The network for 'positive regulation of leukocyte chemotaxis' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

positive regulation of leukocyte chemotaxis

Any process that activates or increases the frequency, rate, or extent of leukocyte chemotaxis.

Homo sapiens
Name Description Probability Func Analog Organism
CCR5 chemokine (C-C motif) receptor 5 0.999
CXCL9 chemokine (C-X-C motif) ligand 9 0.995
FLT1 fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor) 0.984
PDGFRB platelet-derived growth factor receptor, beta polypeptide 0.982
CDC42 cell division cycle 42 (GTP binding protein, 25kDa) 0.981
CCL5 chemokine (C-C motif) ligand 5 0.976
PDGFRA platelet-derived growth factor receptor, alpha polypeptide 0.964
CCL4 chemokine (C-C motif) ligand 4 0.957
VEGFA vascular endothelial growth factor A 0.940
CCR1 chemokine (C-C motif) receptor 1 0.931
AXL AXL receptor tyrosine kinase 0.913
S100B S100 calcium binding protein B 0.901
CXCL10 chemokine (C-X-C motif) ligand 10 0.857
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) 0.848
S100A14 S100 calcium binding protein A14 0.815
S100A16 S100 calcium binding protein A16 0.793
CCR7 chemokine (C-C motif) receptor 7 0.789
PDIA3 protein disulfide isomerase family A, member 3 0.785
IFNG interferon, gamma 0.783
NRP1 neuropilin 1 0.760
S100A1 S100 calcium binding protein A1 0.759
CCL22 chemokine (C-C motif) ligand 22 0.742
CCL2 chemokine (C-C motif) ligand 2 0.739
CXCL11 chemokine (C-X-C motif) ligand 11 0.622
DPP4 dipeptidyl-peptidase 4 0.617
CCL19 chemokine (C-C motif) ligand 19 0.595
KDR kinase insert domain receptor (a type III receptor tyrosine kinase) 0.561
CXCL13 chemokine (C-X-C motif) ligand 13 0.519
CCL8 chemokine (C-C motif) ligand 8 0.515
IL12B interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40) 0.490
CCL13 chemokine (C-C motif) ligand 13 0.489
MMP2 matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) 0.479
CCL7 chemokine (C-C motif) ligand 7 0.468
CCR2 chemokine (C-C motif) receptor 2 0.463
MMP9 matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) 0.456
PLAU plasminogen activator, urokinase 0.427
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta 0.415
S100A6 S100 calcium binding protein A6 0.409
IL2RB interleukin 2 receptor, beta 0.409
ABI2 abl-interactor 2 0.400
PLAT plasminogen activator, tissue 0.365
PLAUR plasminogen activator, urokinase receptor 0.335
HCK hemopoietic cell kinase 0.329
PDGFB platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog) 0.314
MAD2L2 MAD2 mitotic arrest deficient-like 2 (yeast) 0.312
MMP12 matrix metallopeptidase 12 (macrophage elastase) 0.312
IL8 interleukin 8 0.308
COL4A1 collagen, type IV, alpha 1 0.306
PLEK pleckstrin 0.302
FYN FYN oncogene related to SRC, FGR, YES 0.299
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.295
CCL18 chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated) 0.292
CCR4 chemokine (C-C motif) receptor 4 0.287
IL2RG interleukin 2 receptor, gamma 0.262
CCL3 chemokine (C-C motif) ligand 3 0.250
CXCR4 chemokine (C-X-C motif) receptor 4 0.246
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) 0.242
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1 0.236
IL1B interleukin 1, beta 0.224
LCP2 lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa) 0.216
CYBB cytochrome b-245, beta polypeptide 0.208
CCL11 chemokine (C-C motif) ligand 11 0.207
C2 complement component 2 0.207
CXCR6 chemokine (C-X-C motif) receptor 6 0.206
TNF tumor necrosis factor 0.206
CAV1 caveolin 1, caveolae protein, 22kDa 0.205
