The network for 'negative regulation of muscle tissue development' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

negative regulation of muscle tissue development

Any process that stops, prevents or reduces the frequency, rate or extent of muscle tissue development.

Danio rerio
Name Description Probability Func Analog Organism
bmp2b bone morphogenetic protein 2b 0.952
bmp4 bone morphogenetic protein 4 0.867
wnt5b wingless-type MMTV integration site family, member 5b 0.681
chd chordin 0.505
myod1 myogenic differentiation 1 0.504
pitx2 paired-like homeodomain transcription factor 2 0.376
hoxa9b homeo box A9b 0.335
hoxa11b homeo box A11b 0.329
dlx5a distal-less homeobox gene 5a 0.275
osr1 odd-skipped related 1 (Drosophila) 0.230
mstnb myostatin b 0.230
hoxa11a homeo box A11a 0.226
foxa3 forkhead box A3 0.225
fgf24 fibroblast growth factor 24 0.210
pcdh8 protocadherin 8 0.201
bmp2a bone morphogenetic protein 2a 0.201
fsta follistatin a 0.185
hoxd11a homeo box D11a 0.174
dkk1b dickkopf 1b 0.159
msxc muscle segment homeobox C 0.154
tbx2a T-box gene 2a 0.148
hoxd10a homeo box D10a 0.145
fabp11a fatty acid binding protein 11a 0.144
gpr126 G protein-coupled receptor 126 0.139
nkx2.5 NK2 transcription factor related 5 0.138
hoxd13a homeo box D13a 0.132
hoxa13b homeo box A13b 0.118
six4a sine oculis homeobox homolog 4a 0.118
hoxa10b homeo box A10b 0.115
hoxa13a homeo box A13a 0.110
tbx18 T-box 18 0.106
foxd5 forkhead box D5 0.102
myf5 myogenic factor 5 0.093
fgf3 fibroblast growth factor 3 0.090
hoxc6a homeo box C6a 0.086
vcana versican a 0.081
tbx1 T-box 1 0.080
tbx5b T-box 5b 0.080
slc6a6 solute carrier family 6 (neurotransmitter transporter, taurine), member 6 0.080
tbx2b T-box 2b 0.079
tgfb3 transforming growth factor, beta 3 0.078
hoxa9a homeo box A9a 0.077
hoxd9a homeo box D9a 0.072
foxa1 forkhead box A1 0.072
klf4 Kruppel-like factor 4 0.071
hand2 heart and neural crest derivatives expressed transcript 2 0.070
fgf4 fibroblast growth factor 4 0.069
msxd muscle segment homeobox D 0.067
myh6 myosin, heavy polypeptide 6, cardiac muscle, alpha 0.066
mstna myostatin a 0.063
pkd2 polycystic kidney disease 2 0.062
spry2 sprouty homolog 2 0.056
fgf10a fibroblast growth factor 10a 0.056
nkd1 naked cuticle homolog 1 (Drosophila) 0.055
igf2a insulin-like growth factor 2a 0.054
notch1a notch homolog 1a 0.054
foxa2 forkhead box A2 0.053
hoxd4a homeo box D4a 0.052
hoxb1b homeo box B1b 0.051
lft1 lefty1 0.050
gata5 GATA-binding protein 5 0.048
eve1 even-skipped-like1 0.047
prickle1a prickle-like 1 (Drosophila) a 0.045
hoxc10a homeo box C10a and homeobox protein Hox-C10a-like 0.044
evx2 even-skipped homeobox 2 0.044
hoxb5b homeo box B5b 0.044
chsy1 chondroitin sulfate synthase 1 0.044
hprt1 hypoxanthine phosphoribosyltransferase 1 0.042
dhrs3a dehydrogenase/reductase (SDR family) member 3a 0.042
admp anti-dorsalizing morphogenic protein 0.042
cx30.3 connexin 30.3 0.041
cxcr4a chemokine (C-X-C motif) receptor 4a 0.041
cx27.5 connexin 27.5 0.041
kdrl kinase insert domain receptor like 0.040
mapk3 mitogen-activated protein kinase 3 0.039
shhb sonic hedgehog b 0.038
dct dopachrome tautomerase 0.037
gata6 GATA-binding protein 6 0.036
tfap2c transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma) 0.036
fgfrl1b fibroblast growth factor receptor-like 1b 0.036
crabp1b cellular retinoic acid binding protein 1b 0.036
has2 hyaluronan synthase 2 0.035
dlx4a distal-less homeobox gene 4a 0.035
nkx2.3 NK2 transcription factor related 3 0.035
hspb7 heat shock protein family, alpha-crystallin-related, b7 0.034
wt1a wilms tumor 1a 0.034
msxb muscle segment homeobox B 0.034
nppa natriuretic peptide precursor A 0.033
frem2a Fras1 related extracellular matrix protein 2a 0.033
hoxc9a homeo box C9a 0.033
podxl podocalyxin-like 0.032
lama4 laminin, alpha 4 0.032
acvr1b activin A receptor, type IB 0.032
tcf7 transcription factor 7 (T-cell specific, HMG-box) 0.032
cldn12 claudin 12 0.032
bambia BMP and activin membrane-bound inhibitor (Xenopus laevis) homolog a 0.031
itga3b integrin, alpha 3b 0.031
cacnb4a calcium channel, voltage-dependent, beta 4a subunit 0.031
nog1 noggin 1 0.031
ednra endothelin receptor type A 0.030
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Homo sapiens
Name Description Probability Func Analog Organism
FGFR2 fibroblast growth factor receptor 2 1.000
SRF serum response factor (c-fos serum response element-binding transcription factor) 0.997
SETD8 SET domain containing (lysine methyltransferase) 8 0.826
NKX2-5 NK2 transcription factor related, locus 5 (Drosophila) 0.684
FGF10 fibroblast growth factor 10 0.647
TGFB3 transforming growth factor, beta 3 0.586
FGF1 fibroblast growth factor 1 (acidic) 0.571
FSTL1 follistatin-like 1 0.551
TGFB1 transforming growth factor, beta 1 0.486
BMPR1A bone morphogenetic protein receptor, type IA 0.436
ENG endoglin 0.261
CDC14B CDC14 cell division cycle 14 homolog B (S. cerevisiae) 0.152
CABLES1 Cdk5 and Abl enzyme substrate 1 0.101
TTR transthyretin 0.075
FGF8 fibroblast growth factor 8 (androgen-induced) 0.070
FGF3 fibroblast growth factor 3 0.059
SMAD7 SMAD family member 7 0.056
MYOD1 myogenic differentiation 1 0.054
WWOX WW domain containing oxidoreductase 0.047
SMAD1 SMAD family member 1 0.045
TGFBR1 transforming growth factor, beta receptor 1 0.042
RASSF5 Ras association (RalGDS/AF-6) domain family member 5 0.041
YAP1 Yes-associated protein 1 0.039
GSK3B glycogen synthase kinase 3 beta 0.038
THBS1 thrombospondin 1 0.038
FZR1 fizzy/cell division cycle 20 related 1 (Drosophila) 0.037
STK3 serine/threonine kinase 3 0.034
GATA4 GATA binding protein 4 0.034
FGF7 fibroblast growth factor 7 0.033
HPCAL4 hippocalcin like 4 0.033
NCL nucleolin 0.029
SATB2 SATB homeobox 2 0.029
TP73 tumor protein p73 0.028
PTPN14 protein tyrosine phosphatase, non-receptor type 14 0.027
WFIKKN2 WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2 0.026
DEAF1 deformed epidermal autoregulatory factor 1 (Drosophila) 0.025
BMP7 bone morphogenetic protein 7 0.025
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.025
SNX9 sorting nexin 9 0.024
FGFR1 fibroblast growth factor receptor 1 0.022
TBX5 T-box 5 0.021
MOBKL1B MOB1, Mps One Binder kinase activator-like 1B (yeast) 0.020
NEURL4 neuralized homolog 4 (Drosophila) 0.020
PDGFB platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog) 0.019
SRI sorcin 0.018
MKL1 megakaryoblastic leukemia (translocation) 1 0.018
PRDM8 PR domain containing 8 0.017
NRP1 neuropilin 1 0.017
FGF2 fibroblast growth factor 2 (basic) 0.017
FGFR3 fibroblast growth factor receptor 3 0.016
WNT1 wingless-type MMTV integration site family, member 1 0.016
TXNIP thioredoxin interacting protein 0.015
DR1 down-regulator of transcription 1, TBP-binding (negative cofactor 2) 0.015
SEC16A SEC16 homolog A (S. cerevisiae) 0.013
LBX1 ladybird homeobox 1 0.013
PLCE1 phospholipase C, epsilon 1 0.012
DAB2 disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila) 0.012
MYOCD myocardin 0.012
CDKN2A cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4) 0.011
FGF4 fibroblast growth factor 4 0.011
WFIKKN1 WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 1 0.011
LATS2 LATS, large tumor suppressor, homolog 2 (Drosophila) 0.010
TBX1 T-box 1 0.010
CFTR cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7) 0.010
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.010
ACVR2B activin A receptor, type IIB 0.010
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Mus musculus
Name Description Probability Func Analog Organism
Shh sonic hedgehog 0.994
Fgfr2 fibroblast growth factor receptor 2 0.948
Gli3 GLI-Kruppel family member GLI3 0.860
Pax3 paired box gene 3 0.784
Otx2 orthodenticle homolog 2 (Drosophila) 0.723
Pax6 paired box gene 6 0.693
Sox2 SRY-box containing gene 2 0.651
Lef1 lymphoid enhancer binding factor 1 0.617
Msx1 homeobox, msh-like 1 0.599
Ctnnb1 catenin (cadherin associated protein), beta 1 0.557
Tbx3 T-box 3 0.551
Sox9 SRY-box containing gene 9 0.488
Ascl1 achaete-scute complex homolog 1 (Drosophila) 0.426
Tcfap2a transcription factor AP-2, alpha 0.312
Ror2 receptor tyrosine kinase-like orphan receptor 2 0.259
Nkx2-5 NK2 transcription factor related, locus 5 (Drosophila) 0.221
Kras v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog 0.218
Trp53 transformation related protein 53 0.202
Msx2 homeobox, msh-like 2 0.183
Isl1 ISL1 transcription factor, LIM/homeodomain 0.174
Smo smoothened homolog (Drosophila) 0.170
Hand1 heart and neural crest derivatives expressed transcript 1 0.156
Gli2 GLI-Kruppel family member GLI2 0.154
Bmp4 bone morphogenetic protein 4 0.140
Prrx1 paired related homeobox 1 0.136
Pdgfra platelet derived growth factor receptor, alpha polypeptide 0.136
Axin1 axin 1 0.126
Bmp7 bone morphogenetic protein 7 0.121
Runx2 runt related transcription factor 2 0.119
Lrp6 low density lipoprotein receptor-related protein 6 0.114
Fgfr1 fibroblast growth factor receptor 1 0.107
Six1 sine oculis-related homeobox 1 homolog (Drosophila) 0.106
Nos3 nitric oxide synthase 3, endothelial cell 0.105
Prrx2 paired related homeobox 2 0.104
Eya1 eyes absent 1 homolog (Drosophila) 0.102
Fgf8 fibroblast growth factor 8 0.093
Fgfr3 fibroblast growth factor receptor 3 0.093
Tgfb2 transforming growth factor, beta 2 0.092
Hes1 hairy and enhancer of split 1 (Drosophila) 0.090
Sox11 SRY-box containing gene 11 0.090
Neurod1 neurogenic differentiation 1 0.088
Hoxa5 homeobox A5 0.087
Pitx1 paired-like homeodomain transcription factor 1 0.087
Emx1 empty spiracles homolog 1 (Drosophila) 0.082
Lmx1b LIM homeobox transcription factor 1 beta 0.080
Mecom MDS1 and EVI1 complex locus 0.077
Meox2 mesenchyme homeobox 2 0.070
Twist2 twist homolog 2 (Drosophila) 0.069
Kiss1 KiSS-1 metastasis-suppressor 0.066
Sox17 SRY-box containing gene 17 0.066
Hes5 hairy and enhancer of split 5 (Drosophila) 0.065
Pitx2 paired-like homeodomain transcription factor 2 0.064
Tbx15 T-box 15 0.061
Nkx2-1 NK2 homeobox 1 0.061
Igdcc3 immunoglobulin superfamily, DCC subclass, member 3 0.059
Tbx5 T-box 5 0.058
Gbx2 gastrulation brain homeobox 2 0.057
Neurog2 neurogenin 2 0.056
Hcn4 hyperpolarization-activated, cyclic nucleotide-gated K+ 4 0.056
Gas1 growth arrest specific 1 0.056
Hand2 heart and neural crest derivatives expressed transcript 2 0.055
Smad6 MAD homolog 6 (Drosophila) 0.054
Hoxd11 homeobox D11 0.051
Pkd1 polycystic kidney disease 1 homolog 0.050
Per1 period homolog 1 (Drosophila) 0.050
Hdac1 histone deacetylase 1 0.047
Foxa2 forkhead box A2 0.046
Sox3 SRY-box containing gene 3 0.045
Sox18 SRY-box containing gene 18 0.045
Pten phosphatase and tensin homolog 0.044
Gsc goosecoid homeobox 0.041
Mycn v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian) 0.041
T brachyury 0.041
Neurod4 neurogenic differentiation 4 0.041
Rspo2 R-spondin 2 homolog (Xenopus laevis) 0.041
Myl2 myosin, light polypeptide 2, regulatory, cardiac, slow 0.041
Hic1 hypermethylated in cancer 1 0.040
Eng endoglin 0.039
Lep leptin 0.038
Dlx6 distal-less homeobox 6 0.037
Tbx2 T-box 2 0.037
Raf1 v-raf-leukemia viral oncogene 1 0.036
Mmp14 matrix metallopeptidase 14 (membrane-inserted) 0.036
Pthlh parathyroid hormone-like peptide 0.036
Bmp2 bone morphogenetic protein 2 0.035
Alx1 ALX homeobox 1 0.034
Lrp2 low density lipoprotein receptor-related protein 2 0.034
Gja1 gap junction protein, alpha 1 0.033
Pdx1 pancreatic and duodenal homeobox 1 0.033
Hhex hematopoietically expressed homeobox 0.032
Scn5a sodium channel, voltage-gated, type V, alpha 0.031
Aplnr apelin receptor 0.030
Hspg2 perlecan (heparan sulfate proteoglycan 2) 0.030
Gata1 GATA binding protein 1 0.029
Wnt3a wingless-related MMTV integration site 3A 0.029
Dlx5 distal-less homeobox 5 0.029
Tal1 T-cell acute lymphocytic leukemia 1 0.028
Alx4 aristaless-like homeobox 4 0.028
Pbx1 pre B-cell leukemia transcription factor 1 0.028
Ptch1 patched homolog 1 0.028
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Rattus norvegicus
Name Description Probability Func Analog Organism
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism