The network for 'determination of left right symmetry' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

determination of left right symmetry

The establishment of an organism's body plan or part of an organism with respect to the left and right halves. The pattern can either be symmetric, such that the halves are mirror images, or asymmetric where the pattern deviates from this symmetry.

Mus musculus
Name Description Probability Func Analog Organism
Pitx2 paired-like homeodomain transcription factor 2 1.000
Nodal nodal 1.000
Shh sonic hedgehog 1.000
Fgfr2 fibroblast growth factor receptor 2 0.999
Vangl2 vang-like 2 (van gogh, Drosophila) 0.998
Fgf8 fibroblast growth factor 8 0.997
Zic3 zinc finger protein of the cerebellum 3 0.997
Otx2 orthodenticle homolog 2 (Drosophila) 0.997
Pax2 paired box gene 2 0.995
Pax3 paired box gene 3 0.995
Meox2 mesenchyme homeobox 2 0.994
Foxh1 forkhead box H1 0.994
Tbx3 T-box 3 0.994
Gata4 GATA binding protein 4 0.993
Nkx2-5 NK2 transcription factor related, locus 5 (Drosophila) 0.992
Invs inversin 0.992
Gli3 GLI-Kruppel family member GLI3 0.989
Hoxa13 homeobox A13 0.984
Gli2 GLI-Kruppel family member GLI2 0.977
Hoxa1 homeobox A1 0.975
Kif3a kinesin family member 3A 0.973
Six1 sine oculis-related homeobox 1 homolog (Drosophila) 0.970
Sox9 SRY-box containing gene 9 0.958
Fgf10 fibroblast growth factor 10 0.952
Foxc1 forkhead box C1 0.950
Ctnnb1 catenin (cadherin associated protein), beta 1 0.948
Fgfr1 fibroblast growth factor receptor 1 0.947
Bmp4 bone morphogenetic protein 4 0.945
Rarg retinoic acid receptor, gamma 0.931
Chrd chordin 0.929
Dnahc11 dynein, axonemal, heavy chain 11 0.922
Hand1 heart and neural crest derivatives expressed transcript 1 0.909
Foxc2 forkhead box C2 0.906
Mks1 Meckel syndrome, type 1 0.906
Smad6 MAD homolog 6 (Drosophila) 0.900
Uncx UNC homeobox 0.885
Notch1 Notch gene homolog 1 (Drosophila) 0.881
Psen1 presenilin 1 0.875
Wnt3a wingless-related MMTV integration site 3A 0.873
Rbpj recombination signal binding protein for immunoglobulin kappa J region 0.873
Jag1 jagged 1 0.839
Lmx1a LIM homeobox transcription factor 1 alpha 0.833
Pitx1 paired-like homeodomain transcription factor 1 0.833
Wt1 Wilms tumor 1 homolog 0.821
Chd7 chromodomain helicase DNA binding protein 7 0.809
Acvr1 activin A receptor, type 1 0.806
Ror2 receptor tyrosine kinase-like orphan receptor 2 0.793
Lhx1 LIM homeobox protein 1 0.792
Hoxd13 homeobox D13 0.791
Tgfb2 transforming growth factor, beta 2 0.781
Vegfa vascular endothelial growth factor A 0.776
Msx1 homeobox, msh-like 1 0.774
Nog noggin 0.773
Hoxa11 homeobox A11 0.766
Bbs4 Bardet-Biedl syndrome 4 (human) 0.756
Pbx1 pre B-cell leukemia transcription factor 1 0.747
Hoxa3 homeobox A3 0.737
Gsc goosecoid homeobox 0.711
Tgfbr2 transforming growth factor, beta receptor II 0.698
Hoxa10 homeobox A10 0.696
Notch2 Notch gene homolog 2 (Drosophila) 0.696
Eya1 eyes absent 1 homolog (Drosophila) 0.692
Zfpm2 zinc finger protein, multitype 2 0.665
Foxf1a forkhead box F1a 0.663
Pax7 paired box gene 7 0.661
Acvr2b activin receptor IIB 0.637
Nos3 nitric oxide synthase 3, endothelial cell 0.634
Cfc1 cripto, FRL-1, cryptic family 1 0.624
Mesp1 mesoderm posterior 1 0.618
Hoxd11 homeobox D11 0.596
Lrp6 low density lipoprotein receptor-related protein 6 0.592
Smad4 MAD homolog 4 (Drosophila) 0.585
Tcf21 transcription factor 21 0.577
Nr5a1 nuclear receptor subfamily 5, group A, member 1 0.565
Pcsk5 proprotein convertase subtilisin/kexin type 5 0.565
Foxa2 forkhead box A2 0.557
Rarb retinoic acid receptor, beta 0.555
Scn5a sodium channel, voltage-gated, type V, alpha 0.550
Ptf1a pancreas specific transcription factor, 1a 0.546
Smad3 MAD homolog 3 (Drosophila) 0.546
En1 engrailed 1 0.536
Snai1 snail homolog 1 (Drosophila) 0.532
Ptk7 PTK7 protein tyrosine kinase 7 0.521
Gata6 GATA binding protein 6 0.517
Smo smoothened homolog (Drosophila) 0.515
Btbd17 BTB (POZ) domain containing 17 0.510
Twist2 twist homolog 2 (Drosophila) 0.509
Myl2 myosin, light polypeptide 2, regulatory, cardiac, slow 0.505
Ascl1 achaete-scute complex homolog 1 (Drosophila) 0.500
Hoxa2 homeobox A2 0.498
Rac1 RAS-related C3 botulinum substrate 1 0.496
Sox7 SRY-box containing gene 7 0.495
Bmpr1a bone morphogenetic protein receptor, type 1A 0.495
Pax8 paired box gene 8 0.495
Fgf3 fibroblast growth factor 3 0.494
Lfng LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase 0.494
Isl1 ISL1 transcription factor, LIM/homeodomain 0.492
Nkx2-3 NK2 transcription factor related, locus 3 (Drosophila) 0.485
Pou3f3 POU domain, class 3, transcription factor 3 0.479
Hand2 heart and neural crest derivatives expressed transcript 2 0.479
Loading network...
Caenorhabditis elegans
Name Description Probability Func Analog Organism
che-13 Protein CHE-13 0.133
osm-5 Protein OSM-5 0.121
mec-2 Protein MEC-2 0.087
lin-29 Protein LIN-29 0.084
unc-7 Protein UNC-7 0.072
che-2 Protein CHE-2 0.070
che-3 Protein CHE-3 0.066
egl-18 Protein EGL-18 0.063
nhr-143 Protein NHR-143 0.055
inx-4 Protein INX-4 0.053
bar-1 Protein BAR-1 0.050
lin-17 Protein LIN-17 0.046
eat-4 Protein EAT-4 0.042
daf-10 Protein DAF-10 0.039
madd-4 Protein MADD-4 0.030
hlh-2 Protein HLH-2 0.030
glp-1 Protein GLP-1 0.025
unc-73 Protein UNC-73 0.024
che-11 Protein CHE-11 0.024
pdfr-1 Protein PDFR-1 0.024
nphp-1 Protein NPHP-1 0.024
unc-62 Protein UNC-62 0.023
osm-6 Protein OSM-6 0.022
T27A3.1 Protein T27A3.1 0.021
unc-6 Protein UNC-6 0.020
lin-11 Protein LIN-11 0.018
CELE_H12D21.9 Protein H12D21.9 0.018
vab-3 Protein VAB-3 0.017
ric-3 Protein RIC-3 0.016
unc-9 Protein UNC-9 0.016
rig-6 Protein RIG-6 0.015
prmt-3 Protein PRMT-3 0.015
unc-115 Protein UNC-115 0.015
cam-1 Protein CAM-1 0.014
K08E3.5 Protein K08E3.5 0.014
arl-6 Protein ARL-6 0.014
bli-1 Protein BLI-1 0.014
cdf-1 Protein CDF-1 0.013
nmgp-1 Protein NMGP-1 0.013
hlh-1 Protein HLH-1 0.013
CELE_Y11D7A.5 Protein Y11D7A.5 0.013
sop-3 Protein SOP-3 0.013
CELE_W05H12.1 Protein W05H12.1 0.013
sdha-1 Protein SDHA-1 0.012
dhs-21 Protein DHS-21 0.012
C45G9.6 Protein C45G9.6 0.012
che-14 Protein CHE-14 0.012
daf-12 Protein DAF-12 0.012
kin-3 Protein KIN-3 0.012
efn-2 Protein EFN-2 0.011
nhr-67 Protein NHR-67 0.011
cgef-2 Protein CGEF-2 0.011
lbp-7 Protein LBP-7 0.010
let-756 Protein LET-756 0.010
ahr-1 Protein AHR-1 0.010
Loading network...
Danio rerio
Name Description Probability Func Analog Organism
pax2a paired box gene 2a 0.999
hnf1ba HNF1 homeobox Ba 0.998
fgf8a fibroblast growth factor 8 a 0.997
chd chordin 0.990
gata3 GATA-binding protein 3 0.989
tbx16 T-box gene 16 0.988
tbx1 T-box 1 0.987
shha sonic hedgehog a 0.987
ift88 intraflagellar transport 88 homolog 0.984
ntla no tail a 0.984
bmp4 bone morphogenetic protein 4 0.968
aldh1a2 aldehyde dehydrogenase 1 family, member A2 0.967
lrrc6 leucine rich repeat containing 6 0.964
zic1 zic family member 1 (odd-paired homolog, Drosophila) 0.962
tbx20 T-box 20 0.958
cdh2 cadherin 2, neuronal 0.941
pkd2 polycystic kidney disease 2 0.941
smo smoothened homolog (Drosophila) 0.937
sulf1 sulfatase 1 0.934
wnt11 wingless-type MMTV integration site family, member 11 0.917
six4b sine oculis homeobox homolog 4b 0.908
fzd10 frizzled homolog 10 0.906
sox9a SRY-box containing gene 9a 0.902
flh floating head 0.890
bmp2b bone morphogenetic protein 2b 0.887
wnt11r wingless-type MMTV integration site family, member 11, related 0.887
shhb sonic hedgehog b 0.884
ndr2 nodal-related 2 0.884
snai1b snail homolog 1b (Drosophila) 0.881
oep one-eyed pinhead 0.875
myf5 myogenic factor 5 0.871
msxc muscle segment homeobox C 0.865
nkx2.5 NK2 transcription factor related 5 0.864
atp1a1 ATPase, Na+/K+ transporting, alpha 1 polypeptide 0.858
fzd8a frizzled homolog 8a 0.853
gro1 groucho 1 0.852
gata5 GATA-binding protein 5 0.850
dld deltaD 0.842
sox17 SRY-box containing gene 17 0.837
lhx1a LIM homeobox 1a 0.835
foxa2 forkhead box A2 0.822
dcc deleted in colorectal carcinoma 0.819
rfx2 regulatory factor X, 2 (influences HLA class II expression) 0.818
twist1b twist1b 0.813
jag2 jagged 2 0.796
smad9 MAD homolog 9 (Drosophila) 0.795
hspb7 heat shock protein family, alpha-crystallin-related, b7 0.786
zgc:100838 zgc:100838 0.767
pcdh8 protocadherin 8 0.740
ephb4b eph receptor B4b 0.739
gli2a GLI-Kruppel family member GLI2a 0.729
arl13b ADP-ribosylation factor-like 13b 0.727
twist1a twist1a 0.722
lft1 lefty1 0.693
zic3 zic family member 3 heterotaxy 1 (odd-paired homolog, Drosophila) 0.691
lfng lunatic fringe homolog 0.682
wnt1 wingless-type MMTV integration site family, member 1 0.677
lrrc50 leucine rich repeat containing 50 0.676
si:ch211-173o4.2 si:ch211-173o4.2 0.669
tbx2b T-box 2b 0.668
sox32 SRY-box containing gene 32 0.668
ccdc40 coiled-coil domain containing 40 0.665
ptenb phosphatase and tensin homolog B (mutated in multiple advanced cancers 1) 0.664
gdf6a growth differentiation factor 6a 0.664
foxe3 forkhead box E3 0.663
lft2 lefty2 0.649
notch1b notch homolog 1b 0.643
prdm5 PR domain containing 5 0.635
neo1 neogenin 1 0.631
robo3 roundabout homolog 3 0.628
cc2d2a coiled-coil and C2 domain containing 2A 0.626
kif17 kinesin family member 17 0.614
foxg1a forkhead box G1a 0.612
hoxa13b homeo box A13b 0.610
eya4 eyes absent homolog 4 (Drosophila) 0.608
gpc4 glypican 4 0.607
fgf4 fibroblast growth factor 4 0.605
dmrt2a doublesex and mab-3 related transcription factor 2a 0.598
fgf3 fibroblast growth factor 3 0.594
wnt3 wingless-type MMTV integration site family, member 3 0.592
gpia glucose phosphate isomerase a 0.591
hey2 hairy/enhancer-of-split related with YRPW motif 2 0.590
tbx18 T-box 18 0.588
wnt9b wingless-type MMTV integration site family, member 9B 0.570
runx2b runt-related transcription factor 2b 0.569
vcana versican a 0.568
tp53 tumor protein p53 0.567
npnt nephronectin 0.552
bmp2a bone morphogenetic protein 2a 0.549
mapk1 mitogen-activated protein kinase 1 0.548
her7 hairy and enhancer of split related-7 0.545
mib mind bomb 0.543
foxh1 forkhead box H1 0.541
ift57 intraflagellar transport protein 57 0.539
mef2cb myocyte enhancer factor 2cb 0.531
sox3 SRY-box containing gene 3 0.528
arhgef7b Rho guanine nucleotide exchange factor (GEF) 7b 0.523
foxi1 forkhead box I1 0.520
dkk1b dickkopf 1b 0.514
atoh1b atonal homolog 1b 0.513
Loading network...
Drosophila melanogaster
Name Description Probability Func Analog Organism
tkv thickveins 0.491
dsh dishevelled 0.386
G-oalpha47A G protein oalpha 47A 0.383
arm armadillo 0.363
Dl Delta 0.360
Myo31DF Myosin 31DF 0.282
wg wingless 0.233
fng fringe 0.196
baz bazooka 0.183
if inflated 0.149
stumps CG31317 gene product from transcript CG31317-RC 0.137
dpp decapentaplegic 0.137
lin lines 0.131
comt comatose 0.121
emc extra macrochaetae 0.113
ci cubitus interruptus 0.113
shi shibire 0.103
twi twist 0.094
en engrailed 0.094
cindr CIN85 and CD2AP orthologue 0.094
ovo CG6824 gene product from transcript CG6824-RE 0.092
bs blistered 0.083
Lim1 CG11354 gene product from transcript CG11354-RA 0.075
ap apterous 0.075
Cdc42 CG12530 gene product from transcript CG12530-RA 0.072
slou slouch 0.070
Syx1A Syntaxin 1A 0.070
kn knot 0.065
H Hairless 0.062
fj four-jointed 0.061
WASp CG1520 gene product from transcript CG1520-RA 0.050
rhea CG6831 gene product from transcript CG6831-RA 0.049
mys myospheroid 0.047
eve even skipped 0.047
Rac1 CG2248 gene product from transcript CG2248-RA 0.045
Ppcs Phosphopantothenoylcysteine synthetase 0.043
scb scab 0.042
kst karst 0.041
dally division abnormally delayed 0.041
hh hedgehog 0.040
Pvr PDGF- and VEGF-receptor related 0.040
crb crumbs 0.040
rok Rho-kinase 0.039
sn singed 0.036
bowl brother of odd with entrails limited 0.035
Doc2 Dorsocross2 0.035
sha shavenoid 0.034
fz frizzled 0.033
Med Medea 0.032
lbl ladybird late 0.032
dia diaphanous 0.031
kibra kibra ortholog 0.031
kirre kin of irre 0.025
tin tinman 0.024
ttk tramtrack 0.023
pb proboscipedia 0.023
jar jaguar 0.023
ft fat 0.023
opa odd paired 0.023
smo smoothened 0.022
ash2 absent, small, or homeotic discs 2 0.022
flw flapwing 0.022
Hmgcr HMG Coenzyme A reductase 0.021
drm drumstick 0.021
zfh1 Zn finger homeodomain 1 0.020
enc encore 0.020
htl heartless 0.020
wun wunen 0.019
Snap25 Synapse protein 25 0.019
trc tricornered 0.019
unc uncoordinated 0.018
neur neuralized 0.018
Cbl CG7037 gene product from transcript CG7037-RB 0.018
pbl pebble 0.018
Wnt4 Wnt oncogene analog 4 0.018
inv invected 0.018
rempA reduced mechanoreceptor potential A 0.018
put punt 0.017
Caf1 Chromatin assembly factor 1 subunit 0.017
Myo61F Myosin 61F 0.016
abd-A abdominal A 0.016
Cul-5 Cullin-5 0.016
nompA no mechanoreceptor potential A 0.015
beat-Ia beaten path Ia 0.015
HLH54F CG5005 gene product from transcript CG5005-RA 0.014
defl deflated 0.014
Kr Kruppel 0.014
L Lobe 0.014
mew multiple edematous wings 0.013
Vha55 Vacuolar H[+]-ATPase 55kD B subunit 0.013
sax saxophone 0.013
eya eyes absent 0.013
Mad Mothers against dpp 0.013
bi bifid 0.013
p38b CG7393 gene product from transcript CG7393-RA 0.013
Nelf-E Negative elongation factor E 0.012
ena enabled 0.012
Dad Daughters against dpp 0.012
hkb huckebein 0.012
GluRIIA Glutamate receptor IIA 0.012
Loading network...
Homo sapiens
Name Description Probability Func Analog Organism
RHOA ras homolog gene family, member A 0.918
BMPR1A bone morphogenetic protein receptor, type IA 0.433
SMAD3 SMAD family member 3 0.430
NKX2-5 NK2 transcription factor related, locus 5 (Drosophila) 0.394
SMAD2 SMAD family member 2 0.377
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) 0.375
MAPK8 mitogen-activated protein kinase 8 0.367
SMAD1 SMAD family member 1 0.357
NOTCH1 notch 1 0.265
ATF2 activating transcription factor 2 0.215
SMAD7 SMAD family member 7 0.169
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.145
TJP1 tight junction protein 1 (zona occludens 1) 0.137
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.132
TBX5 T-box 5 0.123
JUN jun proto-oncogene 0.118
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) 0.116
GSK3B glycogen synthase kinase 3 beta 0.114
ARHGAP1 Rho GTPase activating protein 1 0.105
ARHGDIA Rho GDP dissociation inhibitor (GDI) alpha 0.098
MAP2K4 mitogen-activated protein kinase kinase 4 0.093
MAFA v-maf musculoaponeurotic fibrosarcoma oncogene homolog A (avian) 0.088
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) 0.083
MARK3 MAP/microtubule affinity-regulating kinase 3 0.073
SMAD5 SMAD family member 5 0.069
FLNC filamin C, gamma 0.067
SMAD4 SMAD family member 4 0.059
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.056
CD44 CD44 molecule (Indian blood group) 0.052
GATA4 GATA binding protein 4 0.050
BMP2 bone morphogenetic protein 2 0.042
MKL1 megakaryoblastic leukemia (translocation) 1 0.041
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.040
SIN3A SIN3 homolog A, transcription regulator (yeast) 0.037
CDC42 cell division cycle 42 (GTP binding protein, 25kDa) 0.036
SASS6 spindle assembly 6 homolog (C. elegans) 0.033
PSEN2 presenilin 2 (Alzheimer disease 4) 0.031
EP300 E1A binding protein p300 0.030
PCM1 pericentriolar material 1 0.029
TSC2 tuberous sclerosis 2 0.028
FZD1 frizzled homolog 1 (Drosophila) 0.027
JAG1 jagged 1 0.027
FGF10 fibroblast growth factor 10 0.026
SEPT2 septin 2 0.025
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide 0.024
HIPK2 homeodomain interacting protein kinase 2 0.024
EXOC7 exocyst complex component 7 0.023
HMGA1 high mobility group AT-hook 1 0.023
GLI1 GLI family zinc finger 1 0.022
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.022
BBS7 Bardet-Biedl syndrome 7 0.022
PELP1 proline, glutamate and leucine rich protein 1 0.022
PTCH1 patched 1 0.021
TMED10 transmembrane emp24-like trafficking protein 10 (yeast) 0.021
FSTL1 follistatin-like 1 0.021
TGFB1 transforming growth factor, beta 1 0.020
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta 0.017
LRP6 low density lipoprotein receptor-related protein 6 0.017
PKD1 polycystic kidney disease 1 (autosomal dominant) 0.017
LMAN1 lectin, mannose-binding, 1 0.016
CENPJ centromere protein J 0.016
CXXC5 CXXC finger protein 5 0.016
MAML1 mastermind-like 1 (Drosophila) 0.015
SNX5 sorting nexin 5 0.014
FGF1 fibroblast growth factor 1 (acidic) 0.014
NOG noggin 0.014
PML promyelocytic leukemia 0.014
BMP1 bone morphogenetic protein 1 0.014
NFIX nuclear factor I/X (CCAAT-binding transcription factor) 0.013
SORBS3 sorbin and SH3 domain containing 3 0.013
PRKG1 protein kinase, cGMP-dependent, type I 0.013
NCF2 neutrophil cytosolic factor 2 0.013
YY1 YY1 transcription factor 0.013
HDAC9 histone deacetylase 9 0.012
FOS FBJ murine osteosarcoma viral oncogene homolog 0.012
PLXNB1 plexin B1 0.012
SP1 Sp1 transcription factor 0.012
BBS2 Bardet-Biedl syndrome 2 0.011
ZEB2 zinc finger E-box binding homeobox 2 0.011
CLIC4 chloride intracellular channel 4 0.011
RHOG ras homolog gene family, member G (rho G) 0.010
EGLN1 egl nine homolog 1 (C. elegans) 0.010
NLK nemo-like kinase 0.010
CANX calnexin 0.010
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha) 0.010
MKL2 MKL/myocardin-like 2 0.010
ACVR1 activin A receptor, type I 0.010
Loading network...
Rattus norvegicus
Name Description Probability Func Analog Organism
Loading network...
Saccharomyces cerevisiae
Name Description Probability Func Analog Organism