The network for 'myotube cell development' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

myotube cell development

The process aimed at the progression of a myotube cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. Myotubes are multinucleated cells that are formed when proliferating myoblasts exit the cell cycle, differentiate and fuse.

Mus musculus
Name Description Probability Func Analog Organism
Shh sonic hedgehog 0.997
Pitx2 paired-like homeodomain transcription factor 2 0.995
Six1 sine oculis-related homeobox 1 homolog (Drosophila) 0.987
Pax3 paired box gene 3 0.983
Mef2d myocyte enhancer factor 2D 0.911
Rarg retinoic acid receptor, gamma 0.844
Emx1 empty spiracles homolog 1 (Drosophila) 0.835
Mapk14 mitogen-activated protein kinase 14 0.826
Mybph myosin binding protein H 0.821
Ldb3 LIM domain binding 3 0.809
Cacna1s calcium channel, voltage-dependent, L type, alpha 1S subunit 0.795
Fgfr1 fibroblast growth factor receptor 1 0.786
Gli3 GLI-Kruppel family member GLI3 0.757
Ccl2 chemokine (C-C motif) ligand 2 0.747
Fgfr2 fibroblast growth factor receptor 2 0.678
Emx2 empty spiracles homolog 2 (Drosophila) 0.635
Hrc histidine rich calcium binding protein 0.632
Id1 inhibitor of DNA binding 1 0.629
Tcf3 transcription factor 3 0.623
Myl2 myosin, light polypeptide 2, regulatory, cardiac, slow 0.599
Jag2 jagged 2 0.586
Id3 inhibitor of DNA binding 3 0.563
Msx1 homeobox, msh-like 1 0.548
Nog noggin 0.542
Tnni2 troponin I, skeletal, fast 2 0.533
Smo smoothened homolog (Drosophila) 0.532
Wnt3a wingless-related MMTV integration site 3A 0.526
Ncoa2 nuclear receptor coactivator 2 0.521
Tbx1 T-box 1 0.520
Meox2 mesenchyme homeobox 2 0.514
Nkx2-5 NK2 transcription factor related, locus 5 (Drosophila) 0.508
Prkce protein kinase C, epsilon 0.486
Nf1 neurofibromatosis 1 0.474
Otx2 orthodenticle homolog 2 (Drosophila) 0.470
Actc1 actin, alpha, cardiac muscle 1 0.462
Acta1 actin, alpha 1, skeletal muscle 0.461
Foxc1 forkhead box C1 0.426
Hes1 hairy and enhancer of split 1 (Drosophila) 0.398
Tnnc2 troponin C2, fast 0.391
Nos3 nitric oxide synthase 3, endothelial cell 0.368
Tcfap2a transcription factor AP-2, alpha 0.368
Ret ret proto-oncogene 0.345
Cd14 CD14 antigen 0.343
Hcn4 hyperpolarization-activated, cyclic nucleotide-gated K+ 4 0.341
Hesx1 homeobox gene expressed in ES cells 0.321
Mapk8ip3 mitogen-activated protein kinase 8 interacting protein 3 0.317
Csf3 colony stimulating factor 3 (granulocyte) 0.315
Rara retinoic acid receptor, alpha 0.311
Des desmin 0.308
Hoxd13 homeobox D13 0.307
Ptrf polymerase I and transcript release factor 0.301
Foxg1 forkhead box G1 0.300
Otx1 orthodenticle homolog 1 (Drosophila) 0.287
Actn3 actinin alpha 3 0.285
Sox2 SRY-box containing gene 2 0.281
Atp2a1 ATPase, Ca++ transporting, cardiac muscle, fast twitch 1 0.277
Ncor2 nuclear receptor co-repressor 2 0.277
Fgf8 fibroblast growth factor 8 0.273
Myf6 myogenic factor 6 0.269
Dmd dystrophin, muscular dystrophy 0.261
Isl1 ISL1 transcription factor, LIM/homeodomain 0.261
Cxcl2 chemokine (C-X-C motif) ligand 2 0.254
Six4 sine oculis-related homeobox 4 homolog (Drosophila) 0.253
Bax BCL2-associated X protein 0.249
Acvr1 activin A receptor, type 1 0.249
Dkk1 dickkopf homolog 1 (Xenopus laevis) 0.247
Eya1 eyes absent 1 homolog (Drosophila) 0.246
Cxcl13 chemokine (C-X-C motif) ligand 13 0.245
Casq2 calsequestrin 2 0.244
Camk2a calcium/calmodulin-dependent protein kinase II alpha 0.242
Vegfa vascular endothelial growth factor A 0.242
Ryr1 ryanodine receptor 1, skeletal muscle 0.240
Kcnj11 potassium inwardly rectifying channel, subfamily J, member 11 0.235
Irx5 Iroquois related homeobox 5 (Drosophila) 0.235
Csf1 colony stimulating factor 1 (macrophage) 0.233
Bcl2l11 BCL2-like 11 (apoptosis facilitator) 0.233
Nos1 nitric oxide synthase 1, neuronal 0.232
Cxcl1 chemokine (C-X-C motif) ligand 1 0.231
Prrx2 paired related homeobox 2 0.228
Fgf3 fibroblast growth factor 3 0.224
Cd40 CD40 antigen 0.222
Fgf10 fibroblast growth factor 10 0.220
Fuz fuzzy homolog (Drosophila) 0.219
Cdon cell adhesion molecule-related/down-regulated by oncogenes 0.209
Ltb lymphotoxin B 0.209
Fos FBJ osteosarcoma oncogene 0.208
Pou3f1 POU domain, class 3, transcription factor 1 0.208
Bmp7 bone morphogenetic protein 7 0.207
Tcfap2c transcription factor AP-2, gamma 0.203
Zeb1 zinc finger E-box binding homeobox 1 0.202
Myod1 myogenic differentiation 1 0.196
Rpgrip1l Rpgrip1-like 0.193
Chd7 chromodomain helicase DNA binding protein 7 0.193
Tnnt3 troponin T3, skeletal, fast 0.192
Aldh1a2 aldehyde dehydrogenase family 1, subfamily A2 0.185
Ednra endothelin receptor type A 0.182
Rarb retinoic acid receptor, beta 0.180
Ikzf1 IKAROS family zinc finger 1 0.177
Dll1 delta-like 1 (Drosophila) 0.174
Il1rn interleukin 1 receptor antagonist 0.174
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
actn3a actinin alpha 3a 0.984
sox9a SRY-box containing gene 9a 0.967
myog myogenin 0.943
ptch2 patched 2 0.854
myf5 myogenic factor 5 0.850
smyd1b SET and MYND domain containing 1b 0.836
ambra1 autophagy/beclin-1 regulator 1 0.766
myod1 myogenic differentiation 1 0.740
myhz2 myosin, heavy polypeptide 2, fast muscle specific 0.718
actn2 actinin, alpha 2 0.704
ryr1b ryanodine receptor 1b (skeletal) 0.699
rx3 retinal homeobox gene 3 0.597
hsp90a.1 heat shock protein 90-alpha 1 0.587
gli2a GLI-Kruppel family member GLI2a 0.534
lama2 laminin, alpha 2 0.526
cdh2 cadherin 2, neuronal 0.443
tcf12 transcription factor 12 0.443
runx2b runt-related transcription factor 2b 0.421
tnni1al troponin I, skeletal, slow like 0.394
tbx24 T-box 24 0.380
grifin galectin related inter-fiber protein 0.371
xirp1 xin actin-binding repeat containing 1 0.369
tnnc1b troponin C type 1b (slow) 0.362
gli1 GLI-Kruppel family member 1 0.297
runx2a runt-related transcription factor 2a 0.287
six4b sine oculis homeobox homolog 4b 0.281
ptch1 patched 1 0.273
chrna1 cholinergic receptor, nicotinic, alpha polypeptide 1 0.273
dmd dystrophin 0.271
nphs2 nephrosis 2, idiopathic, steroid-resistant (podocin) 0.270
gli2b GLI-Kruppel family member GLI2b 0.260
wt1b wilms tumor 1b 0.258
six1b sine oculis homeobox homolog 1b 0.255
bmp2b bone morphogenetic protein 2b 0.255
actn3b actinin alpha 3b 0.253
ryr1a ryanodine receptor 1a (skeletal) 0.242
acta1a actin, alpha 1a, skeletal muscle 0.215
lamc1 laminin, gamma 1 0.211
irx4b iroquois homeobox protein 4b 0.208
pcdh8 protocadherin 8 0.200
wu:fv91b12 wu:fv91b12 0.194
vasp vasodilator-stimulated phosphoprotein 0.190
mylz2 myosin, light polypeptide 2, skeletal muscle 0.184
smyd1a SET and MYND domain containing 1a 0.184
tnnt3a troponin T3a, skeletal, fast 0.171
ckma creatine kinase, muscle a 0.162
vgll2b vestigial like 2b 0.143
camk1d calcium/calmodulin-dependent protein kinase 1D 0.142
srf serum response factor 0.137
robo3 roundabout homolog 3 0.129
scinla scinderin like a 0.128
smad7 MAD, mothers against decapentaplegic homolog 7 (Drosophila) 0.126
rx2 retinal homeobox gene 2 0.122
dmrta2 doublesex and mab-3 related transcription factor like family A2 0.119
gdf6b growth differentiation factor 6b 0.119
unc45b unc-45 homolog B (C. elegans) 0.119
smo smoothened homolog (Drosophila) 0.118
cacna1c calcium channel, voltage-dependent, L type, alpha 1C subunit 0.116
xirp2a xin actin-binding repeat containing 2a 0.114
igf3 insulin-like growth factor 3 0.113
hoxa11a homeo box A11a 0.112
mtm1 myotubularin 1 0.107
hhip hedgehog interacting protein 0.102
zgc:113210 zgc:113210 0.102
lgi1b leucine-rich, glioma inactivated 1b 0.099
im:7146310 im:7146310 0.099
chd chordin 0.097
vegfaa vascular endothelial growth factor Aa 0.096
kbtbd10b kelch repeat and BTB (POZ) domain containing 10b 0.095
smyhc2 slow myosin heavy chain 2 0.094
spata2 spermatogenesis associated 2 0.093
slc12a2 solute carrier family 12 (potassium/chloride transporters), member 2 0.092
tfap2c transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma) 0.090
rad54b RAD54 homolog B (S. cerevisiae) 0.087
foxd5 forkhead box D5 0.085
notch1a notch homolog 1a 0.084
mipa major intrinsic protein of lens fiber a 0.084
rerea arginine-glutamic acid dipeptide (RE) repeats a 0.083
tnni1b troponin I, skeletal, slow b 0.082
ptprsa protein tyrosine phosphatase, receptor type, s, a 0.081
tnnt1 troponin T1, skeletal, slow 0.081
myf6 myogenic factor 6 0.079
atp1a2a ATPase, Na+/K+ transporting, alpha 2a polypeptide 0.077
ryr3 ryanodine receptor 3 0.077
wnt10a wingless-type MMTV integration site family, member 10a 0.077
ddx26b DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 26B 0.076
xirp2b xin actin-binding repeat containing 2b 0.073
cdh4 cadherin 4, retinal 0.073
glb1 galactosidase, beta 1 0.070
lgals2b lectin, galactoside-binding, soluble, 2b 0.069
dlx3b distal-less homeobox gene 3b 0.069
nkx3.2 NK3 homeobox 2 0.068
ifnphi1 interferon phi 1 0.068
syn2b synapsin IIb 0.065
zp3 zona pellucida glycoprotein 3 0.065
plagl2 pleiomorphic adenoma gene-like 2 0.064
plce1 phospholipase C, epsilon 1 0.064
suv39h1a suppressor of variegation 3-9 homolog 1a 0.064
pax7b paired box gene 7b 0.062
isl2a islet2a 0.060
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Drosophila melanogaster
Name Description Probability Func Analog Organism
dpp decapentaplegic 0.651
rho rhomboid 0.637
Pp2B-14D Protein phosphatase 2B at 14D 0.564
sty sprouty 0.530
ci cubitus interruptus 0.528
hth homothorax 0.494
Mad Mothers against dpp 0.472
Prm Paramyosin 0.463
Nrg Neuroglian 0.458
ptc patched 0.457
wupA wings up A 0.435
Vrp1 Verprolin 1 0.429
rst roughest 0.427
Cbl CG7037 gene product from transcript CG7037-RB 0.414
G-oalpha47A G protein oalpha 47A 0.387
kirre kin of irre 0.385
norpA no receptor potential A 0.362
wg wingless 0.354
Egfr Epidermal growth factor receptor 0.336
myoglianin CG1838 gene product from transcript CG1838-RD 0.335
stck steamer duck 0.301
htl heartless 0.291
if inflated 0.288
hbs hibris 0.272
pan pangolin 0.254
stumps CG31317 gene product from transcript CG31317-RC 0.252
gbb glass bottom boat 0.238
Rac2 CG8556 gene product from transcript CG8556-RA 0.212
egh egghead 0.201
kn knot 0.179
p38b CG7393 gene product from transcript CG7393-RA 0.178
slou slouch 0.174
sr stripe 0.173
InR Insulin-like receptor 0.167
Gug Grunge 0.166
vg vestigial 0.165
VAChT CG32848 gene product from transcript CG32848-RA 0.163
rols rolling pebbles 0.159
sbb scribbler 0.156
Rya-r44F Ryanodine receptor 44F 0.149
stan starry night 0.136
phyl phyllopod 0.135
blow blown fuse 0.134
LanB1 CG7123 gene product from transcript CG7123-RA 0.134
Btk29A Btk family kinase at 29A 0.131
Pkc98E Protein C kinase 98E 0.128
trx trithorax 0.127
Imp IGF-II mRNA-binding protein 0.123
CG32810 CG32810 gene product from transcript CG32810-RB 0.123
Arp66B Actin-related protein 66B 0.123
Wnt4 Wnt oncogene analog 4 0.122
nau nautilus 0.121
wit wishful thinking 0.108
Akt1 CG4006 gene product from transcript CG4006-RA 0.107
hts hu li tai shao 0.107
Actbeta Activin-beta 0.106
zfh1 Zn finger homeodomain 1 0.105
fj four-jointed 0.105
RhoGAP100F CG1976 gene product from transcript CG1976-RB 0.101
Act88F Actin 88F 0.101
flw flapwing 0.099
rost rolling stone 0.098
in inturned 0.097
Tm2 Tropomyosin 2 0.097
flr flare 0.097
dco discs overgrown 0.096
lmd lame duck 0.095
sina seven in absentia 0.093
en engrailed 0.092
Dat Dopamine N acetyltransferase 0.092
hh hedgehog 0.089
betaTub60D beta-Tubulin at 60D 0.087
mew multiple edematous wings 0.086
argos CG4531 gene product from transcript CG4531-RA 0.085
S6k RPS6-p70-protein kinase 0.084
Fs(2)Ket Female sterile (2) Ketel 0.083
Act87E Actin 87E 0.082
Akap200 A kinase anchor protein 200 0.082
CG32528 CG32528 gene product from transcript CG32528-RA 0.081
Mhc Myosin heavy chain 0.081
sns sticks and stones 0.080
Mlc1 Myosin alkali light chain 1 0.077
Ubx Ultrabithorax 0.077
Cdc42 CG12530 gene product from transcript CG12530-RA 0.076
sd scalloped 0.076
foxo forkhead box, sub-group O 0.075
l(2)gl lethal (2) giant larvae 0.075
sens senseless 0.074
grh grainy head 0.074
Rbp9 RNA-binding protein 9 0.074
klg klingon 0.071
mth methuselah 0.070
Eip75B Ecdysone-induced protein 75B 0.069
Thor CG8846 gene product from transcript CG8846-RA 0.068
Dad Daughters against dpp 0.068
scny scrawny 0.067
H Hairless 0.067
mys myospheroid 0.067
byn brachyenteron 0.067
HLH54F CG5005 gene product from transcript CG5005-RA 0.066
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Homo sapiens
Name Description Probability Func Analog Organism
TTN titin 0.971
HDAC4 histone deacetylase 4 0.755
TRIM63 tripartite motif containing 63 0.747
JAG1 jagged 1 0.636
SRF serum response factor (c-fos serum response element-binding transcription factor) 0.306
NOTCH1 notch 1 0.187
BCL6 B-cell CLL/lymphoma 6 0.180
CBL Cas-Br-M (murine) ecotropic retroviral transforming sequence 0.169
IGF2 insulin-like growth factor 2 (somatomedin A) 0.130
FSTL1 follistatin-like 1 0.097
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein 0.096
NOTCH3 notch 3 0.096
MYH7B myosin, heavy chain 7B, cardiac muscle, beta 0.090
CAV1 caveolin 1, caveolae protein, 22kDa 0.089
TCAP titin-cap (telethonin) 0.087
CNOT8 CCR4-NOT transcription complex, subunit 8 0.085
BMPR1A bone morphogenetic protein receptor, type IA 0.082
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide 0.079
TESK1 testis-specific kinase 1 0.074
MEF2C myocyte enhancer factor 2C 0.071
NKX2-5 NK2 transcription factor related, locus 5 (Drosophila) 0.069
FN1 fibronectin 1 0.062
CSRP3 cysteine and glycine-rich protein 3 (cardiac LIM protein) 0.054
JUN jun proto-oncogene 0.053
SMAD3 SMAD family member 3 0.049
BCL2L1 BCL2-like 1 0.049
TCF3 transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47) 0.047
DMD dystrophin 0.045
LTA lymphotoxin alpha (TNF superfamily, member 1) 0.043
ITGB1BP3 integrin beta 1 binding protein 3 0.040
CEBPB CCAAT/enhancer binding protein (C/EBP), beta 0.040
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma 0.038
MYOD1 myogenic differentiation 1 0.037
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.035
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 0.035
UTRN utrophin 0.035
PLCG1 phospholipase C, gamma 1 0.034
ATF3 activating transcription factor 3 0.032
DTNA dystrobrevin, alpha 0.029
MTMR12 myotubularin related protein 12 0.027
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.027
PTCH1 patched 1 0.026
PPP3R1 protein phosphatase 3, regulatory subunit B, alpha 0.025
DTNB dystrobrevin, beta 0.024
DAG1 dystroglycan 1 (dystrophin-associated glycoprotein 1) 0.024
SMAD4 SMAD family member 4 0.022
PARVA parvin, alpha 0.022
ZFYVE9 zinc finger, FYVE domain containing 9 0.020
DLL1 delta-like 1 (Drosophila) 0.020
EPAS1 endothelial PAS domain protein 1 0.018
FBLN1 fibulin 1 0.017
CXCL11 chemokine (C-X-C motif) ligand 11 0.017
HDAC9 histone deacetylase 9 0.016
IGFBP5 insulin-like growth factor binding protein 5 0.016
H3F3C H3 histone, family 3C 0.015
MEF2A myocyte enhancer factor 2A 0.015
IQGAP1 IQ motif containing GTPase activating protein 1 0.015
INO80B INO80 complex subunit B 0.014
EP300 E1A binding protein p300 0.014
IGFBP3 insulin-like growth factor binding protein 3 0.013
SKIL SKI-like oncogene 0.013
MYOG myogenin (myogenic factor 4) 0.013
SIN3A SIN3 homolog A, transcription regulator (yeast) 0.012
EGLN1 egl nine homolog 1 (C. elegans) 0.012
ENG endoglin 0.012
SMAD7 SMAD family member 7 0.012
TGFB3 transforming growth factor, beta 3 0.011
ATF4 activating transcription factor 4 (tax-responsive enhancer element B67) 0.011
SMAD1 SMAD family member 1 0.011
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide 0.011
TMSB10 thymosin beta 10 0.011
TNNT3 troponin T type 3 (skeletal, fast) 0.010
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Rattus norvegicus
Name Description Probability Func Analog Organism
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism