The network for 'negative regulation of striated muscle tissue development' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

negative regulation of striated muscle tissue development

Any process that stops, prevents, or reduces the frequency, rate or extent of striated muscle development.

Danio rerio
Name Description Probability Func Analog Organism
bmp2b bone morphogenetic protein 2b 0.958
bmp4 bone morphogenetic protein 4 0.642
nkx2.5 NK2 transcription factor related 5 0.578
tbx1 T-box 1 0.435
wnt5b wingless-type MMTV integration site family, member 5b 0.383
gpr126 G protein-coupled receptor 126 0.249
dlx5a distal-less homeobox gene 5a 0.236
itga3b integrin, alpha 3b 0.236
bmp2a bone morphogenetic protein 2a 0.231
sox9a SRY-box containing gene 9a 0.214
fgf3 fibroblast growth factor 3 0.211
chd chordin 0.198
foxa3 forkhead box A3 0.188
kdrl kinase insert domain receptor like 0.185
hoxa13b homeo box A13b 0.156
fgf24 fibroblast growth factor 24 0.154
tbx2b T-box 2b 0.153
msxc muscle segment homeobox C 0.145
hey2 hairy/enhancer-of-split related with YRPW motif 2 0.136
six4a sine oculis homeobox homolog 4a 0.130
hoxa9b homeo box A9b 0.125
tgfb3 transforming growth factor, beta 3 0.116
pcdh8 protocadherin 8 0.104
pea3 ETS-domain transcription factor pea3 0.101
fgfrl1b fibroblast growth factor receptor-like 1b 0.100
hand2 heart and neural crest derivatives expressed transcript 2 0.097
hoxa11a homeo box A11a 0.096
myod1 myogenic differentiation 1 0.094
hnf1ba HNF1 homeobox Ba 0.092
fgf8a fibroblast growth factor 8 a 0.080
ved ventrally expressed dharma/bozozok antagonist 0.078
igfbp3 insulin-like growth factor binding protein 3 0.073
nkx2.3 NK2 transcription factor related 3 0.072
myh6 myosin, heavy polypeptide 6, cardiac muscle, alpha 0.068
tbx20 T-box 20 0.068
atp2a2a ATPase, Ca++ transporting, cardiac muscle, slow twitch 2a 0.068
msxd muscle segment homeobox D 0.066
tll1 tolloid-like 1 0.066
tp73 tumor protein p73 0.064
eve1 even-skipped-like1 0.063
lama4 laminin, alpha 4 0.062
tbx18 T-box 18 0.062
twist3 twist3 0.062
igf1rb insulin-like growth factor 1b receptor 0.061
ntla no tail a 0.061
fgf10a fibroblast growth factor 10a 0.060
cx30.3 connexin 30.3 0.059
twist1a twist1a 0.054
fgf4 fibroblast growth factor 4 0.054
tcf7 transcription factor 7 (T-cell specific, HMG-box) 0.053
flh floating head 0.052
hoxa11b homeo box A11b 0.051
dct dopachrome tautomerase 0.051
tbx5b T-box 5b 0.051
frem2a Fras1 related extracellular matrix protein 2a 0.050
tbx2a T-box gene 2a 0.050
eng1a engrailed 1a 0.049
atoh1a atonal homolog 1a 0.048
igf2a insulin-like growth factor 2a 0.048
tbx5a T-box 5a 0.048
bmp3 bone morphogenetic protein 3 0.045
hoxc6a homeo box C6a 0.045
pkd2 polycystic kidney disease 2 0.044
cdh2 cadherin 2, neuronal 0.044
fgf20a fibroblast growth factor 20a 0.043
gdnf glial cell derived neurotrophic factor 0.042
hoxc13a homeo box C13a 0.042
fabp11a fatty acid binding protein 11a 0.042
mstnb myostatin b 0.039
spry2 sprouty homolog 2 0.039
has2 hyaluronan synthase 2 0.038
fras1 Fraser syndrome 1 0.038
myf5 myogenic factor 5 0.038
dlx4a distal-less homeobox gene 4a 0.037
il17rd interleukin 17 receptor D 0.037
msxb muscle segment homeobox B 0.036
gdf6a growth differentiation factor 6a 0.036
klf4 Kruppel-like factor 4 0.035
or111-7 odorant receptor, family D, subfamily 111, member 7 0.035
osr1 odd-skipped related 1 (Drosophila) 0.035
nkx3.2 NK3 homeobox 2 0.034
ltbp3 latent transforming growth factor beta binding protein 3 0.034
pax9 paired box gene 9 0.034
vmhc ventricular myosin heavy chain 0.033
hspb7 heat shock protein family, alpha-crystallin-related, b7 0.033
lpp LIM domain containing preferred translocation partner in lipoma 0.032
myog myogenin 0.032
vcana versican a 0.031
smo smoothened homolog (Drosophila) 0.031
ptpn21 protein tyrosine phosphatase, non-receptor type 21 0.031
sp7 Sp7 transcription factor 0.031
fzd9b frizzled homolog 9b 0.030
foxi1 forkhead box I1 0.030
prdm1a PR domain containing 1a, with ZNF domain 0.030
ndr2 nodal-related 2 0.030
fzd10 frizzled homolog 10 0.029
notch1a notch homolog 1a 0.029
insrb insulin receptor b 0.029
hmx4 H6 family homeobox 4 0.028
shha sonic hedgehog a 0.028
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Homo sapiens
Name Description Probability Func Analog Organism
FGFR2 fibroblast growth factor receptor 2 1.000
SRF serum response factor (c-fos serum response element-binding transcription factor) 1.000
SETD8 SET domain containing (lysine methyltransferase) 8 0.989
FGF1 fibroblast growth factor 1 (acidic) 0.975
BMPR1A bone morphogenetic protein receptor, type IA 0.970
NKX2-5 NK2 transcription factor related, locus 5 (Drosophila) 0.930
HDAC1 histone deacetylase 1 0.891
TGFB3 transforming growth factor, beta 3 0.799
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.755
SMAD1 SMAD family member 1 0.660
FSTL1 follistatin-like 1 0.650
FGF10 fibroblast growth factor 10 0.645
BMP2 bone morphogenetic protein 2 0.488
YAP1 Yes-associated protein 1 0.473
SATB2 SATB homeobox 2 0.382
MYOD1 myogenic differentiation 1 0.344
ENG endoglin 0.335
CDC14B CDC14 cell division cycle 14 homolog B (S. cerevisiae) 0.322
BMP7 bone morphogenetic protein 7 0.277
FZR1 fizzy/cell division cycle 20 related 1 (Drosophila) 0.263
STK3 serine/threonine kinase 3 0.262
TTR transthyretin 0.253
KRT5 keratin 5 0.239
CABLES1 Cdk5 and Abl enzyme substrate 1 0.227
AXIN1 axin 1 0.193
STK4 serine/threonine kinase 4 0.181
DKK1 dickkopf homolog 1 (Xenopus laevis) 0.160
LRP6 low density lipoprotein receptor-related protein 6 0.145
HDAC6 histone deacetylase 6 0.140
WFIKKN2 WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2 0.106
TGFBR3 transforming growth factor, beta receptor III 0.096
GATA4 GATA binding protein 4 0.091
TGFB1 transforming growth factor, beta 1 0.087
FGF8 fibroblast growth factor 8 (androgen-induced) 0.079
HPCAL4 hippocalcin like 4 0.077
TGFBR1 transforming growth factor, beta receptor 1 0.075
NEURL4 neuralized homolog 4 (Drosophila) 0.073
LATS2 LATS, large tumor suppressor, homolog 2 (Drosophila) 0.073
PTPN14 protein tyrosine phosphatase, non-receptor type 14 0.072
WWOX WW domain containing oxidoreductase 0.070
FGF3 fibroblast growth factor 3 0.068
ITCH itchy E3 ubiquitin protein ligase homolog (mouse) 0.066
KCNQ1 potassium voltage-gated channel, KQT-like subfamily, member 1 0.063
FGFR3 fibroblast growth factor receptor 3 0.061
SMAD7 SMAD family member 7 0.056
MDM2 Mdm2 p53 binding protein homolog (mouse) 0.052
KRT15 keratin 15 0.044
MKL1 megakaryoblastic leukemia (translocation) 1 0.038
NRP1 neuropilin 1 0.037
WNT3A wingless-type MMTV integration site family, member 3A 0.037
GNAI3 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 0.036
PRDM8 PR domain containing 8 0.035
FGF7 fibroblast growth factor 7 0.034
ADRBK1 adrenergic, beta, receptor kinase 1 0.032
WNT1 wingless-type MMTV integration site family, member 1 0.032
RASSF1 Ras association (RalGDS/AF-6) domain family member 1 0.032
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.031
TP73 tumor protein p73 0.030
UNC45A unc-45 homolog A (C. elegans) 0.028
TBX5 T-box 5 0.027
NEDD9 neural precursor cell expressed, developmentally down-regulated 9 0.026
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila) 0.026
LBX1 ladybird homeobox 1 0.026
MYOCD myocardin 0.025
TBX1 T-box 1 0.025
HNRNPCL1 heterogeneous nuclear ribonucleoprotein C-like 1 0.024
NOG noggin 0.023
BDNF brain-derived neurotrophic factor 0.023
DEAF1 deformed epidermal autoregulatory factor 1 (Drosophila) 0.022
NEDD4 neural precursor cell expressed, developmentally down-regulated 4 0.022
DDIT4 DNA-damage-inducible transcript 4 0.022
WFIKKN1 WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 1 0.021
PDGFB platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog) 0.020
KRT6C keratin 6C 0.018
FGF2 fibroblast growth factor 2 (basic) 0.016
SNX9 sorting nexin 9 0.016
LRRK2 leucine-rich repeat kinase 2 0.016
HNF1A HNF1 homeobox A 0.016
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.015
FGF4 fibroblast growth factor 4 0.015
DMWD dystrophia myotonica, WD repeat containing 0.015
TXNIP thioredoxin interacting protein 0.015
PLCE1 phospholipase C, epsilon 1 0.015
RASSF3 Ras association (RalGDS/AF-6) domain family member 3 0.015
RASSF5 Ras association (RalGDS/AF-6) domain family member 5 0.014
FOXA2 forkhead box A2 0.014
MYOG myogenin (myogenic factor 4) 0.014
MKL2 MKL/myocardin-like 2 0.013
ROD1 ROD1 regulator of differentiation 1 (S. pombe) 0.013
SGK3 serum/glucocorticoid regulated kinase family, member 3 0.013
FOXL1 forkhead box L1 0.013
FOXC2 forkhead box C2 (MFH-1, mesenchyme forkhead 1) 0.013
NPAS1 neuronal PAS domain protein 1 0.013
ACVR2B activin A receptor, type IIB 0.013
TP53 tumor protein p53 0.013
AR androgen receptor 0.013
WNT3 wingless-type MMTV integration site family, member 3 0.012
HOXD12 homeobox D12 0.012
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) 0.011
KLF5 Kruppel-like factor 5 (intestinal) 0.011
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Mus musculus
Name Description Probability Func Analog Organism
Shh sonic hedgehog 0.883
Fgfr2 fibroblast growth factor receptor 2 0.831
Msx1 homeobox, msh-like 1 0.728
Lef1 lymphoid enhancer binding factor 1 0.720
Hand1 heart and neural crest derivatives expressed transcript 1 0.693
Isl1 ISL1 transcription factor, LIM/homeodomain 0.693
Pax3 paired box gene 3 0.649
Pax6 paired box gene 6 0.561
Gli3 GLI-Kruppel family member GLI3 0.506
Sox2 SRY-box containing gene 2 0.428
Prrx1 paired related homeobox 1 0.374
Apc adenomatosis polyposis coli 0.354
Six1 sine oculis-related homeobox 1 homolog (Drosophila) 0.329
Otx2 orthodenticle homolog 2 (Drosophila) 0.321
Tbx3 T-box 3 0.305
Nkx2-5 NK2 transcription factor related, locus 5 (Drosophila) 0.294
Neurod1 neurogenic differentiation 1 0.284
Pbx1 pre B-cell leukemia transcription factor 1 0.282
Ascl1 achaete-scute complex homolog 1 (Drosophila) 0.252
Cdx2 caudal type homeobox 2 0.245
Sox9 SRY-box containing gene 9 0.236
Axin1 axin 1 0.216
Foxc2 forkhead box C2 0.199
Prrx2 paired related homeobox 2 0.186
Hes1 hairy and enhancer of split 1 (Drosophila) 0.183
Smo smoothened homolog (Drosophila) 0.176
Bmp7 bone morphogenetic protein 7 0.172
Tcfap2a transcription factor AP-2, alpha 0.158
Eng endoglin 0.148
Fgfr1 fibroblast growth factor receptor 1 0.138
Hand2 heart and neural crest derivatives expressed transcript 2 0.136
Ror2 receptor tyrosine kinase-like orphan receptor 2 0.129
Ctnnb1 catenin (cadherin associated protein), beta 1 0.126
Msx2 homeobox, msh-like 2 0.125
Dlx5 distal-less homeobox 5 0.121
Eya1 eyes absent 1 homolog (Drosophila) 0.114
Runx2 runt related transcription factor 2 0.114
Bmp4 bone morphogenetic protein 4 0.104
Rspo2 R-spondin 2 homolog (Xenopus laevis) 0.100
Gsc goosecoid homeobox 0.087
Fgf8 fibroblast growth factor 8 0.087
Nkx2-1 NK2 homeobox 1 0.082
Gli2 GLI-Kruppel family member GLI2 0.081
Bmp2 bone morphogenetic protein 2 0.081
Tcf15 transcription factor 15 0.079
Mecom MDS1 and EVI1 complex locus 0.075
Hoxa5 homeobox A5 0.072
Emx1 empty spiracles homolog 1 (Drosophila) 0.068
Hdac2 histone deacetylase 2 0.065
Twist2 twist homolog 2 (Drosophila) 0.063
Sox11 SRY-box containing gene 11 0.060
Sall4 sal-like 4 (Drosophila) 0.058
Pdgfra platelet derived growth factor receptor, alpha polypeptide 0.057
Alx1 ALX homeobox 1 0.055
Pkd1 polycystic kidney disease 1 homolog 0.054
Neurog2 neurogenin 2 0.052
Pax9 paired box gene 9 0.051
Ptf1a pancreas specific transcription factor, 1a 0.051
Kras v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog 0.051
Pitx2 paired-like homeodomain transcription factor 2 0.051
Myl2 myosin, light polypeptide 2, regulatory, cardiac, slow 0.051
Pou4f2 POU domain, class 4, transcription factor 2 0.050
Gja1 gap junction protein, alpha 1 0.050
En1 engrailed 1 0.048
Six4 sine oculis-related homeobox 4 homolog (Drosophila) 0.046
Gata4 GATA binding protein 4 0.045
Pitx1 paired-like homeodomain transcription factor 1 0.045
Gas1 growth arrest specific 1 0.045
Foxg1 forkhead box G1 0.044
Mapk8ip1 mitogen-activated protein kinase 8 interacting protein 1 0.044
Tgfb2 transforming growth factor, beta 2 0.044
Neurod4 neurogenic differentiation 4 0.043
Tal1 T-cell acute lymphocytic leukemia 1 0.043
Hoxa13 homeobox A13 0.038
Alx4 aristaless-like homeobox 4 0.038
Hic1 hypermethylated in cancer 1 0.036
Trp53 transformation related protein 53 0.035
Pdx1 pancreatic and duodenal homeobox 1 0.034
Alx3 aristaless-like homeobox 3 0.033
T brachyury 0.033
Rara retinoic acid receptor, alpha 0.032
Wnt3a wingless-related MMTV integration site 3A 0.031
Tbx5 T-box 5 0.031
Meox2 mesenchyme homeobox 2 0.031
Plin1 perilipin 1 0.030
Cldn5 claudin 5 0.028
Mycn v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian) 0.028
Tbx2 T-box 2 0.027
Pou3f4 POU domain, class 3, transcription factor 4 0.027
Igdcc3 immunoglobulin superfamily, DCC subclass, member 3 0.027
Ebf3 early B-cell factor 3 0.026
Hoxa10 homeobox A10 0.026
Lrp6 low density lipoprotein receptor-related protein 6 0.026
Fgf4 fibroblast growth factor 4 0.026
Dkk1 dickkopf homolog 1 (Xenopus laevis) 0.026
Myf5 myogenic factor 5 0.026
Sox3 SRY-box containing gene 3 0.025
Mdm2 transformed mouse 3T3 cell double minute 2 0.025
Tbx1 T-box 1 0.025
Pick1 protein interacting with C kinase 1 0.025
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Rattus norvegicus
Name Description Probability Func Analog Organism
S100a9 S100 calcium binding protein A9 0.091
S100a8 S100 calcium binding protein A8 0.070
Cav1 caveolin 1, caveolae protein 0.057
Adam10 ADAM metallopeptidase domain 10 0.052
S100a6 S100 calcium binding protein A6 0.037
Cav2 caveolin 2 0.021
Anxa2 annexin A2 0.021
Hspb2 heat shock protein beta 2 0.015
Mbp myelin basic protein 0.012
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism