The network for 'specification of symmetry' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

specification of symmetry

The establishment of an organism's body plan or part of an organism such that a similar arrangement in form and relationship of parts around a common axis, or around each side of a plane is created.

Danio rerio
Name Description Probability Func Analog Organism
fgf8a fibroblast growth factor 8 a 1.000
pax2a paired box gene 2a 0.998
shha sonic hedgehog a 0.997
tbx1 T-box 1 0.996
lrrc6 leucine rich repeat containing 6 0.995
fzd10 frizzled homolog 10 0.994
ift88 intraflagellar transport 88 homolog 0.993
ntla no tail a 0.992
cdh2 cadherin 2, neuronal 0.987
pkd2 polycystic kidney disease 2 0.983
jag2 jagged 2 0.981
tbx16 T-box gene 16 0.979
wnt11r wingless-type MMTV integration site family, member 11, related 0.977
neurod neurogenic differentiation 0.969
bmp2b bone morphogenetic protein 2b 0.969
zgc:100838 zgc:100838 0.968
gata3 GATA-binding protein 3 0.962
ndr2 nodal-related 2 0.957
oep one-eyed pinhead 0.949
pitx2 paired-like homeodomain transcription factor 2 0.948
chd chordin 0.947
aldh1a2 aldehyde dehydrogenase 1 family, member A2 0.941
gli2a GLI-Kruppel family member GLI2a 0.939
lhx1a LIM homeobox 1a 0.936
wnt11 wingless-type MMTV integration site family, member 11 0.932
cc2d2a coiled-coil and C2 domain containing 2A 0.928
bmp2a bone morphogenetic protein 2a 0.926
hand2 heart and neural crest derivatives expressed transcript 2 0.922
tbx20 T-box 20 0.921
shhb sonic hedgehog b 0.914
twist3 twist3 0.907
lrrc50 leucine rich repeat containing 50 0.907
lft1 lefty1 0.896
col8a1a collagen, type VIII, alpha 1a 0.893
sesn1 sestrin 1 0.893
sulf1 sulfatase 1 0.892
flh floating head 0.863
cav1 caveolin 1 0.862
neo1 neogenin 1 0.861
notch1a notch homolog 1a 0.858
fgf3 fibroblast growth factor 3 0.853
rfx2 regulatory factor X, 2 (influences HLA class II expression) 0.849
etv5b ets variant 5b 0.846
e2f5 E2F transcription factor 5 0.829
pdlim7 PDZ and LIM domain 7 0.829
tcf7l2 transcription factor 7-like 2 (T-cell specific, HMG-box) 0.826
dlc deltaC 0.814
dla deltaA 0.805
olfm2 olfactomedin 2 0.798
atp1a1 ATPase, Na+/K+ transporting, alpha 1 polypeptide 0.791
six4b sine oculis homeobox homolog 4b 0.790
crabp2a cellular retinoic acid binding protein 2, a 0.790
spaw southpaw 0.782
tfap2a transcription factor AP-2 alpha 0.768
myl7 myosin, light polypeptide 7, regulatory 0.767
irx1a iroquois homeobox protein 1, a 0.759
ef1a elongation factor 1-alpha 0.757
eomesa eomesodermin homolog a 0.750
mstna myostatin a 0.741
gbx2 gastrulation brain homeo box 2 0.735
dlx4b distal-less homeobox gene 4b 0.733
mib mind bomb 0.724
hey2 hairy/enhancer-of-split related with YRPW motif 2 0.724
hspb7 heat shock protein family, alpha-crystallin-related, b7 0.723
hnf1ba HNF1 homeobox Ba 0.711
nipblb novel protein similar to vertebrate Nipped-B homolog and nipped-b homolog b (Drosophila) 0.706
fzd8a frizzled homolog 8a 0.702
zic1 zic family member 1 (odd-paired homolog, Drosophila) 0.696
trpm7 transient receptor potential cation channel, subfamily M, member 7 0.695
rarab retinoic acid receptor, alpha b 0.690
rarga retinoic acid receptor gamma a 0.673
raraa retinoic acid receptor, alpha a 0.673
cdh1 cadherin 1, epithelial 0.672
robo3 roundabout homolog 3 0.672
hhex hematopoietically expressed homeobox 0.663
gata4 GATA-binding protein 4 0.663
dlx4a distal-less homeobox gene 4a 0.656
sulf2 sulfatase 2 0.652
tp63 tumor protein p63 0.641
fibin fin bud initiation factor 0.639
smo smoothened homolog (Drosophila) 0.638
dkk1b dickkopf 1b 0.637
smad9 MAD homolog 9 (Drosophila) 0.636
sox1a SRY-box containing gene 1a 0.636
myf5 myogenic factor 5 0.632
otpb orthopedia homolog b 0.630
emx3 empty spiracles homeobox 3 0.628
eya1 eyes absent homolog 1 0.620
sox17 SRY-box containing gene 17 0.610
gro1 groucho 1 0.610
fbn2b fibrillin 2b 0.606
ccdc40 coiled-coil domain containing 40 0.603
efnb1 ephrin B1 0.598
six3b sine oculis homeobox homolog 3b 0.597
dlx1a distal-less homeobox gene 1a 0.593
eya4 eyes absent homolog 4 (Drosophila) 0.592
sox32 SRY-box containing gene 32 0.590
foxa2 forkhead box A2 0.582
gli1 GLI-Kruppel family member 1 0.576
zic3 zic family member 3 heterotaxy 1 (odd-paired homolog, Drosophila) 0.573
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
osm-5 Protein OSM-5 0.669
che-2 Protein CHE-2 0.330
soc-2 Protein SOC-2 0.114
daf-10 Protein DAF-10 0.088
lin-17 Protein LIN-17 0.050
nphp-1 Protein NPHP-1 0.043
eat-4 Protein EAT-4 0.041
hlh-2 Protein HLH-2 0.033
bar-1 Protein BAR-1 0.031
egl-19 Protein EGL-19 0.030
inx-13 Protein INX-13 0.027
glp-1 Protein GLP-1 0.026
hlh-1 Protein HLH-1 0.025
che-13 Protein CHE-13 0.024
pdfr-1 Protein PDFR-1 0.024
egl-18 Protein EGL-18 0.023
efn-2 Protein EFN-2 0.021
unc-9 Protein UNC-9 0.021
nhr-67 Protein NHR-67 0.021
unc-62 Protein UNC-62 0.019
atn-1 Protein ATN-1 0.019
sma-6 Protein SMA-6 0.018
ser-4 Protein SER-4 0.017
unc-13 Protein UNC-13 0.017
mec-2 Protein MEC-2 0.016
let-60 Protein LET-60 0.015
cwn-1 Protein CWN-1 0.015
ist-1 Protein IST-1 0.015
sax-7 Protein SAX-7 0.015
pde-4 Protein PDE-4 0.015
egl-46 Protein EGL-46 0.015
unc-104 Protein UNC-104 0.014
fkh-2 Protein FKH-2 0.014
unc-6 Protein UNC-6 0.014
lin-29 Protein LIN-29 0.014
daf-12 Protein DAF-12 0.013
unc-32 Protein UNC-32 0.013
nhr-143 Protein NHR-143 0.013
dhs-21 Protein DHS-21 0.013
unc-7 Protein UNC-7 0.013
pry-1 Protein PRY-1 0.013
inx-5 Protein INX-5 0.012
cam-1 Protein CAM-1 0.012
K01A2.9 Protein K01A2.9 0.012
lin-11 Protein LIN-11 0.011
che-11 Protein CHE-11 0.011
nmgp-1 Protein NMGP-1 0.011
ajm-1 Protein AJM-1 0.011
vab-3 Protein VAB-3 0.011
madd-4 Protein MADD-4 0.011
pyc-1 Protein PYC-1 0.010
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Drosophila melanogaster
Name Description Probability Func Analog Organism
Rac1 CG2248 gene product from transcript CG2248-RA 0.774
en engrailed 0.388
dsh dishevelled 0.259
mys myospheroid 0.254
stumps CG31317 gene product from transcript CG31317-RC 0.248
comt comatose 0.193
hh hedgehog 0.180
Ras85D Ras oncogene at 85D 0.173
baz bazooka 0.173
dpp decapentaplegic 0.158
rhea CG6831 gene product from transcript CG6831-RA 0.145
htl heartless 0.139
mew multiple edematous wings 0.132
wg wingless 0.131
fng fringe 0.119
arm armadillo 0.112
Lim1 CG11354 gene product from transcript CG11354-RA 0.107
bowl brother of odd with entrails limited 0.105
ci cubitus interruptus 0.090
mirr mirror 0.090
LanB2 Laminin B2 0.089
ptc patched 0.086
emc extra macrochaetae 0.082
smo smoothened 0.078
robo roundabout 0.075
tin tinman 0.073
if inflated 0.071
ovo CG6824 gene product from transcript CG6824-RE 0.064
twi twist 0.058
Su(H) Suppressor of Hairless 0.057
Pvr PDGF- and VEGF-receptor related 0.055
kst karst 0.055
insc inscuteable 0.055
Dad Daughters against dpp 0.053
lin lines 0.051
bnl branchless 0.049
tgo tango 0.049
dia diaphanous 0.048
sax saxophone 0.047
Tsc1 CG6147 gene product from transcript CG6147-RA 0.047
nkd naked cuticle 0.046
Mad Mothers against dpp 0.045
ap apterous 0.044
Wnt4 Wnt oncogene analog 4 0.042
rok Rho-kinase 0.042
Doc2 Dorsocross2 0.041
in inturned 0.040
N Notch 0.038
dock dreadlocks 0.037
pnr pannier 0.037
Cdc42 CG12530 gene product from transcript CG12530-RA 0.035
LanB1 CG7123 gene product from transcript CG7123-RA 0.032
fz frizzled 0.031
dve defective proventriculus 0.030
pod1 CG4532 gene product from transcript CG4532-RF 0.030
eya eyes absent 0.030
ena enabled 0.030
slou slouch 0.028
shi shibire 0.028
fj four-jointed 0.027
Hem HEM-protein 0.027
G-oalpha47A G protein oalpha 47A 0.027
eve even skipped 0.026
kuz kuzbanian 0.026
dally division abnormally delayed 0.025
p38b CG7393 gene product from transcript CG7393-RA 0.025
scb scab 0.025
Acsl Acyl-CoA synthetase long-chain 0.025
zip zipper 0.025
CG14869 CG14869 gene product from transcript CG14869-RB 0.025
kn knot 0.024
Tl Toll 0.023
ck crinkled 0.023
nrv2 nervana 2 0.023
zfh1 Zn finger homeodomain 1 0.022
sns sticks and stones 0.022
sd scalloped 0.022
kibra kibra ortholog 0.022
Lis-1 Lissencephaly-1 0.021
wun wunen 0.021
neuroligin CG13772 gene product from transcript CG13772-RA 0.021
vri vrille 0.021
slp1 sloppy paired 1 0.021
mbc myoblast city 0.020
Dcr-1 Dicer-1 0.019
lola longitudinals lacking 0.019
sli slit 0.019
RhoGAP93B CG3421 gene product from transcript CG3421-RA 0.019
fru fruitless 0.019
robo3 CG5423 gene product from transcript CG5423-RA 0.019
hkb huckebein 0.018
sr stripe 0.018
nompC no mechanoreceptor potential C 0.017
Myd88 CG2078 gene product from transcript CG2078-RA 0.017
Cul-5 Cullin-5 0.017
JIL-1 CG6297 gene product from transcript CG6297-RA 0.017
Hs6st Heparan sulfate 6-O-sulfotransferase 0.017
unc uncoordinated 0.016
nct nicastrin 0.016
Snap25 Synapse protein 25 0.016
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Homo sapiens
Name Description Probability Func Analog Organism
SMAD3 SMAD family member 3 0.991
CDC42 cell division cycle 42 (GTP binding protein, 25kDa) 0.561
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.546
SMAD2 SMAD family member 2 0.541
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.522
NKX2-5 NK2 transcription factor related, locus 5 (Drosophila) 0.432
BMPR1A bone morphogenetic protein receptor, type IA 0.423
SMAD7 SMAD family member 7 0.419
SMAD1 SMAD family member 1 0.410
RHOA ras homolog gene family, member A 0.259
NOTCH1 notch 1 0.257
TGFB1 transforming growth factor, beta 1 0.217
ARHGDIA Rho GDP dissociation inhibitor (GDI) alpha 0.202
MAP2K4 mitogen-activated protein kinase kinase 4 0.199
TSC2 tuberous sclerosis 2 0.190
BMP2 bone morphogenetic protein 2 0.188
TBX5 T-box 5 0.171
GSK3B glycogen synthase kinase 3 beta 0.171
ATF2 activating transcription factor 2 0.162
FSTL1 follistatin-like 1 0.160
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.136
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) 0.119
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) 0.099
FLNC filamin C, gamma 0.093
TP53 tumor protein p53 0.085
JAG1 jagged 1 0.084
YY1 YY1 transcription factor 0.077
FKBP1A FK506 binding protein 1A, 12kDa 0.075
TGFBR1 transforming growth factor, beta receptor 1 0.065
CHRD chordin 0.063
SMAD4 SMAD family member 4 0.062
MYC v-myc myelocytomatosis viral oncogene homolog (avian) 0.061
ARHGAP1 Rho GTPase activating protein 1 0.059
GATA4 GATA binding protein 4 0.058
PBX1 pre-B-cell leukemia homeobox 1 0.057
SMAD5 SMAD family member 5 0.052
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 0.047
TIRAP toll-interleukin 1 receptor (TIR) domain containing adaptor protein 0.044
PDGFRA platelet-derived growth factor receptor, alpha polypeptide 0.043
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta 0.040
EZR ezrin 0.036
ZFYVE9 zinc finger, FYVE domain containing 9 0.035
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.035
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide 0.035
SASS6 spindle assembly 6 homolog (C. elegans) 0.034
TJP1 tight junction protein 1 (zona occludens 1) 0.033
SIN3A SIN3 homolog A, transcription regulator (yeast) 0.032
AXIN1 axin 1 0.032
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma 0.032
ACVR1 activin A receptor, type I 0.032
CD44 CD44 molecule (Indian blood group) 0.029
SLC9A3R1 solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1 0.028
TCF4 transcription factor 4 0.028
CDT1 chromatin licensing and DNA replication factor 1 0.028
PKD1 polycystic kidney disease 1 (autosomal dominant) 0.028
GDF5 growth differentiation factor 5 0.028
MAPK8 mitogen-activated protein kinase 8 0.027
SIRT1 sirtuin 1 0.026
PML promyelocytic leukemia 0.026
MARK3 MAP/microtubule affinity-regulating kinase 3 0.026
PKP4 plakophilin 4 0.025
MAFA v-maf musculoaponeurotic fibrosarcoma oncogene homolog A (avian) 0.025
FGF10 fibroblast growth factor 10 0.025
MKL2 MKL/myocardin-like 2 0.024
LRP6 low density lipoprotein receptor-related protein 6 0.024
ARRB2 arrestin, beta 2 0.024
PTCH1 patched 1 0.023
APC adenomatous polyposis coli 0.023
MAPK9 mitogen-activated protein kinase 9 0.022
CXXC5 CXXC finger protein 5 0.022
EPAS1 endothelial PAS domain protein 1 0.022
BMP1 bone morphogenetic protein 1 0.022
GLI1 GLI family zinc finger 1 0.022
HDAC2 histone deacetylase 2 0.021
JUN jun proto-oncogene 0.020
SMAD6 SMAD family member 6 0.020
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.020
MAP3K1 mitogen-activated protein kinase kinase kinase 1 0.019
FZD1 frizzled homolog 1 (Drosophila) 0.019
NOTCH3 notch 3 0.019
RBBP7 retinoblastoma binding protein 7 0.018
EP300 E1A binding protein p300 0.018
CENPJ centromere protein J 0.018
PSEN2 presenilin 2 (Alzheimer disease 4) 0.018
BBS2 Bardet-Biedl syndrome 2 0.018
MKL1 megakaryoblastic leukemia (translocation) 1 0.018
FGF1 fibroblast growth factor 1 (acidic) 0.017
ARPC4 actin related protein 2/3 complex, subunit 4, 20kDa 0.017
SNIP1 Smad nuclear interacting protein 1 0.016
DAB2 disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila) 0.016
TTC8 tetratricopeptide repeat domain 8 0.016
MYOD1 myogenic differentiation 1 0.016
NFIX nuclear factor I/X (CCAAT-binding transcription factor) 0.015
MEIS2 Meis homeobox 2 0.015
NOG noggin 0.015
NCOR1 nuclear receptor corepressor 1 0.015
NEK1 NIMA (never in mitosis gene a)-related kinase 1 0.014
DIP2A DIP2 disco-interacting protein 2 homolog A (Drosophila) 0.014
RUNX1 runt-related transcription factor 1 0.014
NOTCH2 notch 2 0.014
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Mus musculus
Name Description Probability Func Analog Organism
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Rattus norvegicus
Name Description Probability Func Analog Organism
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism