IMP
Process View
The network for 'transdifferentiation' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.
Multiple Organisms
transdifferentiation
The conversion of a differentiated cell of one fate into a differentiated cell of another fate without first undergoing cell division or reversion to a more primitive or stem cell-like fate.
| Name | Description | Probability | Func Analog Organism |
|---|---|---|---|
| Pou5f1 | POU domain, class 5, transcription factor 1 | 1.000 | |
| Sall4 | sal-like 4 (Drosophila) | 1.000 | |
| Neurod1 | neurogenic differentiation 1 | 1.000 | |
| Nanog | Nanog homeobox | 1.000 | |
| Ascl1 | achaete-scute complex homolog 1 (Drosophila) | 0.999 | |
| Sox2 | SRY-box containing gene 2 | 0.999 | |
| Otx2 | orthodenticle homolog 2 (Drosophila) | 0.998 | |
| Esrrb | estrogen related receptor, beta | 0.997 | |
| Sall3 | sal-like 3 (Drosophila) | 0.997 | |
| Rbbp5 | retinoblastoma binding protein 5 | 0.987 | |
| Sall1 | sal-like 1 (Drosophila) | 0.986 | |
| Neurog2 | neurogenin 2 | 0.982 | |
| Pax6 | paired box gene 6 | 0.971 | |
| Wdr5 | WD repeat domain 5 | 0.961 | |
| Pdx1 | pancreatic and duodenal homeobox 1 | 0.961 | |
| Mta1 | metastasis associated 1 | 0.958 | |
| Neurod4 | neurogenic differentiation 4 | 0.957 | |
| Nr0b1 | nuclear receptor subfamily 0, group B, member 1 | 0.955 | |
| Isl1 | ISL1 transcription factor, LIM/homeodomain | 0.943 | |
| Onecut1 | one cut domain, family member 1 | 0.938 | |
| Rnf2 | ring finger protein 2 | 0.916 | |
| Six6 | sine oculis-related homeobox 6 homolog (Drosophila) | 0.911 | |
| Shh | sonic hedgehog | 0.902 | |
| Tcfcp2l1 | transcription factor CP2-like 1 | 0.895 | |
| Robo3 | roundabout homolog 3 (Drosophila) | 0.885 | |
| Mta2 | metastasis-associated gene family, member 2 | 0.851 | |
| Lhx5 | LIM homeobox protein 5 | 0.836 | |
| Fgf8 | fibroblast growth factor 8 | 0.815 | |
| Insm1 | insulinoma-associated 1 | 0.797 | |
| Lhx3 | LIM homeobox protein 3 | 0.784 | |
| Nkx6-1 | NK6 homeobox 1 | 0.778 | |
| Neurog3 | neurogenin 3 | 0.770 | |
| Gata1 | GATA binding protein 1 | 0.752 | |
| Alx3 | aristaless-like homeobox 3 | 0.735 | |
| Sox1 | SRY-box containing gene 1 | 0.722 | |
| Hand1 | heart and neural crest derivatives expressed transcript 1 | 0.719 | |
| Igdcc3 | immunoglobulin superfamily, DCC subclass, member 3 | 0.711 | |
| Ptf1a | pancreas specific transcription factor, 1a | 0.695 | |
| Zic2 | zinc finger protein of the cerebellum 2 | 0.692 | |
| Fgf17 | fibroblast growth factor 17 | 0.688 | |
| Mbd3 | methyl-CpG binding domain protein 3 | 0.676 | |
| Kiss1 | KiSS-1 metastasis-suppressor | 0.671 | |
| Smad4 | MAD homolog 4 (Drosophila) | 0.666 | |
| Sox3 | SRY-box containing gene 3 | 0.659 | |
| Nkx2-2 | NK2 transcription factor related, locus 2 (Drosophila) | 0.652 | |
| Neurog1 | neurogenin 1 | 0.642 | |
| Pou3f2 | POU domain, class 3, transcription factor 2 | 0.628 | |
| Hmx1 | H6 homeobox 1 | 0.620 | |
| Fgf15 | fibroblast growth factor 15 | 0.615 | |
| Six1 | sine oculis-related homeobox 1 homolog (Drosophila) | 0.612 | |
| T | brachyury | 0.606 | |
| Tlx3 | T-cell leukemia, homeobox 3 | 0.589 | |
| Hes5 | hairy and enhancer of split 5 (Drosophila) | 0.589 | |
| Efna2 | ephrin A2 | 0.587 | |
| Nr5a1 | nuclear receptor subfamily 5, group A, member 1 | 0.581 | |
| Cdk5r1 | cyclin-dependent kinase 5, regulatory subunit 1 (p35) | 0.579 | |
| Chd4 | chromodomain helicase DNA binding protein 4 | 0.578 | |
| En1 | engrailed 1 | 0.577 | |
| Foxd2 | forkhead box D2 | 0.574 | |
| Hdac1 | histone deacetylase 1 | 0.572 | |
| Arx | aristaless related homeobox | 0.572 | |
| Ash2l | ash2 (absent, small, or homeotic)-like (Drosophila) | 0.544 | |
| Dlx1 | distal-less homeobox 1 | 0.541 | |
| Lhx9 | LIM homeobox protein 9 | 0.525 | |
| Six3 | sine oculis-related homeobox 3 homolog (Drosophila) | 0.521 | |
| Hand2 | heart and neural crest derivatives expressed transcript 2 | 0.521 | |
| Zic1 | zinc finger protein of the cerebellum 1 | 0.484 | |
| Ncan | neurocan | 0.480 | |
| Hoxd13 | homeobox D13 | 0.473 | |
| Emx1 | empty spiracles homolog 1 (Drosophila) | 0.454 | |
| Tbr1 | T-box brain gene 1 | 0.449 | |
| Nacc1 | nucleus accumbens associated 1, BEN and BTB (POZ) domain containing | 0.445 | |
| Dlx2 | distal-less homeobox 2 | 0.443 | |
| Pou3f3 | POU domain, class 3, transcription factor 3 | 0.429 | |
| Ngfr | nerve growth factor receptor (TNFR superfamily, member 16) | 0.427 | |
| Uncx | UNC homeobox | 0.425 | |
| Tal1 | T-cell acute lymphocytic leukemia 1 | 0.424 | |
| Igfbpl1 | insulin-like growth factor binding protein-like 1 | 0.423 | |
| Hoxd3 | homeobox D3 | 0.408 | |
| Fgf4 | fibroblast growth factor 4 | 0.406 | |
| Col22a1 | collagen, type XXII, alpha 1 | 0.401 | |
| Mecom | MDS1 and EVI1 complex locus | 0.381 | |
| Atoh7 | atonal homolog 7 (Drosophila) | 0.353 | |
| Snai1 | snail homolog 1 (Drosophila) | 0.352 | |
| Gdnf | glial cell line derived neurotrophic factor | 0.351 | |
| Pou4f2 | POU domain, class 4, transcription factor 2 | 0.350 | |
| Gpr50 | G-protein-coupled receptor 50 | 0.346 | |
| Hmx3 | H6 homeobox 3 | 0.344 | |
| Hoxc5 | homeobox C5 | 0.322 | |
| Srrm4 | serine/arginine repetitive matrix 4 | 0.320 | |
| Hoxd1 | homeobox D1 | 0.308 | |
| Nhlh1 | nescient helix loop helix 1 | 0.307 | |
| Wnt6 | wingless-related MMTV integration site 6 | 0.304 | |
| Gata4 | GATA binding protein 4 | 0.304 | |
| Cbfa2t3 | core-binding factor, runt domain, alpha subunit 2, translocated to, 3 (human) | 0.294 | |
| Foxd3 | forkhead box D3 | 0.294 | |
| Nkx2-5 | NK2 transcription factor related, locus 5 (Drosophila) | 0.287 | |
| Nog | noggin | 0.283 | |
| Tcfap2c | transcription factor AP-2, gamma | 0.280 | |
| Prph2 | peripherin 2 | 0.277 |
Loading network...
Homo sapiens
| Name | Description | Probability | Func Analog Organism |
|---|---|---|---|
| NKX2-5 | NK2 transcription factor related, locus 5 (Drosophila) | 0.816 | |
| SMAD2 | SMAD family member 2 | 0.778 | |
| WDR5 | WD repeat domain 5 | 0.741 | |
| MLL | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila) | 0.668 | |
| RBBP5 | retinoblastoma binding protein 5 | 0.483 | |
| CXXC1 | CXXC finger protein 1 | 0.442 | |
| ASH2L | ash2 (absent, small, or homeotic)-like (Drosophila) | 0.416 | |
| SETD1A | SET domain containing 1A | 0.338 | |
| PAX3 | paired box 3 | 0.198 | |
| MEN1 | multiple endocrine neoplasia I | 0.171 | |
| MLL2 | myeloid/lymphoid or mixed-lineage leukemia 2 | 0.167 | |
| CHD8 | chromodomain helicase DNA binding protein 8 | 0.130 | |
| S100B | S100 calcium binding protein B | 0.076 | |
| MYST1 | MYST histone acetyltransferase 1 | 0.045 | |
| HCFC1 | host cell factor C1 (VP16-accessory protein) | 0.036 | |
| WDR82 | WD repeat domain 82 | 0.035 | |
| C16orf53 | chromosome 16 open reading frame 53 | 0.033 | |
| SP1 | Sp1 transcription factor | 0.032 | |
| SOX10 | SRY (sex determining region Y)-box 10 | 0.032 | |
| NCOA6 | nuclear receptor coactivator 6 | 0.031 | |
| MLL3 | myeloid/lymphoid or mixed-lineage leukemia 3 | 0.026 | |
| PAXIP1 | PAX interacting (with transcription-activation domain) protein 1 | 0.019 | |
| TBX5 | T-box 5 | 0.018 | |
| GATA4 | GATA binding protein 4 | 0.017 | |
| EGLN3 | egl nine homolog 3 (C. elegans) | 0.015 | |
| WHSC2 | Wolf-Hirschhorn syndrome candidate 2 | 0.015 | |
| CTBP1 | C-terminal binding protein 1 | 0.014 | |
| RB1 | retinoblastoma 1 | 0.014 | |
| KHSRP | KH-type splicing regulatory protein | 0.014 | |
| CHD4 | chromodomain helicase DNA binding protein 4 | 0.013 | |
| GATAD2A | GATA zinc finger domain containing 2A | 0.012 | |
| HIST1H3B | histone cluster 1, H3b | 0.012 | |
| POU3F3 | POU class 3 homeobox 3 | 0.012 | |
| SOX1 | SRY (sex determining region Y)-box 1 | 0.011 | |
| MLL4 | myeloid/lymphoid or mixed-lineage leukemia 4 | 0.011 | |
| SETD1B | SET domain containing 1B | 0.010 | |
| MBD3 | methyl-CpG binding domain protein 3 | 0.010 | |
| NOVA2 | neuro-oncological ventral antigen 2 | 0.010 |