The network for 'cholesterol efflux' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

cholesterol efflux

The directed movement of cholesterol, cholest-5-en-3-beta-ol, out of a cell or organelle.

Homo sapiens
Name Description Probability Func Analog Organism
REL v-rel reticuloendotheliosis viral oncogene homolog (avian) 0.959
ALB albumin 0.950
NFKBIB nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta 0.757
APOA1 apolipoprotein A-I 0.746
C1QA complement component 1, q subcomponent, A chain 0.612
RELB v-rel reticuloendotheliosis viral oncogene homolog B 0.527
IRAK2 interleukin-1 receptor-associated kinase 2 0.456
MED15 mediator complex subunit 15 0.443
APOE apolipoprotein E 0.410
TNIP2 TNFAIP3 interacting protein 2 0.390
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.286
APOC1 apolipoprotein C-I 0.212
RRAGC Ras-related GTP binding C 0.211
C1QB complement component 1, q subcomponent, B chain 0.179
STX12 syntaxin 12 0.177
SNTB2 syntrophin, beta 2 (dystrophin-associated protein A1, 59kDa, basic component 2) 0.176
HP haptoglobin 0.169
APBB1 amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65) 0.129
PELI3 pellino homolog 3 (Drosophila) 0.115
SMO smoothened homolog (Drosophila) 0.112
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.085
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100) 0.073
RRAGA Ras-related GTP binding A 0.065
RELA v-rel reticuloendotheliosis viral oncogene homolog A (avian) 0.061
C1QC complement component 1, q subcomponent, C chain 0.057
APOA2 apolipoprotein A-II 0.055
NFKBIE nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon 0.051
NCOA1 nuclear receptor coactivator 1 0.049
C7orf59 chromosome 7 open reading frame 59 0.048
LSS lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase) 0.045
SMPD1 sphingomyelin phosphodiesterase 1, acid lysosomal 0.044
TIRAP toll-interleukin 1 receptor (TIR) domain containing adaptor protein 0.044
SNX3 sorting nexin 3 0.039
CREBBP CREB binding protein 0.039
APOC2 apolipoprotein C-II 0.039
NSF N-ethylmaleimide-sensitive factor 0.038
A2M alpha-2-macroglobulin 0.038
MSTO1 misato homolog 1 (Drosophila) 0.038
AHSG alpha-2-HS-glycoprotein 0.036
LCAT lecithin-cholesterol acyltransferase 0.035
APOB apolipoprotein B (including Ag(x) antigen) 0.033
CACNA1A calcium channel, voltage-dependent, P/Q type, alpha 1A subunit 0.032
ANXA4 annexin A4 0.030
TRIM11 tripartite motif containing 11 0.029
DHCR7 7-dehydrocholesterol reductase 0.029
VAMP4 vesicle-associated membrane protein 4 0.026
FOXO3 forkhead box O3 0.025
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.025
LDLR low density lipoprotein receptor 0.022
FCN2 ficolin (collagen/fibrinogen domain containing lectin) 2 (hucolin) 0.022
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta 0.021
GPNMB glycoprotein (transmembrane) nmb 0.021
OSTM1 osteopetrosis associated transmembrane protein 1 0.020
TTR transthyretin 0.019
INSIG1 insulin induced gene 1 0.019
SIGLEC1 sialic acid binding Ig-like lectin 1, sialoadhesin 0.019
MBL2 mannose-binding lectin (protein C) 2, soluble 0.019
APOC3 apolipoprotein C-III 0.018
VAMP8 vesicle-associated membrane protein 8 (endobrevin) 0.018
CHUK conserved helix-loop-helix ubiquitous kinase 0.017
ASAH1 N-acylsphingosine amidohydrolase (acid ceramidase) 1 0.017
PLTP phospholipid transfer protein 0.016
TREM2 triggering receptor expressed on myeloid cells 2 0.015
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 0.015
FASN fatty acid synthase 0.015
CCPG1 cell cycle progression 1 0.014
SREBF1 sterol regulatory element binding transcription factor 1 0.014
LAMP2 lysosomal-associated membrane protein 2 0.014
SOCS3 suppressor of cytokine signaling 3 0.014
PRCP prolylcarboxypeptidase (angiotensinase C) 0.014
ATP6V1B2 ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B2 0.013
HEXB hexosaminidase B (beta polypeptide) 0.013
MVD mevalonate (diphospho) decarboxylase 0.013
CREBL2 cAMP responsive element binding protein-like 2 0.013
LIPC lipase, hepatic 0.013
STX6 syntaxin 6 0.013
ARL6IP5 ADP-ribosylation-like factor 6 interacting protein 5 0.013
CRP C-reactive protein, pentraxin-related 0.012
LAMTOR3 late endosomal/lysosomal adaptor, MAPK and MTOR activator 3 0.012
KAT2B K(lysine) acetyltransferase 2B 0.012
DUSP23 dual specificity phosphatase 23 0.012
RRAGD Ras-related GTP binding D 0.012
CSTB cystatin B (stefin B) 0.012
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor) 0.012
C4B complement component 4B (Chido blood group) 0.012
HPD 4-hydroxyphenylpyruvate dioxygenase 0.011
FADS1 fatty acid desaturase 1 0.011
GPLD1 glycosylphosphatidylinositol specific phospholipase D1 0.011
SWAP70 SWAP switching B-cell complex 70kDa subunit 0.011
SLCO2B1 solute carrier organic anion transporter family, member 2B1 0.011
KAT5 K(lysine) acetyltransferase 5 0.011
SCARB1 scavenger receptor class B, member 1 0.011
BRI3 brain protein I3 0.011
GPR137B G protein-coupled receptor 137B 0.011
RAD52 RAD52 homolog (S. cerevisiae) 0.011
RRP8 ribosomal RNA processing 8, methyltransferase, homolog (yeast) 0.010
UBL3 ubiquitin-like 3 0.010
MFSD1 major facilitator superfamily domain containing 1 0.010
MVK mevalonate kinase 0.010
ACP5 acid phosphatase 5, tartrate resistant 0.010
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Mus musculus
Name Description Probability Func Analog Organism
Apoe apolipoprotein E 0.997
Abca1 ATP-binding cassette, sub-family A (ABC1), member 1 0.988
Npc1 Niemann Pick type C1 0.975
Apoa1 apolipoprotein A-I 0.943
Pten phosphatase and tensin homolog 0.887
Cebpa CCAAT/enhancer binding protein (C/EBP), alpha 0.879
Traf6 TNF receptor-associated factor 6 0.874
Kiss1 KiSS-1 metastasis-suppressor 0.437
Lrp1 low density lipoprotein receptor-related protein 1 0.396
Ldlr low density lipoprotein receptor 0.313
Abcg5 ATP-binding cassette, sub-family G (WHITE), member 5 0.250
Fgfr2 fibroblast growth factor receptor 2 0.239
Ghr growth hormone receptor 0.235
Abcg8 ATP-binding cassette, sub-family G (WHITE), member 8 0.216
Tbx3 T-box 3 0.209
Abcg1 ATP-binding cassette, sub-family G (WHITE), member 1 0.190
Nfkb1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p105 0.178
Rdh8 retinol dehydrogenase 8 0.170
Relb avian reticuloendotheliosis viral (v-rel) oncogene related B 0.160
Myd88 myeloid differentiation primary response gene 88 0.151
Hnf4a hepatic nuclear factor 4, alpha 0.149
Apob apolipoprotein B 0.146
Gpr116 G protein-coupled receptor 116 0.132
Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) 0.127
Plg plasminogen 0.108
Mapk8ip1 mitogen-activated protein kinase 8 interacting protein 1 0.099
Nr0b2 nuclear receptor subfamily 0, group B, member 2 0.083
Cav1 caveolin 1, caveolae protein 0.082
C3 complement component 3 0.081
Serpinf2 serine (or cysteine) peptidase inhibitor, clade F, member 2 0.080
Pparg peroxisome proliferator activated receptor gamma 0.074
Aldob aldolase B, fructose-bisphosphate 0.072
Nr5a1 nuclear receptor subfamily 5, group A, member 1 0.072
Lyz2 lysozyme 2 0.069
Foxa2 forkhead box A2 0.066
Nr1h3 nuclear receptor subfamily 1, group H, member 3 0.060
Clock circadian locomotor output cycles kaput 0.059
Zeb1 zinc finger E-box binding homeobox 1 0.055
Pick1 protein interacting with C kinase 1 0.055
Apoa2 apolipoprotein A-II 0.053
Ndst1 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1 0.052
Fgg fibrinogen gamma chain 0.050
Cfh complement component factor h 0.049
Cebpb CCAAT/enhancer binding protein (C/EBP), beta 0.048
Slc2a4 solute carrier family 2 (facilitated glucose transporter), member 4 0.048
Atp4a ATPase, H+/K+ exchanging, gastric, alpha polypeptide 0.048
Klf15 Kruppel-like factor 15 0.047
Lrp6 low density lipoprotein receptor-related protein 6 0.046
Peli2 pellino 2 0.046
Lpl lipoprotein lipase 0.045
Pltp phospholipid transfer protein 0.044
Apoc3 apolipoprotein C-III 0.042
Fgfr3 fibroblast growth factor receptor 3 0.042
Fabp2 fatty acid binding protein 2, intestinal 0.040
Stat3 signal transducer and activator of transcription 3 0.040
Ihh Indian hedgehog 0.040
Pzp pregnancy zone protein 0.040
Slc12a6 solute carrier family 12, member 6 0.040
Mertk c-mer proto-oncogene tyrosine kinase 0.040
Ar androgen receptor 0.040
Lrp5 low density lipoprotein receptor-related protein 5 0.039
Dhcr7 7-dehydrocholesterol reductase 0.038
Aqp8 aquaporin 8 0.038
Hoxd10 homeobox D10 0.036
Fbp2 fructose bisphosphatase 2 0.035
Hgd homogentisate 1, 2-dioxygenase 0.034
Slc22a1 solute carrier family 22 (organic cation transporter), member 1 0.034
Lgals2 lectin, galactose-binding, soluble 2 0.034
Ahsg alpha-2-HS-glycoprotein 0.033
Cdhr5 cadherin-related family member 5 0.033
Hpd 4-hydroxyphenylpyruvic acid dioxygenase 0.033
Slc22a2 solute carrier family 22 (organic cation transporter), member 2 0.033
Amhr2 anti-Mullerian hormone type 2 receptor 0.032
Irak4 interleukin-1 receptor-associated kinase 4 0.032
Arntl aryl hydrocarbon receptor nuclear translocator-like 0.031
Ctrb1 chymotrypsinogen B1 0.031
Mogat2 monoacylglycerol O-acyltransferase 2 0.031
Ctnnb1 catenin (cadherin associated protein), beta 1 0.030
Spp2 secreted phosphoprotein 2 0.030
Pcyt1a phosphate cytidylyltransferase 1, choline, alpha isoform 0.030
Slc7a9 solute carrier family 7 (cationic amino acid transporter, y+ system), member 9 0.030
Gsk3b glycogen synthase kinase 3 beta 0.029
Hand1 heart and neural crest derivatives expressed transcript 1 0.029
Hgfac hepatocyte growth factor activator 0.029
Col4a4 collagen, type IV, alpha 4 0.029
Otx2 orthodenticle homolog 2 (Drosophila) 0.029
Slc4a1 solute carrier family 4 (anion exchanger), member 1 0.028
Notch2 Notch gene homolog 2 (Drosophila) 0.028
Hpx hemopexin 0.027
Gnrh1 gonadotropin releasing hormone 1 0.027
Srf serum response factor 0.027
Lrp2 low density lipoprotein receptor-related protein 2 0.026
Ambp alpha 1 microglobulin/bikunin 0.026
Timd2 T-cell immunoglobulin and mucin domain containing 2 0.026
Fgb fibrinogen beta chain 0.026
Gli3 GLI-Kruppel family member GLI3 0.026
Cfi complement component factor i 0.025
Rab11a RAB11a, member RAS oncogene family 0.025
Aspdh aspartate dehydrogenase domain containing 0.025
Gata4 GATA binding protein 4 0.024
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Rattus norvegicus
Name Description Probability Func Analog Organism
Cav1 caveolin 1, caveolae protein 0.896
LOC100362824 caveolin 2-like 0.892
Cav2 caveolin 2 0.545
Zfp36 zinc finger protein 36 0.151
Ehd2 EH-domain containing 2 0.064
Sdpr serum deprivation response 0.053
Errfi1 ERBB receptor feedback inhibitor 1 0.050
Emp1 epithelial membrane protein 1 0.045
Cd9 CD9 molecule 0.029
Pmp22 peripheral myelin protein 22 0.019
Sgk1 serum/glucocorticoid regulated kinase 1 0.018
Cebpb CCAAT/enhancer binding protein (C/EBP), beta 0.017
Btg2 BTG family, member 2 0.015
Ddit4 DNA-damage-inducible transcript 4 0.014
Nedd4 neural precursor cell expressed, developmentally down-regulated 4 0.012
Cxcr7 chemokine (C-X-C motif) receptor 7 0.011
LOC100365118 rCG54747-like 0.011
Gpr116 G protein-coupled receptor 116 0.011
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism