The network for 'embryonic heart tube development' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

embryonic heart tube development

The process whose specific outcome is the progression of the embryonic heart tube over time, from its formation to the mature structure. The heart tube forms as the heart rudiment from the heart field.

Danio rerio
Name Description Probability Func Analog Organism
cdh2 cadherin 2, neuronal 0.991
nkx2.5 NK2 transcription factor related 5 0.982
tbx1 T-box 1 0.975
tbx5a T-box 5a 0.968
tbx20 T-box 20 0.968
ndr2 nodal-related 2 0.966
neurod neurogenic differentiation 0.964
fn1 fibronectin 1 0.955
aldh1a2 aldehyde dehydrogenase 1 family, member A2 0.944
fgf8a fibroblast growth factor 8 a 0.943
ift88 intraflagellar transport 88 homolog 0.933
pcdh8 protocadherin 8 0.932
sox9b SRY-box containing gene 9b 0.920
sox9a SRY-box containing gene 9a 0.916
lrrc6 leucine rich repeat containing 6 0.904
isl1 islet1 0.895
myh6 myosin, heavy polypeptide 6, cardiac muscle, alpha 0.890
six3b sine oculis homeobox homolog 3b 0.883
foxh1 forkhead box H1 0.882
wnt11r wingless-type MMTV integration site family, member 11, related 0.881
six4b sine oculis homeobox homolog 4b 0.864
ttna titin a 0.862
sox32 SRY-box containing gene 32 0.853
tbx16 T-box gene 16 0.851
tp53 tumor protein p53 0.848
gata5 GATA-binding protein 5 0.839
pkd2 polycystic kidney disease 2 0.838
cc2d2a coiled-coil and C2 domain containing 2A 0.837
tbx2b T-box 2b 0.834
chd chordin 0.833
foxn4 forkhead box N4 0.830
gata3 GATA-binding protein 3 0.824
foxa2 forkhead box A2 0.789
shha sonic hedgehog a 0.783
lft2 lefty2 0.777
gata4 GATA-binding protein 4 0.773
epb41l5 erythrocyte membrane protein band 4.1 like 5 0.747
lamc1 laminin, gamma 1 0.722
ephb4b eph receptor B4b 0.713
bmp2a bone morphogenetic protein 2a 0.710
fbn2b fibrillin 2b 0.706
fzd10 frizzled homolog 10 0.703
notch1b notch homolog 1b 0.703
dld deltaD 0.701
twist1a twist1a 0.699
gata6 GATA-binding protein 6 0.697
wnt11 wingless-type MMTV integration site family, member 11 0.695
etv5b ets variant 5b 0.690
fgf17 fibroblast growth factor 17 0.689
sox1a SRY-box containing gene 1a 0.683
hnf1ba HNF1 homeobox Ba 0.677
flh floating head 0.669
spaw southpaw 0.660
wnt4a wingless-type MMTV integration site family, member 4a 0.658
foxc1a forkhead box C1a 0.640
tyr tyrosinase 0.633
hmgcrb 3-hydroxy-3-methylglutaryl-Coenzyme A reductase b 0.624
myl7 myosin, light polypeptide 7, regulatory 0.610
skia nuclear oncoprotein skia 0.609
sulf1 sulfatase 1 0.605
gro1 groucho 1 0.604
gli2a GLI-Kruppel family member GLI2a 0.599
hmx4 H6 family homeobox 4 0.586
barhl2 BarH-like 2 0.579
s1pr2 sphingosine-1-phosphate receptor 2 0.575
atoh1a atonal homolog 1a 0.561
rfx2 regulatory factor X, 2 (influences HLA class II expression) 0.556
acvr1l activin A receptor, type I like 0.553
rbfox1l RNA binding protein, fox-1 homolog (C. elegans) 1-like 0.553
otx2 orthodenticle homolog 2 0.548
cx27.5 connexin 27.5 0.545
oep one-eyed pinhead 0.543
wnt1 wingless-type MMTV integration site family, member 1 0.543
desma desmin a 0.540
bmp4 bone morphogenetic protein 4 0.539
pdlim7 PDZ and LIM domain 7 0.534
zic1 zic family member 1 (odd-paired homolog, Drosophila) 0.523
si:dkeyp-50f5.1 si:dkeyp-50f5.1 0.519
snai1b snail homolog 1b (Drosophila) 0.514
spry4 sprouty (Drosophila) homolog 4 0.513
mapk1 mitogen-activated protein kinase 1 0.512
ptf1a pancreas specific transcription factor, 1a 0.512
ncor1 nuclear receptor co-repressor 1 0.511
ptgs1 prostaglandin-endoperoxide synthase 1 0.509
gamt guanidinoacetate N-methyltransferase 0.496
mespa mesoderm posterior a 0.494
cdh5 cadherin 5 0.493
efnb1 ephrin B1 0.492
ilk integrin linked kinase 0.492
mapk4 mitogen-activated protein kinase 4 0.488
tnnt2a troponin T2a, cardiac 0.485
ctnnb1 catenin (cadherin-associated protein), beta 1 0.485
tcf7l2 transcription factor 7-like 2 (T-cell specific, HMG-box) 0.483
twist3 twist3 0.479
fzd7b frizzled homolog 7b 0.478
atp1a1a.4 ATPase, Na+/K+ transporting, alpha 1a.4 polypeptide 0.475
kif17 kinesin family member 17 0.471
flr fleer 0.470
prkci protein kinase C, iota 0.470
tpm4 tropomyosin 4 0.468
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
stumps CG31317 gene product from transcript CG31317-RC 0.974
Doc2 Dorsocross2 0.972
wg wingless 0.966
pnr pannier 0.948
dpp decapentaplegic 0.873
aop anterior open 0.869
baz bazooka 0.850
ci cubitus interruptus 0.816
htl heartless 0.778
slou slouch 0.690
ush u-shaped 0.660
zfh1 Zn finger homeodomain 1 0.658
Egfr Epidermal growth factor receptor 0.650
N Notch 0.618
brk brinker 0.616
hh hedgehog 0.612
en engrailed 0.599
Mad Mothers against dpp 0.575
bin biniou 0.551
sli slit 0.543
tin tinman 0.536
eve even skipped 0.525
shn schnurri 0.522
tkv thickveins 0.471
Dl Delta 0.466
srp serpent 0.439
Tl Toll 0.408
put punt 0.403
LanB2 Laminin B2 0.346
HLH54F CG5005 gene product from transcript CG5005-RA 0.342
Su(H) Suppressor of Hairless 0.314
Stat92E Signal-transducer and activator of transcription protein at 92E 0.312
mid midline 0.271
pb proboscipedia 0.267
eya eyes absent 0.221
abd-A abdominal A 0.202
mew multiple edematous wings 0.197
numb CG3779 gene product from transcript CG3779-RB 0.179
twi twist 0.179
Hand CG18144 gene product from transcript CG18144-RA 0.177
lea leak 0.167
robo roundabout 0.165
qm quemao 0.165
L Lobe 0.156
CG14869 CG14869 gene product from transcript CG14869-RB 0.143
tsh teashirt 0.140
Rac1 CG2248 gene product from transcript CG2248-RA 0.138
fkh fork head 0.128
hkb huckebein 0.128
wb wing blister 0.123
Cdc42 CG12530 gene product from transcript CG12530-RA 0.119
stmA stambha A 0.118
da daughterless 0.114
Ggamma1 G protein gamma 1 0.111
sens senseless 0.106
Ubx Ultrabithorax 0.106
LanA Laminin A 0.104
ttv tout-velu 0.103
slp1 sloppy paired 1 0.095
kirre kin of irre 0.095
vg vestigial 0.093
Six4 CG3871 gene product from transcript CG3871-RA 0.092
unc uncoordinated 0.091
ato atonal 0.091
Ser Serrate 0.089
Trim9 CG31721 gene product from transcript CG31721-RB 0.086
nau nautilus 0.086
emc extra macrochaetae 0.084
Dad Daughters against dpp 0.084
eIF3-S8 CG4954 gene product from transcript CG4954-RA 0.078
spdo sanpodo 0.077
lqf liquid facets 0.075
lin lines 0.072
Lim1 CG11354 gene product from transcript CG11354-RA 0.070
lbe ladybird early 0.068
dally division abnormally delayed 0.066
side sidestep 0.065
csw corkscrew 0.062
byn brachyenteron 0.062
simj simjang 0.057
insc inscuteable 0.057
prc pericardin 0.055
sr stripe 0.053
kuz kuzbanian 0.053
mbc myoblast city 0.053
dm diminutive 0.052
zfh2 Zn finger homeodomain 2 0.052
Mef2 Myocyte enhancer factor 2 0.050
osa CG7467 gene product from transcript CG7467-RD 0.050
gbb glass bottom boat 0.049
kn knot 0.049
sog short gastrulation 0.048
Hmgcr HMG Coenzyme A reductase 0.047
rap retina aberrant in pattern 0.046
ap apterous 0.046
Ras85D Ras oncogene at 85D 0.045
if inflated 0.045
pan pangolin 0.044
pyr pyramus 0.044
lola longitudinals lacking 0.043
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Homo sapiens
Name Description Probability Func Analog Organism
SMAD3 SMAD family member 3 0.413
JAG1 jagged 1 0.304
PRKCZ protein kinase C, zeta 0.264
BMPR1A bone morphogenetic protein receptor, type IA 0.252
NKX2-5 NK2 transcription factor related, locus 5 (Drosophila) 0.236
SMAD1 SMAD family member 1 0.216
TGFB1 transforming growth factor, beta 1 0.203
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide 0.197
SMAD4 SMAD family member 4 0.189
BMP2 bone morphogenetic protein 2 0.144
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) 0.112
TBX5 T-box 5 0.102
PARD6A par-6 partitioning defective 6 homolog alpha (C. elegans) 0.090
PBX1 pre-B-cell leukemia homeobox 1 0.089
SASS6 spindle assembly 6 homolog (C. elegans) 0.080
PARD6B par-6 partitioning defective 6 homolog beta (C. elegans) 0.073
GATA4 GATA binding protein 4 0.068
FSTL1 follistatin-like 1 0.067
SMAD2 SMAD family member 2 0.067
FKBP1A FK506 binding protein 1A, 12kDa 0.062
INADL InaD-like (Drosophila) 0.055
TJP1 tight junction protein 1 (zona occludens 1) 0.053
ENG endoglin 0.049
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) 0.041
SIN3A SIN3 homolog A, transcription regulator (yeast) 0.039
SP1 Sp1 transcription factor 0.039
SQSTM1 sequestosome 1 0.035
TRAF6 TNF receptor-associated factor 6 0.032
GLI1 GLI family zinc finger 1 0.032
GATA2 GATA binding protein 2 0.032
EP300 E1A binding protein p300 0.030
HIPK2 homeodomain interacting protein kinase 2 0.030
RBFOX1 RNA binding protein, fox-1 homolog (C. elegans) 1 0.030
EPAS1 endothelial PAS domain protein 1 0.025
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.025
PARD6G par-6 partitioning defective 6 homolog gamma (C. elegans) 0.025
GSK3B glycogen synthase kinase 3 beta 0.024
BTRC beta-transducin repeat containing 0.024
HMGA1 high mobility group AT-hook 1 0.023
EXOC7 exocyst complex component 7 0.023
DAB2 disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila) 0.022
XIAP X-linked inhibitor of apoptosis 0.021
ZFYVE9 zinc finger, FYVE domain containing 9 0.021
YAP1 Yes-associated protein 1 0.020
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.020
TCF4 transcription factor 4 0.020
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.020
CSNK1D casein kinase 1, delta 0.018
SMAD7 SMAD family member 7 0.016
PDGFRA platelet-derived growth factor receptor, alpha polypeptide 0.016
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.015
YY1 YY1 transcription factor 0.015
MKL1 megakaryoblastic leukemia (translocation) 1 0.015
PKP4 plakophilin 4 0.014
PARD3 par-3 partitioning defective 3 homolog (C. elegans) 0.014
XRCC6 X-ray repair complementing defective repair in Chinese hamster cells 6 0.013
GATA1 GATA binding protein 1 (globin transcription factor 1) 0.013
LRP6 low density lipoprotein receptor-related protein 6 0.013
PTCH1 patched 1 0.013
BBS2 Bardet-Biedl syndrome 2 0.013
PAX8 paired box 8 0.013
PKD1 polycystic kidney disease 1 (autosomal dominant) 0.012
NRP1 neuropilin 1 0.012
MEIS2 Meis homeobox 2 0.012
HDAC4 histone deacetylase 4 0.012
SKI v-ski sarcoma viral oncogene homolog (avian) 0.011
ACVR1 activin A receptor, type I 0.011
NOG noggin 0.011
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) 0.011
TGFB3 transforming growth factor, beta 3 0.011
PTPN14 protein tyrosine phosphatase, non-receptor type 14 0.011
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.011
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Mus musculus
Name Description Probability Func Analog Organism
Nodal nodal 1.000
Pitx2 paired-like homeodomain transcription factor 2 1.000
Vangl2 vang-like 2 (van gogh, Drosophila) 1.000
Gli3 GLI-Kruppel family member GLI3 1.000
Shh sonic hedgehog 1.000
Fgfr1 fibroblast growth factor receptor 1 1.000
Fgfr2 fibroblast growth factor receptor 2 1.000
Fgf8 fibroblast growth factor 8 1.000
Gata4 GATA binding protein 4 1.000
Gli2 GLI-Kruppel family member GLI2 1.000
Bmp4 bone morphogenetic protein 4 0.999
Foxc2 forkhead box C2 0.999
Otx2 orthodenticle homolog 2 (Drosophila) 0.999
Foxc1 forkhead box C1 0.999
Nkx2-5 NK2 transcription factor related, locus 5 (Drosophila) 0.999
Foxh1 forkhead box H1 0.999
Jag1 jagged 1 0.998
Pax3 paired box gene 3 0.997
Hoxa1 homeobox A1 0.996
Pax2 paired box gene 2 0.996
Six1 sine oculis-related homeobox 1 homolog (Drosophila) 0.995
Invs inversin 0.995
Tgfb2 transforming growth factor, beta 2 0.993
Zic3 zinc finger protein of the cerebellum 3 0.989
Vegfa vascular endothelial growth factor A 0.989
Hand2 heart and neural crest derivatives expressed transcript 2 0.989
Tbx1 T-box 1 0.987
Foxa2 forkhead box A2 0.985
Nog noggin 0.984
Notch1 Notch gene homolog 1 (Drosophila) 0.982
Tbx3 T-box 3 0.973
Psen1 presenilin 1 0.969
Hand1 heart and neural crest derivatives expressed transcript 1 0.968
Mks1 Meckel syndrome, type 1 0.963
Foxg1 forkhead box G1 0.957
Eya1 eyes absent 1 homolog (Drosophila) 0.957
Robo1 roundabout homolog 1 (Drosophila) 0.956
Mesp1 mesoderm posterior 1 0.955
Nos3 nitric oxide synthase 3, endothelial cell 0.954
Pax6 paired box gene 6 0.953
Gata6 GATA binding protein 6 0.952
Rarg retinoic acid receptor, gamma 0.947
Meox2 mesenchyme homeobox 2 0.938
Efnb2 ephrin B2 0.937
Chd7 chromodomain helicase DNA binding protein 7 0.933
Lmx1a LIM homeobox transcription factor 1 alpha 0.927
Chrd chordin 0.927
Smad3 MAD homolog 3 (Drosophila) 0.923
Gbx2 gastrulation brain homeobox 2 0.907
Acvr1 activin A receptor, type 1 0.899
Lhx1 LIM homeobox protein 1 0.899
Myl2 myosin, light polypeptide 2, regulatory, cardiac, slow 0.897
Smo smoothened homolog (Drosophila) 0.886
Prrx2 paired related homeobox 2 0.885
Scn5a sodium channel, voltage-gated, type V, alpha 0.879
Pitx1 paired-like homeodomain transcription factor 1 0.872
Gsc goosecoid homeobox 0.871
Rxra retinoid X receptor alpha 0.867
Wt1 Wilms tumor 1 homolog 0.840
She src homology 2 domain-containing transforming protein E 0.813
Tcfap2a transcription factor AP-2, alpha 0.811
Notch2 Notch gene homolog 2 (Drosophila) 0.809
Smad6 MAD homolog 6 (Drosophila) 0.805
Pkd1 polycystic kidney disease 1 homolog 0.801
Yap1 yes-associated protein 1 0.796
Wnt3a wingless-related MMTV integration site 3A 0.795
Dnahc11 dynein, axonemal, heavy chain 11 0.793
Sox2 SRY-box containing gene 2 0.793
Dll1 delta-like 1 (Drosophila) 0.789
Sox9 SRY-box containing gene 9 0.777
Pbx1 pre B-cell leukemia transcription factor 1 0.768
Aldh1a2 aldehyde dehydrogenase family 1, subfamily A2 0.762
Ctnnb1 catenin (cadherin associated protein), beta 1 0.758
Pten phosphatase and tensin homolog 0.755
Hoxa13 homeobox A13 0.752
Ptpn11 protein tyrosine phosphatase, non-receptor type 11 0.749
Rarb retinoic acid receptor, beta 0.733
En1 engrailed 1 0.731
Fgf10 fibroblast growth factor 10 0.726
Apc adenomatosis polyposis coli 0.713
Bmp7 bone morphogenetic protein 7 0.711
Lmx1b LIM homeobox transcription factor 1 beta 0.709
Ascl1 achaete-scute complex homolog 1 (Drosophila) 0.707
Fgfr3 fibroblast growth factor receptor 3 0.704
Hoxd13 homeobox D13 0.703
Nr5a1 nuclear receptor subfamily 5, group A, member 1 0.672
Hoxd3 homeobox D3 0.657
Pax1 paired box gene 1 0.657
Hes1 hairy and enhancer of split 1 (Drosophila) 0.653
T brachyury 0.649
Prrx1 paired related homeobox 1 0.649
Pax9 paired box gene 9 0.642
Ptk7 PTK7 protein tyrosine kinase 7 0.639
Megf8 multiple EGF-like-domains 8 0.637
Zic2 zinc finger protein of the cerebellum 2 0.627
Fgf15 fibroblast growth factor 15 0.625
Neurog2 neurogenin 2 0.598
Hoxa2 homeobox A2 0.590
Kif3a kinesin family member 3A 0.578
Uncx UNC homeobox 0.576
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Rattus norvegicus
Name Description Probability Func Analog Organism
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism