The network for 'positive regulation of lipase activity' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

positive regulation of lipase activity

Any process that increases the frequency, rate or extent of lipase activity, the hydrolysis of a lipid or phospholipid.

Homo sapiens
Name Description Probability Func Analog Organism
FGFR2 fibroblast growth factor receptor 2 1.000
FGF1 fibroblast growth factor 1 (acidic) 1.000
FGFR1 fibroblast growth factor receptor 1 1.000
CCR5 chemokine (C-C motif) receptor 5 0.994
ARRB1 arrestin, beta 1 0.989
CRK v-crk sarcoma virus CT10 oncogene homolog (avian) 0.988
PDGFRA platelet-derived growth factor receptor, alpha polypeptide 0.986
PLCG1 phospholipase C, gamma 1 0.913
CCL4 chemokine (C-C motif) ligand 4 0.906
FGF10 fibroblast growth factor 10 0.892
CTGF connective tissue growth factor 0.823
SPRR2A small proline-rich protein 2A 0.818
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.809
CCL2 chemokine (C-C motif) ligand 2 0.793
CCL5 chemokine (C-C motif) ligand 5 0.727
ARFIP2 ADP-ribosylation factor interacting protein 2 0.722
CXCL9 chemokine (C-X-C motif) ligand 9 0.620
ANG angiogenin, ribonuclease, RNase A family, 5 0.619
RNASE4 ribonuclease, RNase A family, 4 0.490
NRP1 neuropilin 1 0.478
CCL13 chemokine (C-C motif) ligand 13 0.461
FYB FYN binding protein 0.423
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha) 0.421
PDGFRB platelet-derived growth factor receptor, beta polypeptide 0.373
HP haptoglobin 0.325
SMPD1 sphingomyelin phosphodiesterase 1, acid lysosomal 0.306
LAT linker for activation of T cells 0.297
CCR7 chemokine (C-C motif) receptor 7 0.295
CXCL10 chemokine (C-X-C motif) ligand 10 0.290
RLN3 relaxin 3 0.270
NEDD4 neural precursor cell expressed, developmentally down-regulated 4 0.260
CXCL13 chemokine (C-X-C motif) ligand 13 0.260
GAB1 GRB2-associated binding protein 1 0.252
CBL Cas-Br-M (murine) ecotropic retroviral transforming sequence 0.251
CDH5 cadherin 5, type 2 (vascular endothelium) 0.244
SOS1 son of sevenless homolog 1 (Drosophila) 0.235
PAG1 phosphoprotein associated with glycosphingolipid microdomains 1 0.229
IL8 interleukin 8 0.224
AKT2 v-akt murine thymoma viral oncogene homolog 2 0.208
DARC Duffy blood group, chemokine receptor 0.201
SELE selectin E 0.196
APOC1 apolipoprotein C-I 0.194
TIMP3 TIMP metallopeptidase inhibitor 3 0.185
PTPRB protein tyrosine phosphatase, receptor type, B 0.183
IFNG interferon, gamma 0.176
CCL8 chemokine (C-C motif) ligand 8 0.173
ERBB3 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) 0.173
IDE insulin-degrading enzyme 0.173
BCAR1 breast cancer anti-estrogen resistance 1 0.172
FGF7 fibroblast growth factor 7 0.167
APOC3 apolipoprotein C-III 0.167
ERBB2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) 0.160
CCL18 chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated) 0.158
RAPGEF1 Rap guanine nucleotide exchange factor (GEF) 1 0.155
AKT1 v-akt murine thymoma viral oncogene homolog 1 0.152
CRKL v-crk sarcoma virus CT10 oncogene homolog (avian)-like 0.151
SLC9A3R1 solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1 0.150
CCL11 chemokine (C-C motif) ligand 11 0.142
CCL3 chemokine (C-C motif) ligand 3 0.142
RARA retinoic acid receptor, alpha 0.139
SELP selectin P (granule membrane protein 140kDa, antigen CD62) 0.137
CD2 CD2 molecule 0.116
CCR3 chemokine (C-C motif) receptor 3 0.113
CPA3 carboxypeptidase A3 (mast cell) 0.111
MLF2 myeloid leukemia factor 2 0.106
FASLG Fas ligand (TNF superfamily, member 6) 0.106
PDGFB platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog) 0.106
IL2RB interleukin 2 receptor, beta 0.104
CCL22 chemokine (C-C motif) ligand 22 0.103
CCL19 chemokine (C-C motif) ligand 19 0.102
SHC2 SHC (Src homology 2 domain containing) transforming protein 2 0.101
CXCL5 chemokine (C-X-C motif) ligand 5 0.101
KITLG KIT ligand 0.100
MSTO1 misato homolog 1 (Drosophila) 0.092
FGF2 fibroblast growth factor 2 (basic) 0.090
PTEN phosphatase and tensin homolog 0.088
VCAM1 vascular cell adhesion molecule 1 0.086
TMED2 transmembrane emp24 domain trafficking protein 2 0.086
HPGDS hematopoietic prostaglandin D synthase 0.084
PDGFA platelet-derived growth factor alpha polypeptide 0.082
LCP2 lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa) 0.082
IL7R interleukin 7 receptor 0.081
FGFR3 fibroblast growth factor receptor 3 0.080
STAT4 signal transducer and activator of transcription 4 0.075
CCR2 chemokine (C-C motif) receptor 2 0.073
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.070
ADORA3 adenosine A3 receptor 0.069
KLRB1 killer cell lectin-like receptor subfamily B, member 1 0.069
KDELR2 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2 0.067
AKAP2 A kinase (PRKA) anchor protein 2 0.067
PGF placental growth factor 0.066
KLRD1 killer cell lectin-like receptor subfamily D, member 1 0.066
LCAT lecithin-cholesterol acyltransferase 0.065
VEGFA vascular endothelial growth factor A 0.065
CCR1 chemokine (C-C motif) receptor 1 0.065
APOE apolipoprotein E 0.061
MAPK10 mitogen-activated protein kinase 10 0.060
CYTH2 cytohesin 2 0.059
CDC42 cell division cycle 42 (GTP binding protein, 25kDa) 0.057
CXCL12 chemokine (C-X-C motif) ligand 12 0.056
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
egl-36 Protein EGL-36 0.020
unc-53 Protein UNC-53 0.020
egl-23 Protein EGL-23 0.018
egl-13 Protein EGL-13 0.013
dcn-1 Protein DCN-1 0.012
ZK484.3 Protein ZK484.3 0.012
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Danio rerio
Name Description Probability Func Analog Organism
sema3aa semaphorin 3aa 0.388
ptprsa protein tyrosine phosphatase, receptor type, s, a 0.125
prox1 prospero-related homeobox gene 1 0.088
si:ch73-60e21.1 si:ch73-60e21.1 0.085
fgfr1b fibroblast growth factor receptor 1b 0.082
wif1 wnt inhibitory factor 1 0.079
fgfr2 fibroblast growth factor receptor 2 0.073
abcc5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 0.054
tie2 endothelium-specific receptor tyrosine kinase 2 0.053
il8 interleukin 8 0.033
phex phosphate regulating gene with homologues to endopeptidases on the X chromosome 0.031
ca8 carbonic anhydrase VIII 0.031
rassf8b Ras association (RalGDS/AF-6) domain family 8b 0.031
ptgs1 prostaglandin-endoperoxide synthase 1 0.030
prkcea protein kinase C, epsilon a 0.028
desma desmin a 0.028
sdc2 syndecan 2 0.027
pth1a parathyroid hormone 1a 0.026
tcf12 transcription factor 12 0.026
prdm5 PR domain containing 5 0.026
dcc deleted in colorectal carcinoma 0.026
sgpp1 sphingosine-1-phosphate phosphatase 1 0.026
wu:fj34h01 wu:fj34h01 0.025
cnga5 cyclic nucleotide gated channel alpha 5 0.025
adrbk2 adrenergic, beta, receptor kinase 2 0.024
tfe3b transcription factor binding to IGHM enhancer 3b 0.024
wu:fv91b12 wu:fv91b12 0.024
actn1 actinin, alpha 1 0.023
tln1 talin 1 0.023
keap1b kelch-like ECH-associated protein 1b 0.023
gli3 GLI-Kruppel family member GLI3 0.022
pafah1b1b platelet-activating factor acetylhydrolase, isoform Ib, alpha subunit b 0.022
rcn3 reticulocalbin 3, EF-hand calcium binding domain 0.021
appb amyloid beta (A4) precursor protein b 0.021
sulf1 sulfatase 1 0.021
lrrtm1 leucine rich repeat transmembrane neuronal 1 0.021
cdk8 cyclin-dependent kinase 8 0.021
dlg2 discs, large (Drosophila) homolog 2 0.020
nadl1.1 neural adhesion molecule L1.1 0.020
aplp2 amyloid beta (A4) precursor-like protein 2 0.020
sc:d0319 sc:d0319 0.019
pbx1a pre-B-cell leukemia transcription factor 1a 0.018
gna13b guanine nucleotide binding protein (G protein), alpha 13b 0.018
pcsk5a proprotein convertase subtilisin/kexin type 5a 0.018
kirrela kin of IRRE like a 0.017
trim13 tripartite motif-containing 13 0.017
LOC100007758 novel protein similar to vertebrate SLIT and NTRK-like family, member 3 (SLITRK3) 0.017
foxe1 forkhead box E1 (thyroid transcription factor 2) 0.017
katnb1 katanin p80 (WD repeat containing) subunit B 1 0.016
dcn decorin 0.016
cdon cell adhesion molecule-related/down-regulated by oncogenes 0.016
acsl1 acyl-CoA synthetase long-chain family member 1 0.016
col5a2l collagen, type V, alpha 2-like 0.016
col5a1 procollagen, type V, alpha 1 0.016
col1a2 collagen, type I, alpha 2 0.016
tas2r202 taste receptor, type 2, member 202 0.016
gnas GNAS complex locus 0.015
acp5b acid phosphatase 5b, tartrate resistant 0.015
nfatc1 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1 0.015
gna11 guanine nucleotide binding protein (G protein), alpha 11 (Gq class) 0.015
zgc:101761 zgc:101761 0.015
ntn4 netrin 4 0.015
fibp fibroblast growth factor (acidic) intracellular binding protein 0.015
LOC100003514 protein kinase C alpha type-like 0.015
sc:d411 sc:d411 0.015
nf1b neurofibromin 1b 0.014
tgfb1a transforming growth factor, beta 1a 0.014
si:ch211-160j6.2 si:ch211-160j6.2 0.014
hcrt hypocretin (orexin) neuropeptide precursor 0.014
znf451 zinc finger protein 451 0.014
zgc:112986 zgc:112986 0.014
traf6 TNF receptor-associated factor 6 0.014
ldb3a LIM-domain binding factor 3a 0.014
LOC569142 ectonucleoside triphosphate diphosphohydrolase 2-like 0.013
thrap6 thyroid hormone receptor associated protein 6 0.013
dazl daz-like gene 0.013
neo1 neogenin 1 0.013
itpr1a inositol 1,4,5-triphosphate receptor, type 1a 0.013
flt1 fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor) 0.013
itgb4 integrin, beta 4 0.013
fgf8b fibroblast growth factor 8 b 0.013
ptprja protein tyrosine phosphatase, receptor type, J a 0.013
rnasel3 ribonuclease like 3 0.013
exoc7 exocyst complex component 7 0.013
LOC567131 calcitonin gene-related peptide type 1 receptor-like 0.013
rap1b RAS related protein 1b 0.013
accn2b amiloride-sensitive cation channel 2 b 0.012
fkbp10 FK506 binding protein 10 0.012
zbtb16a zinc finger and BTB domain containing 16a 0.012
skiv2l2 superkiller viralicidic activity 2-like 2 0.012
si:ch211-157h5.2 si:ch211-157h5.2 0.012
lrrc67 leucine rich repeat containing 67 0.012
or103-1 odorant receptor, family C, subfamily 103, member 1 0.012
slc30a9 solute carrier family 30 (zinc transporter), member 9 0.012
aldh1l1 aldehyde dehydrogenase 1 family, member L1 0.012
nr2f2 nuclear receptor subfamily 2, group F, member 2 0.012
gpib glucose phosphate isomerase b 0.012
notch3 notch homolog 3 0.012
ddx41 DEAD (Asp-Glu-Ala-Asp) box polypeptide 41 0.012
fancl Fanconi anemia, complementation group L 0.011
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Drosophila melanogaster
Name Description Probability Func Analog Organism
Src42A Src oncogene at 42A 0.023
Ggamma1 G protein gamma 1 0.021
CkIalpha Casein kinase Ialpha 0.017
bnl branchless 0.014
Hcf Host cell factor 0.013
ird1 immune response deficient 1 0.013
NFAT NFAT homolog 0.013
scb scab 0.013
Plc21C Phospholipase C at 21C 0.012
insc inscuteable 0.012
sr stripe 0.011
wb wing blister 0.011
G-oalpha47A G protein oalpha 47A 0.011
CG15080 CG15080 gene product from transcript CG15080-RA 0.010
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Mus musculus
Name Description Probability Func Analog Organism
Cbl Casitas B-lineage lymphoma 0.483
Ldlr low density lipoprotein receptor 0.445
Fgfr3 fibroblast growth factor receptor 3 0.290
Prrx1 paired related homeobox 1 0.238
Lepr leptin receptor 0.197
Pten phosphatase and tensin homolog 0.175
Fgfr2 fibroblast growth factor receptor 2 0.139
Sox9 SRY-box containing gene 9 0.094
Shh sonic hedgehog 0.087
Runx2 runt related transcription factor 2 0.070
Apoe apolipoprotein E 0.068
Ghr growth hormone receptor 0.066
Adamts1 a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 1 0.058
Ptk2 PTK2 protein tyrosine kinase 2 0.057
Cd79a CD79A antigen (immunoglobulin-associated alpha) 0.034
Fgfrl1 fibroblast growth factor receptor-like 1 0.034
Gnaq guanine nucleotide binding protein, alpha q polypeptide 0.032
Duox2 dual oxidase 2 0.032
Grb2 growth factor receptor bound protein 2 0.031
Nos3 nitric oxide synthase 3, endothelial cell 0.029
Bmp5 bone morphogenetic protein 5 0.027
Blnk B-cell linker 0.027
Inpp5d inositol polyphosphate-5-phosphatase D 0.026
Ptpn11 protein tyrosine phosphatase, non-receptor type 11 0.026
Pdgfra platelet derived growth factor receptor, alpha polypeptide 0.025
Fgfr4 fibroblast growth factor receptor 4 0.023
Igh immunoglobulin heavy chain complex 0.023
Fyn Fyn proto-oncogene 0.023
Csf1 colony stimulating factor 1 (macrophage) 0.020
Trp53 transformation related protein 53 0.020
Thrb thyroid hormone receptor beta 0.019
Amhr2 anti-Mullerian hormone type 2 receptor 0.019
Thra thyroid hormone receptor alpha 0.018
Kiss1 KiSS-1 metastasis-suppressor 0.018
Cd22 CD22 antigen 0.017
Cd247 CD247 antigen 0.017
Pnpla2 patatin-like phospholipase domain containing 2 0.016
Pard3 par-3 (partitioning defective 3) homolog (C. elegans) 0.016
Egfr epidermal growth factor receptor 0.016
Ren1 renin 1 structural 0.015
Lpin1 lipin 1 0.015
Cd19 CD19 antigen 0.015
Was Wiskott-Aldrich syndrome homolog (human) 0.015
Eln elastin 0.015
Tnfrsf11b tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin) 0.014
Fgf7 fibroblast growth factor 7 0.014
Pax8 paired box gene 8 0.014
Itgb2 integrin beta 2 0.013
Prlr prolactin receptor 0.013
Lox lysyl oxidase 0.013
Rarb retinoic acid receptor, beta 0.013
Ptprb protein tyrosine phosphatase, receptor type, B 0.013
Cav1 caveolin 1, caveolae protein 0.012
F3 coagulation factor III 0.012
Fbn1 fibrillin 1 0.012
Ctgf connective tissue growth factor 0.012
Becn1 beclin 1, autophagy related 0.012
Plcg1 phospholipase C, gamma 1 0.011
Lcat lecithin cholesterol acyltransferase 0.011
Prkce protein kinase C, epsilon 0.011
Gli3 GLI-Kruppel family member GLI3 0.011
Esr1 estrogen receptor 1 (alpha) 0.010
Fshr follicle stimulating hormone receptor 0.010
Ptgs2 prostaglandin-endoperoxide synthase 2 0.010
Fas Fas (TNF receptor superfamily member 6) 0.010
Plaur plasminogen activator, urokinase receptor 0.010
Bmp4 bone morphogenetic protein 4 0.010
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Rattus norvegicus
Name Description Probability Func Analog Organism
Slc22a7 solute carrier family 22 (organic anion transporter), member 7 0.032
Ahsg alpha-2-HS-glycoprotein 0.023
Gna12 guanine nucleotide binding protein (G protein) alpha 12 0.022
Rnase4 ribonuclease, RNase A family 4 0.015
Htr2b 5-hydroxytryptamine (serotonin) receptor 2B 0.011
Alb albumin 0.010
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism