
lgals3l	lectin, galactoside-binding, soluble, 3 (galectin 3)-like	0.020
wnt8b	wingless-type MMTV integration site family, member 8b	0.020
foxa3	forkhead box A3	0.020
abcg2a	ATP-binding cassette, sub-family G (WHITE), member 2a	0.020
tgfb2	transforming growth factor, beta 2	0.019
vsx2	visual system homeobox 2	0.019
pknox1.2	pbx/knotted 1 homeobox 1.2	0.018	Mouse
otpa	orthopedia homolog a	0.018
si:dkeyp-113d7.7	si:dkeyp-113d7.7	0.018
cbfb	core-binding factor, beta subunit	0.018	Mouse
dact2	dapper homolog 2, antagonist of beta-catenin (xenopus)	0.018
mesp2	mesoderm posterior 2 homolog (mouse)	0.018
tcf7l2	transcription factor 7-like 2 (T-cell specific, HMG-box)	0.017
lratb	lecithin retinol acyltransferase b (phosphatidylcholine--retinol O-acyltransferase b)	0.017
cyp26c1	cytochrome P450, family 26, subfamily C, polypeptide 1	0.017
notch3	notch homolog 3	0.017
spry2	sprouty homolog 2	0.017
epcam	epithelial cell adhesion molecule	0.017
fgf8a	fibroblast growth factor 8 a	0.016
ccr9b	chemokine (C-C motif) receptor 9b	0.016
kitlga	kit ligand a	0.016
ptena	phosphatase and tensin homolog A	0.016
foxa2	forkhead box A2	0.016
nkx2.5	NK2 transcription factor related 5	0.015
lmo4a	LIM domain only 4a	0.015
irx3a	iroquois homeobox protein 3a	0.015
col15a1b	collagen, type XV, alpha 1b	0.015
odc1	ornithine decarboxylase 1	0.015
ryk	receptor-like tyrosine kinase	0.015
fgf20a	fibroblast growth factor 20a	0.015
foxn1	forkhead box N1	0.015	Mouse
fzd7a	frizzled homolog 7a	0.015
ltk	leukocyte tyrosine kinase	0.015
mibp2	muscle-specific beta 1 integrin binding protein 2	0.015
prdm1a	PR domain containing 1a, with ZNF domain	0.015	Mouse
eve1	even-skipped-like1	0.014
ntla	no tail a	0.014
gbx2	gastrulation brain homeo box 2	0.014
cdkn1a	cyclin-dependent kinase inhibitor 1A	0.014
hhex	hematopoietically expressed homeobox	0.013
wtap	Wilms tumor 1 associated protein	0.013
nrarpa	notch-regulated ankyrin repeat protein a	0.013
sart3	squamous cell carcinoma antigen recognised by T cells 3	0.013
foxi3a	forkhead box I3a	0.013
gnb2l1	guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1	0.013
LOC566708	FL cytokine receptor-like	0.013
polr2d	polymerase (RNA) II (DNA directed) polypeptide D	0.013
rarab	retinoic acid receptor, alpha b	0.013	Human
ikzf5	IKAROS family zinc finger 5	0.013
plagl2	pleiomorphic adenoma gene-like 2	0.013
foxa1	forkhead box A1	0.013
zgc:101606	zgc:101606	0.013
ahcy	S-adenosylhomocysteine hydrolase	0.012
sqstm1	sequestosome 1	0.012
si:dkey-204a24.9	si:dkey-204a24.9	0.012
lyz	lysozyme	0.012
mst1rb	macrophage stimulating 1 receptor (c-met-related tyrosine kinase), b	0.012
ndr2	nodal-related 2	0.012
npm4	nucleophosmin/nucleoplasmin, 4	0.012
wu:fb18f06	wu:fb18f06	0.012
col7a1l	collagen type VII alpha 1-like	0.012
fzd10	frizzled homolog 10	0.011
eya2	eyes absent homolog 2 (Drosophila)	0.011
krt4	keratin 4	0.011
zgc:172101	zgc:172101	0.011
tsc22d3	TSC22 domain family, member 3	0.011
tnfrsf18	tumor necrosis factor receptor superfamily, member 18	0.011
irx7	iroquois homeobox protein 7	0.011
lycat	lysocardiolipin acyltransferase	0.011
mpx	myeloid-specific peroxidase	0.011
jak1	Janus kinase 1	0.011
rbfox2	RNA binding protein, fox-1 homolog (C. elegans) 2	0.011
il12bb	interleukin 12B, b	0.010
LOC100151531	zinc finger protein Gfi-1b-like	0.010
itga2b	integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41B)	0.010
boc	brother of CDO	0.010
naca	nascent polypeptide-associated complex alpha polypeptide	0.010
efnb1	ephrin B1	0.010
pmela	premelanosome protein a	0.010
lhx3	LIM homeobox 3	0.010
gclm	glutamate-cysteine ligase, modifier subunit	0.010