SNX9 sorting nexin 9 0.203
VCAM1 vascular cell adhesion molecule 1 0.199
IL7R interleukin 7 receptor 0.187
CCL20 chemokine (C-C motif) ligand 20 0.177
IL6 interleukin 6 (interferon, beta 2) 0.174
SIGLEC1 sialic acid binding Ig-like lectin 1, sialoadhesin 0.156
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) 0.153
SLAMF7 SLAM family member 7 0.152
CBL Cas-Br-M (murine) ecotropic retroviral transforming sequence 0.152
PLA2G7 phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma) 0.152
PTPRA protein tyrosine phosphatase, receptor type, A 0.146
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.145
AQP9 aquaporin 9 0.143
SLAMF8 SLAM family member 8 0.139
TGFB1 transforming growth factor, beta 1 0.133
CLEC7A C-type lectin domain family 7, member A 0.123
IRF4 interferon regulatory factor 4 0.123
ITGAV integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51) 0.122
FYB FYN binding protein 0.121
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2 0.121
CTNND1 catenin (cadherin-associated protein), delta 1 0.118
VCAN versican 0.116
NCF2 neutrophil cytosolic factor 2 0.116
FN1 fibronectin 1 0.113
LAIR1 leukocyte-associated immunoglobulin-like receptor 1 0.113
COL1A1 collagen, type I, alpha 1 0.112
FGR Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog 0.111
IL18RAP interleukin 18 receptor accessory protein 0.108
FCGR3B Fc fragment of IgG, low affinity IIIb, receptor (CD16b) 0.107
DLG1 discs, large homolog 1 (Drosophila) 0.106
IGFBP5 insulin-like growth factor binding protein 5 0.106
DNM1 dynamin 1 0.105
LST1 leukocyte specific transcript 1 0.103
LAT linker for activation of T cells 0.102
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
cdh5 cadherin 5 0.426
erg v-ets erythroblastosis virus E26 oncogene like (avian) 0.332
fli1a friend leukemia integration 1a 0.289
etv2 ets variant gene 2 0.205
sox7 SRY-box containing gene 7 0.174
tie2 endothelium-specific receptor tyrosine kinase 2 0.165
flt1 fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor) 0.143
plxnd1 plexin D1 0.123
osr1 odd-skipped related 1 (Drosophila) 0.098
kdr kinase insert domain receptor (a type III receptor tyrosine kinase) 0.096
efnb2a ephrin B2a 0.088
tie1 endothelium-specific receptor tyrosine kinase 1 0.083
tll1 tolloid-like 1 0.081
cntn2 contactin 2 0.060
bnc2 basonuclin 2 0.058
dll4 delta-like 4 (Drosophila) 0.053
wu:fv91b12 wu:fv91b12 0.052
cxcl12b chemokine (C-X-C motif) ligand 12b (stromal cell-derived factor 1) 0.051
proc protein C (inactivator of coagulation factors Va and VIIIa) 0.049
nphs1l nephrosis 1, congenital, Finnish type (nephrin)-like 0.047
ltk leukocyte tyrosine kinase 0.044
vegfaa vascular endothelial growth factor Aa 0.044
kita kit receptor a 0.039
hspg2 heparan sulfate proteoglycan 2 0.037
epas1b endothelial PAS domain protein 1b 0.036
emilin1a elastin microfibril interfacer 1a 0.034
nrp1a neuropilin 1a 0.034
postn periostin, osteoblast specific factor 0.033
f2rl1.2 coagulation factor II (thrombin) receptor-like 1.2 0.032
gfi1.1 growth factor independent 1.1 0.030
mmp17a matrix metallopeptidase 17a 0.030
podxl podocalyxin-like 0.029
calcrla calcitonin receptor-like a 0.029
col12a1 collagen, type XII, alpha 1 0.029
si:ch211-173o4.2 si:ch211-173o4.2 0.028
myod1 myogenic differentiation 1 0.028
lyz lysozyme 0.028
myf5 myogenic factor 5 0.028
mafba v-maf musculoaponeurotic fibrosarcoma oncogene family, protein B (avian) 0.027
f2r coagulation factor II (thrombin) receptor 0.027
ptprsa protein tyrosine phosphatase, receptor type, s, a 0.027
emp2 epithelial membrane protein 2 0.026
wt1b wilms tumor 1b 0.026
si:ch211-235f6.2 si:ch211-235f6.2 0.026
ccbe1 collagen and calcium binding EGF domains 1 0.026
col5a1 procollagen, type V, alpha 1 0.025
klf2a Kruppel-like factor 2a 0.025
runx1 runt-related transcription factor 1 0.025
sema3d semaphorin 3d 0.024
bmp4 bone morphogenetic protein 4 0.024
mcamb melanoma cell adhesion molecule b 0.023
ccr9b chemokine (C-C motif) receptor 9b 0.023
fmnl2a formin-like 2a 0.023
tgfb3 transforming growth factor, beta 3 0.022
si:ch73-60e21.1 si:ch73-60e21.1 0.022
plce1 phospholipase C, epsilon 1 0.022
ntn4 netrin 4 0.022
stab2 stabilin 2 0.022
mitfa microphthalmia-associated transcription factor a 0.022
st8sia4 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4 0.021
sulf1 sulfatase 1 0.021
gpr182 G protein-coupled receptor 182 0.021
dab2 disabled homolog 2 (Drosophila) 0.020
kitlga kit ligand a 0.020
sfrp2 secreted frizzled-related protein 2 0.020
si:dkey-261h17.1 si:dkey-261h17.1 0.020
jag1a jagged 1a 0.020
LOC553366 hypothetical protein LOC553366 0.019
vegfc vascular endothelial growth factor c 0.019
pmela premelanosome protein a 0.019
cmyb transcription factor cmyb 0.019
sc:d812 sc:d812 0.019
arap3 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3 0.018
fgf20a fibroblast growth factor 20a 0.018
ptgs1 prostaglandin-endoperoxide synthase 1 0.018
atp6v0d1 ATPase, H+ transporting, V0 subunit D isoform 1 0.018
aplnrb apelin receptor b 0.018
spon2b spondin 2b, extracellular matrix protein 0.018
tal1 T-cell acute lymphocytic leukemia 1 0.017
ren renin 0.017
mrc1a mannose receptor, C type 1a 0.017
si:dkey-12o15.1 si:dkey-12o15.1 0.017
tgfbr2 transforming growth factor, beta receptor II 0.017
rhag Rhesus blood group-associated glycoprotein 0.017
mapk15 mitogen-activated protein kinase 15 0.017
matn4 matrilin 4 0.017
tp63 tumor protein p63 0.016
ptk6a PTK6 protein tyrosine kinase 6a 0.016
csf1ra colony stimulating factor 1 receptor, a 0.016
ca15a carbonic anhydrase XV a 0.016
pax7b paired box gene 7b 0.016
masp2 mannan-binding lectin serine peptidase 2 0.016
ccl25b chemokine (C-C motif) ligand 25b 0.016
nf1b neurofibromin 1b 0.016
ip6k2 inositol hexaphosphate kinase 2 0.016
cbfb core-binding factor, beta subunit 0.016
wtip Wilms tumor 1 interacting protein 0.015
spon2a spondin 2a, extracellular matrix protein 0.015
egr2b early growth response 2b 0.015
ext1b exostoses (multiple) 1b 0.015
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Mus musculus
Name Description Probability Func Analog Organism
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Rattus norvegicus
Name Description Probability Func Analog Organism
Ccl2 chemokine (C-C motif) ligand 2 0.996
Cxcl10 chemokine (C-X-C motif) ligand 10 0.924
Il6 interleukin 6 0.695
Ccl4 chemokine (C-C motif) ligand 4 0.658
Il1b interleukin 1 beta 0.628
Cxcl2 chemokine (C-X-C motif) ligand 2 0.541
Cd14 CD14 molecule 0.524
Cxcl1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) 0.437
RT1-Ba RT1 class II, locus Ba 0.387
Il1a interleukin 1 alpha 0.379
Ccl7 chemokine (C-C motif) ligand 7 0.359
Ccl3 chemokine (C-C motif) ligand 3 0.350
Il2rg interleukin 2 receptor, gamma 0.338
Tcrb T-cell receptor beta chain 0.137
Cd53 Cd53 molecule 0.127
Hck hemopoietic cell kinase 0.109
Il8rb interleukin 8 receptor, beta 0.098
Ccr5 chemokine (C-C motif) receptor 5 0.097
RT1-Da RT1 class II, locus Da 0.092
Icam1 intercellular adhesion molecule 1 0.089
Serpine1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.088
Nkg7 natural killer cell group 7 sequence 0.080
RT1-Bb RT1 class II, locus Bb 0.080
Elk3 ELK3, ETS-domain protein 0.073
Ccl20 chemokine (C-C motif) ligand 20 0.073
Fosl1 fos-like antigen 1 0.072
Ptger4 prostaglandin E receptor 4 (subtype EP4) 0.069
Plek pleckstrin 0.069
Plau plasminogen activator, urokinase 0.068
Mrgprf MAS-related GPR, member F 0.067
Pla2g2a phospholipase A2, group IIA (platelets, synovial fluid) 0.065
Il2rb interleukin 2 receptor, beta 0.064
Thbd thrombomodulin 0.063
Reg3g regenerating islet-derived 3 gamma 0.059
Casp1 caspase 1 0.055
Cd68 Cd68 molecule 0.053
Ccr2 chemokine (C-C motif) receptor 2 0.053
Cd37 CD37 molecule 0.051
Igsf6 immunoglobulin superfamily, member 6 0.051
Laptm5 lysosomal protein transmembrane 5 0.048
Ptprc protein tyrosine phosphatase, receptor type, C 0.047
Socs3 suppressor of cytokine signaling 3 0.046
St8sia4 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4 0.045
Olr1 oxidized low density lipoprotein (lectin-like) receptor 1 0.039
Cd83 CD83 molecule 0.039
Calcrl calcitonin receptor-like 0.039
Ubd ubiquitin D 0.039
Reg3b regenerating islet-derived 3 beta 0.035
Rhoj ras homolog gene family, member J 0.033
Col12a1 collagen, type XII, alpha 1 0.033
Edn1 endothelin 1 0.032
Tyrobp Tyro protein tyrosine kinase binding protein 0.032
P2ry6 pyrimidinergic receptor P2Y, G-protein coupled, 6 0.030
Klrd1 killer cell lectin-like receptor, subfamily D, member 1 0.030
Jak1 Janus kinase 1 0.030
Sele selectin E 0.030
Fcn1 ficolin (collagen/fibrinogen domain containing) 1 0.029
Gzmb granzyme B 0.029
F2rl2 coagulation factor II (thrombin) receptor-like 2 0.029
Prkacb protein kinase, cAMP dependent, catalytic, beta 0.028
Il1rn interleukin 1 receptor antagonist 0.028
Slco2b1 solute carrier organic anion transporter family, member 2b1 0.028
Ly86 lymphocyte antigen 86 0.028
Rab20 RAB20, member RAS oncogene family 0.027
Xcl1 chemokine (C motif) ligand 1 0.027
Gzmk granzyme K 0.026
Pla2g4a phospholipase A2, group IVA (cytosolic, calcium-dependent) 0.026
Cd86 CD86 molecule 0.025
F2rl1 coagulation factor II (thrombin) receptor-like 1 0.025
Pld4 phospholipase D family, member 4 0.024
Neurl3 neuralized homolog 3 (Drosophila) 0.024
Cd8a CD8a molecule 0.023
Ptgs2 prostaglandin-endoperoxide synthase 2 0.023
Lilrb4 leukocyte immunoglobulin-like receptor, subfamily B, member 4 0.023
Csf2rb colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage) 0.023
F13a1 coagulation factor XIII, A1 polypeptide 0.022
Cd69 Cd69 molecule 0.022
Timp3 TIMP metallopeptidase inhibitor 3 0.022
Mmp3 matrix metallopeptidase 3 0.020
Iapp islet amyloid polypeptide 0.019
Cxcl11 chemokine (C-X-C motif) ligand 11 0.019
S1pr2 sphingosine-1-phosphate receptor 2 0.019
Cd4 Cd4 molecule 0.019
Cd44 Cd44 molecule 0.018
Timp1 TIMP metallopeptidase inhibitor 1 0.017
Tfpi2 tissue factor pathway inhibitor 2 0.017
Met met proto-oncogene 0.016
Arl5c ADP-ribosylation factor-like 5C 0.016
Itgad integrin, alpha D 0.016
Arhgdib Rho, GDP dissociation inhibitor (GDI) beta 0.016
Tmem88 transmembrane protein 88 0.016
Sell selectin L 0.015
Lyn v-yes-1 Yamaguchi sarcoma viral related oncogene homolog 0.015
Ngf nerve growth factor (beta polypeptide) 0.015
Ly6c Ly6-C antigen 0.014
Cfd complement factor D (adipsin) 0.014
Fgfr2 fibroblast growth factor receptor 2 0.014
Mmp12 matrix metallopeptidase 12 0.013
Slpi secretory leukocyte peptidase inhibitor 0.013
Ch25h cholesterol 25-hydroxylase 0.013
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism