The network for 'negative regulation of mesenchymal cell proliferation' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

negative regulation of mesenchymal cell proliferation

Any process that decreases the frequency, rate or extent of mesenchymal cell proliferation. A mesenchymal cell is a cell that normally gives rise to other cells that are organized as three-dimensional masses, rather than sheets.

Mus musculus
Name Description Probability Func Analog Organism
Gli3 GLI-Kruppel family member GLI3 0.997
Shh sonic hedgehog 0.996
Fgfr2 fibroblast growth factor receptor 2 0.990
Pax2 paired box gene 2 0.986
Fgf8 fibroblast growth factor 8 0.985
Foxc1 forkhead box C1 0.975
Dkk1 dickkopf homolog 1 (Xenopus laevis) 0.969
Fgfr1 fibroblast growth factor receptor 1 0.966
Nfix nuclear factor I/X 0.965
Rarg retinoic acid receptor, gamma 0.956
Wnt3a wingless-related MMTV integration site 3A 0.933
Otx1 orthodenticle homolog 1 (Drosophila) 0.924
Chrd chordin 0.914
Lhx1 LIM homeobox protein 1 0.912
Gli2 GLI-Kruppel family member GLI2 0.906
Sox9 SRY-box containing gene 9 0.904
Pax8 paired box gene 8 0.898
Bmp7 bone morphogenetic protein 7 0.890
Ece1 endothelin converting enzyme 1 0.875
T brachyury 0.870
Rarb retinoic acid receptor, beta 0.792
Tbx1 T-box 1 0.787
Smo smoothened homolog (Drosophila) 0.762
Ror2 receptor tyrosine kinase-like orphan receptor 2 0.736
Gdnf glial cell line derived neurotrophic factor 0.690
Lrp6 low density lipoprotein receptor-related protein 6 0.680
Fgf18 fibroblast growth factor 18 0.612
Pitx2 paired-like homeodomain transcription factor 2 0.594
Foxc2 forkhead box C2 0.583
Tgfb2 transforming growth factor, beta 2 0.571
Msx1 homeobox, msh-like 1 0.566
Fzd8 frizzled homolog 8 (Drosophila) 0.555
Thra thyroid hormone receptor alpha 0.530
Wnt6 wingless-related MMTV integration site 6 0.530
Amhr2 anti-Mullerian hormone type 2 receptor 0.528
Prrx2 paired related homeobox 2 0.491
Gata6 GATA binding protein 6 0.466
Wnt4 wingless-related MMTV integration site 4 0.454
Six1 sine oculis-related homeobox 1 homolog (Drosophila) 0.441
Col13a1 collagen, type XIII, alpha 1 0.429
Gas1 growth arrest specific 1 0.426
Gsc goosecoid homeobox 0.423
Emx1 empty spiracles homolog 1 (Drosophila) 0.407
Nfic nuclear factor I/C 0.403
Otx2 orthodenticle homolog 2 (Drosophila) 0.393
Dlx5 distal-less homeobox 5 0.370
Rara retinoic acid receptor, alpha 0.358
Nfib nuclear factor I/B 0.349
Smad6 MAD homolog 6 (Drosophila) 0.344
Foxf2 forkhead box F2 0.340
Fgf10 fibroblast growth factor 10 0.335
Wnt3 wingless-related MMTV integration site 3 0.323
Wnt10b wingless related MMTV integration site 10b 0.315
Hoxa2 homeobox A2 0.304
Pou3f3 POU domain, class 3, transcription factor 3 0.291
Wnt11 wingless-related MMTV integration site 11 0.282
Pbx1 pre B-cell leukemia transcription factor 1 0.282
En1 engrailed 1 0.276
Pax3 paired box gene 3 0.265
Dact1 dapper homolog 1, antagonist of beta-catenin (xenopus) 0.261
Zfp503 zinc finger protein 503 0.261
Hoxd9 homeobox D9 0.258
Kl klotho 0.244
Lmx1b LIM homeobox transcription factor 1 beta 0.234
Zbtb20 zinc finger and BTB domain containing 20 0.232
Twist2 twist homolog 2 (Drosophila) 0.230
Meox2 mesenchyme homeobox 2 0.226
Gata4 GATA binding protein 4 0.221
Rxra retinoid X receptor alpha 0.221
Foxf1a forkhead box F1a 0.217
Nr2f2 nuclear receptor subfamily 2, group F, member 2 0.211
Gli1 GLI-Kruppel family member GLI1 0.206
BC024139 cDNA sequence BC024139 0.205
Fzd4 frizzled homolog 4 (Drosophila) 0.198
Alx4 aristaless-like homeobox 4 0.197
Tbx2 T-box 2 0.185
Wnt5a wingless-related MMTV integration site 5A 0.183
Ptpn14 protein tyrosine phosphatase, non-receptor type 14 0.181
Prrx1 paired related homeobox 1 0.178
Fzd10 frizzled homolog 10 (Drosophila) 0.176
Lmx1a LIM homeobox transcription factor 1 alpha 0.173
Hoxd11 homeobox D11 0.165
Fgf17 fibroblast growth factor 17 0.159
Sim2 single-minded homolog 2 (Drosophila) 0.157
Adcy9 adenylate cyclase 9 0.151
Efnb1 ephrin B1 0.151
Fzd7 frizzled homolog 7 (Drosophila) 0.147
Msx2 homeobox, msh-like 2 0.146
Emp2 epithelial membrane protein 2 0.145
Six4 sine oculis-related homeobox 4 homolog (Drosophila) 0.144
Wnt2b wingless related MMTV integration site 2b 0.144
Tbx3 T-box 3 0.138
Fgfr3 fibroblast growth factor receptor 3 0.138
Porcn porcupine homolog (Drosophila) 0.137
Irx3 Iroquois related homeobox 3 (Drosophila) 0.134
Ctnnb1 catenin (cadherin associated protein), beta 1 0.131
Zfp651 zinc finger protein 651 0.129
Hsd11b2 hydroxysteroid 11-beta dehydrogenase 2 0.122
Rspo1 R-spondin homolog (Xenopus laevis) 0.121
Nynrin NYN domain and retroviral integrase containing 0.121
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Homo sapiens
Name Description Probability Func Analog Organism
BMPR1A bone morphogenetic protein receptor, type IA 1.000
JUP junction plakoglobin 0.998
FZD1 frizzled homolog 1 (Drosophila) 0.868
WFIKKN2 WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2 0.552
ZFYVE9 zinc finger, FYVE domain containing 9 0.531
LRP6 low density lipoprotein receptor-related protein 6 0.453
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.317
NFIA nuclear factor I/A 0.285
NOG noggin 0.277
MEIS2 Meis homeobox 2 0.169
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) 0.142
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) 0.138
PBX1 pre-B-cell leukemia homeobox 1 0.101
FZD8 frizzled homolog 8 (Drosophila) 0.090
FSTL1 follistatin-like 1 0.068
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.057
NFIX nuclear factor I/X (CCAAT-binding transcription factor) 0.039
CDH1 cadherin 1, type 1, E-cadherin (epithelial) 0.038
WDYHV1 WDYHV motif containing 1 0.036
DSP desmoplakin 0.036
BMPR1B bone morphogenetic protein receptor, type IB 0.035
MPDZ multiple PDZ domain protein 0.033
MEIS1 Meis homeobox 1 0.031
BMP2 bone morphogenetic protein 2 0.028
LIMCH1 LIM and calponin homology domains 1 0.024
ENAH enabled homolog (Drosophila) 0.021
DIP2A DIP2 disco-interacting protein 2 homolog A (Drosophila) 0.021
FZD2 frizzled homolog 2 (Drosophila) 0.020
WFIKKN1 WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 1 0.020
BMP4 bone morphogenetic protein 4 0.020
GLIS2 GLIS family zinc finger 2 0.020
FGF4 fibroblast growth factor 4 0.017
CDH2 cadherin 2, type 1, N-cadherin (neuronal) 0.017
PDGFC platelet derived growth factor C 0.017
TGFB2 transforming growth factor, beta 2 0.016
ZMYND11 zinc finger, MYND-type containing 11 0.015
TCF4 transcription factor 4 0.014
MID1 midline 1 (Opitz/BBB syndrome) 0.014
TGFB1 transforming growth factor, beta 1 0.014
AR androgen receptor 0.013
WNT3 wingless-type MMTV integration site family, member 3 0.013
FERMT2 fermitin family member 2 0.013
F3 coagulation factor III (thromboplastin, tissue factor) 0.012
EMD emerin 0.012
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.011
LBX1 ladybird homeobox 1 0.011
NFIC nuclear factor I/C (CCAAT-binding transcription factor) 0.011
PNMA2 paraneoplastic antigen MA2 0.010
RBM12B RNA binding motif protein 12B 0.010
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Rattus norvegicus
Name Description Probability Func Analog Organism
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism