The network for 'cellular response to vascular endothelial growth factor stimulus' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

cellular response to vascular endothelial growth factor stimulus

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vascular endothelial growth factor stimulus.

Homo sapiens
Name Description Probability Func Analog Organism
VEGFA vascular endothelial growth factor A 0.999
PDGFRA platelet-derived growth factor receptor, alpha polypeptide 0.997
HSPB1 heat shock 27kDa protein 1 0.995
FLT1 fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor) 0.992
MT1H metallothionein 1H 0.991
MT1E metallothionein 1E 0.984
PDGFRB platelet-derived growth factor receptor, beta polypeptide 0.983
MT1F metallothionein 1F 0.983
MT2A metallothionein 2A 0.980
MT1X metallothionein 1X 0.975
KDR kinase insert domain receptor (a type III receptor tyrosine kinase) 0.929
JAG1 jagged 1 0.929
NOTCH1 notch 1 0.912
NOTCH3 notch 3 0.829
PCYT2 phosphate cytidylyltransferase 2, ethanolamine 0.707
ARRB1 arrestin, beta 1 0.668
SNTA1 syntrophin, alpha 1 (dystrophin-associated protein A1, 59kDa, acidic component) 0.456
MAP3K5 mitogen-activated protein kinase kinase kinase 5 0.453
EGR2 early growth response 2 0.437
NRP1 neuropilin 1 0.435
CRYAB crystallin, alpha B 0.396
NR4A2 nuclear receptor subfamily 4, group A, member 2 0.391
BAG3 BCL2-associated athanogene 3 0.388
FOS FBJ murine osteosarcoma viral oncogene homolog 0.358
MAPK14 mitogen-activated protein kinase 14 0.356
PKN1 protein kinase N1 0.348
MAP2K4 mitogen-activated protein kinase kinase 4 0.325
NR4A3 nuclear receptor subfamily 4, group A, member 3 0.316
MT1G metallothionein 1G 0.302
EGR3 early growth response 3 0.275
PDGFB platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog) 0.259
HSF1 heat shock transcription factor 1 0.235
FBXO7 F-box protein 7 0.229
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.213
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.204
HSPB8 heat shock 22kDa protein 8 0.184
FLNA filamin A, alpha 0.148
TCEAL5 transcription elongation factor A (SII)-like 5 0.141
GFI1B growth factor independent 1B transcription repressor 0.136
PGF placental growth factor 0.135
FOSB FBJ murine osteosarcoma viral oncogene homolog B 0.133
GPR50 G protein-coupled receptor 50 0.093
MAPK8 mitogen-activated protein kinase 8 0.090
NR4A1 nuclear receptor subfamily 4, group A, member 1 0.089
ATF2 activating transcription factor 2 0.089
KITLG KIT ligand 0.077
PDGFC platelet derived growth factor C 0.076
TIMP1 TIMP metallopeptidase inhibitor 1 0.075
ARRB2 arrestin, beta 2 0.069
MAPK6 mitogen-activated protein kinase 6 0.068
HSPB2 heat shock 27kDa protein 2 0.063
HDAC7 histone deacetylase 7 0.062
PDGFA platelet-derived growth factor alpha polypeptide 0.062
CPNE6 copine VI (neuronal) 0.056
CRKL v-crk sarcoma virus CT10 oncogene homolog (avian)-like 0.056
CRK v-crk sarcoma virus CT10 oncogene homolog (avian) 0.055
JAG2 jagged 2 0.055
JUN jun proto-oncogene 0.053
MT1M metallothionein 1M 0.052
FAF1 Fas (TNFRSF6) associated factor 1 0.050
MAPKAPK3 mitogen-activated protein kinase-activated protein kinase 3 0.049
DLL1 delta-like 1 (Drosophila) 0.048
CDH5 cadherin 5, type 2 (vascular endothelium) 0.047
HSPB7 heat shock 27kDa protein family, member 7 (cardiovascular) 0.046
EGR1 early growth response 1 0.044
MAPK1 mitogen-activated protein kinase 1 0.043
SNAI1 snail homolog 1 (Drosophila) 0.043
PTPRB protein tyrosine phosphatase, receptor type, B 0.042
CHRD chordin 0.039
FERMT3 fermitin family member 3 0.039
COL6A1 collagen, type VI, alpha 1 0.037
SOCS3 suppressor of cytokine signaling 3 0.037
IGF2 insulin-like growth factor 2 (somatomedin A) 0.036
PLCG1 phospholipase C, gamma 1 0.036
ENG endoglin 0.036
NOTCH2NL notch 2 N-terminal like 0.034
MAPK11 mitogen-activated protein kinase 11 0.033
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2 0.032
MT1A metallothionein 1A 0.030
DUSP1 dual specificity phosphatase 1 0.028
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 0.027
CUL7 cullin 7 0.026
DVL3 dishevelled, dsh homolog 3 (Drosophila) 0.026
FLT4 fms-related tyrosine kinase 4 0.026
MAML1 mastermind-like 1 (Drosophila) 0.025
BHLHE40 basic helix-loop-helix family, member e40 0.025
CD9 CD9 molecule 0.024
HSPB6 heat shock protein, alpha-crystallin-related, B6 0.024
MT1B metallothionein 1B 0.023
SUMO3 SMT3 suppressor of mif two 3 homolog 3 (S. cerevisiae) 0.023
ZFP36L1 zinc finger protein 36, C3H type-like 1 0.023
PAG1 phosphoprotein associated with glycosphingolipid microdomains 1 0.023
LIMK1 LIM domain kinase 1 0.023
STC1 stanniocalcin 1 0.022
RRBP1 ribosome binding protein 1 homolog 180kDa (dog) 0.022
CSF1 colony stimulating factor 1 (macrophage) 0.022
GAB1 GRB2-associated binding protein 1 0.021
BCL2 B-cell CLL/lymphoma 2 0.021
PHC2 polyhomeotic homolog 2 (Drosophila) 0.020
ILK integrin-linked kinase 0.020
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
kdrl kinase insert domain receptor like 0.585
efnb2a ephrin B2a 0.521
nrp1a neuropilin 1a 0.434
cdh5 cadherin 5 0.380
vegfc vascular endothelial growth factor c 0.373
vegfaa vascular endothelial growth factor Aa 0.133
tie2 endothelium-specific receptor tyrosine kinase 2 0.101
tfec transcription factor EC 0.094
gata2a GATA-binding protein 2a 0.081
crestin crestin 0.073
si:ch73-60e21.1 si:ch73-60e21.1 0.062
prox1b prospero-related homeobox gene 1b 0.062
wt1b wilms tumor 1b 0.061
hdac4 histone deacetylase 4 0.053
ptrfb polymerase I and transcript release factor b 0.048
col12a1 collagen, type XII, alpha 1 0.046
cdh2 cadherin 2, neuronal 0.045
etv2 ets variant gene 2 0.045
dlc deltaC 0.044
nrp2b neuropilin 2b 0.043
unc45b unc-45 homolog B (C. elegans) 0.041
itga5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) 0.040
foxc1b forkhead box C1b 0.039
foxc1a forkhead box C1a 0.036
si:ch211-212m21.5 si:ch211-212m21.5 0.035
flt4 fms-related tyrosine kinase 4 0.031
kdr kinase insert domain receptor (a type III receptor tyrosine kinase) 0.031
sim1a single-minded homolog 1a (Drosophila) 0.030
tie1 endothelium-specific receptor tyrosine kinase 1 0.029
nfatc1 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1 0.028
dll4 delta-like 4 (Drosophila) 0.027
fabp11a fatty acid binding protein 11a 0.027
phox2b paired-like homeobox 2b 0.026
aplnrb apelin receptor b 0.026
cldn5b claudin 5b 0.026
mmp2 matrix metalloproteinase 2 0.026
tbx20 T-box 20 0.025
jag2 jagged 2 0.025
birc2 baculoviral IAP repeat-containing 2 0.025
micall2a mical-like 2a 0.025
tshb thyroid stimulating hormone, beta subunit 0.025
si:dkey-97i18.2 si:dkey-97i18.2 0.024
pax7b paired box gene 7b 0.023
cald1 caldesmon 1 0.023
myod1 myogenic differentiation 1 0.023
ncs1a neuronal calcium sensor 1a 0.023
dnmt8 DNA (cytosine-5-)-methyltransferase 8 0.022
ptgs1 prostaglandin-endoperoxide synthase 1 0.022
acvrl1 activin A receptor type II-like 1 0.022
cxcr4a chemokine (C-X-C motif) receptor 4a 0.022
antxr1 anthrax toxin receptor 1 0.022
igf2b insulin-like growth factor 2b 0.021
sox9a SRY-box containing gene 9a 0.021
flt1 fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor) 0.021
efna2 ephrin A2 0.020
slc25a25a solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 25a 0.020
ubiad1 UbiA prenyltransferase domain containing 1 0.020
tagln2 transgelin 2 0.020
hspa12b heat shock protein 12B 0.019
her7 hairy and enhancer of split related-7 0.019
ntd5 ntl-dependent gene 5 0.019
nppa natriuretic peptide precursor A 0.019
zgc:64114 zgc:64114 0.019
plxna3 plexin A3 0.019
ren renin 0.019
pard6gb par-6 partitioning defective 6 homolog gamma B (C. elegans) 0.019
runx1 runt-related transcription factor 1 0.018
egr1 early growth response 1 0.018
sulf1 sulfatase 1 0.018
calcrla calcitonin receptor-like a 0.018
pak2a p21 (CDKN1A)-activated kinase 2a 0.018
lmx1b.1 LIM homeobox transcription factor 1, beta 1 0.018
fos v-fos FBJ murine osteosarcoma viral oncogene homolog 0.018
nr4a3 nuclear receptor subfamily 4, group A, member 3 0.018
arhgef7b Rho guanine nucleotide exchange factor (GEF) 7b 0.018
lhx6 LIM homeobox 6 0.017
zgc:112421 zgc:112421 0.017
crb2a crumbs homolog 2a 0.016
ccm2 cerebral cavernous malformation 2 0.016
hoxd9a homeo box D9a 0.016
trpc1 transient receptor potential cation channel, subfamily C, member 1 0.016
nrp1b neuropilin 1b 0.016
ptpn21 protein tyrosine phosphatase, non-receptor type 21 0.016
ttll6 tubulin tyrosine ligase-like family, member 6 0.015
bmp4 bone morphogenetic protein 4 0.015
plxnd1 plexin D1 0.015
dusp5 dual specificity phosphatase 5 0.015
ntn4 netrin 4 0.015
igfbp1a insulin-like growth factor binding protein 1a 0.015
myf5 myogenic factor 5 0.015
prkci protein kinase C, iota 0.015
plcg1 phospholipase C, gamma 1 0.015
hoxa13a homeo box A13a 0.015
arl3l2 ADP-ribosylation factor-like 3, like 2 0.014
nr4a2b nuclear receptor subfamily 4, group A, member 2b 0.014
fzd7b frizzled homolog 7b 0.014
lama4 laminin, alpha 4 0.014
par1 paraxis 0.014
mcamb melanoma cell adhesion molecule b 0.014
sgk1 serum/glucocorticoid regulated kinase 1 0.014
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Mus musculus
Name Description Probability Func Analog Organism
Kdr kinase insert domain protein receptor 0.960
Nrp1 neuropilin 1 0.810
Pdgfrb platelet derived growth factor receptor, beta polypeptide 0.782
Eng endoglin 0.764
Flt4 FMS-like tyrosine kinase 4 0.616
Rbpj recombination signal binding protein for immunoglobulin kappa J region 0.519
Vegfc vascular endothelial growth factor C 0.482
Flt1 FMS-like tyrosine kinase 1 0.430
Fzd4 frizzled homolog 4 (Drosophila) 0.405
Plxnd1 plexin D1 0.318
Ptk2 PTK2 protein tyrosine kinase 2 0.271
Vegfa vascular endothelial growth factor A 0.270
Itgb1 integrin beta 1 (fibronectin receptor beta) 0.248
Slc9a3r2 solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 2 0.224
Cxcl12 chemokine (C-X-C motif) ligand 12 0.160
Cdh5 cadherin 5 0.160
Tie1 tyrosine kinase with immunoglobulin-like and EGF-like domains 1 0.158
Sox18 SRY-box containing gene 18 0.141
Rasip1 Ras interacting protein 1 0.110
Ece1 endothelin converting enzyme 1 0.103
Ptprb protein tyrosine phosphatase, receptor type, B 0.092
Mapk14 mitogen-activated protein kinase 14 0.089
Phc2 polyhomeotic-like 2 (Drosophila) 0.080
Notch2 Notch gene homolog 2 (Drosophila) 0.079
Tmem204 transmembrane protein 204 0.077
Mapk11 mitogen-activated protein kinase 11 0.075
Tek endothelial-specific receptor tyrosine kinase 0.069
Mapkapk2 MAP kinase-activated protein kinase 2 0.057
Efnb2 ephrin B2 0.054
Ppap2b phosphatidic acid phosphatase type 2B 0.052
Foxc2 forkhead box C2 0.044
Cfh complement component factor h 0.042
Tenc1 tensin like C1 domain-containing phosphatase 0.035
Lamb2 laminin, beta 2 0.035
Acvr1 activin A receptor, type 1 0.033
Sema3f sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F 0.032
Bmp4 bone morphogenetic protein 4 0.031
Kitl kit ligand 0.030
Pdgfc platelet-derived growth factor, C polypeptide 0.030
Prrx1 paired related homeobox 1 0.029
Smad6 MAD homolog 6 (Drosophila) 0.028
Sox7 SRY-box containing gene 7 0.028
Tgfb1 transforming growth factor, beta 1 0.026
Emcn endomucin 0.026
Mmrn2 multimerin 2 0.026
Bcar1 breast cancer anti-estrogen resistance 1 0.025
Notch1 Notch gene homolog 1 (Drosophila) 0.022
Stab1 stabilin 1 0.022
Itga5 integrin alpha 5 (fibronectin receptor alpha) 0.021
Wwc2 WW, C2 and coiled-coil domain containing 2 0.021
Cldn5 claudin 5 0.020
Nos3 nitric oxide synthase 3, endothelial cell 0.020
Mapk12 mitogen-activated protein kinase 12 0.020
Fbln1 fibulin 1 0.019
Phc1 polyhomeotic-like 1 (Drosophila) 0.019
Mmp2 matrix metallopeptidase 2 0.019
C1qa complement component 1, q subcomponent, alpha polypeptide 0.019
Bgn biglycan 0.019
Rbpms RNA binding protein gene with multiple splicing 0.019
Thbd thrombomodulin 0.018
Cryab crystallin, alpha B 0.018
Pecam1 platelet/endothelial cell adhesion molecule 1 0.018
Apbb2 amyloid beta (A4) precursor protein-binding, family B, member 2 0.017
Tgfbr2 transforming growth factor, beta receptor II 0.017
Tbx18 T-box18 0.016
C1qc complement component 1, q subcomponent, C chain 0.016
Clec14a C-type lectin domain family 14, member a 0.015
She src homology 2 domain-containing transforming protein E 0.015
Pxn paxillin 0.015
Jag1 jagged 1 0.014
Hes1 hairy and enhancer of split 1 (Drosophila) 0.014
Mknk2 MAP kinase-interacting serine/threonine kinase 2 0.014
Ptch1 patched homolog 1 0.014
Fgfr1 fibroblast growth factor receptor 1 0.014
Esam endothelial cell-specific adhesion molecule 0.014
Igfbp3 insulin-like growth factor binding protein 3 0.014
Notch3 Notch gene homolog 3 (Drosophila) 0.013
Ypel3 yippee-like 3 (Drosophila) 0.013
Fos FBJ osteosarcoma oncogene 0.013
Reck reversion-inducing-cysteine-rich protein with kazal motifs 0.013
Ednra endothelin receptor type A 0.013
Serping1 serine (or cysteine) peptidase inhibitor, clade G, member 1 0.013
Abl1 c-abl oncogene 1, non-receptor tyrosine kinase 0.013
Tinagl1 tubulointerstitial nephritis antigen-like 1 0.013
Pros1 protein S (alpha) 0.013
Id1 inhibitor of DNA binding 1 0.012
C1qb complement component 1, q subcomponent, beta polypeptide 0.012
Gsn gelsolin 0.012
Mrc1 mannose receptor, C type 1 0.012
Crip2 cysteine rich protein 2 0.012
Nphp4 nephronophthisis 4 (juvenile) homolog (human) 0.012
Smad7 MAD homolog 7 (Drosophila) 0.011
Cbs cystathionine beta-synthase 0.011
Adm adrenomedullin 0.011
Jup junction plakoglobin 0.011
Cyr61 cysteine rich protein 61 0.011
Phldb2 pleckstrin homology-like domain, family B, member 2 0.011
Rbp1 retinol binding protein 1, cellular 0.011
Ghr growth hormone receptor 0.011
Nr2f1 nuclear receptor subfamily 2, group F, member 1 0.011
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Rattus norvegicus
Name Description Probability Func Analog Organism
Nr4a3 nuclear receptor subfamily 4, group A, member 3 0.413
Lamc1 laminin, gamma 1 0.326
Axl Axl receptor tyrosine kinase 0.200
C1s complement component 1, s subcomponent 0.188
Dusp1 dual specificity phosphatase 1 0.179
Junb jun B proto-oncogene 0.166
Egr1 early growth response 1 0.129
Fos FBJ osteosarcoma oncogene 0.107
Wipf1 WAS/WASL interacting protein family, member 1 0.086
Nfib nuclear factor I/B 0.083
Pdgfra platelet derived growth factor receptor, alpha polypeptide 0.067
Elk3 ELK3, ETS-domain protein 0.066
Bgn biglycan 0.062
Tns1 tensin 1 0.058
Btg2 BTG family, member 2 0.057
Tcf4 transcription factor 4 0.047
Zfp36l1 zinc finger protein 36, C3H type-like 1 0.042
Dab2 disabled homolog 2 (Drosophila) 0.041
Mrc1 mannose receptor, C type 1 0.040
Lgals3 lectin, galactoside-binding, soluble, 3 0.040
Ets1 v-ets erythroblastosis virus E26 oncogene homolog 1 (avian) 0.039
Colec12 collectin sub-family member 12 0.037
Zfp36 zinc finger protein 36 0.034
Gpr116 G protein-coupled receptor 116 0.032
Tek TEK tyrosine kinase, endothelial 0.031
Lrp1 low density lipoprotein-related protein 1 (alpha-2-macroglobulin receptor) 0.029
P4hb prolyl 4-hydroxylase, beta polypeptide 0.029
Eef2 eukaryotic translation elongation factor 2 0.028
Fgfr1 Fibroblast growth factor receptor 1 0.027
Ctss cathepsin S 0.026
Nr4a2 nuclear receptor subfamily 4, group A, member 2 0.025
Ms4a6b membrane-spanning 4-domains, subfamily A, member 6B 0.024
Chp calcium binding protein p22 0.024
Timp3 TIMP metallopeptidase inhibitor 3 0.022
Col3a1 collagen, type III, alpha 1 0.021
Col4a1 collagen, type IV, alpha 1 0.021
Nos3 nitric oxide synthase 3, endothelial cell 0.021
Plxnd1 plexin D1 0.019
Pxdn peroxidasin homolog (Drosophila) 0.018
Npc2 Niemann-Pick disease, type C2 0.017
Notch1 Notch homolog 1, translocation-associated (Drosophila) 0.017
Sh2b3 SH2B adaptor protein 3 0.016
Myo1b myosin Ib 0.016
Rin2 Ras and Rab interactor 2 0.015
Ier2 immediate early response 2 0.015
Pecam1 platelet/endothelial cell adhesion molecule 1 0.015
Kdr kinase insert domain receptor 0.015
Jak1 Janus kinase 1 0.014
Fcer1g Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide 0.014
C1qa complement component 1, q subcomponent, A chain 0.014
Mgll monoglyceride lipase 0.014
Ddr2 discoidin domain receptor tyrosine kinase 2 0.013
C1qc complement component 1, q subcomponent, C chain 0.013
Mgp matrix Gla protein 0.013
Nrarp Notch-regulated ankyrin repeat protein 0.013
C1r complement component 1, r subcomponent 0.012
Ltbp4 latent transforming growth factor beta binding protein 4 0.012
Nr2f2 nuclear receptor subfamily 2, group F, member 2 0.012
Ppp1r15a protein phosphatase 1, regulatory (inhibitor) subunit 15A 0.012
Pld4 phospholipase D family, member 4 0.012
Sf1 splicing factor 1 0.012
Ece1 endothelin converting enzyme 1 0.011
Col5a2 collagen, type V, alpha 2 0.011
Ftl ferritin, light polypeptide 0.011
Ctsl1 cathepsin L1 0.011
Egr2 early growth response 2 0.011
Gna12 guanine nucleotide binding protein (G protein) alpha 12 0.010
Cdh5 cadherin 5 0.010
Hsd11b1 hydroxysteroid 11-beta dehydrogenase 1 0.010
Nfix nuclear factor I/X (CCAAT-binding transcription factor) 0.010
Flt1 FMS-related tyrosine kinase 1 0.010
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism