The network for 'tube closure' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

tube closure

Creation of the central hole of a tube in an anatomical structure by sealing the edges of an epithelial fold.

Mus musculus
Name Description Probability Func Analog Organism
Gli3 GLI-Kruppel family member GLI3 1.000
Pax3 paired box gene 3 1.000
Shh sonic hedgehog 1.000
Vangl2 vang-like 2 (van gogh, Drosophila) 1.000
Otx2 orthodenticle homolog 2 (Drosophila) 0.998
Pitx2 paired-like homeodomain transcription factor 2 0.997
Fgfr2 fibroblast growth factor receptor 2 0.995
Tbx3 T-box 3 0.993
Pax6 paired box gene 6 0.991
Dvl2 dishevelled 2, dsh homolog (Drosophila) 0.989
Pbx1 pre B-cell leukemia transcription factor 1 0.986
Pax2 paired box gene 2 0.984
Smo smoothened homolog (Drosophila) 0.981
Gli2 GLI-Kruppel family member GLI2 0.976
Tcfap2a transcription factor AP-2, alpha 0.975
Rarg retinoic acid receptor, gamma 0.972
Six1 sine oculis-related homeobox 1 homolog (Drosophila) 0.972
Msx1 homeobox, msh-like 1 0.967
Fgf10 fibroblast growth factor 10 0.963
Dvl3 dishevelled 3, dsh homolog (Drosophila) 0.961
Wt1 Wilms tumor 1 homolog 0.955
Sox2 SRY-box containing gene 2 0.947
Six4 sine oculis-related homeobox 4 homolog (Drosophila) 0.942
Sall4 sal-like 4 (Drosophila) 0.939
Rarb retinoic acid receptor, beta 0.922
Lhx1 LIM homeobox protein 1 0.906
Foxc1 forkhead box C1 0.905
Hoxa13 homeobox A13 0.901
Eya1 eyes absent 1 homolog (Drosophila) 0.901
Hoxa11 homeobox A11 0.891
Zic3 zinc finger protein of the cerebellum 3 0.891
Alx4 aristaless-like homeobox 4 0.886
Fgf8 fibroblast growth factor 8 0.885
Pitx1 paired-like homeodomain transcription factor 1 0.876
Prrx1 paired related homeobox 1 0.868
Hoxa1 homeobox A1 0.866
Lhx3 LIM homeobox protein 3 0.856
Msx2 homeobox, msh-like 2 0.849
Dvl1 dishevelled, dsh homolog 1 (Drosophila) 0.841
Nodal nodal 0.839
Sema6a sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A 0.817
Ascl1 achaete-scute complex homolog 1 (Drosophila) 0.810
Hoxd13 homeobox D13 0.808
Ror2 receptor tyrosine kinase-like orphan receptor 2 0.806
Apc adenomatosis polyposis coli 0.805
Arhgef11 Rho guanine nucleotide exchange factor (GEF) 11 0.776
Sox11 SRY-box containing gene 11 0.766
Tcf15 transcription factor 15 0.760
Hoxd11 homeobox D11 0.753
Pax8 paired box gene 8 0.746
Hoxa2 homeobox A2 0.738
Efna2 ephrin A2 0.725
Hoxa9 homeobox A9 0.718
Bmp4 bone morphogenetic protein 4 0.700
Bmp7 bone morphogenetic protein 7 0.695
Igdcc3 immunoglobulin superfamily, DCC subclass, member 3 0.678
Neurog2 neurogenin 2 0.676
Pou5f1 POU domain, class 5, transcription factor 1 0.671
Hes5 hairy and enhancer of split 5 (Drosophila) 0.668
Rnf2 ring finger protein 2 0.654
Nog noggin 0.643
Wnt3a wingless-related MMTV integration site 3A 0.643
Hoxb4 homeobox B4 0.640
Tbx2 T-box 2 0.637
Dkk1 dickkopf homolog 1 (Xenopus laevis) 0.637
Shox2 short stature homeobox 2 0.619
Chrd chordin 0.614
Pax7 paired box gene 7 0.606
Fgfr1 fibroblast growth factor receptor 1 0.606
Zic2 zinc finger protein of the cerebellum 2 0.604
Foxc2 forkhead box C2 0.599
Emx2 empty spiracles homolog 2 (Drosophila) 0.596
Fzd1 frizzled homolog 1 (Drosophila) 0.588
Ptf1a pancreas specific transcription factor, 1a 0.585
Nr5a1 nuclear receptor subfamily 5, group A, member 1 0.580
Ptk7 PTK7 protein tyrosine kinase 7 0.568
Lmx1a LIM homeobox transcription factor 1 alpha 0.555
Dlx5 distal-less homeobox 5 0.552
Wnt5a wingless-related MMTV integration site 5A 0.542
Insm1 insulinoma-associated 1 0.530
Wnt6 wingless-related MMTV integration site 6 0.527
Gbx2 gastrulation brain homeobox 2 0.525
Hoxd9 homeobox D9 0.525
Nhlh1 nescient helix loop helix 1 0.521
T brachyury 0.519
Tsc2 tuberous sclerosis 2 0.518
Foxg1 forkhead box G1 0.510
Tcfap2c transcription factor AP-2, gamma 0.504
Gsc goosecoid homeobox 0.499
Hoxa5 homeobox A5 0.497
Alx3 aristaless-like homeobox 3 0.497
Pax9 paired box gene 9 0.490
Smad1 MAD homolog 1 (Drosophila) 0.479
Meox2 mesenchyme homeobox 2 0.473
Foxf1a forkhead box F1a 0.468
Hand2 heart and neural crest derivatives expressed transcript 2 0.467
Pou3f3 POU domain, class 3, transcription factor 3 0.457
Ptch1 patched homolog 1 0.454
Neurod1 neurogenic differentiation 1 0.451
Hoxa3 homeobox A3 0.449
Loading network...
Caenorhabditis elegans
Name Description Probability Func Analog Organism
Loading network...
Danio rerio
Name Description Probability Func Analog Organism
chd chordin 0.863
wnt5b wingless-type MMTV integration site family, member 5b 0.633
fgf3 fibroblast growth factor 3 0.600
ift88 intraflagellar transport 88 homolog 0.578
gpc4 glypican 4 0.483
tbx2b T-box 2b 0.436
boc brother of CDO 0.426
sp5l Sp5 transcription factor-like 0.423
tbx1 T-box 1 0.410
tll1 tolloid-like 1 0.406
bmp2b bone morphogenetic protein 2b 0.404
foxd3 forkhead box D3 0.385
wnt11 wingless-type MMTV integration site family, member 11 0.358
gli2a GLI-Kruppel family member GLI2a 0.289
flh floating head 0.283
dact1 dapper homolog 1, antagonist of beta-catenin (xenopus) 0.280
lrrc6 leucine rich repeat containing 6 0.278
gyltl1b glycosyltransferase-like 1b 0.273
foxi1 forkhead box I1 0.252
pkd2 polycystic kidney disease 2 0.236
arl13b ADP-ribosylation factor-like 13b 0.230
twist1a twist1a 0.206
ext1a exostoses (multiple) 1a 0.206
gli1 GLI-Kruppel family member 1 0.181
celsr2 cadherin, EGF LAG seven-pass G-type receptor 2 and cadherin, EGF LAG seven-pass G-type receptor 2 (flamingo homolog, Drosophila) 0.179
cdon cell adhesion molecule-related/down-regulated by oncogenes 0.178
lamb1a laminin, beta 1a 0.159
alcamb activated leukocyte cell adhesion molecule b 0.158
fgf8a fibroblast growth factor 8 a 0.156
smo smoothened homolog (Drosophila) 0.156
nkd1 naked cuticle homolog 1 (Drosophila) 0.151
kif17 kinesin family member 17 0.146
eya1 eyes absent homolog 1 0.142
sox3 SRY-box containing gene 3 0.141
dzip1 DAZ interacting protein 1 0.136
dync1h1 dynein, cytoplasmic 1, heavy chain 1 0.134
spns2 spinster homolog 2 (Drosophila) 0.132
rarga retinoic acid receptor gamma a 0.132
hoxb1b homeo box B1b 0.131
tcf7l1a transcription factor 7-like 1a (T-cell specific, HMG-box) 0.131
npnt nephronectin 0.130
flr fleer 0.128
gpr98 G protein-coupled receptor 98 0.127
plxnb2a plexin b2a 0.127
mab21l2 mab-21-like 2 0.127
wnt4a wingless-type MMTV integration site family, member 4a 0.126
efnb3b ephrin B3b 0.125
ift57 intraflagellar transport protein 57 0.116
myh10 myosin, heavy polypeptide 10, non-muscle and myosin, heavy chain 10, non-muscle 0.115
zic2b zic family member 2 (odd-paired homolog, Drosophila) b 0.113
spry2 sprouty homolog 2 0.113
cc2d2a coiled-coil and C2 domain containing 2A 0.112
six2a sine oculis-related homeobox 2a 0.108
prdm14 PR domain containing 14 0.107
epb41l5 erythrocyte membrane protein band 4.1 like 5 0.106
disp1 dispatched homolog 1 (Drosophila) 0.105
fgf24 fibroblast growth factor 24 0.101
fzd7a frizzled homolog 7a 0.099
rerea arginine-glutamic acid dipeptide (RE) repeats a 0.099
zeb1 zinc finger E-box binding homeobox 1 0.097
pcdh19 protocadherin 19 0.096
zgc:66100 zgc:66100 0.094
otx1b orthodenticle homolog 1b 0.094
fzd10 frizzled homolog 10 0.094
wu:fb76c12 wu:fb76c12 0.093
fgfr2 fibroblast growth factor receptor 2 0.090
bmpr1ab bone morphogenetic protein receptor, type 1ab 0.090
shha sonic hedgehog a 0.089
tpbgl trophoblast glycoprotein-like 0.088
crtap cartilage associated protein 0.087
raraa retinoic acid receptor, alpha a 0.086
ier2 immediate early response 2 0.085
cxcl12b chemokine (C-X-C motif) ligand 12b (stromal cell-derived factor 1) 0.085
mbtps1 membrane-bound transcription factor protease, site 1 0.085
fn1 fibronectin 1 0.084
vangl2 vang-like 2 (van gogh, Drosophila) 0.083
axin1 axin 1 0.081
irx1a iroquois homeobox protein 1, a 0.080
efhc1 EF-hand domain (C-terminal) containing 1 0.080
zic5 zic family member 5 (odd-paired homolog, Drosophila) 0.078
ryk receptor-like tyrosine kinase 0.076
rarab retinoic acid receptor, alpha b 0.074
dixdc1a DIX domain containing 1a 0.074
sema6dl sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D, like 0.073
zic2a zic family member 2 (odd-paired homolog, Drosophila), a 0.073
kif3b kinesin family member 3B 0.072
pard6gb par-6 partitioning defective 6 homolog gamma B (C. elegans) 0.072
efnb2a ephrin B2a 0.072
zeb2a zinc finger E-box binding homeobox 2a 0.071
dctn1a dynactin 1a 0.071
ctbp2 C-terminal binding protein 2 0.071
wnt2bb wingless-type MMTV integration site family, member 2Bb 0.070
derl1 Der1-like domain family, member 1 0.070
lrmp lymphoid-restricted membrane protein 0.069
plod1a procollagen-lysine 1, 2-oxoglutarate 5-dioxygenase 1a 0.067
lama5 laminin, alpha 5 0.067
loxl2b lysyl oxidase-like 2b 0.067
ier5l immediate early response 5-like 0.067
ptprfb protein tyrosine phosphatase, receptor type, f, b 0.067
ccdc40 coiled-coil domain containing 40 0.066
Loading network...
Drosophila melanogaster
Name Description Probability Func Analog Organism
Loading network...
Homo sapiens
Name Description Probability Func Analog Organism
TSC2 tuberous sclerosis 2 0.820
LRRK2 leucine-rich repeat kinase 2 0.796
CASP9 caspase 9, apoptosis-related cysteine peptidase 0.742
BCOR BCL6 corepressor 0.678
TRRAP transformation/transcription domain-associated protein 0.649
DVL3 dishevelled, dsh homolog 3 (Drosophila) 0.628
MEOX2 mesenchyme homeobox 2 0.548
SOX10 SRY (sex determining region Y)-box 10 0.454
PPP1R16A protein phosphatase 1, regulatory (inhibitor) subunit 16A 0.446
BBS1 Bardet-Biedl syndrome 1 0.421
APC adenomatous polyposis coli 0.417
MED25 mediator complex subunit 25 0.361
EP300 E1A binding protein p300 0.344
USP9X ubiquitin specific peptidase 9, X-linked 0.337
CNKSR2 connector enhancer of kinase suppressor of Ras 2 0.333
SMAD3 SMAD family member 3 0.324
AXIN1 axin 1 0.317
SEC24D SEC24 family, member D (S. cerevisiae) 0.286
CASP3 caspase 3, apoptosis-related cysteine peptidase 0.277
SEC23A Sec23 homolog A (S. cerevisiae) 0.273
CSNK1E casein kinase 1, epsilon 0.250
AKAP11 A kinase (PRKA) anchor protein 11 0.250
RXRA retinoid X receptor, alpha 0.244
DVL1 dishevelled, dsh homolog 1 (Drosophila) 0.242
SETD8 SET domain containing (lysine methyltransferase) 8 0.234
KIAA1377 KIAA1377 0.218
WASF2 WAS protein family, member 2 0.215
TAF4 TAF4 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 135kDa 0.211
C9orf89 chromosome 9 open reading frame 89 0.205
FAT1 FAT tumor suppressor homolog 1 (Drosophila) 0.198
TSC1 tuberous sclerosis 1 0.191
MBD2 methyl-CpG binding domain protein 2 0.190
ARID1B AT rich interactive domain 1B (SWI1-like) 0.182
MED29 mediator complex subunit 29 0.159
ZFX zinc finger protein, X-linked 0.146
LDB1 LIM domain binding 1 0.145
USP22 ubiquitin specific peptidase 22 0.141
ABI1 abl-interactor 1 0.135
PUM1 pumilio homolog 1 (Drosophila) 0.133
LIN28B lin-28 homolog B (C. elegans) 0.131
PCM1 pericentriolar material 1 0.128
ZRANB1 zinc finger, RAN-binding domain containing 1 0.117
ZFYVE9 zinc finger, FYVE domain containing 9 0.116
XIAP X-linked inhibitor of apoptosis 0.111
MALT1 mucosa associated lymphoid tissue lymphoma translocation gene 1 0.111
CLASP2 cytoplasmic linker associated protein 2 0.110
WNT3A wingless-type MMTV integration site family, member 3A 0.109
CARD11 caspase recruitment domain family, member 11 0.109
PEX26 peroxisomal biogenesis factor 26 0.109
PHLPP1 PH domain and leucine rich repeat protein phosphatase 1 0.109
BBS2 Bardet-Biedl syndrome 2 0.107
CRMP1 collapsin response mediator protein 1 0.102
MED24 mediator complex subunit 24 0.101
SMAD4 SMAD family member 4 0.099
VASP vasodilator-stimulated phosphoprotein 0.096
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.096
CTBP2 C-terminal binding protein 2 0.089
SORBS3 sorbin and SH3 domain containing 3 0.088
ZYX zyxin 0.087
PLEKHF2 pleckstrin homology domain containing, family F (with FYVE domain) member 2 0.084
DLG5 discs, large homolog 5 (Drosophila) 0.082
EPAS1 endothelial PAS domain protein 1 0.080
NFIX nuclear factor I/X (CCAAT-binding transcription factor) 0.079
TFAP2C transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma) 0.077
BMP7 bone morphogenetic protein 7 0.077
DKK1 dickkopf homolog 1 (Xenopus laevis) 0.076
GLI1 GLI family zinc finger 1 0.075
DAB2 disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila) 0.075
AKIP1 A kinase (PRKA) interacting protein 1 0.074
TRIP6 thyroid hormone receptor interactor 6 0.074
WT1 Wilms tumor 1 0.070
CDC37 cell division cycle 37 homolog (S. cerevisiae) 0.069
PKP4 plakophilin 4 0.069
CSNK1D casein kinase 1, delta 0.068
WNT5A wingless-type MMTV integration site family, member 5A 0.068
ATXN7 ataxin 7 0.068
ANKRD28 ankyrin repeat domain 28 0.067
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha) 0.066
BMP2 bone morphogenetic protein 2 0.065
SEC24A SEC24 family, member A (S. cerevisiae) 0.065
SMARCA2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 0.064
MID1IP1 MID1 interacting protein 1 (gastrulation specific G12 homolog (zebrafish)) 0.064
WASF1 WAS protein family, member 1 0.064
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta 0.064
GSK3B glycogen synthase kinase 3 beta 0.062
STK36 serine/threonine kinase 36 0.061
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 0.061
TADA2A transcriptional adaptor 2A 0.060
AARSD1 alanyl-tRNA synthetase domain containing 1 0.060
KCTD1 potassium channel tetramerisation domain containing 1 0.059
FZD1 frizzled homolog 1 (Drosophila) 0.058
MED16 mediator complex subunit 16 0.058
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.058
ZMYND11 zinc finger, MYND-type containing 11 0.058
AMMECR1 Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1 0.057
PFN1 profilin 1 0.057
MTMR4 myotubularin related protein 4 0.057
SMAD1 SMAD family member 1 0.054
RYR2 ryanodine receptor 2 (cardiac) 0.054
SIN3A SIN3 homolog A, transcription regulator (yeast) 0.054
Loading network...
Rattus norvegicus
Name Description Probability Func Analog Organism
Loading network...
Saccharomyces cerevisiae
Name Description Probability Func Analog Organism