The network for 'positive regulation of t cell mediated cytotoxicity' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

positive regulation of t cell mediated cytotoxicity

Any process that activates or increases the frequency, rate or extent of T cell mediated cytotoxicity.

Mus musculus
Name Description Probability Func Analog Organism
B2m beta-2 microglobulin 1.000
H2-K1 histocompatibility 2, K1, K region 1.000
Tapbp TAP binding protein 1.000
H2-D1 histocompatibility 2, D region locus 1 1.000
Psmb8 proteasome (prosome, macropain) subunit, beta type 8 (large multifunctional peptidase 7) 1.000
H2-Q7 histocompatibility 2, Q region locus 7 1.000
Tap1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) 1.000
Tap2 transporter 2, ATP-binding cassette, sub-family B (MDR/TAP) 1.000
Fyn Fyn proto-oncogene 1.000
Psmb9 proteasome (prosome, macropain) subunit, beta type 9 (large multifunctional peptidase 2) 1.000
Pnp2 purine-nucleoside phosphorylase 2 0.999
Il2rg interleukin 2 receptor, gamma chain 0.985
Lck lymphocyte protein tyrosine kinase 0.981
Tcra T-cell receptor alpha chain 0.980
Lat linker for activation of T cells 0.907
Cd247 CD247 antigen 0.894
Casp8 caspase 8 0.885
H2-Q6 histocompatibility 2, Q region locus 6 0.879
H2-Q8 histocompatibility 2, Q region locus 8 0.753
Psmb10 proteasome (prosome, macropain) subunit, beta type 10 0.654
C920025E04Rik RIKEN cDNA C920025E04 gene 0.622
H2-Ab1 histocompatibility 2, class II antigen A, beta 1 0.569
Gbp2 guanylate binding protein 2 0.550
Il23a interleukin 23, alpha subunit p19 0.520
Cp ceruloplasmin 0.518
Fas Fas (TNF receptor superfamily member 6) 0.514
Slc40a1 solute carrier family 40 (iron-regulated transporter), member 1 0.511
Gbp7 guanylate binding protein 7 0.463
H2-M3 histocompatibility 2, M region locus 3 0.383
Stat1 signal transducer and activator of transcription 1 0.351
Sh2d2a SH2 domain protein 2A 0.341
Shisa5 shisa homolog 5 (Xenopus laevis) 0.311
Ptprc protein tyrosine phosphatase, receptor type, C 0.300
Irf1 interferon regulatory factor 1 0.247
H2-T10 histocompatibility 2, T region locus 10 0.242
Il10rb interleukin 10 receptor, beta 0.230
Dnm2 dynamin 2 0.226
Cyp4v3 cytochrome P450, family 4, subfamily v, polypeptide 3 0.218
Ikzf1 IKAROS family zinc finger 1 0.217
Ciita class II transactivator 0.209
Nmi N-myc (and STAT) interactor 0.199
Hsd3b7 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7 0.185
Psme1 proteasome (prosome, macropain) 28 subunit, alpha 0.178
Rap1b RAS related protein 1b 0.177
H2-T18 histocompatibility 2, T region locus 18 0.177
Psme2 proteasome (prosome, macropain) 28 subunit, beta 0.173
H2-Bl histocompatibility 2, blastocyst 0.153
P2rx2 purinergic receptor P2X, ligand-gated ion channel, 2 0.148
Bst2 bone marrow stromal cell antigen 2 0.143
Itm2b integral membrane protein 2B 0.136
Sp100 nuclear antigen Sp100 0.130
Parp14 poly (ADP-ribose) polymerase family, member 14 0.130
Gbp3 guanylate binding protein 3 0.126
P2rx4 purinergic receptor P2X, ligand-gated ion channel 4 0.126
Cd74 CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated) 0.117
Trim21 tripartite motif-containing 21 0.115
Il12b interleukin 12b 0.114
C3 complement component 3 0.112
Pag1 phosphoprotein associated with glycosphingolipid microdomains 1 0.090
Ghrl ghrelin 0.089
Pon3 paraoxonase 3 0.078
Tapbpl TAP binding protein-like 0.078
Tnfsf10 tumor necrosis factor (ligand) superfamily, member 10 0.071
Grb2 growth factor receptor bound protein 2 0.069
H2-Q5 histocompatibility 2, Q region locus 5 0.069
Tgtp2 T-cell specific GTPase 2 0.067
P2rx3 purinergic receptor P2X, ligand-gated ion channel, 3 0.066
Shc1 src homology 2 domain-containing transforming protein C1 0.065
AW112010 expressed sequence AW112010 0.057
Spry4 sprouty homolog 4 (Drosophila) 0.056
