The network for 'diencephalon development' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

diencephalon development

The process whose specific outcome is the progression of the diencephalon over time, from its formation to the mature structure. The diencephalon is the paired caudal parts of the prosencephalon from which the thalamus, hypothalamus, epithalamus and subthalamus are derived; these regions regulate autonomic, visceral and endocrine function, and process information directed to the cerebral cortex.

Mus musculus
Name Description Probability Func Analog Organism
Otx2 orthodenticle homolog 2 (Drosophila) 1.000
Shh sonic hedgehog 1.000
Pax6 paired box gene 6 1.000
Sox2 SRY-box containing gene 2 1.000
Nodal nodal 1.000
Fgfr2 fibroblast growth factor receptor 2 1.000
Emx1 empty spiracles homolog 1 (Drosophila) 1.000
Fgf10 fibroblast growth factor 10 1.000
Hand1 heart and neural crest derivatives expressed transcript 1 1.000
Fgf8 fibroblast growth factor 8 1.000
Nog noggin 1.000
Pitx2 paired-like homeodomain transcription factor 2 1.000
Gli3 GLI-Kruppel family member GLI3 1.000
Eya1 eyes absent 1 homolog (Drosophila) 1.000
Pax3 paired box gene 3 1.000
Pax2 paired box gene 2 0.999
Chrd chordin 0.999
Hand2 heart and neural crest derivatives expressed transcript 2 0.999
Lhx3 LIM homeobox protein 3 0.999
Isl1 ISL1 transcription factor, LIM/homeodomain 0.998
Tbx3 T-box 3 0.998
Chd7 chromodomain helicase DNA binding protein 7 0.998
Tcfap2a transcription factor AP-2, alpha 0.998
Msx1 homeobox, msh-like 1 0.997
Rarg retinoic acid receptor, gamma 0.997
Gbx2 gastrulation brain homeobox 2 0.996
Fgfr1 fibroblast growth factor receptor 1 0.996
Lef1 lymphoid enhancer binding factor 1 0.995
Nkx2-5 NK2 transcription factor related, locus 5 (Drosophila) 0.995
Emx2 empty spiracles homolog 2 (Drosophila) 0.994
Dlx5 distal-less homeobox 5 0.993
Foxh1 forkhead box H1 0.992
Foxg1 forkhead box G1 0.991
Pax8 paired box gene 8 0.991
Wnt3a wingless-related MMTV integration site 3A 0.989
Hes5 hairy and enhancer of split 5 (Drosophila) 0.987
Fgfr3 fibroblast growth factor receptor 3 0.985
Pitx1 paired-like homeodomain transcription factor 1 0.985
Six1 sine oculis-related homeobox 1 homolog (Drosophila) 0.985
Hoxa1 homeobox A1 0.981
Insm1 insulinoma-associated 1 0.980
Ascl1 achaete-scute complex homolog 1 (Drosophila) 0.979
Prrx1 paired related homeobox 1 0.979
Sox9 SRY-box containing gene 9 0.968
Drd2 dopamine receptor D2 0.963
Zic3 zinc finger protein of the cerebellum 3 0.959
Msx2 homeobox, msh-like 2 0.958
Foxc1 forkhead box C1 0.953
Rarb retinoic acid receptor, beta 0.952
Kiss1 KiSS-1 metastasis-suppressor 0.951
T brachyury 0.949
Neurog2 neurogenin 2 0.947
Tbx15 T-box 15 0.946
Alx4 aristaless-like homeobox 4 0.946
Fgf15 fibroblast growth factor 15 0.945
Lmx1a LIM homeobox transcription factor 1 alpha 0.944
Ntrk2 neurotrophic tyrosine kinase, receptor, type 2 0.942
Hes1 hairy and enhancer of split 1 (Drosophila) 0.942
Wnt1 wingless-related MMTV integration site 1 0.942
Gsc goosecoid homeobox 0.939
En1 engrailed 1 0.939
Bmp4 bone morphogenetic protein 4 0.938
Lhx1 LIM homeobox protein 1 0.935
Sall4 sal-like 4 (Drosophila) 0.924
Runx2 runt related transcription factor 2 0.917
Nr5a1 nuclear receptor subfamily 5, group A, member 1 0.915
Foxc2 forkhead box C2 0.914
Bcl2 B-cell leukemia/lymphoma 2 0.913
Aldh1a2 aldehyde dehydrogenase family 1, subfamily A2 0.912
Twist2 twist homolog 2 (Drosophila) 0.912
Tbx1 T-box 1 0.909
Foxf1a forkhead box F1a 0.907
Tgfbr2 transforming growth factor, beta receptor II 0.903
Gdnf glial cell line derived neurotrophic factor 0.901
Pax9 paired box gene 9 0.897
Hoxd13 homeobox D13 0.889
Pthlh parathyroid hormone-like peptide 0.887
Bdnf brain derived neurotrophic factor 0.887
Alx3 aristaless-like homeobox 3 0.885
Prrx2 paired related homeobox 2 0.884
Sall3 sal-like 3 (Drosophila) 0.881
Foxa2 forkhead box A2 0.873
Six2 sine oculis-related homeobox 2 homolog (Drosophila) 0.871
Col2a1 collagen, type II, alpha 1 0.869
Pou5f1 POU domain, class 5, transcription factor 1 0.869
Otx1 orthodenticle homolog 1 (Drosophila) 0.868
Atoh7 atonal homolog 7 (Drosophila) 0.866
Hoxd3 homeobox D3 0.860
Ptf1a pancreas specific transcription factor, 1a 0.851
Pou4f3 POU domain, class 4, transcription factor 3 0.846
Nr2e1 nuclear receptor subfamily 2, group E, member 1 0.845
Zeb1 zinc finger E-box binding homeobox 1 0.842
Ror2 receptor tyrosine kinase-like orphan receptor 2 0.831
Pitx3 paired-like homeodomain transcription factor 3 0.831
Tlx3 T-cell leukemia, homeobox 3 0.828
Zic2 zinc finger protein of the cerebellum 2 0.819
Gli2 GLI-Kruppel family member GLI2 0.819
Neurod1 neurogenic differentiation 1 0.815
Hoxa2 homeobox A2 0.813
Sox11 SRY-box containing gene 11 0.812
Loading network...
Caenorhabditis elegans
Name Description Probability Func Analog Organism
Loading network...
Danio rerio
Name Description Probability Func Analog Organism
dld deltaD 1.000
dla deltaA 1.000
shha sonic hedgehog a 1.000
rx3 retinal homeobox gene 3 1.000
gli1 GLI-Kruppel family member 1 1.000
mib mind bomb 0.999
tbx1 T-box 1 0.999
lhx2b LIM homeobox 2b 0.999
fgf3 fibroblast growth factor 3 0.999
otpa orthopedia homolog a 0.998
pax2a paired box gene 2a 0.997
chd chordin 0.997
ndr2 nodal-related 2 0.997
dbx1a developing brain homeobox 1a 0.995
fgf8a fibroblast growth factor 8 a 0.994
lmx1b.1 LIM homeobox transcription factor 1, beta 1 0.994
ascl1a achaete-scute complex-like 1a (Drosophila) 0.993
lft1 lefty1 0.990
eya1 eyes absent homolog 1 0.989
fezf2 FEZ family zinc finger 2 0.988
neurog1 neurogenin 1 0.988
notch1a notch homolog 1a 0.986
bmp4 bone morphogenetic protein 4 0.986
gli2a GLI-Kruppel family member GLI2a 0.984
dharma dharma 0.983
sim1a single-minded homolog 1a (Drosophila) 0.976
foxd3 forkhead box D3 0.969
otpb orthopedia homolog b 0.968
lef1 lymphocyte enhancer binding factor 1 0.968
rx2 retinal homeobox gene 2 0.967
emx3 empty spiracles homeobox 3 0.963
flh floating head 0.963
ntla no tail a 0.954
cyp26c1 cytochrome P450, family 26, subfamily C, polypeptide 1 0.952
spry4 sprouty (Drosophila) homolog 4 0.947
otx2 orthodenticle homolog 2 0.947
tbx16 T-box gene 16 0.945
gata3 GATA-binding protein 3 0.944
mecom MDS1 and EVI1 complex locus 0.930
sox2 SRY-box containing gene 2 0.927
tbx20 T-box 20 0.906
pitx3 paired-like homeodomain transcription factor 3 0.905
cdh2 cadherin 2, neuronal 0.898
dlb deltaB 0.897
tbx2b T-box 2b 0.896
foxg1a forkhead box G1a 0.882
dlc deltaC 0.877
pcdh8 protocadherin 8 0.870
nkx2.1a NK2 homeobox 1a 0.866
sox1a SRY-box containing gene 1a 0.861
arx aristaless related homeobox 0.861
wnt1 wingless-type MMTV integration site family, member 1 0.860
nr2e1 nuclear receptor subfamily 2, group E, member 1 0.855
wnt11 wingless-type MMTV integration site family, member 11 0.851
fzd8a frizzled homolog 8a 0.848
dlx2a distal-less homeobox gene 2a 0.844
lhx5 LIM homeobox 5 0.839
wnt8b wingless-type MMTV integration site family, member 8b 0.834
zic2b zic family member 2 (odd-paired homolog, Drosophila) b 0.834
six3a sine oculis homeobox homolog 3a 0.830
vax1 ventral anterior homeobox 1 0.811
her15.1 hairy and enhancer of split-related 15.1 0.803
wnt2bb wingless-type MMTV integration site family, member 2Bb 0.792
eomesa eomesodermin homolog a 0.792
lhx1a LIM homeobox 1a 0.782
tfap2a transcription factor AP-2 alpha 0.779
gata2a GATA-binding protein 2a 0.777
zic2a zic family member 2 (odd-paired homolog, Drosophila), a 0.774
jag2 jagged 2 0.773
otx1b orthodenticle homolog 1b 0.772
olig2 oligodendrocyte lineage transcription factor 2 0.761
fgf10a fibroblast growth factor 10a 0.753
lhx3 LIM homeobox 3 0.749
foxi1 forkhead box I1 0.745
robo3 roundabout homolog 3 0.739
epha4a eph receptor A4a 0.737
klf4 Kruppel-like factor 4 0.737
pitx2 paired-like homeodomain transcription factor 2 0.734
cdx4 caudal type homeo box transcription factor 4 0.718
nkx2.1b NK2 homeobox 1b 0.707
pax8 paired box gene 8 0.705
wnt4a wingless-type MMTV integration site family, member 4a 0.701
zic3 zic family member 3 heterotaxy 1 (odd-paired homolog, Drosophila) 0.701
barhl2 BarH-like 2 0.697
bmp2b bone morphogenetic protein 2b 0.695
cdkn1c cyclin-dependent kinase inhibitor 1C (p57, Kip2) 0.688
gsc goosecoid 0.672
mll myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila) 0.667
osr2 odd-skipped related 2 (Drosophila) 0.662
zic1 zic family member 1 (odd-paired homolog, Drosophila) 0.659
hnf1ba HNF1 homeobox Ba 0.658
itgav integrin, alpha V 0.655
tac1 tachykinin 1 0.648
vax2 ventral anterior homeobox 2 0.645
lfng lunatic fringe homolog 0.643
traf4a tnf receptor-associated factor 4a 0.642
emx1 empty spiracles homeobox 1 0.638
cxcr4b chemokine (C-X-C motif), receptor 4b 0.632
gli2b GLI-Kruppel family member GLI2b 0.627
pax6b paired box gene 6b 0.622
Loading network...
Drosophila melanogaster
Name Description Probability Func Analog Organism
Loading network...
Homo sapiens
Name Description Probability Func Analog Organism
PAX3 paired box 3 0.479
POU3F2 POU class 3 homeobox 2 0.333
ATXN1 ataxin 1 0.185
BMPR1A bone morphogenetic protein receptor, type IA 0.109
BMP2 bone morphogenetic protein 2 0.108
TCF4 transcription factor 4 0.106
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.102
TBX5 T-box 5 0.095
SMAD7 SMAD family member 7 0.092
NR4A1 nuclear receptor subfamily 4, group A, member 1 0.074
SLC6A3 solute carrier family 6 (neurotransmitter transporter, dopamine), member 3 0.061
RBFOX2 RNA binding protein, fox-1 homolog (C. elegans) 2 0.047
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase) 0.040
ESR1 estrogen receptor 1 0.037
PICK1 protein interacting with PRKCA 1 0.033
TAL1 T-cell acute lymphocytic leukemia 1 0.032
VEGFA vascular endothelial growth factor A 0.032
RBPMS RNA binding protein with multiple splicing 0.030
SOX2 SRY (sex determining region Y)-box 2 0.030
FGFR1 fibroblast growth factor receptor 1 0.029
BMP7 bone morphogenetic protein 7 0.028
SUFU suppressor of fused homolog (Drosophila) 0.028
PAX8 paired box 8 0.027
PTCH1 patched 1 0.026
FOXD3 forkhead box D3 0.025
JAG1 jagged 1 0.025
DRD2 dopamine receptor D2 0.024
KDR kinase insert domain receptor (a type III receptor tyrosine kinase) 0.022
PAX6 paired box 6 0.018
PSEN1 presenilin 1 0.017
QKI quaking homolog, KH domain RNA binding (mouse) 0.017
HIC1 hypermethylated in cancer 1 0.016
GSK3B glycogen synthase kinase 3 beta 0.016
SOX11 SRY (sex determining region Y)-box 11 0.015
PAX7 paired box 7 0.015
SOX1 SRY (sex determining region Y)-box 1 0.014
NOTCH3 notch 3 0.014
FZD1 frizzled homolog 1 (Drosophila) 0.013
RUNX1 runt-related transcription factor 1 0.012
TCEAL5 transcription elongation factor A (SII)-like 5 0.011
ADORA2A adenosine A2a receptor 0.011
MYOD1 myogenic differentiation 1 0.011
FOXG1 forkhead box G1 0.011
FSTL1 follistatin-like 1 0.011
C1QL1 complement component 1, q subcomponent-like 1 0.011
Loading network...
Rattus norvegicus
Name Description Probability Func Analog Organism
Nr4a3 nuclear receptor subfamily 4, group A, member 3 0.165
Chrna7 cholinergic receptor, nicotinic, alpha 7 0.091
Slc6a3 solute carrier family 6 (neurotransmitter transporter, dopamine), member 3 0.082
Aqp4 aquaporin 4 0.067
Pax8 paired box 8 0.051
Bcl2 B-cell CLL/lymphoma 2 0.051
Trhr thyrotropin releasing hormone receptor 0.046
Ncan neurocan 0.042
Tbx2 T-box 2 0.040
Cyp21a1 cytochrome P450, family 21, subfamily a, polypeptide 1 0.039
Lepr leptin receptor 0.039
Slc10a2 solute carrier family 10 (sodium/bile acid cotransporter family), member 2 0.037
Il9r interleukin 9 receptor 0.037
Chrnb2 cholinergic receptor, nicotinic, beta 2 (neuronal) 0.034
Drd2 dopamine receptor D2 0.034
Fgfr2 fibroblast growth factor receptor 2 0.034
Mmp16 matrix metallopeptidase 16 0.034
Gabrb3 gamma-aminobutyric acid (GABA) A receptor, beta 3 0.033
Pdyn prodynorphin 0.033
Gja6 gap junction protein, alpha 6 0.033
Hoxa1 homeo box A1 0.032
Grm7 glutamate receptor, metabotropic 7 0.031
Cckar cholecystokinin A receptor 0.029
Kcnj6 potassium inwardly-rectifying channel, subfamily J, member 6 0.028
Gja3 gap junction protein, alpha 3 0.028
Galr3 galanin receptor 3 0.027
Zfp382 zinc finger protein 382 0.027
Mylk2 myosin light chain kinase 2 0.027
Fam65a family with sequence similarity 65, member A 0.026
Trim17 tripartite motif-containing 17 0.026
Ucn urocortin 0.026
Ntrk1 neurotrophic tyrosine kinase, receptor, type 1 0.025
Cdk5r1 cyclin-dependent kinase 5, regulatory subunit 1 0.025
Nfib nuclear factor I/B 0.025
Gcnt3 glucosaminyl (N-acetyl) transferase 3, mucin type 0.025
Adrb1 adrenergic, beta-1-, receptor 0.025
Hes5 hairy and enhancer of split 5 (Drosophila) 0.024
Nrxn3 neurexin 3 0.024
Slc22a7 solute carrier family 22 (organic anion transporter), member 7 0.024
Hlf hepatic leukemia factor 0.024
P2rx2 purinergic receptor P2X, ligand-gated ion channel, 2 0.023
Grin1 glutamate receptor, ionotropic, N-methyl D-aspartate 1 0.023
Calcrl calcitonin receptor-like 0.023
Ndst1 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1 0.023
Sdc3 syndecan 3 0.023
Arnt2 aryl hydrocarbon receptor nuclear translocator 2 0.022
Robo1 roundabout homolog 1 (Drosophila) 0.021
Prlhr prolactin releasing hormone receptor 0.021
Hand2 heart and neural crest derivatives expressed 2 0.021
Lama5 laminin, alpha 5 0.021
Unc5b unc-5 homolog B (C. elegans) 0.021
Cyss cystatin S 0.021
Th tyrosine hydroxylase 0.021
Zp1 zona pellucida glycoprotein 1 (sperm receptor) 0.020
Ahr aryl hydrocarbon receptor 0.020
Tcf4 transcription factor 4 0.020
Nrg1 neuregulin 1 0.020
Cga glycoprotein hormones, alpha polypeptide 0.020
Epor erythropoietin receptor 0.020
Syt8 synaptotagmin VIII 0.020
Mc5r melanocortin 5 receptor 0.020
Foxs1 forkhead box S1 0.020
Mr1 major histocompatibility complex, class I-related 0.019
Slc1a2 solute carrier family 1 (glial high affinity glutamate transporter), member 2 0.019
Igf2 insulin-like growth factor 2 0.019
Nos1 nitric oxide synthase 1, neuronal 0.019
Kdr kinase insert domain receptor 0.019
Grik1 glutamate receptor, ionotropic, kainate 1 0.018
Mapk4 mitogen-activated protein kinase 4 0.018
Vip vasoactive intestinal peptide 0.018
Gipr gastric inhibitory polypeptide receptor 0.018
Gpr176 G protein-coupled receptor 176 0.018
Ednra endothelin receptor type A 0.018
Gria4 glutamate receptor, ionotrophic, AMPA 4 0.018
Il8ra interleukin 8 receptor, alpha 0.018
Ngfr nerve growth factor receptor (TNFR superfamily, member 16) 0.018
Cxcl2 chemokine (C-X-C motif) ligand 2 0.017
Myl7 myosin, light chain 7, regulatory 0.017
Kcnj5 potassium inwardly-rectifying channel, subfamily J, member 5 0.017
Htr5b 5-hydroxytryptamine (serotonin) receptor 5B 0.017
Sstr5 somatostatin receptor 5 0.017
Pacs1 phosphofurin acidic cluster sorting protein 1 0.017
Tcof1 Treacher Collins-Franceschetti syndrome 1 homolog (human) 0.017
Megf6 multiple EGF-like-domains 6 0.017
Hoxd3 homeo box D3 0.017
Olr1867 olfactory receptor 1867 0.017
C8b complement component 8, beta polypeptide 0.017
Kcnh7 potassium voltage-gated channel, subfamily H (eag-related), member 7 0.017
Avp arginine vasopressin 0.017
Gabra4 gamma-aminobutyric acid (GABA) A receptor, alpha 4 0.016
Slc14a2 solute carrier family 14 (urea transporter), member 2 0.016
Dlx5 distal-less homeobox 5 0.016
Ghsr growth hormone secretagogue receptor 0.016
Lrp3 low density lipoprotein receptor-related protein 3 0.016
Atf3 activating transcription factor 3 0.016
Hoxa2 homeo box A2 0.016
Slc28a1 solute carrier family 28 (sodium-coupled nucleoside transporter), member 1 0.016
Onecut1 one cut homeobox 1 0.016
Tacr3 tachykinin receptor 3 0.015
Kcng1 potassium voltage-gated channel, subfamily G, member 1 0.015
Loading network...
Saccharomyces cerevisiae
Name Description Probability Func Analog Organism