The network for 'positive regulation of type i interferon production' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

positive regulation of type i interferon production

Any process that activates or increases the frequency, rate, or extent of type I interferon production. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families.

Homo sapiens
Name Description Probability Func Analog Organism
DDX58 DEAD (Asp-Glu-Ala-Asp) box polypeptide 58 0.956
STAT1 signal transducer and activator of transcription 1, 91kDa 0.939
STAT2 signal transducer and activator of transcription 2, 113kDa 0.835
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 0.790
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.753
IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma 0.742
MYD88 myeloid differentiation primary response gene (88) 0.733
SP110 SP110 nuclear body protein 0.586
CYLD cylindromatosis (turban tumor syndrome) 0.568
IRF9 interferon regulatory factor 9 0.531
TRIM21 tripartite motif containing 21 0.524
IRF7 interferon regulatory factor 7 0.509
PIAS4 protein inhibitor of activated STAT, 4 0.470
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1 0.431
MED15 mediator complex subunit 15 0.408
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta 0.223
UBE2D4 ubiquitin-conjugating enzyme E2D 4 (putative) 0.222
OAS2 2'-5'-oligoadenylate synthetase 2, 69/71kDa 0.183
TICAM2 toll-like receptor adaptor molecule 2 0.175
IRF1 interferon regulatory factor 1 0.165
SAMD9 sterile alpha motif domain containing 9 0.153
TIRAP toll-interleukin 1 receptor (TIR) domain containing adaptor protein 0.152
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 0.148
TRIM5 tripartite motif containing 5 0.128
IFIH1 interferon induced with helicase C domain 1 0.124
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.104
OAS1 2',5'-oligoadenylate synthetase 1, 40/46kDa 0.091
ZNF263 zinc finger protein 263 0.091
MAVS mitochondrial antiviral signaling protein 0.087
IFI44 interferon-induced protein 44 0.074
TRIM26 tripartite motif containing 26 0.074
TRIM25 tripartite motif containing 25 0.073
ZNF473 zinc finger protein 473 0.068
SP100 SP100 nuclear antigen 0.067
NMI N-myc (and STAT) interactor 0.062
TBK1 TANK-binding kinase 1 0.061
IRF2 interferon regulatory factor 2 0.061
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa 0.059
KAT2B K(lysine) acetyltransferase 2B 0.055
IL15 interleukin 15 0.053
BIRC3 baculoviral IAP repeat containing 3 0.053
XAF1 XIAP associated factor 1 0.051
IRF3 interferon regulatory factor 3 0.050
TRIM39 tripartite motif containing 39 0.048
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10 0.048
OASL 2'-5'-oligoadenylate synthetase-like 0.047
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 0.045
RTP4 receptor (chemosensory) transporter protein 4 0.044
RELB v-rel reticuloendotheliosis viral oncogene homolog B 0.041
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced 0.040
TRAF3 TNF receptor-associated factor 3 0.039
IFI35 interferon-induced protein 35 0.038
IFNAR2 interferon (alpha, beta and omega) receptor 2 0.037
PARP12 poly (ADP-ribose) polymerase family, member 12 0.036
TRANK1 tetratricopeptide repeat and ankyrin repeat containing 1 0.035
TRIM32 tripartite motif containing 32 0.034
IFNGR1 interferon gamma receptor 1 0.032
APOL6 apolipoprotein L, 6 0.028
MX1 myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse) 0.028
MR1 major histocompatibility complex, class I-related 0.027
CREBBP CREB binding protein 0.027
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.027
AZI2 5-azacytidine induced 2 0.027
POLR3E polymerase (RNA) III (DNA directed) polypeptide E (80kD) 0.027
MX2 myxovirus (influenza virus) resistance 2 (mouse) 0.027
BTN3A3 butyrophilin, subfamily 3, member A3 0.026
NLRC5 NLR family, CARD domain containing 5 0.026
TRIM52 tripartite motif containing 52 0.024
IRAK1 interleukin-1 receptor-associated kinase 1 0.024
ADAR adenosine deaminase, RNA-specific 0.024
TLR1 toll-like receptor 1 0.023
TLR2 toll-like receptor 2 0.022
IFNAR1 interferon (alpha, beta and omega) receptor 1 0.022
HERC5 hect domain and RLD 5 0.021
PHF11 PHD finger protein 11 0.021
TRAF2 TNF receptor-associated factor 2 0.020
TRIM22 tripartite motif containing 22 0.020
SPOP speckle-type POZ protein 0.020
CXCL10 chemokine (C-X-C motif) ligand 10 0.019
USP18 ubiquitin specific peptidase 18 0.019
TMEM173 transmembrane protein 173 0.018
TRIM17 tripartite motif containing 17 0.018
TLR4 toll-like receptor 4 0.018
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.018
PML promyelocytic leukemia 0.018
FKBP5 FK506 binding protein 5 0.018
TDRD7 tudor domain containing 7 0.018
MAP3K14 mitogen-activated protein kinase kinase kinase 14 0.018
C19orf66 chromosome 19 open reading frame 66 0.017
EPSTI1 epithelial stromal interaction 1 (breast) 0.017
IFIT5 interferon-induced protein with tetratricopeptide repeats 5 0.017
POLR3H polymerase (RNA) III (DNA directed) polypeptide H (22.9kD) 0.017
PRKRA protein kinase, interferon-inducible double stranded RNA dependent activator 0.017
LY96 lymphocyte antigen 96 0.016
TMEM140 transmembrane protein 140 0.016
TRAFD1 TRAF-type zinc finger domain containing 1 0.016
SPI1 spleen focus forming virus (SFFV) proviral integration oncogene spi1 0.016
IRF8 interferon regulatory factor 8 0.015
IFI16 interferon, gamma-inducible protein 16 0.015
PPP2R2B protein phosphatase 2, regulatory subunit B, beta 0.015
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
hspa5 heat shock protein 5 0.237
hspa9 heat shock protein 9 0.128
zgc:86841 zgc:86841 0.079
zfp36l1a zinc finger protein 36, C3H type-like 1a 0.048
hsp90a.2 heat shock protein 90-alpha 2 0.046
tlr18 toll-like receptor 18 0.035
yars tyrosyl-tRNA synthetase 0.032
nos2a nitric oxide synthase 2a, inducible 0.031
LOC100534776 toll-like receptor 7-like 0.028
hspa4a heat shock protein 4a 0.028
phb prohibitin 0.026
slc11a2 solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2 0.024
pwp2h PWP2 periodic tryptophan protein homolog (yeast) 0.021
zgc:152873 zgc:152873 0.019
hspe1 heat shock 10 protein 1 (chaperonin 10) 0.018
nos2b nitric oxide synthase 2b, inducible 0.018
traf6 TNF receptor-associated factor 6 0.018
cad carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase 0.017
tlr20a toll-like receptor 20a 0.016
igfbp1a insulin-like growth factor binding protein 1a 0.016
c1qb complement component 1, q subcomponent, B chain 0.015
tlr20f toll-like receptor 20f 0.014
hprt1 hypoxanthine phosphoribosyltransferase 1 0.014
atad3b ATPase family, AAA domain containing 3B 0.014
cpox coproporphyrinogen oxidase 0.013
timm13 translocase of inner mitochondrial membrane 13 homolog (yeast) 0.012
tirap toll-interleukin 1 receptor (TIR) domain containing adaptor protein 0.012
chchd10 coiled-coil-helix-coiled-coil-helix domain containing 10 0.012
mtr 5-methyltetrahydrofolate-homocysteine methyltransferase 0.011
lonp1 lon peptidase 1, mitochondrial 0.011
isg15 ISG15 ubiquitin-like modifier 0.011
tufm Tu translation elongation factor, mitochondrial 0.011
hbae1 hemoglobin alpha embryonic-1 0.011
illr1 immune-related, lectin-like receptor 1 0.010
crabp2a cellular retinoic acid binding protein 2, a 0.010
LOC794824 hypothetical protein LOC794824 0.010
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Mus musculus
Name Description Probability Func Analog Organism
Myd88 myeloid differentiation primary response gene 88 0.992
Tlr4 toll-like receptor 4 0.972
Stat1 signal transducer and activator of transcription 1 0.884
Ccr2 chemokine (C-C motif) receptor 2 0.749
Ticam1 toll-like receptor adaptor molecule 1 0.678
Ddx60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 0.663
Il10 interleukin 10 0.636
Ikbkg inhibitor of kappaB kinase gamma 0.599
Unc93b1 unc-93 homolog B1 (C. elegans) 0.587
Ifit1 interferon-induced protein with tetratricopeptide repeats 1 0.472
Ddx58 DEAD (Asp-Glu-Ala-Asp) box polypeptide 58 0.462
Irf9 interferon regulatory factor 9 0.446
Tapbp TAP binding protein 0.433
Trim21 tripartite motif-containing 21 0.413
Tnfrsf1b tumor necrosis factor receptor superfamily, member 1b 0.381
Irgm1 immunity-related GTPase family M member 1 0.377
Irgm2 immunity-related GTPase family M member 2 0.363
Tnfrsf1a tumor necrosis factor receptor superfamily, member 1a 0.361
Tax1bp1 Tax1 (human T-cell leukemia virus type I) binding protein 1 0.351
Nfkb1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p105 0.349
Map3k8 mitogen-activated protein kinase kinase kinase 8 0.340
Stat2 signal transducer and activator of transcription 2 0.321
Tnf tumor necrosis factor 0.300
Uba7 ubiquitin-like modifier activating enzyme 7 0.279
Trim25 tripartite motif-containing 25 0.251
Parp14 poly (ADP-ribose) polymerase family, member 14 0.177
Mavs mitochondrial antiviral signaling protein 0.161
Ifi35 interferon-induced protein 35 0.157
Nfkb2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100 0.146
Psmb9 proteasome (prosome, macropain) subunit, beta type 9 (large multifunctional peptidase 2) 0.146
Dhx58 DEXH (Asp-Glu-X-His) box polypeptide 58 0.139
Tor3a torsin family 3, member A 0.137
Relb avian reticuloendotheliosis viral (v-rel) oncogene related B 0.123
Ikbkb inhibitor of kappaB kinase beta 0.118
Birc3 baculoviral IAP repeat-containing 3 0.105
Ifi47 interferon gamma inducible protein 47 0.101
Gbp3 guanylate binding protein 3 0.100
Igtp interferon gamma induced GTPase 0.099
Parp9 poly (ADP-ribose) polymerase family, member 9 0.096
Ifi44 interferon-induced protein 44 0.095
Sfpi1 SFFV proviral integration 1 0.093
Usp18 ubiquitin specific peptidase 18 0.093
BC006779 cDNA sequence BC006779 0.092
Rtp4 receptor transporter protein 4 0.090
Stat3 signal transducer and activator of transcription 3 0.089
Chuk conserved helix-loop-helix ubiquitous kinase 0.088
Nmi N-myc (and STAT) interactor 0.086
Ifnar1 interferon (alpha and beta) receptor 1 0.084
Gbp7 guanylate binding protein 7 0.082
Oasl2 2'-5' oligoadenylate synthetase-like 2 0.072
Mx2 myxovirus (influenza virus) resistance 2 0.072
Casp4 caspase 4, apoptosis-related cysteine peptidase 0.071
Hspa9 heat shock protein 9 0.064
Irf7 interferon regulatory factor 7 0.064
Ccl2 chemokine (C-C motif) ligand 2 0.062
Rnf31 ring finger protein 31 0.062
Pik3ap1 phosphoinositide-3-kinase adaptor protein 1 0.055
Parp10 poly (ADP-ribose) polymerase family, member 10 0.053
Samd9l sterile alpha motif domain containing 9-like 0.050
Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) 0.049
Pml promyelocytic leukemia 0.048
Rnf135 ring finger protein 135 0.047
Tmem106a transmembrane protein 106A 0.047
Irf5 interferon regulatory factor 5 0.046
Casp1 caspase 1 0.044
Eif2ak2 eukaryotic translation initiation factor 2-alpha kinase 2 0.044
Bcl3 B-cell leukemia/lymphoma 3 0.042
Sykb spleen tyrosine kinase 0.041
Trim30a tripartite motif-containing 30A 0.041
Tlr2 toll-like receptor 2 0.041
Ms4a4c membrane-spanning 4-domains, subfamily A, member 4C 0.041
Traf3 TNF receptor-associated factor 3 0.039
Lyz2 lysozyme 2 0.039
Irak4 interleukin-1 receptor-associated kinase 4 0.038
Il10ra interleukin 10 receptor, alpha 0.037
Erap1 endoplasmic reticulum aminopeptidase 1 0.037
Gsdmd gasdermin D 0.036
Tap1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) 0.035
Ikbke inhibitor of kappaB kinase epsilon 0.035
Cd19 CD19 antigen 0.035
Nfkbia nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.034
Ikzf1 IKAROS family zinc finger 1 0.034
Atr ataxia telangiectasia and Rad3 related 0.033
Psmb8 proteasome (prosome, macropain) subunit, beta type 8 (large multifunctional peptidase 7) 0.032
Isg15 ISG15 ubiquitin-like modifier 0.032
Samhd1 SAM domain and HD domain, 1 0.030
Tgfb1 transforming growth factor, beta 1 0.029
Cd14 CD14 antigen 0.029
Il1r1 interleukin 1 receptor, type I 0.028
Cd180 CD180 antigen 0.027
Tap2 transporter 2, ATP-binding cassette, sub-family B (MDR/TAP) 0.027
Ccl4 chemokine (C-C motif) ligand 4 0.027
Gbp2 guanylate binding protein 2 0.027
Ly96 lymphocyte antigen 96 0.024
Cd40 CD40 antigen 0.024
1810019J16Rik RIKEN cDNA 1810019J16 gene 0.024
Ankfy1 ankyrin repeat and FYVE domain containing 1 0.024
Ciita class II transactivator 0.024
Apobec1 apolipoprotein B mRNA editing enzyme, catalytic polypeptide 1 0.023
Adar adenosine deaminase, RNA-specific 0.023
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Rattus norvegicus
Name Description Probability Func Analog Organism
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism