The network for 'cardiac cell fate determination' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

cardiac cell fate determination

The process involved in cardiac cell fate commitment. Once determination has taken place, a cell becomes committed to differentiate down a particular pathway regardless of its environment.

Mus musculus
Name Description Probability Func Analog Organism
Pitx2 paired-like homeodomain transcription factor 2 1.000
Fgf8 fibroblast growth factor 8 1.000
Nkx2-5 NK2 transcription factor related, locus 5 (Drosophila) 1.000
Otx2 orthodenticle homolog 2 (Drosophila) 1.000
Gata4 GATA binding protein 4 1.000
Pax2 paired box gene 2 0.999
Shh sonic hedgehog 0.999
Hand2 heart and neural crest derivatives expressed transcript 2 0.999
Pax3 paired box gene 3 0.998
Pax6 paired box gene 6 0.998
Isl1 ISL1 transcription factor, LIM/homeodomain 0.997
Emx1 empty spiracles homolog 1 (Drosophila) 0.992
Emx2 empty spiracles homolog 2 (Drosophila) 0.990
Foxc2 forkhead box C2 0.986
Gli3 GLI-Kruppel family member GLI3 0.978
Mesp1 mesoderm posterior 1 0.978
Nr5a1 nuclear receptor subfamily 5, group A, member 1 0.977
Foxc1 forkhead box C1 0.975
Tbx1 T-box 1 0.974
Lhx3 LIM homeobox protein 3 0.964
Gata6 GATA binding protein 6 0.961
Gbx2 gastrulation brain homeobox 2 0.961
Nodal nodal 0.953
Hand1 heart and neural crest derivatives expressed transcript 1 0.947
Jag1 jagged 1 0.946
Wt1 Wilms tumor 1 homolog 0.939
Bmp4 bone morphogenetic protein 4 0.925
Zfpm2 zinc finger protein, multitype 2 0.925
Foxg1 forkhead box G1 0.916
Tcfap2a transcription factor AP-2, alpha 0.916
Rxra retinoid X receptor alpha 0.916
Hoxa1 homeobox A1 0.908
Tgfb2 transforming growth factor, beta 2 0.871
Six1 sine oculis-related homeobox 1 homolog (Drosophila) 0.870
Sox2 SRY-box containing gene 2 0.853
Lhx1 LIM homeobox protein 1 0.823
Chd7 chromodomain helicase DNA binding protein 7 0.819
Lhx9 LIM homeobox protein 9 0.795
Vegfa vascular endothelial growth factor A 0.793
Sox11 SRY-box containing gene 11 0.759
Hes5 hairy and enhancer of split 5 (Drosophila) 0.749
Sall4 sal-like 4 (Drosophila) 0.737
Lmx1b LIM homeobox transcription factor 1 beta 0.721
Hey2 hairy/enhancer-of-split related with YRPW motif 2 0.709
Eya1 eyes absent 1 homolog (Drosophila) 0.620
Rarg retinoic acid receptor, gamma 0.576
Ntf3 neurotrophin 3 0.573
Fshr follicle stimulating hormone receptor 0.541
Insm1 insulinoma-associated 1 0.502
Pitx1 paired-like homeodomain transcription factor 1 0.493
Zic3 zinc finger protein of the cerebellum 3 0.468
Bnc1 basonuclin 1 0.462
Sox3 SRY-box containing gene 3 0.455
Nog noggin 0.440
Tbx3 T-box 3 0.422
Hoxd13 homeobox D13 0.410
Sox9 SRY-box containing gene 9 0.389
Vangl2 vang-like 2 (van gogh, Drosophila) 0.375
Sall3 sal-like 3 (Drosophila) 0.372
Neurog2 neurogenin 2 0.371
Wnt3a wingless-related MMTV integration site 3A 0.360
Aldh1a2 aldehyde dehydrogenase family 1, subfamily A2 0.344
Pou4f2 POU domain, class 4, transcription factor 2 0.338
Foxh1 forkhead box H1 0.324
Prop1 paired like homeodomain factor 1 0.323
Ptpn11 protein tyrosine phosphatase, non-receptor type 11 0.319
Nkx2-6 NK2 transcription factor related, locus 6 (Drosophila) 0.315
Neurod1 neurogenic differentiation 1 0.312
Rarb retinoic acid receptor, beta 0.299
Fgf3 fibroblast growth factor 3 0.295
Otx1 orthodenticle homolog 1 (Drosophila) 0.290
Ednra endothelin receptor type A 0.286
Onecut1 one cut domain, family member 1 0.280
Meox2 mesenchyme homeobox 2 0.279
Fgfr2 fibroblast growth factor receptor 2 0.270
Gsc goosecoid homeobox 0.262
Pou4f3 POU domain, class 4, transcription factor 3 0.261
Ascl1 achaete-scute complex homolog 1 (Drosophila) 0.257
Nanog Nanog homeobox 0.255
En1 engrailed 1 0.254
Msx1 homeobox, msh-like 1 0.246
Gdnf glial cell line derived neurotrophic factor 0.243
Nos3 nitric oxide synthase 3, endothelial cell 0.227
Sema5b sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5B 0.221
Ldb2 LIM domain binding 2 0.220
Atoh7 atonal homolog 7 (Drosophila) 0.214
Fgf10 fibroblast growth factor 10 0.212
Arx aristaless related homeobox 0.210
Hes1 hairy and enhancer of split 1 (Drosophila) 0.202
Nr2e1 nuclear receptor subfamily 2, group E, member 1 0.182
Uncx UNC homeobox 0.180
Hoxa13 homeobox A13 0.177
Mycn v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian) 0.175
Acvr1 activin A receptor, type 1 0.173
Wnt9b wingless-type MMTV integration site 9B 0.169
Hmx3 H6 homeobox 3 0.168
Fgf15 fibroblast growth factor 15 0.166
Osr1 odd-skipped related 1 (Drosophila) 0.160
Barx1 BarH-like homeobox 1 0.159
Foxe3 forkhead box E3 0.158
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
shn schnurri 0.713
tup tailup 0.585
ush u-shaped 0.558
bowl brother of odd with entrails limited 0.511
hth homothorax 0.340
insc inscuteable 0.234
pnr pannier 0.219
SoxN SoxNeuro 0.136
nkd naked cuticle 0.126
opa odd paired 0.123
lea leak 0.116
htl heartless 0.089
spdo sanpodo 0.086
kn knot 0.084
btd buttonhead 0.081
srp serpent 0.073
grn grain 0.069
zfh2 Zn finger homeodomain 2 0.068
raw CG12437 gene product from transcript CG12437-RB 0.067
Ser Serrate 0.067
odd odd skipped 0.063
Dfd Deformed 0.062
scb scab 0.058
stumps CG31317 gene product from transcript CG31317-RC 0.052
cbt cabut 0.041
pdm2 POU domain protein 2 0.038
osp outspread 0.038
zfh1 Zn finger homeodomain 1 0.038
lab labial 0.034
unk unkempt 0.033
slp1 sloppy paired 1 0.033
Tl Toll 0.033
fkh fork head 0.032
emc extra macrochaetae 0.031
nub nubbin 0.031
nau nautilus 0.029
NFAT NFAT homolog 0.028
repo reversed polarity 0.026
if inflated 0.025
Hand CG18144 gene product from transcript CG18144-RA 0.024
Kr Kruppel 0.022
l(3)82Fd CG32464 gene product from transcript CG32464-RR 0.022
cnc cap-n-collar 0.021
vnd ventral nervous system defective 0.020
CG12424 CG12424 gene product from transcript CG12424-RC 0.019
rols rolling pebbles 0.019
fas faint sausage 0.019
Lim1 CG11354 gene product from transcript CG11354-RA 0.018
rib ribbon 0.018
ds dachsous 0.017
kkv krotzkopf verkehrt 0.017
5-HT2 Serotonin receptor 2 0.017
ems empty spiracles 0.017
LanB2 Laminin B2 0.017
Cyp18a1 Cytochrome P450-18a1 0.017
scw screw 0.016
en engrailed 0.016
Su(z)2 Suppressor of zeste 2 0.016
Lim3 CG10699 gene product from transcript CG10699-RB 0.015
Fas3 Fasciclin 3 0.015
kni knirps 0.015
Adgf-A Adenosine deaminase-related growth factor A 0.015
glec gliolectin 0.014
rtv retroactive 0.014
dve defective proventriculus 0.014
disco disconnected 0.014
B-H1 BarH1 0.013
wb wing blister 0.012
mirr mirror 0.012
how held out wings 0.012
Tollo CG6890 gene product from transcript CG6890-RA 0.011
gsb-n gooseberry-neuro 0.011
sm smooth 0.011
byn brachyenteron 0.011
Mef2 Myocyte enhancer factor 2 0.011
ftz fushi tarazu 0.010
sli slit 0.010
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Homo sapiens
Name Description Probability Func Analog Organism
FOXD3 forkhead box D3 1.000
PAX3 paired box 3 1.000
POU3F2 POU class 3 homeobox 2 1.000
WWP2 WW domain containing E3 ubiquitin protein ligase 2 1.000
SMAD7 SMAD family member 7 1.000
SOX2 SRY (sex determining region Y)-box 2 1.000
POU5F1 POU class 5 homeobox 1 1.000
SP1 Sp1 transcription factor 1.000
NKX2-5 NK2 transcription factor related, locus 5 (Drosophila) 0.999
SOX10 SRY (sex determining region Y)-box 10 0.998
MEOX2 mesenchyme homeobox 2 0.997
OTP orthopedia homeobox 0.936
TBX5 T-box 5 0.916
LHX3 LIM homeobox 3 0.832
SOX11 SRY (sex determining region Y)-box 11 0.831
PAX6 paired box 6 0.829
POU3F3 POU class 3 homeobox 3 0.817
LBX1 ladybird homeobox 1 0.807
HCFC1 host cell factor C1 (VP16-accessory protein) 0.797
SOX21 SRY (sex determining region Y)-box 21 0.774
POU3F1 POU class 3 homeobox 1 0.757
NR5A1 nuclear receptor subfamily 5, group A, member 1 0.743
LHX1 LIM homeobox 1 0.727
SOX1 SRY (sex determining region Y)-box 1 0.687
TBX2 T-box 2 0.626
SFRP5 secreted frizzled-related protein 5 0.600
PDX1 pancreatic and duodenal homeobox 1 0.569
GATA4 GATA binding protein 4 0.566
LMX1A LIM homeobox transcription factor 1, alpha 0.566
NOVA2 neuro-oncological ventral antigen 2 0.560
BHLHE23 basic helix-loop-helix family, member e23 0.554
LHX5 LIM homeobox 5 0.539
FOXG1 forkhead box G1 0.524
FOXE1 forkhead box E1 (thyroid transcription factor 2) 0.520
TLX2 T-cell leukemia homeobox 2 0.511
HOXB13 homeobox B13 0.448
HTT huntingtin 0.440
OLIG2 oligodendrocyte lineage transcription factor 2 0.440
NR0B1 nuclear receptor subfamily 0, group B, member 1 0.440
GATA5 GATA binding protein 5 0.438
MARCKSL1 MARCKS-like 1 0.434
FGF8 fibroblast growth factor 8 (androgen-induced) 0.432
MSX1 msh homeobox 1 0.408
ASCL1 achaete-scute complex homolog 1 (Drosophila) 0.402
PAX2 paired box 2 0.402
GBX2 gastrulation brain homeobox 2 0.401
RAX retina and anterior neural fold homeobox 0.396
HOXD12 homeobox D12 0.388
SALL2 sal-like 2 (Drosophila) 0.385
POU4F1 POU class 4 homeobox 1 0.382
FOXC2 forkhead box C2 (MFH-1, mesenchyme forkhead 1) 0.360
TP73 tumor protein p73 0.343
NEUROG3 neurogenin 3 0.315
CACNA1G calcium channel, voltage-dependent, T type, alpha 1G subunit 0.301
PAX7 paired box 7 0.298
TBX1 T-box 1 0.287
GABPA GA binding protein transcription factor, alpha subunit 60kDa 0.283
NR2F1 nuclear receptor subfamily 2, group F, member 1 0.281
POU3F4 POU class 3 homeobox 4 0.273
SIX2 SIX homeobox 2 0.270
SALL3 sal-like 3 (Drosophila) 0.269
HAND2 heart and neural crest derivatives expressed 2 0.262
NKX2-8 NK2 homeobox 8 0.256
VAX2 ventral anterior homeobox 2 0.250
HRK harakiri, BCL2 interacting protein (contains only BH3 domain) 0.241
FOXA2 forkhead box A2 0.240
NKX6-1 NK6 homeobox 1 0.229
HOXD1 homeobox D1 0.221
HOXD9 homeobox D9 0.219
FOXB1 forkhead box B1 0.217
DLX4 distal-less homeobox 4 0.217
SOX3 SRY (sex determining region Y)-box 3 0.216
FGF3 fibroblast growth factor 3 0.212
ESR1 estrogen receptor 1 0.210
ALX3 ALX homeobox 3 0.210
HMGA1 high mobility group AT-hook 1 0.209
ZIC3 Zic family member 3 (odd-paired homolog, Drosophila) 0.205
ISL1 ISL LIM homeobox 1 0.203
SIX6 SIX homeobox 6 0.200
EMX1 empty spiracles homeobox 1 0.200
JPH3 junctophilin 3 0.198
HOXD3 homeobox D3 0.192
POU4F3 POU class 4 homeobox 3 0.184
WT1 Wilms tumor 1 0.183
SLC9A3R2 solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 2 0.177
ETS2 v-ets erythroblastosis virus E26 oncogene homolog 2 (avian) 0.173
BARX1 BARX homeobox 1 0.169
BCL11A B-cell CLL/lymphoma 11A (zinc finger protein) 0.168
ALX4 ALX homeobox 4 0.164
ST8SIA2 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2 0.163
DCX doublecortin 0.162
HOXD13 homeobox D13 0.158
NKX2-1 NK2 homeobox 1 0.151
COL2A1 collagen, type II, alpha 1 0.141
POU4F2 POU class 4 homeobox 2 0.140
HES2 hairy and enhancer of split 2 (Drosophila) 0.133
PYY peptide YY 0.131
NPAS1 neuronal PAS domain protein 1 0.131
C1QL1 complement component 1, q subcomponent-like 1 0.131
PRDM13 PR domain containing 13 0.126
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Rattus norvegicus
Name Description Probability Func Analog Organism
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism