The network for 'heart looping' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

heart looping

The tube morphogenesis process in which the primitive heart tube loops asymmetrically. This looping brings the primitive heart chambers into alignment preceding their future integration. Heart looping begins with dextral-looping and ends when the main regional divisions of the mature heart and primordium of the great arterial trunks become established preceeding septation.

Danio rerio
Name Description Probability Func Analog Organism
cdh2 cadherin 2, neuronal 0.998
hnf1ba HNF1 homeobox Ba 0.998
tbx1 T-box 1 0.991
wnt11 wingless-type MMTV integration site family, member 11 0.988
wnt11r wingless-type MMTV integration site family, member 11, related 0.983
ndr2 nodal-related 2 0.981
tbx5a T-box 5a 0.976
aldh1a2 aldehyde dehydrogenase 1 family, member A2 0.950
tbx2b T-box 2b 0.948
oep one-eyed pinhead 0.935
vmhc ventricular myosin heavy chain 0.933
bmp4 bone morphogenetic protein 4 0.930
foxh1 forkhead box H1 0.921
tbx20 T-box 20 0.919
ntla no tail a 0.900
tbx2a T-box gene 2a 0.894
pkd2 polycystic kidney disease 2 0.889
lrrc6 leucine rich repeat containing 6 0.882
foxi1 forkhead box I1 0.880
fzd10 frizzled homolog 10 0.879
hoxd4a homeo box D4a 0.875
nkx2.5 NK2 transcription factor related 5 0.874
fgf8a fibroblast growth factor 8 a 0.873
ptch2 patched 2 0.862
tp53 tumor protein p53 0.862
atp1a1 ATPase, Na+/K+ transporting, alpha 1 polypeptide 0.855
foxa2 forkhead box A2 0.839
shha sonic hedgehog a 0.834
tcf7l2 transcription factor 7-like 2 (T-cell specific, HMG-box) 0.831
fn1 fibronectin 1 0.792
ift88 intraflagellar transport 88 homolog 0.785
smo smoothened homolog (Drosophila) 0.770
six4b sine oculis homeobox homolog 4b 0.769
foxj1a forkhead box J1a 0.765
smad9 MAD homolog 9 (Drosophila) 0.746
ttna titin a 0.746
gli2a GLI-Kruppel family member GLI2a 0.735
pax2a paired box gene 2a 0.724
fgf3 fibroblast growth factor 3 0.715
gro2 groucho 2 0.709
sox32 SRY-box containing gene 32 0.708
flh floating head 0.680
myh6 myosin, heavy polypeptide 6, cardiac muscle, alpha 0.679
pdlim7 PDZ and LIM domain 7 0.678
igf1rb insulin-like growth factor 1b receptor 0.651
gata5 GATA-binding protein 5 0.639
dld deltaD 0.635
gata3 GATA-binding protein 3 0.632
sulf1 sulfatase 1 0.620
wnt9a wingless-type MMTV integration site family, member 9A 0.618
axin1 axin 1 0.604
fzd7a frizzled homolog 7a 0.603
rx3 retinal homeobox gene 3 0.591
gpc4 glypican 4 0.584
tfap2a transcription factor AP-2 alpha 0.574
hey2 hairy/enhancer-of-split related with YRPW motif 2 0.573
tnni1b troponin I, skeletal, slow b 0.572
rbm24a RNA binding motif protein 24a 0.564
tcf21 transcription factor 21 0.558
hand2 heart and neural crest derivatives expressed transcript 2 0.556
otx1b orthodenticle homolog 1b 0.554
sox2 SRY-box containing gene 2 0.553
dzip1 DAZ interacting protein 1 0.535
cacnb4a calcium channel, voltage-dependent, beta 4a subunit 0.529
bmp2b bone morphogenetic protein 2b 0.519
tal1 T-cell acute lymphocytic leukemia 1 0.509
mstna myostatin a 0.499
lamb1a laminin, beta 1a 0.498
chd chordin 0.497
fzd5 frizzled homolog 5 0.495
lhx1a LIM homeobox 1a 0.490
znf503 zinc finger protein 503 0.490
lft2 lefty2 0.481
pdlim3b PDZ and LIM domain 3b 0.480
fzd7b frizzled homolog 7b 0.476
lrrc50 leucine rich repeat containing 50 0.473
gro1 groucho 1 0.472
prkci protein kinase C, iota 0.472
twist3 twist3 0.471
spry4 sprouty (Drosophila) homolog 4 0.470
tnnc1a troponin C type 1a (slow) 0.470
tbx5b T-box 5b 0.469
robo3 roundabout homolog 3 0.465
atp6v0ca ATPase, H+ transporting, lysosomal, V0 subunit c, a 0.458
col8a1a collagen, type VIII, alpha 1a 0.457
cdx4 caudal type homeo box transcription factor 4 0.457
wnt5b wingless-type MMTV integration site family, member 5b 0.457
rfx2 regulatory factor X, 2 (influences HLA class II expression) 0.451
dhrs3a dehydrogenase/reductase (SDR family) member 3a 0.450
tpm4 tropomyosin 4 0.449
eya1 eyes absent homolog 1 0.442
slc8a1a solute carrier family 8 (sodium/calcium exchanger), member 1a 0.439
cc2d2a coiled-coil and C2 domain containing 2A 0.438
runx2b runt-related transcription factor 2b 0.438
tnnt2a troponin T2a, cardiac 0.438
si:ch211-173o4.2 si:ch211-173o4.2 0.432
mbnl2 muscleblind-like 2 (Drosophila) 0.424
bmp2a bone morphogenetic protein 2a 0.416
fgf17 fibroblast growth factor 17 0.412
myl7 myosin, light polypeptide 7, regulatory 0.412
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Homo sapiens
Name Description Probability Func Analog Organism
NKX2-5 NK2 transcription factor related, locus 5 (Drosophila) 0.739
JAG1 jagged 1 0.452
TBX5 T-box 5 0.370
SMAD3 SMAD family member 3 0.275
BMP2 bone morphogenetic protein 2 0.216
MARK3 MAP/microtubule affinity-regulating kinase 3 0.153
SMAD1 SMAD family member 1 0.143
PBX1 pre-B-cell leukemia homeobox 1 0.126
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.104
SMAD2 SMAD family member 2 0.088
TJP1 tight junction protein 1 (zona occludens 1) 0.086
TGFB1 transforming growth factor, beta 1 0.076
NOTCH3 notch 3 0.075
GATA4 GATA binding protein 4 0.068
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.053
HIPK2 homeodomain interacting protein kinase 2 0.051
FZD1 frizzled homolog 1 (Drosophila) 0.049
BMPR1A bone morphogenetic protein receptor, type IA 0.049
FSTL1 follistatin-like 1 0.048
BBS2 Bardet-Biedl syndrome 2 0.047
PRKG1 protein kinase, cGMP-dependent, type I 0.044
GLI1 GLI family zinc finger 1 0.041
PKD1 polycystic kidney disease 1 (autosomal dominant) 0.040
SASS6 spindle assembly 6 homolog (C. elegans) 0.040
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.036
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) 0.035
CENPJ centromere protein J 0.034
ATP6V0C ATPase, H+ transporting, lysosomal 16kDa, V0 subunit c 0.028
LRP6 low density lipoprotein receptor-related protein 6 0.027
PTCH1 patched 1 0.026
SP1 Sp1 transcription factor 0.026
ACVR1 activin A receptor, type I 0.025
GSK3B glycogen synthase kinase 3 beta 0.025
SMAD4 SMAD family member 4 0.023
NFIX nuclear factor I/X (CCAAT-binding transcription factor) 0.023
MAML1 mastermind-like 1 (Drosophila) 0.022
ZFYVE9 zinc finger, FYVE domain containing 9 0.021
SMAD7 SMAD family member 7 0.020
BMP1 bone morphogenetic protein 1 0.020
TOP1 topoisomerase (DNA) I 0.019
DSP desmoplakin 0.018
PKP4 plakophilin 4 0.015
MEIS2 Meis homeobox 2 0.015
CAV1 caveolin 1, caveolae protein, 22kDa 0.015
LMAN1 lectin, mannose-binding, 1 0.015
EPAS1 endothelial PAS domain protein 1 0.014
MYOD1 myogenic differentiation 1 0.014
AR androgen receptor 0.013
XIAP X-linked inhibitor of apoptosis 0.013
SFPQ splicing factor proline/glutamine-rich 0.013
TRPC1 transient receptor potential cation channel, subfamily C, member 1 0.012
YBX1 Y box binding protein 1 0.012
MYOCD myocardin 0.012
SNX5 sorting nexin 5 0.011
HDAC4 histone deacetylase 4 0.011
ATXN3 ataxin 3 0.011
LRRK2 leucine-rich repeat kinase 2 0.011
TGFBR1 transforming growth factor, beta receptor 1 0.011
CANX calnexin 0.011
TCF4 transcription factor 4 0.011
MEF2A myocyte enhancer factor 2A 0.010
NOG noggin 0.010
GNB5 guanine nucleotide binding protein (G protein), beta 5 0.010
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Mus musculus
Name Description Probability Func Analog Organism
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Rattus norvegicus
Name Description Probability Func Analog Organism
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism