The network for 'positive regulation of muscle organ development' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

positive regulation of muscle organ development

Any process that activates, maintains or increases the rate of muscle development.

Danio rerio
Name Description Probability Func Analog Organism
tbx1 T-box 1 0.996
bmp4 bone morphogenetic protein 4 0.980
bmp2b bone morphogenetic protein 2b 0.967
fgf8a fibroblast growth factor 8 a 0.917
gli1 GLI-Kruppel family member 1 0.906
sox9a SRY-box containing gene 9a 0.848
tbx5a T-box 5a 0.781
aldh1a2 aldehyde dehydrogenase 1 family, member A2 0.722
oep one-eyed pinhead 0.601
tbx20 T-box 20 0.494
ndr1 nodal-related 1 0.475
bmp2a bone morphogenetic protein 2a 0.473
igfbp3 insulin-like growth factor binding protein 3 0.471
cdh2 cadherin 2, neuronal 0.414
ptch2 patched 2 0.414
gpr126 G protein-coupled receptor 126 0.411
gro1 groucho 1 0.398
LOC100000687 signal peptide, CUB and EGF-like domain-containing protein 3-like 0.398
wnt10a wingless-type MMTV integration site family, member 10a 0.384
mib mind bomb 0.357
gata6 GATA-binding protein 6 0.356
klf4a Kruppel-like transcription factor 4a 0.351
gli2a GLI-Kruppel family member GLI2a 0.350
wnt5b wingless-type MMTV integration site family, member 5b 0.337
twist1a twist1a 0.334
gbx2 gastrulation brain homeo box 2 0.329
brd2a bromodomain-containing 2a 0.325
stac3 SH3 and cysteine rich domain 3 0.316
pax2a paired box gene 2a 0.314
hey2 hairy/enhancer-of-split related with YRPW motif 2 0.291
szl sizzled 0.287
mef2cb myocyte enhancer factor 2cb 0.282
chd chordin 0.273
wnt11r wingless-type MMTV integration site family, member 11, related 0.271
fgf8b fibroblast growth factor 8 b 0.270
fgf24 fibroblast growth factor 24 0.262
nanos3 nanos homolog 3 0.258
hmx4 H6 family homeobox 4 0.254
dcc deleted in colorectal carcinoma 0.251
mef2ca myocyte enhancer factor 2ca 0.246
twist3 twist3 0.241
bmp7b bone morphogenetic protein 7b 0.240
wnt4a wingless-type MMTV integration site family, member 4a 0.240
pcdh8 protocadherin 8 0.228
pcdh18b protocadherin 18b 0.221
her7 hairy and enhancer of split related-7 0.220
prdm1a PR domain containing 1a, with ZNF domain 0.218
aldh1a3 aldehyde dehydrogenase 1 family, member A3 0.212
hand2 heart and neural crest derivatives expressed transcript 2 0.212
lhx2b LIM homeobox 2b 0.211
irf6 interferon regulatory factor 6 0.210
wls wntless homolog (Drosophila) 0.204
ptenb phosphatase and tensin homolog B (mutated in multiple advanced cancers 1) 0.196
tp73 tumor protein p73 0.190
nkx2.5 NK2 transcription factor related 5 0.186
ntla no tail a 0.175
tbx18 T-box 18 0.173
cobl cordon-bleu homolog (mouse) 0.169
mll myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila) 0.169
lef1 lymphocyte enhancer binding factor 1 0.166
siah2l seven in absentia homolog 2 (Drosophila)-like 0.166
ptch1 patched 1 0.164
frem3 Fras1 related extracellular matrix 3 0.162
ncam1a neural cell adhesion molecule 1a 0.152
runx1 runt-related transcription factor 1 0.151
pdlim7 PDZ and LIM domain 7 0.150
ihha Indian hedgehog homolog a 0.149
pard6gb par-6 partitioning defective 6 homolog gamma B (C. elegans) 0.148
myh6 myosin, heavy polypeptide 6, cardiac muscle, alpha 0.147
fn1 fibronectin 1 0.147
cyp26c1 cytochrome P450, family 26, subfamily C, polypeptide 1 0.147
tnnt2a troponin T2a, cardiac 0.144
sox32 SRY-box containing gene 32 0.144
pwp2h PWP2 periodic tryptophan protein homolog (yeast) 0.143
pacsin3 protein kinase C and casein kinase substrate in neurons 3 0.143
scube2 signal peptide, CUB domain, EGF-like 2 0.142
notch1b notch homolog 1b 0.141
wnt8a wingless-type MMTV integration site family, member 8a 0.139
hnf1ba HNF1 homeobox Ba 0.139
fgf10a fibroblast growth factor 10a 0.137
has2 hyaluronan synthase 2 0.136
tll1 tolloid-like 1 0.135
vcana versican a 0.133
fgfr1a fibroblast growth factor receptor 1a 0.132
foxh1 forkhead box H1 0.131
atp1b2b ATPase, Na+/K+ transporting, beta 2b polypeptide 0.131
adrb2a adrenergic receptor, beta 2a 0.131
msxd muscle segment homeobox D 0.127
acvr1b activin A receptor, type IB 0.127
wnt2bb wingless-type MMTV integration site family, member 2Bb 0.127
gdf6a growth differentiation factor 6a 0.127
dhrs3a dehydrogenase/reductase (SDR family) member 3a 0.125
bmp7a bone morphogenetic protein 7a 0.124
fgf17 fibroblast growth factor 17 0.123
ntn2 netrin 2 0.123
pld1a phospholipase D1a 0.123
arnt2 aryl hydrocarbon receptor nuclear translocator 2 0.122
myod1 myogenic differentiation 1 0.121
brd2b bromodomain containing 2b 0.120
sema3aa semaphorin 3aa 0.117
Loading network...
Caenorhabditis elegans
Name Description Probability Func Analog Organism
Loading network...
Drosophila melanogaster
Name Description Probability Func Analog Organism
tkv thickveins 0.978
dpp decapentaplegic 0.930
hh hedgehog 0.812
wg wingless 0.735
Mad Mothers against dpp 0.599
ci cubitus interruptus 0.599
Egfr Epidermal growth factor receptor 0.451
N Notch 0.390
stumps CG31317 gene product from transcript CG31317-RC 0.218
htl heartless 0.168
InR Insulin-like receptor 0.160
eya eyes absent 0.158
sns sticks and stones 0.105
eve even skipped 0.098
ptc patched 0.092
en engrailed 0.083
slou slouch 0.083
EcR Ecdysone receptor 0.079
Ser Serrate 0.072
H Hairless 0.070
Dad Daughters against dpp 0.063
Abd-B Abdominal B 0.058
Dl Delta 0.057
tld tolloid 0.056
gbb glass bottom boat 0.054
Doc2 Dorsocross2 0.044
sr stripe 0.043
twi twist 0.035
rst roughest 0.031
Eip93F CG18389 gene product from transcript CG18389-RB 0.029
tin tinman 0.029
HLH54F CG5005 gene product from transcript CG5005-RA 0.028
dap dacapo 0.027
Ubx Ultrabithorax 0.025
abd-A abdominal A 0.025
pan pangolin 0.025
bnl branchless 0.023
Snoo Sno oncogene 0.023
sog short gastrulation 0.022
dally division abnormally delayed 0.020
svr silver 0.019
kn knot 0.018
sd scalloped 0.017
salm spalt major 0.016
Him Holes in muscle 0.016
pb proboscipedia 0.016
nau nautilus 0.016
kirre kin of irre 0.016
ash2 absent, small, or homeotic discs 2 0.016
sli slit 0.015
Mef2 Myocyte enhancer factor 2 0.014
rho rhomboid 0.014
hbs hibris 0.013
spdo sanpodo 0.013
lbe ladybird early 0.013
vg vestigial 0.012
ap apterous 0.012
Pi3K92E CG4141 gene product from transcript CG4141-RB 0.012
argos CG4531 gene product from transcript CG4531-RA 0.011
srp serpent 0.011
Akt1 CG4006 gene product from transcript CG4006-RA 0.011
Ras85D Ras oncogene at 85D 0.010
wb wing blister 0.010
LanB1 CG7123 gene product from transcript CG7123-RA 0.010
Loading network...
Homo sapiens
Name Description Probability Func Analog Organism
FGF1 fibroblast growth factor 1 (acidic) 1.000
SRF serum response factor (c-fos serum response element-binding transcription factor) 1.000
BMP2 bone morphogenetic protein 2 0.976
NKX2-5 NK2 transcription factor related, locus 5 (Drosophila) 0.891
FGFR1 fibroblast growth factor receptor 1 0.843
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.837
FGFR2 fibroblast growth factor receptor 2 0.749
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase) 0.580
HDAC4 histone deacetylase 4 0.507
BMPR1A bone morphogenetic protein receptor, type IA 0.460
FGF2 fibroblast growth factor 2 (basic) 0.437
BCL2L1 BCL2-like 1 0.303
JAG1 jagged 1 0.243
TJP1 tight junction protein 1 (zona occludens 1) 0.230
CDK2 cyclin-dependent kinase 2 0.191
FZD1 frizzled homolog 1 (Drosophila) 0.131
EP300 E1A binding protein p300 0.128
CLOCK clock homolog (mouse) 0.118
FSTL1 follistatin-like 1 0.105
ERBB3 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) 0.103
CCNB1 cyclin B1 0.083
ARRDC3 arrestin domain containing 3 0.077
NOG noggin 0.061
NEDD4 neural precursor cell expressed, developmentally down-regulated 4 0.060
SMAD1 SMAD family member 1 0.060
MAML1 mastermind-like 1 (Drosophila) 0.055
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) 0.053
FGF10 fibroblast growth factor 10 0.051
MKL1 megakaryoblastic leukemia (translocation) 1 0.046
CCNE1 cyclin E1 0.046
MEF2A myocyte enhancer factor 2A 0.043
TBX5 T-box 5 0.042
AMBRA1 autophagy/beclin-1 regulator 1 0.040
AR androgen receptor 0.040
KLF13 Kruppel-like factor 13 0.040
FRS2 fibroblast growth factor receptor substrate 2 0.039
WFIKKN2 WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2 0.037
ANKS1B ankyrin repeat and sterile alpha motif domain containing 1B 0.037
HDAC9 histone deacetylase 9 0.028
NCK2 NCK adaptor protein 2 0.027
FGFR3 fibroblast growth factor receptor 3 0.027
MEF2C myocyte enhancer factor 2C 0.025
SIRT1 sirtuin 1 0.024
MYOD1 myogenic differentiation 1 0.022
FUNDC2 FUN14 domain containing 2 0.022
NAP1L1 nucleosome assembly protein 1-like 1 0.022
NOTCH3 notch 3 0.021
CKS2 CDC28 protein kinase regulatory subunit 2 0.021
CCNA2 cyclin A2 0.019
PIK3R2 phosphoinositide-3-kinase, regulatory subunit 2 (beta) 0.019
CCNB2 cyclin B2 0.018
CKS1B CDC28 protein kinase regulatory subunit 1B 0.018
SLC9A3R1 solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1 0.017
KCNA1 potassium voltage-gated channel, shaker-related subfamily, member 1 (episodic ataxia with myokymia) 0.016
MAPK8 mitogen-activated protein kinase 8 0.015
JUN jun proto-oncogene 0.015
CTGF connective tissue growth factor 0.015
ATXN1L ataxin 1-like 0.015
PLCG1 phospholipase C, gamma 1 0.014
NCOA1 nuclear receptor coactivator 1 0.013
DLG3 discs, large homolog 3 (Drosophila) 0.013
ZFYVE9 zinc finger, FYVE domain containing 9 0.012
SPEN spen homolog, transcriptional regulator (Drosophila) 0.012
CDK1 cyclin-dependent kinase 1 0.012
AHR aryl hydrocarbon receptor 0.011
DLG2 discs, large homolog 2 (Drosophila) 0.011
PDK1 pyruvate dehydrogenase kinase, isozyme 1 0.011
ERBB2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) 0.011
KCNQ1 potassium voltage-gated channel, KQT-like subfamily, member 1 0.010
FGF7 fibroblast growth factor 7 0.010
Loading network...
Mus musculus
Name Description Probability Func Analog Organism
Loading network...
Rattus norvegicus
Name Description Probability Func Analog Organism
Erbb4 v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian) 0.147
Acat3 acetyl-Coenzyme A acetyltransferase 3 0.110
Fgfr2 fibroblast growth factor receptor 2 0.105
Cyp51 cytochrome P450, family 51 0.089
Sc4mol sterol-C4-methyl oxidase-like 0.088
Hmgcs1 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1 (soluble) 0.070
Idi1 isopentenyl-diphosphate delta isomerase 1 0.057
Prrx1 paired related homeobox 1 0.055
Sqle squalene epoxidase 0.038
Racgap1 Rac GTPase-activating protein 1 0.036
Cdc20 cell division cycle 20 homolog (S. cerevisiae) 0.036
Insig1 insulin induced gene 1 0.034
Mdga1 MAM domain containing glycosylphosphatidylinositol anchor 1 0.029
Ms4a2 membrane-spanning 4-domains, subfamily A, member 2 (Fc fragment of IgE, high affinity I, receptor for; beta polypeptide) 0.028
Creb1 cAMP responsive element binding protein 1 0.028
Tnni1 troponin I type 1 (skeletal, slow) 0.027
Dmd dystrophin 0.027
Met met proto-oncogene 0.027
Top2a topoisomerase (DNA) II alpha 0.025
Cdh6 cadherin 6 0.024
Il2ra interleukin 2 receptor, alpha 0.022
Cdkn3 cyclin-dependent kinase inhibitor 3 0.021
Htr1b 5-hydroxytryptamine (serotonin) receptor 1B 0.020
Phkg1 phosphorylase kinase, gamma 1 0.019
Gabra4 gamma-aminobutyric acid (GABA) A receptor, alpha 4 0.019
Fgf10 fibroblast growth factor 10 0.018
Fgf5 fibroblast growth factor 5 0.018
Otx1 orthodenticle homeobox 1 0.017
Kcnh5 potassium voltage-gated channel, subfamily H (eag-related), member 5 0.017
Cacng8 calcium channel, voltage-dependent, gamma subunit 8 0.016
Fgf7 fibroblast growth factor 7 0.016
Actc1 actin, alpha, cardiac muscle 1 0.015
Jak1 Janus kinase 1 0.015
Egr3 early growth response 3 0.015
Strn striatin, calmodulin binding protein 0.015
Adrb1 adrenergic, beta-1-, receptor 0.015
Ppp1ca protein phosphatase 1, catalytic subunit, alpha isoform 0.014
Oprm1 opioid receptor, mu 1 0.014
Musk muscle, skeletal, receptor tyrosine kinase 0.014
Fdft1 farnesyl diphosphate farnesyl transferase 1 0.014
Shox2 short stature homeobox 2 0.014
siat7D alpha-2,6-sialyltransferase ST6GalNAc IV 0.013
Ube2c ubiquitin-conjugating enzyme E2C 0.013
Ar androgen receptor 0.013
Traf4af1 TRAF4 associated factor 1 0.013
Slc2a13 solute carrier family 2 (facilitated glucose transporter), member 13 0.013
Slc8a1 solute carrier family 8 (sodium/calcium exchanger), member 1 0.013
Gja3 gap junction protein, alpha 3 0.012
Prkca protein kinase C, alpha 0.012
Syt8 synaptotagmin VIII 0.012
Rrm2 ribonucleotide reductase M2 0.012
Kcnh7 potassium voltage-gated channel, subfamily H (eag-related), member 7 0.012
Btc betacellulin 0.012
Rph3a rabphilin 3A 0.012
Col11a2 collagen, type XI, alpha 2 0.012
Rgs8 regulator of G-protein signaling 8 0.011
Ccl4 chemokine (C-C motif) ligand 4 0.011
Htr2a 5-hydroxytryptamine (serotonin) receptor 2A 0.011
Srd5a2 steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 2) 0.011
LOC689399 hypothetical protein LOC689399 0.011
Cmtm2a CKLF-like MARVEL transmembrane domain containing 2A 0.011
Kitlg KIT ligand 0.011
Kif2c kinesin family member 2C 0.011
Mki67 antigen identified by monoclonal antibody Ki-67 0.011
Clcn1 chloride channel 1 0.011
Cdk1 cyclin-dependent kinase 1 0.011
Igfbp5 insulin-like growth factor binding protein 5 0.011
Olr1500 olfactory receptor 1500 0.011
Kl Klotho 0.011
Prl prolactin 0.010
Esr2 estrogen receptor 2 (ER beta) 0.010
Slc2a3 solute carrier family 2 (facilitated glucose transporter), member 3 0.010
Znf503 zinc finger protein 503 0.010
Scn5a sodium channel, voltage-gated, type V, alpha subunit 0.010
Stip1 stress-induced phosphoprotein 1 0.010
Unc5b unc-5 homolog B (C. elegans) 0.010
Loading network...
Saccharomyces cerevisiae
Name Description Probability Func Analog Organism