Ephx1 epoxide hydrolase 1, microsomal 0.056
Cd47 CD47 antigen (Rh-related antigen, integrin-associated signal transducer) 0.055
Itk IL2-inducible T-cell kinase 0.055
Ptafr platelet-activating factor receptor 0.050
Skap2 src family associated phosphoprotein 2 0.049
Tnf tumor necrosis factor 0.048
Ifi35 interferon-induced protein 35 0.046
Fcer1g Fc receptor, IgE, high affinity I, gamma polypeptide 0.044
F2rl3 coagulation factor II (thrombin) receptor-like 3 0.043
Lgals3bp lectin, galactoside-binding, soluble, 3 binding protein 0.043
Uba7 ubiquitin-like modifier activating enzyme 7 0.043
Ifi27l1 interferon, alpha-inducible protein 27 like 1 0.042
Ctsz cathepsin Z 0.042
Ly6e lymphocyte antigen 6 complex, locus E 0.041
Ccrl2 chemokine (C-C motif) receptor-like 2 0.040
C2 complement component 2 (within H-2S) 0.040
Il15 interleukin 15 0.039
Irgm2 immunity-related GTPase family M member 2 0.039
Cflar CASP8 and FADD-like apoptosis regulator 0.038
5133401N09Rik RIKEN cDNA 5133401N09 gene 0.038
Pip4k2a phosphatidylinositol-5-phosphate 4-kinase, type II, alpha 0.037
Lgals8 lectin, galactose binding, soluble 8 0.037
Ctsc cathepsin C 0.035
Gm2a GM2 ganglioside activator protein 0.035
Vti1b vesicle transport through interaction with t-SNAREs 1B homolog 0.034
Dnase1l1 deoxyribonuclease 1-like 1 0.034
Adora2a adenosine A2a receptor 0.033
Chl1 cell adhesion molecule with homology to L1CAM 0.032
Cd302 CD302 antigen 0.032
H2-Q10 histocompatibility 2, Q region locus 10 0.032
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Homo sapiens
Name Description Probability Func Analog Organism
MLLT4 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4 0.806
HLA-A major histocompatibility complex, class I, A 0.766
B2M beta-2-microglobulin 0.745
HLA-G major histocompatibility complex, class I, G 0.590
HLA-C major histocompatibility complex, class I, C 0.418
HLA-B major histocompatibility complex, class I, B 0.348
TAP1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) 0.287
HLA-E major histocompatibility complex, class I, E 0.202
TAPBP TAP binding protein (tapasin) 0.139
HLA-F major histocompatibility complex, class I, F 0.122
IL12B interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40) 0.052
CCR5 chemokine (C-C motif) receptor 5 0.039
CCL4 chemokine (C-C motif) ligand 4 0.025
CCL5 chemokine (C-C motif) ligand 5 0.014
PVRL4 poliovirus receptor-related 4 0.012
CXCL9 chemokine (C-X-C motif) ligand 9 0.011
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Rattus norvegicus
Name Description Probability Func Analog Organism
RT1-EC2 RT1 class Ib, locus EC2 0.990
Hsph1 heat shock 105/110 protein 1 0.799
Psmb9 proteasome (prosome, macropain) subunit, beta type 9 (large multifunctional peptidase 2) 0.742
RT1-CE12 RT1 class I, locus CE12 0.607
Tap2 transporter 2, ATP-binding cassette, sub-family B (MDR/TAP) 0.333
Gbp2 guanylate binding protein 2 0.311
Tap1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) 0.297
Hsp90ab1 heat shock protein 90 alpha (cytosolic), class B member 1 0.271
Psmb8 proteasome (prosome, macropain) subunit, beta type 8 (large multifunctional peptidase 7) 0.177
Casp1 caspase 1 0.174
LOC100364500 RT1 class I, locus CE11-like 0.162
Hspd1 heat shock protein 1 (chaperonin) 0.155
RT1-S3 RT1 class Ib, locus S3 0.127
RT1-Cl RT1 class Ib, locus Cl 0.103
Irf1 interferon regulatory factor 1 0.100
Fth1 ferritin, heavy polypeptide 1 0.093
RT1-M3-1 RT1 class Ib, locus M3, gene 1 0.085
Dnaja4 DnaJ (Hsp40) homolog, subfamily A, member 4 0.085
Irf7 interferon regulatory factor 7 0.083
Aif1 allograft inflammatory factor 1 0.074
Ccl5 chemokine (C-C motif) ligand 5 0.069
Rt1.aa MHC class I RT1.Aa alpha-chain 0.068
Cxcl10 chemokine (C-X-C motif) ligand 10 0.057
Hspb1 heat shock protein 1 0.054
Cxcr4 chemokine (C-X-C motif) receptor 4 0.052
RT1-CE16 RT1 class I, locus CE16 0.050
Ubb ubiquitin B 0.049
Lgals3bp lectin, galactoside-binding, soluble, 3 binding protein 0.048
Oas1a 2'-5' oligoadenylate synthetase 1A 0.043
Cd37 CD37 molecule 0.042
Ifit3 interferon-induced protein with tetratricopeptide repeats 3 0.037
Fcgr3a Fc fragment of IgG, low affinity IIIa, receptor 0.037
Itm2b integral membrane protein 2B 0.035
Gadd45a growth arrest and DNA-damage-inducible, alpha 0.034
Cd81 Cd81 molecule 0.033
Lgals9 lectin, galactoside-binding, soluble, 9 0.032
Atf3 activating transcription factor 3 0.032
Kmo kynurenine 3-monooxygenase (kynurenine 3-hydroxylase) 0.031
Mx1 myxovirus (influenza virus) resistance 1 0.030
Lgals5 lectin, galactose binding, soluble 5 0.029
Cd8a CD8a molecule 0.027
Rsad2 radical S-adenosyl methionine domain containing 2 0.027
Nmi N-myc (and STAT) interactor 0.027
Lyn v-yes-1 Yamaguchi sarcoma viral related oncogene homolog 0.026
Tnfrsf12a tumor necrosis factor receptor superfamily, member 12a 0.023
Casp8 caspase 8 0.022
Mapk3 mitogen activated protein kinase 3 0.021
Otc ornithine carbamoyltransferase 0.021
Cyp2f4 cytochrome P450, family 2, subfamily f, polypeptide 4 0.021
RT1-N3 RT1 class Ib, locus N3 0.020
RT1-Ba RT1 class II, locus Ba 0.020
Cdkn1a cyclin-dependent kinase inhibitor 1A 0.019
Cebpb CCAAT/enhancer binding protein (C/EBP), beta 0.019
Stat1 signal transducer and activator of transcription 1 0.019
Ugt1a7c UDP glucuronosyltransferase 1 family, polypeptide A7C 0.019
Fos FBJ osteosarcoma oncogene 0.019
Ifi35 interferon-induced protein 35 0.018
Hsp90aa1 heat shock protein 90, alpha (cytosolic), class A member 1 0.018
Erbb3 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) 0.018
Slc22a18 solute carrier family 22, member 18 0.018
Ppp1r15a protein phosphatase 1, regulatory (inhibitor) subunit 15A 0.018
Tapbp TAP binding protein 0.018
Dock8 dedicator of cytokinesis 8 0.018
Foxc2 forkhead box C2 0.017
Serpinb9 serpin peptidase inhibitor, clade B (ovalbumin), member 9 0.017
Trim5 tripartite motif-containing 5 0.017
Fcgrt Fc fragment of IgG, receptor, transporter, alpha 0.016
C4-2 complement component 4, gene 2 0.016
Ephx1 epoxide hydrolase 1, microsomal 0.016
RT1-Da RT1 class II, locus Da 0.016
Cd82 Cd82 molecule 0.015
Tcrb T-cell receptor beta chain 0.015
Bst2 bone marrow stromal cell antigen 2 0.015
Grin2d glutamate receptor, ionotropic, N-methyl D-aspartate 2D 0.015
Asgr1 asialoglycoprotein receptor 1 0.015
Ifitm3 interferon induced transmembrane protein 3 0.015
RT1-DOb RT1 class II, locus DOb 0.014
Ptpn6 protein tyrosine phosphatase, non-receptor type 6 0.014
Skiv2l superkiller viralicidic activity 2-like (S. cerevisiae ) 0.014
Mafk v-maf musculoaponeurotic fibrosarcoma oncogene homolog K (avian) 0.014
Akr1c14 aldo-keto reductase family 1, member C14 0.014
Cyb5r1 cytochrome b5 reductase 1 0.014
Jun Jun oncogene 0.014
Cxcl9 chemokine (C-X-C motif) ligand 9 0.014
Pld1 phospholipase D1 0.014
RGD1309534 similar to RIKEN cDNA 4931406C07 0.013
Tmsb4x thymosin beta 4, X-linked 0.013
Myo1d myosin ID 0.013
Tceal1 transcription elongation factor A (SII)-like 1 0.013
Gbp5 guanylate binding protein 5 0.013
Nkg7 natural killer cell group 7 sequence 0.013
Cnn3 calponin 3, acidic 0.013
Gzmk granzyme K 0.013
RGD1309537 similar to Myosin regulatory light chain 2-A, smooth muscle isoform (Myosin RLC-A) 0.013
Cyp4b1 cytochrome P450, family 4, subfamily b, polypeptide 1 0.013
Anpep alanyl (membrane) aminopeptidase 0.013
Cr1l complement component (3b/4b) receptor 1-like 0.013
Serpine1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.013
RT1-CE1 RT1 class I, locus1 0.013
Sepp1 selenoprotein P, plasma, 1 0.013
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism