The network for 'vasculogenesis' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

vasculogenesis

The differentiation of endothelial cells from progenitor cells during blood vessel development, and the de novo formation of blood vessels and tubes.

Danio rerio
Name Description Probability Func Analog Organism
tbx1 T-box 1 0.980
nrp1a neuropilin 1a 0.974
pax2a paired box gene 2a 0.967
dlc deltaC 0.933
kdrl kinase insert domain receptor like 0.915
twist1a twist1a 0.883
sulf1 sulfatase 1 0.872
etv2 ets variant gene 2 0.865
fn1 fibronectin 1 0.821
isl1 islet1 0.797
otx2 orthodenticle homolog 2 0.777
dld deltaD 0.730
fbn2b fibrillin 2b 0.725
notch3 notch homolog 3 0.716
foxc1a forkhead box C1a 0.715
tbx16 T-box gene 16 0.704
spry4 sprouty (Drosophila) homolog 4 0.634
spaw southpaw 0.627
large like-glycosyltransferase 0.613
hand2 heart and neural crest derivatives expressed transcript 2 0.585
cxcl12b chemokine (C-X-C motif) ligand 12b (stromal cell-derived factor 1) 0.578
gli2a GLI-Kruppel family member GLI2a 0.574
sox7 SRY-box containing gene 7 0.568
fgf8a fibroblast growth factor 8 a 0.556
dll4 delta-like 4 (Drosophila) 0.547
efnb2a ephrin B2a 0.539
hoxa9b homeo box A9b 0.516
dlb deltaB 0.503
flt1 fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor) 0.502
cdh5 cadherin 5 0.496
erg v-ets erythroblastosis virus E26 oncogene like (avian) 0.484
wu:fv91b12 wu:fv91b12 0.460
shha sonic hedgehog a 0.440
pax7a paired box gene 7a 0.426
sox19a SRY-box containing gene 19a 0.415
tie2 endothelium-specific receptor tyrosine kinase 2 0.404
isl2a islet2a 0.395
ccm2 cerebral cavernous malformation 2 0.394
wnt5b wingless-type MMTV integration site family, member 5b 0.381
cdh2 cadherin 2, neuronal 0.380
dlx2a distal-less homeobox gene 2a 0.369
vcana versican a 0.365
calcrla calcitonin receptor-like a 0.365
csnk1a1 casein kinase 1, alpha 1 0.355
myf5 myogenic factor 5 0.353
alcama activated leukocyte cell adhesion molecule a 0.350
jag2 jagged 2 0.348
ets1a v-ets erythroblastosis virus E26 oncogene homolog 1a 0.344
edn1 endothelin 1 0.344
runx1 runt-related transcription factor 1 0.322
ndr2 nodal-related 2 0.321
kdr kinase insert domain receptor (a type III receptor tyrosine kinase) 0.320
flncb filamin C, gamma b (actin binding protein 280) 0.307
rx3 retinal homeobox gene 3 0.303
lft1 lefty1 0.292
pax6a paired box gene 6a 0.289
fsta follistatin a 0.284
cxcr4b chemokine (C-X-C motif), receptor 4b 0.283
tmem88a transmembrane protein 88 a 0.275
nrp2a neuropilin 2a 0.273
neo1 neogenin 1 0.266
barhl2 BarH-like 2 0.257
hey1 hairy/enhancer-of-split related with YRPW motif 1 0.257
dhrs3a dehydrogenase/reductase (SDR family) member 3a 0.235
sox9a SRY-box containing gene 9a 0.231
vegfaa vascular endothelial growth factor Aa 0.231
ptgs1 prostaglandin-endoperoxide synthase 1 0.230
six3a sine oculis homeobox homolog 3a 0.215
tmem2 transmembrane protein 2 0.209
nrarpa notch-regulated ankyrin repeat protein a 0.200
fgf10a fibroblast growth factor 10a 0.197
sox1a SRY-box containing gene 1a 0.196
rx2 retinal homeobox gene 2 0.195
flt4 fms-related tyrosine kinase 4 0.195
osr2 odd-skipped related 2 (Drosophila) 0.195
ephb4a eph receptor B4a 0.194
otx1b orthodenticle homolog 1b 0.193
dla deltaA 0.191
tal1 T-cell acute lymphocytic leukemia 1 0.189
nrp1b neuropilin 1b 0.184
ptch2 patched 2 0.183
flh floating head 0.181
pcdh8 protocadherin 8 0.177
gata2a GATA-binding protein 2a 0.176
rarab retinoic acid receptor, alpha b 0.175
nppa natriuretic peptide precursor A 0.171
foxd3 forkhead box D3 0.169
krit1 KRIT1, ankyrin repeat containing 0.164
hey2 hairy/enhancer-of-split related with YRPW motif 2 0.160
osr1 odd-skipped related 1 (Drosophila) 0.158
s1pr1 sphingosine-1-phosphate receptor 1 0.157
her9 hairy-related 9 0.156
emx3 empty spiracles homeobox 3 0.154
zic3 zic family member 3 heterotaxy 1 (odd-paired homolog, Drosophila) 0.153
sox4a SRY-box containing gene 4a 0.147
tbx20 T-box 20 0.144
msxb muscle segment homeobox B 0.140
tp63 tumor protein p63 0.138
bmp4 bone morphogenetic protein 4 0.137
fgfr4 fibroblast growth factor receptor 4 0.132
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Homo sapiens
Name Description Probability Func Analog Organism
VEGFA vascular endothelial growth factor A 0.686
KDR kinase insert domain receptor (a type III receptor tyrosine kinase) 0.630
PDGFRA platelet-derived growth factor receptor, alpha polypeptide 0.450
CCNE1 cyclin E1 0.313
NRP1 neuropilin 1 0.188
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain 0.151
TBX5 T-box 5 0.146
CDH5 cadherin 5, type 2 (vascular endothelium) 0.142
TGFB1 transforming growth factor, beta 1 0.142
DUSP1 dual specificity phosphatase 1 0.138
ANGPT2 angiopoietin 2 0.137
AMOTL1 angiomotin like 1 0.118
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) 0.086
NEDD4 neural precursor cell expressed, developmentally down-regulated 4 0.085
CTNND1 catenin (cadherin-associated protein), delta 1 0.067
JAG1 jagged 1 0.065
MAFF v-maf musculoaponeurotic fibrosarcoma oncogene homolog F (avian) 0.054
TCF4 transcription factor 4 0.052
PTPRB protein tyrosine phosphatase, receptor type, B 0.042
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.042
FLT1 fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor) 0.037
TIE1 tyrosine kinase with immunoglobulin-like and EGF-like domains 1 0.037
PDGFB platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog) 0.036
EFNA1 ephrin-A1 0.036
PKD2 polycystic kidney disease 2 (autosomal dominant) 0.034
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2 0.030
GATA2 GATA binding protein 2 0.028
PLCG1 phospholipase C, gamma 1 0.027
SMAD7 SMAD family member 7 0.026
TEK TEK tyrosine kinase, endothelial 0.026
PGF placental growth factor 0.026
RUNX1 runt-related transcription factor 1 0.026
RAF1 v-raf-1 murine leukemia viral oncogene homolog 1 0.025
PRKD2 protein kinase D2 0.025
PTEN phosphatase and tensin homolog 0.024
FBXW11 F-box and WD repeat domain containing 11 0.024
ANGPT1 angiopoietin 1 0.023
PTPN1 protein tyrosine phosphatase, non-receptor type 1 0.023
FOS FBJ murine osteosarcoma viral oncogene homolog 0.023
MMP2 matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) 0.022
NOTCH3 notch 3 0.022
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.020
DLC1 deleted in liver cancer 1 0.020
NTF4 neurotrophin 4 0.018
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) 0.018
ZFP36 zinc finger protein 36, C3H type, homolog (mouse) 0.017
UHRF2 ubiquitin-like with PHD and ring finger domains 2 0.016
CDK2 cyclin-dependent kinase 2 0.016
PTCH1 patched 1 0.016
GJA4 gap junction protein, alpha 4, 37kDa 0.015
CREBBP CREB binding protein 0.015
ANGPTL2 angiopoietin-like 2 0.015
RBFOX2 RNA binding protein, fox-1 homolog (C. elegans) 2 0.014
PDGFRB platelet-derived growth factor receptor, beta polypeptide 0.014
RPLP2 ribosomal protein, large, P2 0.014
TGFB1I1 transforming growth factor beta 1 induced transcript 1 0.014
FGFR1 fibroblast growth factor receptor 1 0.014
GAB1 GRB2-associated binding protein 1 0.014
SRF serum response factor (c-fos serum response element-binding transcription factor) 0.013
JUN jun proto-oncogene 0.013
DVL3 dishevelled, dsh homolog 3 (Drosophila) 0.013
CD34 CD34 molecule 0.013
TCF3 transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47) 0.012
FSTL1 follistatin-like 1 0.012
CRK v-crk sarcoma virus CT10 oncogene homolog (avian) 0.012
TP53BP1 tumor protein p53 binding protein 1 0.012
LAPTM5 lysosomal protein transmembrane 5 0.012
SMAD3 SMAD family member 3 0.011
PDGFA platelet-derived growth factor alpha polypeptide 0.011
VWF von Willebrand factor 0.011
DPP4 dipeptidyl-peptidase 4 0.011
GATA4 GATA binding protein 4 0.010
GRB10 growth factor receptor-bound protein 10 0.010
XRCC6 X-ray repair complementing defective repair in Chinese hamster cells 6 0.010
SMARCA4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 0.010
RAP1A RAP1A, member of RAS oncogene family 0.010
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Mus musculus
Name Description Probability Func Analog Organism
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Rattus norvegicus
Name Description Probability Func Analog Organism
Pecam1 platelet/endothelial cell adhesion molecule 1 0.753
Tie1 tyrosine kinase with immunoglobulin-like and EGF-like domains 1 0.645
Cdh5 cadherin 5 0.501
Prkch protein kinase C, eta 0.489
Emcn endomucin 0.477
Vwf von Willebrand factor 0.325
Plxnd1 plexin D1 0.309
Ednrb endothelin receptor type B 0.287
Acvrl1 activin A receptor type II-like 1 0.206
Lamb2 laminin, beta 2 0.200
Elk3 ELK3, ETS-domain protein 0.196
Npr1 natriuretic peptide receptor A/guanylate cyclase A (atrionatriuretic peptide receptor A) 0.158
Tgfbr2 transforming growth factor, beta receptor II 0.137
Kdr kinase insert domain receptor 0.128
Tek TEK tyrosine kinase, endothelial 0.122
Gja4 gap junction protein, alpha 4 0.120
Gpr116 G protein-coupled receptor 116 0.119
Lama5 laminin, alpha 5 0.118
Ets1 v-ets erythroblastosis virus E26 oncogene homolog 1 (avian) 0.116
Eltd1 EGF, latrophilin and seven transmembrane domain containing 1 0.113
Megf6 multiple EGF-like-domains 6 0.112
Nek9 NIMA (never in mitosis gene a)- related kinase 9 0.111
Gata2 GATA binding protein 2 0.108
Icam2 intercellular adhesion molecule 2 0.104
Adam17 ADAM metallopeptidase domain 17 0.100
Itpr2 inositol 1,4,5-triphosphate receptor, type 2 0.093
Nos3 nitric oxide synthase 3, endothelial cell 0.092
Stard8 StAR-related lipid transfer (START) domain containing 8 0.088
Snrk SNF related kinase 0.077
Agrn agrin 0.074
Notch2 Notch homolog 2 (Drosophila) 0.074
Smad7 SMAD family member 7 0.073
Gng11 guanine nucleotide binding protein (G protein), gamma 11 0.071
Sox13 SRY (sex determining region Y)-box 13 0.069
Ltbp3 latent transforming growth factor beta binding protein 3 0.068
Chd4 chromodomain helicase DNA binding protein 4 0.065
Plcg1 phospholipase C, gamma 1 0.063
Tns1 tensin 1 0.062
Egfl7 EGF-like-domain, multiple 7 0.062
Pear1 platelet endothelial aggregation receptor 1 0.060
Cast calpastatin 0.060
Lphn2 latrophilin 2 0.059
Fgfr1 Fibroblast growth factor receptor 1 0.053
Fgfr2 fibroblast growth factor receptor 2 0.051
Dock6 dedicator of cytokinesis 6 0.049
Ggta1 glycoprotein, alpha-galactosyltransferase 1 0.049
Tcfe2a transcription factor E2a 0.047
Timp3 TIMP metallopeptidase inhibitor 3 0.045
Myo1b myosin Ib 0.045
Lamc1 laminin, gamma 1 0.045
Ehd4 EH-domain containing 4 0.044
Myh9 myosin, heavy chain 9, non-muscle 0.044
Aif1l allograft inflammatory factor 1-like 0.043
Ctnnd1 catenin (cadherin associated protein), delta 1 0.043
Sod3 superoxide dismutase 3, extracellular 0.041
Kcnj8 potassium inwardly-rectifying channel, subfamily J, member 8 0.041
Cyth3 cytohesin 3 0.041
Casp2 caspase 2 0.041
Sf3b2 splicing factor 3b, subunit 2 0.040
Lig3 ligase III, DNA, ATP-dependent 0.039
Gja1 gap junction protein, alpha 1 0.038
Igfbp5 insulin-like growth factor binding protein 5 0.038
Atp7b ATPase, Cu++ transporting, beta polypeptide 0.038
Rfc1 replication factor C (activator 1) 1 0.037
Dmd dystrophin 0.037
Ubtf upstream binding transcription factor, RNA polymerase I 0.037
Insr insulin receptor 0.037
Stat6 signal transducer and activator of transcription 6 0.036
Sox17 SRY (sex determining region Y)-box 17 0.036
Kank3 KN motif and ankyrin repeat domains 3 0.036
Mprip myosin phosphatase Rho interacting protein 0.036
Clcn7 chloride channel 7 0.035
Zeb1 zinc finger E-box binding homeobox 1 0.035
Lmcd1 LIM and cysteine-rich domains 1 0.035
Calcrl calcitonin receptor-like 0.035
Pdgfra platelet derived growth factor receptor, alpha polypeptide 0.034
Gata6 GATA binding protein 6 0.034
Sox18 SRY (sex determining region Y)-box 18 0.034
Nod1 nucleotide-binding oligomerization domain containing 1 0.033
Tmem140 transmembrane protein 140 0.033
Ppp1r12a protein phosphatase 1, regulatory (inhibitor) subunit 12A 0.033
Map3k3 mitogen activated protein kinase kinase kinase 3 0.033
Stx2 syntaxin 2 0.033
Enpp1 ectonucleotide pyrophosphatase/phosphodiesterase 1 0.032
Angpt2 angiopoietin 2 0.032
Podxl podocalyxin-like 0.032
Cdc7 cell division cycle 7 homolog (S. cerevisiae) 0.032
Akt2 v-akt murine thymoma viral oncogene homolog 2 0.031
Igf2r insulin-like growth factor 2 receptor 0.031
Triobp TRIO and F-actin binding protein 0.031
Adcy4 adenylate cyclase 4 0.031
Dram2 DNA-damage regulated autophagy modulator 2 0.031
Pdlim5 PDZ and LIM domain 5 0.031
Pard3 par-3 (partitioning defective 3) homolog (C. elegans) 0.030
Tgfbr3 transforming growth factor, beta receptor III 0.030
Tcf12 transcription factor 12 0.030
Adam10 ADAM metallopeptidase domain 10 0.030
Ireb2 iron responsive element binding protein 2 0.030
Jak2 Janus kinase 2 0.030
Irs1 insulin receptor substrate 1 0.030
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism