The network for 'primary neural tube formation' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

primary neural tube formation

The formation of the neural tube from an epithelial cell sheet (the neuroepithelium or neural plate). In primary neurulation, the cells surrounding the neural plate direct the neural plate cells to proliferate, invaginate, and pinch off from the surface to form a hollow epithelial tube. Primary neurulation is the typical mechanism of formation of the anterior neural tube.

Danio rerio
Name Description Probability Func Analog Organism
fgf3 fibroblast growth factor 3 0.932
boc brother of CDO 0.865
zic2a zic family member 2 (odd-paired homolog, Drosophila), a 0.774
gli1 GLI-Kruppel family member 1 0.742
nkd1 naked cuticle homolog 1 (Drosophila) 0.681
ptch2 patched 2 0.546
wnt5b wingless-type MMTV integration site family, member 5b 0.508
crb2a crumbs homolog 2a 0.507
foxd3 forkhead box D3 0.485
sox9a SRY-box containing gene 9a 0.442
fzd7a frizzled homolog 7a 0.418
cdon cell adhesion molecule-related/down-regulated by oncogenes 0.410
gli2a GLI-Kruppel family member GLI2a 0.406
epb41l5 erythrocyte membrane protein band 4.1 like 5 0.399
gdf6a growth differentiation factor 6a 0.362
hoxb1b homeo box B1b 0.361
ift88 intraflagellar transport 88 homolog 0.347
hoxb3a homeo box B3a 0.334
pkd2 polycystic kidney disease 2 0.332
tcf7l1a transcription factor 7-like 1a (T-cell specific, HMG-box) 0.318
flh floating head 0.318
gpc4 glypican 4 0.305
raraa retinoic acid receptor, alpha a 0.299
efnb3b ephrin B3b 0.291
zic1 zic family member 1 (odd-paired homolog, Drosophila) 0.283
sp5l Sp5 transcription factor-like 0.282
foxi1 forkhead box I1 0.279
cc2d2a coiled-coil and C2 domain containing 2A 0.272
lratb lecithin retinol acyltransferase b (phosphatidylcholine--retinol O-acyltransferase b) 0.261
zic2b zic family member 2 (odd-paired homolog, Drosophila) b 0.260
otx1b orthodenticle homolog 1b 0.259
shha sonic hedgehog a 0.249
dla deltaA 0.238
smo smoothened homolog (Drosophila) 0.235
ptpra protein tyrosine phosphatase, receptor type, A 0.231
irx1a iroquois homeobox protein 1, a 0.230
lama5 laminin, alpha 5 0.229
pax8 paired box gene 8 0.222
meis3 myeloid ecotropic viral integration site 3 0.219
prdm14 PR domain containing 14 0.218
prickle1b prickle homolog 1 (Drosophila) b 0.214
six2a sine oculis-related homeobox 2a 0.209
her8a hairy-related 8a 0.209
pax2a paired box gene 2a 0.203
kif17 kinesin family member 17 0.199
bmp2b bone morphogenetic protein 2b 0.198
robo3 roundabout homolog 3 0.198
znf703 zinc finger protein 703 0.197
nrarpb notch-regulated ankyrin repeat protein b 0.195
znf503 zinc finger protein 503 0.195
rarga retinoic acid receptor gamma a 0.180
alcamb activated leukocyte cell adhesion molecule b 0.178
pitx3 paired-like homeodomain transcription factor 3 0.177
mab21l2 mab-21-like 2 0.176
celsr2 cadherin, EGF LAG seven-pass G-type receptor 2 and cadherin, EGF LAG seven-pass G-type receptor 2 (flamingo homolog, Drosophila) 0.175
nrp1a neuropilin 1a 0.175
spry1 sprouty homolog 1 (Drosophila) 0.175
wnt11 wingless-type MMTV integration site family, member 11 0.170
hmgcrb 3-hydroxy-3-methylglutaryl-Coenzyme A reductase b 0.170
fgfr2 fibroblast growth factor receptor 2 0.168
gyltl1b glycosyltransferase-like 1b 0.165
meis2.2 myeloid ecotropic viral integration site 2.2 0.159
wnt4a wingless-type MMTV integration site family, member 4a 0.157
chd chordin 0.156
dact1 dapper homolog 1, antagonist of beta-catenin (xenopus) 0.156
efnb2a ephrin B2a 0.156
lrrc6 leucine rich repeat containing 6 0.154
met met proto-oncogene (hepatocyte growth factor receptor) 0.154
hoxa3a homeo box A3a 0.152
lama1 laminin, alpha 1 0.152
dbx1b developing brain homeobox 1b 0.149
prickle1a prickle-like 1 (Drosophila) a 0.149
ephb4a eph receptor B4a 0.147
osr1 odd-skipped related 1 (Drosophila) 0.145
dip2c DIP2 disco-interacting protein 2 homolog C (Drosophila) 0.145
ift57 intraflagellar transport protein 57 0.144
dctn1a dynactin 1a 0.144
twist1a twist1a 0.142
cyp26a1 cytochrome P450, subfamily XXVIA, polypeptide 1 0.142
otx2 orthodenticle homolog 2 0.138
bmper BMP binding endothelial regulator 0.137
olig3 oligodendrocyte transcription factor 3 0.134
tbx16 T-box gene 16 0.130
etv5b ets variant 5b 0.130
zeb1 zinc finger E-box binding homeobox 1 0.127
robo1 roundabout homolog 1 0.126
odz4 odd Oz/ten-m homolog 4 0.125
sox1a SRY-box containing gene 1a 0.125
plxnb2a plexin b2a 0.124
tbx2b T-box 2b 0.122
rbfox2 RNA binding protein, fox-1 homolog (C. elegans) 2 0.121
lamb1a laminin, beta 1a 0.120
myh10 myosin, heavy polypeptide 10, non-muscle and myosin, heavy chain 10, non-muscle 0.119
pax6a paired box gene 6a 0.118
emx1 empty spiracles homeobox 1 0.116
itga3b integrin, alpha 3b 0.116
hoxb6b homeo box B6b 0.116
tbx1 T-box 1 0.114
chaf1b chromatin assembly factor 1, subunit B 0.114
tpbgl trophoblast glycoprotein-like 0.113
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Homo sapiens
Name Description Probability Func Analog Organism
TSC2 tuberous sclerosis 2 0.981
SMAD3 SMAD family member 3 0.969
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide 0.940
CASP9 caspase 9, apoptosis-related cysteine peptidase 0.902
APC adenomatous polyposis coli 0.897
AXIN1 axin 1 0.896
SMAD2 SMAD family member 2 0.851
LRRK2 leucine-rich repeat kinase 2 0.849
BBS2 Bardet-Biedl syndrome 2 0.797
TRRAP transformation/transcription domain-associated protein 0.791
DVL3 dishevelled, dsh homolog 3 (Drosophila) 0.773
BCOR BCL6 corepressor 0.660
CASP3 caspase 3, apoptosis-related cysteine peptidase 0.643
MALT1 mucosa associated lymphoid tissue lymphoma translocation gene 1 0.633
MEOX2 mesenchyme homeobox 2 0.585
MBD2 methyl-CpG binding domain protein 2 0.551
MED16 mediator complex subunit 16 0.532
RXRA retinoid X receptor, alpha 0.531
CREBBP CREB binding protein 0.519
CNKSR2 connector enhancer of kinase suppressor of Ras 2 0.518
PRKACA protein kinase, cAMP-dependent, catalytic, alpha 0.511
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide 0.510
PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha (tissue specific extinguisher 1) 0.497
DVL1 dishevelled, dsh homolog 1 (Drosophila) 0.487
ZFX zinc finger protein, X-linked 0.477
GLI1 GLI family zinc finger 1 0.472
TRIP6 thyroid hormone receptor interactor 6 0.465
ZFYVE9 zinc finger, FYVE domain containing 9 0.426
POU3F2 POU class 3 homeobox 2 0.409
SETD8 SET domain containing (lysine methyltransferase) 8 0.394
ACTB actin, beta 0.372
GSK3B glycogen synthase kinase 3 beta 0.363
EPAS1 endothelial PAS domain protein 1 0.340
SEC24D SEC24 family, member D (S. cerevisiae) 0.339
ZRANB1 zinc finger, RAN-binding domain containing 1 0.334
RASA1 RAS p21 protein activator (GTPase activating protein) 1 0.331
ACTG1 actin, gamma 1 0.329
EXOC7 exocyst complex component 7 0.328
SMARCC2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2 0.326
SEC23A Sec23 homolog A (S. cerevisiae) 0.324
C9orf89 chromosome 9 open reading frame 89 0.319
TAB2 TGF-beta activated kinase 1/MAP3K7 binding protein 2 0.315
EP300 E1A binding protein p300 0.305
PPP1R16A protein phosphatase 1, regulatory (inhibitor) subunit 16A 0.296
ARID1B AT rich interactive domain 1B (SWI1-like) 0.287
TAF4 TAF4 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 135kDa 0.281
DLG5 discs, large homolog 5 (Drosophila) 0.274
CTBP1 C-terminal binding protein 1 0.270
SORBS3 sorbin and SH3 domain containing 3 0.270
SASS6 spindle assembly 6 homolog (C. elegans) 0.265
XIAP X-linked inhibitor of apoptosis 0.263
BBS10 Bardet-Biedl syndrome 10 0.256
ERBB2IP erbb2 interacting protein 0.255
WASF2 WAS protein family, member 2 0.247
BBS1 Bardet-Biedl syndrome 1 0.243
AKAP11 A kinase (PRKA) anchor protein 11 0.243
FAT1 FAT tumor suppressor homolog 1 (Drosophila) 0.237
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.223
KIF5B kinesin family member 5B 0.222
LDB1 LIM domain binding 1 0.219
LIN28B lin-28 homolog B (C. elegans) 0.219
USP9X ubiquitin specific peptidase 9, X-linked 0.218
MED25 mediator complex subunit 25 0.218
LMAN1 lectin, mannose-binding, 1 0.210
SFN stratifin 0.208
ESR1 estrogen receptor 1 0.205
WNT3A wingless-type MMTV integration site family, member 3A 0.203
PHLPP1 PH domain and leucine rich repeat protein phosphatase 1 0.202
ZMYND11 zinc finger, MYND-type containing 11 0.196
PIN1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1 0.193
HIVEP1 human immunodeficiency virus type I enhancer binding protein 1 0.191
C14orf1 chromosome 14 open reading frame 1 0.185
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1 0.183
MDM2 Mdm2 p53 binding protein homolog (mouse) 0.181
CSNK1D casein kinase 1, delta 0.178
CTBP2 C-terminal binding protein 2 0.176
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 0.176
ELAVL1 ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R) 0.174
IRAK2 interleukin-1 receptor-associated kinase 2 0.166
SIN3A SIN3 homolog A, transcription regulator (yeast) 0.165
TSC1 tuberous sclerosis 1 0.163
SHOC2 soc-2 suppressor of clear homolog (C. elegans) 0.161
ABI1 abl-interactor 1 0.161
HMOX2 heme oxygenase (decycling) 2 0.156
TJP2 tight junction protein 2 (zona occludens 2) 0.155
ANKRD28 ankyrin repeat domain 28 0.150
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta 0.149
WASF1 WAS protein family, member 1 0.144
BMP7 bone morphogenetic protein 7 0.143
PCM1 pericentriolar material 1 0.142
MTA1 metastasis associated 1 0.141
RAF1 v-raf-1 murine leukemia viral oncogene homolog 1 0.140
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) 0.139
NCOA6 nuclear receptor coactivator 6 0.135
SQSTM1 sequestosome 1 0.134
MLL3 myeloid/lymphoid or mixed-lineage leukemia 3 0.133
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.133
DAB2 disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila) 0.131
ATXN1 ataxin 1 0.130
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor 0.128
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Mus musculus
Name Description Probability Func Analog Organism
Gli3 GLI-Kruppel family member GLI3 1.000
Shh sonic hedgehog 1.000
Fgfr2 fibroblast growth factor receptor 2 1.000
Pitx2 paired-like homeodomain transcription factor 2 1.000
Otx2 orthodenticle homolog 2 (Drosophila) 1.000
Vangl2 vang-like 2 (van gogh, Drosophila) 1.000
Bmp7 bone morphogenetic protein 7 1.000
Pax3 paired box gene 3 1.000
Pax2 paired box gene 2 1.000
Foxc1 forkhead box C1 0.999
Gli2 GLI-Kruppel family member GLI2 0.999
Lhx1 LIM homeobox protein 1 0.999
Pax6 paired box gene 6 0.998
Tcfap2a transcription factor AP-2, alpha 0.998
Sall4 sal-like 4 (Drosophila) 0.998
Msx1 homeobox, msh-like 1 0.998
Pbx1 pre B-cell leukemia transcription factor 1 0.997
Smo smoothened homolog (Drosophila) 0.997
Sox2 SRY-box containing gene 2 0.995
Fgf10 fibroblast growth factor 10 0.995
Six1 sine oculis-related homeobox 1 homolog (Drosophila) 0.994
Hand1 heart and neural crest derivatives expressed transcript 1 0.994
Nodal nodal 0.993
Fgfr1 fibroblast growth factor receptor 1 0.993
Tgfb2 transforming growth factor, beta 2 0.991
Eya1 eyes absent 1 homolog (Drosophila) 0.990
Bmp4 bone morphogenetic protein 4 0.990
Msx2 homeobox, msh-like 2 0.989
Zic3 zinc finger protein of the cerebellum 3 0.987
Prrx1 paired related homeobox 1 0.987
Nog noggin 0.980
Pitx1 paired-like homeodomain transcription factor 1 0.977
Fgf8 fibroblast growth factor 8 0.973
Sema6a sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A 0.971
Dlx5 distal-less homeobox 5 0.968
Emx2 empty spiracles homolog 2 (Drosophila) 0.965
Ror2 receptor tyrosine kinase-like orphan receptor 2 0.965
Chrd chordin 0.948
Dvl2 dishevelled 2, dsh homolog (Drosophila) 0.943
Sox9 SRY-box containing gene 9 0.939
Rarg retinoic acid receptor, gamma 0.934
Fzd8 frizzled homolog 8 (Drosophila) 0.928
Efna2 ephrin A2 0.919
Pten phosphatase and tensin homolog 0.917
Foxc2 forkhead box C2 0.916
Hoxa13 homeobox A13 0.909
Pdgfra platelet derived growth factor receptor, alpha polypeptide 0.905
Sox11 SRY-box containing gene 11 0.904
Rarb retinoic acid receptor, beta 0.898
Ascl1 achaete-scute complex homolog 1 (Drosophila) 0.897
Hand2 heart and neural crest derivatives expressed transcript 2 0.895
Sfrp2 secreted frizzled-related protein 2 0.895
Wnt3a wingless-related MMTV integration site 3A 0.894
Emx1 empty spiracles homolog 1 (Drosophila) 0.892
Hoxd13 homeobox D13 0.887
Pax8 paired box gene 8 0.887
Zic2 zinc finger protein of the cerebellum 2 0.883
Tbx1 T-box 1 0.876
Pou5f1 POU domain, class 5, transcription factor 1 0.874
Wt1 Wilms tumor 1 homolog 0.866
Neurog2 neurogenin 2 0.864
Foxh1 forkhead box H1 0.862
Tbx15 T-box 15 0.859
Jag1 jagged 1 0.859
Wnt5a wingless-related MMTV integration site 5A 0.854
Gdf3 growth differentiation factor 3 0.850
Chd7 chromodomain helicase DNA binding protein 7 0.846
Fgfr3 fibroblast growth factor receptor 3 0.846
Lrp6 low density lipoprotein receptor-related protein 6 0.841
Otx1 orthodenticle homolog 1 (Drosophila) 0.835
Alx4 aristaless-like homeobox 4 0.834
Foxg1 forkhead box G1 0.832
Lmx1a LIM homeobox transcription factor 1 alpha 0.830
Hoxa11 homeobox A11 0.811
Dkk1 dickkopf homolog 1 (Xenopus laevis) 0.810
Megf8 multiple EGF-like-domains 8 0.809
En1 engrailed 1 0.807
Hoxa1 homeobox A1 0.801
Fzd1 frizzled homolog 1 (Drosophila) 0.800
Gbx2 gastrulation brain homeobox 2 0.798
Meox2 mesenchyme homeobox 2 0.797
Dvl3 dishevelled 3, dsh homolog (Drosophila) 0.793
Prrx2 paired related homeobox 2 0.784
Lhx3 LIM homeobox protein 3 0.783
Ptch1 patched homolog 1 0.779
Mycn v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian) 0.765
Fgf15 fibroblast growth factor 15 0.764
Isl1 ISL1 transcription factor, LIM/homeodomain 0.751
Runx2 runt related transcription factor 2 0.745
Apc adenomatosis polyposis coli 0.742
Vasp vasodilator-stimulated phosphoprotein 0.741
Hoxd11 homeobox D11 0.735
Igdcc3 immunoglobulin superfamily, DCC subclass, member 3 0.725
Uncx UNC homeobox 0.723
Tcfap2c transcription factor AP-2, gamma 0.718
Six4 sine oculis-related homeobox 4 homolog (Drosophila) 0.712
Ebf3 early B-cell factor 3 0.711
Ywhaz tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide 0.695
Smarca4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 0.694
Smad6 MAD homolog 6 (Drosophila) 0.688
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Rattus norvegicus
Name Description Probability Func Analog Organism
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism