The network for 'regulation of mesenchymal cell proliferation' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

regulation of mesenchymal cell proliferation

Any process that modulates the frequency, rate or extent of mesenchymal cell proliferation. A mesenchymal cell is a cell that normally gives rise to other cells that are organized as three-dimensional masses, rather than sheets.

Danio rerio
Name Description Probability Func Analog Organism
dlx5a distal-less homeobox gene 5a 0.828
dlx3b distal-less homeobox gene 3b 0.759
shha sonic hedgehog a 0.669
nkx3.2 NK3 homeobox 2 0.660
boc brother of CDO 0.623
bmp4 bone morphogenetic protein 4 0.610
ptch1 patched 1 0.523
bmp2b bone morphogenetic protein 2b 0.507
hoxd4a homeo box D4a 0.459
twist3 twist3 0.404
fgfr4 fibroblast growth factor receptor 4 0.386
sulf1 sulfatase 1 0.355
twist1a twist1a 0.337
fn1 fibronectin 1 0.300
mab21l2 mab-21-like 2 0.292
grem2 gremlin 2, cysteine knot superfamily 0.277
fgf10a fibroblast growth factor 10a 0.268
ndr2 nodal-related 2 0.224
wif1 wnt inhibitory factor 1 0.214
ptch2 patched 2 0.206
bmp2a bone morphogenetic protein 2a 0.203
tcf7l2 transcription factor 7-like 2 (T-cell specific, HMG-box) 0.196
slit3 slit (Drosophila) homolog 3 0.190
fgfrl1a fibroblast growth factor receptor-like 1a 0.187
fli1a friend leukemia integration 1a 0.186
mmp15b matrix metallopeptidase 15b 0.184
itgav integrin, alpha V 0.167
col2a1a collagen type II, alpha-1a 0.165
ptgs1 prostaglandin-endoperoxide synthase 1 0.164
nkx2.5 NK2 transcription factor related 5 0.162
pea3 ETS-domain transcription factor pea3 0.157
hoxb5b homeo box B5b 0.152
mych myelocytomatosis oncogene homolog 0.147
sox9a SRY-box containing gene 9a 0.138
ihha Indian hedgehog homolog a 0.128
pcdh18a protocadherin 18a 0.124
six4b sine oculis homeobox homolog 4b 0.123
oprd1b opioid receptor, delta 1b 0.122
col8a1a collagen, type VIII, alpha 1a 0.122
fgf3 fibroblast growth factor 3 0.122
fzd7a frizzled homolog 7a 0.113
nkx2.1a NK2 homeobox 1a 0.109
alpi alkaline phosphatase, intestinal 0.109
foxi1 forkhead box I1 0.105
dlx4a distal-less homeobox gene 4a 0.104
cdon cell adhesion molecule-related/down-regulated by oncogenes 0.103
flt4 fms-related tyrosine kinase 4 0.100
notch2 notch homolog 2 0.098
wls wntless homolog (Drosophila) 0.094
bmpr1ab bone morphogenetic protein receptor, type 1ab 0.093
jag1b jagged 1b 0.093
flh floating head 0.092
cyp26b1 cytochrome P450, family 26, subfamily b, polypeptide 1 0.092
foxa2 forkhead box A2 0.091
tcf7 transcription factor 7 (T-cell specific, HMG-box) 0.089
wnt9a wingless-type MMTV integration site family, member 9A 0.086
bmp3 bone morphogenetic protein 3 0.086
trpv4 transient receptor potential cation channel, subfamily V, member 4 0.085
lef1 lymphocyte enhancer binding factor 1 0.084
hand2 heart and neural crest derivatives expressed transcript 2 0.083
pmp22a peripheral myelin protein 22a 0.083
flt1 fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor) 0.083
eya1 eyes absent homolog 1 0.082
gli3 GLI-Kruppel family member GLI3 0.079
pdgfaa platelet-derived growth factor alpha a 0.078
hoxc4a homeo box C4a 0.078
sema3aa semaphorin 3aa 0.078
tie2 endothelium-specific receptor tyrosine kinase 2 0.077
dlx1a distal-less homeobox gene 1a 0.077
lhx2b LIM homeobox 2b 0.076
runx2b runt-related transcription factor 2b 0.076
nr2e1 nuclear receptor subfamily 2, group E, member 1 0.075
msxd muscle segment homeobox D 0.074
rarga retinoic acid receptor gamma a 0.074
foxa1 forkhead box A1 0.073
myod1 myogenic differentiation 1 0.072
si:ch211-212m21.5 si:ch211-212m21.5 0.072
arx aristaless related homeobox 0.072
notch3 notch homolog 3 0.072
col5a1 procollagen, type V, alpha 1 0.070
angpt1 angiopoietin 1 0.070
pitx2 paired-like homeodomain transcription factor 2 0.067
emp2 epithelial membrane protein 2 0.067
nkx2.3 NK2 transcription factor related 3 0.067
rerea arginine-glutamic acid dipeptide (RE) repeats a 0.066
dlx4b distal-less homeobox gene 4b 0.065
sox1a SRY-box containing gene 1a 0.065
meis3 myeloid ecotropic viral integration site 3 0.064
dlx2a distal-less homeobox gene 2a 0.064
six2a sine oculis-related homeobox 2a 0.063
rbp4 retinol binding protein 4, plasma 0.062
hoxb6a homeo box B6a 0.061
dlx2b distal-less homeobox gene 2b 0.060
cxcl12b chemokine (C-X-C motif) ligand 12b (stromal cell-derived factor 1) 0.059
mef2ca myocyte enhancer factor 2ca 0.059
fzd7b frizzled homolog 7b 0.058
tie1 endothelium-specific receptor tyrosine kinase 1 0.058
acvr1l activin A receptor, type I like 0.057
tnfsf10l3 tumor necrosis factor (ligand) superfamily, member 10 like 3 0.057
irx5a iroquois homeobox protein 5a 0.056
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Homo sapiens
Name Description Probability Func Analog Organism
PDGFRA platelet-derived growth factor receptor, alpha polypeptide 0.964
INSR insulin receptor 0.876
BMPR1A bone morphogenetic protein receptor, type IA 0.731
BMP2 bone morphogenetic protein 2 0.451
NRP1 neuropilin 1 0.395
GRB10 growth factor receptor-bound protein 10 0.320
EGFR epidermal growth factor receptor 0.311
FGF1 fibroblast growth factor 1 (acidic) 0.310
PDGFRB platelet-derived growth factor receptor, beta polypeptide 0.241
CDKN2A cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4) 0.237
PTPN1 protein tyrosine phosphatase, non-receptor type 1 0.149
APBB1 amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65) 0.143
PDGFB platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog) 0.139
PLCG1 phospholipase C, gamma 1 0.136
JUP junction plakoglobin 0.135
TCF4 transcription factor 4 0.092
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.082
FSTL1 follistatin-like 1 0.069
CDH5 cadherin 5, type 2 (vascular endothelium) 0.057
BMP1 bone morphogenetic protein 1 0.044
FGF10 fibroblast growth factor 10 0.042
APP amyloid beta (A4) precursor protein 0.040
MAX MYC associated factor X 0.038
CTBP1 C-terminal binding protein 1 0.036
FGFR1 fibroblast growth factor receptor 1 0.035
IGF1R insulin-like growth factor 1 receptor 0.034
FGF2 fibroblast growth factor 2 (basic) 0.032
PDGFC platelet derived growth factor C 0.032
FZD1 frizzled homolog 1 (Drosophila) 0.029
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) 0.028
SMAD3 SMAD family member 3 0.028
CAV1 caveolin 1, caveolae protein, 22kDa 0.027
IRS1 insulin receptor substrate 1 0.027
BTRC beta-transducin repeat containing 0.025
SHC2 SHC (Src homology 2 domain containing) transforming protein 2 0.020
FGFR2 fibroblast growth factor receptor 2 0.020
SOCS5 suppressor of cytokine signaling 5 0.019
FGF7 fibroblast growth factor 7 0.019
SATB2 SATB homeobox 2 0.018
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha) 0.017
CABLES1 Cdk5 and Abl enzyme substrate 1 0.015
DKK1 dickkopf homolog 1 (Xenopus laevis) 0.014
PGF placental growth factor 0.013
TGFB1 transforming growth factor, beta 1 0.013
HOXD9 homeobox D9 0.013
DAB2 disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila) 0.012
IRS2 insulin receptor substrate 2 0.012
KRT5 keratin 5 0.012
CRKL v-crk sarcoma virus CT10 oncogene homolog (avian)-like 0.012
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) 0.012
TGFB3 transforming growth factor, beta 3 0.011
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.010
ERBB2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) 0.010
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Mus musculus
Name Description Probability Func Analog Organism
Shh sonic hedgehog 1.000
Fgfr2 fibroblast growth factor receptor 2 1.000
Tbx3 T-box 3 0.999
Gli3 GLI-Kruppel family member GLI3 0.998
Pax3 paired box gene 3 0.998
Sox9 SRY-box containing gene 9 0.995
Nos3 nitric oxide synthase 3, endothelial cell 0.994
Fgf10 fibroblast growth factor 10 0.994
Prrx1 paired related homeobox 1 0.992
Pax2 paired box gene 2 0.991
Gli2 GLI-Kruppel family member GLI2 0.991
Meox2 mesenchyme homeobox 2 0.983
Fgf8 fibroblast growth factor 8 0.982
Fgfr1 fibroblast growth factor receptor 1 0.976
Wnt3a wingless-related MMTV integration site 3A 0.974
Pdgfra platelet derived growth factor receptor, alpha polypeptide 0.972
Zeb1 zinc finger E-box binding homeobox 1 0.970
Pten phosphatase and tensin homolog 0.966
Pitx2 paired-like homeodomain transcription factor 2 0.956
Gata4 GATA binding protein 4 0.950
Bmp4 bone morphogenetic protein 4 0.947
Hoxa1 homeobox A1 0.927
Vegfa vascular endothelial growth factor A 0.909
Chrd chordin 0.908
Sox7 SRY-box containing gene 7 0.900
Pitx1 paired-like homeodomain transcription factor 1 0.894
Ror2 receptor tyrosine kinase-like orphan receptor 2 0.888
Tgfb2 transforming growth factor, beta 2 0.887
Foxc1 forkhead box C1 0.877
Ret ret proto-oncogene 0.858
Tbx15 T-box 15 0.856
Col1a1 collagen, type I, alpha 1 0.785
Twist2 twist homolog 2 (Drosophila) 0.771
Trp63 transformation related protein 63 0.761
Alx4 aristaless-like homeobox 4 0.755
Pax6 paired box gene 6 0.748
Nkx2-5 NK2 transcription factor related, locus 5 (Drosophila) 0.720
Nog noggin 0.718
Smad6 MAD homolog 6 (Drosophila) 0.716
Pax8 paired box gene 8 0.712
Hoxd13 homeobox D13 0.711
Hoxa13 homeobox A13 0.710
Otx1 orthodenticle homolog 1 (Drosophila) 0.699
Fgfr3 fibroblast growth factor receptor 3 0.689
Flt4 FMS-like tyrosine kinase 4 0.683
Lhx1 LIM homeobox protein 1 0.680
Sox2 SRY-box containing gene 2 0.678
Rara retinoic acid receptor, alpha 0.678
Nodal nodal 0.665
Cdh5 cadherin 5 0.660
Apc adenomatosis polyposis coli 0.653
Dkk1 dickkopf homolog 1 (Xenopus laevis) 0.645
Pou3f3 POU domain, class 3, transcription factor 3 0.645
Rarg retinoic acid receptor, gamma 0.641
Tcf21 transcription factor 21 0.633
Hoxd11 homeobox D11 0.624
Tbx2 T-box 2 0.624
Nr5a1 nuclear receptor subfamily 5, group A, member 1 0.620
Hoxa11 homeobox A11 0.620
Six4 sine oculis-related homeobox 4 homolog (Drosophila) 0.602
Six1 sine oculis-related homeobox 1 homolog (Drosophila) 0.601
Ghr growth hormone receptor 0.595
Hand1 heart and neural crest derivatives expressed transcript 1 0.580
Gdnf glial cell line derived neurotrophic factor 0.559
Lrp6 low density lipoprotein receptor-related protein 6 0.532
Tbx1 T-box 1 0.523
Nkx2-1 NK2 homeobox 1 0.522
Pou5f1 POU domain, class 5, transcription factor 1 0.522
Msx1 homeobox, msh-like 1 0.519
Wnt4 wingless-related MMTV integration site 4 0.517
Eng endoglin 0.493
Nfib nuclear factor I/B 0.485
Dlx5 distal-less homeobox 5 0.463
Mycn v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian) 0.460
Foxc2 forkhead box C2 0.457
Amhr2 anti-Mullerian hormone type 2 receptor 0.452
Ar androgen receptor 0.447
Fzd8 frizzled homolog 8 (Drosophila) 0.446
Tcfap2a transcription factor AP-2, alpha 0.445
Kdr kinase insert domain protein receptor 0.422
Ptpn11 protein tyrosine phosphatase, non-receptor type 11 0.411
Isl1 ISL1 transcription factor, LIM/homeodomain 0.407
Slc9a3r2 solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 2 0.403
Ptprb protein tyrosine phosphatase, receptor type, B 0.403
Rarb retinoic acid receptor, beta 0.391
Wt1 Wilms tumor 1 homolog 0.384
Runx2 runt related transcription factor 2 0.378
Erbb3 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) 0.368
Lmx1a LIM homeobox transcription factor 1 alpha 0.356
Lef1 lymphoid enhancer binding factor 1 0.356
Msx2 homeobox, msh-like 2 0.345
Wnt5a wingless-related MMTV integration site 5A 0.342
Gata6 GATA binding protein 6 0.342
En1 engrailed 1 0.334
She src homology 2 domain-containing transforming protein E 0.333
Foxf1a forkhead box F1a 0.332
Bmp7 bone morphogenetic protein 7 0.331
Csf1 colony stimulating factor 1 (macrophage) 0.330
Sox11 SRY-box containing gene 11 0.327
Pax7 paired box gene 7 0.317
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Rattus norvegicus
Name Description Probability Func Analog Organism
LOC100365106 rCG32755-like 0.820
Nek9 NIMA (never in mitosis gene a)- related kinase 9 0.694
Tgfbr2 transforming growth factor, beta receptor II 0.537
Myo1c myosin IC 0.504
Nfkb1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 0.501
Parp14 poly (ADP-ribose) polymerase family, member 14 0.499
Lamc1 laminin, gamma 1 0.487
Gbp2 guanylate binding protein 2 0.344
Myh9 myosin, heavy chain 9, non-muscle 0.329
Akt2 v-akt murine thymoma viral oncogene homolog 2 0.326
Clic4 chloride intracellular channel 4 0.324
Arnt aryl hydrocarbon receptor nuclear translocator 0.318
Unc5b unc-5 homolog B (C. elegans) 0.266
Ddx58 DEAD (Asp-Glu-Ala-Asp) box polypeptide 58 0.254
Itpr2 inositol 1,4,5-triphosphate receptor, type 2 0.250
Calcrl calcitonin receptor-like 0.246
Ednra endothelin receptor type A 0.241
Rnf213 ring finger protein 213 0.240
Stat1 signal transducer and activator of transcription 1 0.238
Timp3 TIMP metallopeptidase inhibitor 3 0.230
Eif2ak2 eukaryotic translation initiation factor 2-alpha kinase 2 0.220
Utrn utrophin 0.218
LOC100360403 ATP-binding cassette, sub-family C, member 9-like 0.203
Ptma prothymosin alpha 0.195
Acvr1 activin A receptor, type I 0.192
Smad7 SMAD family member 7 0.189
Flt1 FMS-related tyrosine kinase 1 0.185
Igtp interferon gamma induced GTPase 0.182
Igfbp5 insulin-like growth factor binding protein 5 0.181
Prrx1 paired related homeobox 1 0.167
Tceb3 transcription elongation factor B (SIII), polypeptide 3 0.160
Irs1 insulin receptor substrate 1 0.155
Entpd1 ectonucleoside triphosphate diphosphohydrolase 1 0.154
Itgb4 integrin, beta 4 0.154
Smad1 SMAD family member 1 0.153
Thbd thrombomodulin 0.152
Notch2 Notch homolog 2 (Drosophila) 0.148
Itga6 integrin, alpha 6 0.144
Ifi35 interferon-induced protein 35 0.143
Capn5 calpain 5 0.140
Elovl5 ELOVL family member 5, elongation of long chain fatty acids (yeast) 0.138
Irf7 interferon regulatory factor 7 0.131
Olfml2b olfactomedin-like 2B 0.122
Map3k3 mitogen activated protein kinase kinase kinase 3 0.118
LOC100362108 poly (ADP-ribose) polymerase family, member 10 0.118
Sod3 superoxide dismutase 3, extracellular 0.114
Rxra retinoid X receptor alpha 0.113
Nab1 Ngfi-A binding protein 1 0.108
Gna12 guanine nucleotide binding protein (G protein) alpha 12 0.105
Irgm immunity-related GTPase family, M 0.103
Lims1 LIM and senescent cell antigen-like domains 1 0.100
Nr2f2 nuclear receptor subfamily 2, group F, member 2 0.100
RT1-S3 RT1 class Ib, locus S3 0.098
Elf1 E74-like factor 1 0.093
Hdac7 histone deacetylase 7 0.092
Lbr lamin B receptor 0.091
Msn moesin 0.091
Socs3 suppressor of cytokine signaling 3 0.090
Cast calpastatin 0.089
Smad3 SMAD family member 3 0.088
Myo1b myosin Ib 0.087
Dtx3l deltex 3-like (Drosophila) 0.086
Epas1 endothelial PAS domain protein 1 0.086
Glg1 golgi apparatus protein 1 0.080
Fgfr2 fibroblast growth factor receptor 2 0.079
Stx2 syntaxin 2 0.077
Tcfe2a transcription factor E2a 0.077
Met met proto-oncogene 0.076
Scarf2 scavenger receptor class F, member 2 0.075
Pik3r1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha) 0.075
Irf9 interferon regulatory factor 9 0.070
Ptpn14 protein tyrosine phosphatase, non-receptor type 14 0.068
Nras neuroblastoma ras oncogene 0.067
Dhx9 DEAH (Asp-Glu-Ala-His) box polypeptide 9 0.066
Gpam glycerol-3-phosphate acyltransferase, mitochondrial 0.063
Antxr1 anthrax toxin receptor 1 0.063
Sardh sarcosine dehydrogenase 0.063
Efnb1 ephrin B1 0.062
Pip4k2b phosphatidylinositol-5-phosphate 4-kinase, type II, beta 0.061
Rtp4 receptor (chemosensory) transporter protein 4 0.060
Ptprk protein tyrosine phosphatase, receptor type, K, extracellular region 0.060
Nmi N-myc (and STAT) interactor 0.060
Ednrb endothelin receptor type B 0.058
Wnt5a wingless-type MMTV integration site family, member 5A 0.057
Podxl podocalyxin-like 0.057
Irf1 interferon regulatory factor 1 0.057
Plcg2 phospholipase C, gamma 2 0.056
Tgfb2 transforming growth factor, beta 2 0.056
Rab3il1 RAB3A interacting protein (rabin3)-like 1 0.055
Itpkb inositol 1,4,5-trisphosphate 3-kinase B 0.053
Gdf11 growth differentiation factor 11 0.053
Srebf1 sterol regulatory element binding transcription factor 1 0.052
Tcf3 transcription factor 3 0.051
Frmd4b FERM domain containing 4B 0.050
Crygb crystallin, gamma B 0.049
Cebpb CCAAT/enhancer binding protein (C/EBP), beta 0.048
Gabra2 gamma-aminobutyric acid (GABA-A) receptor, subunit alpha 2 0.048
Trim5 tripartite motif-containing 5 0.047
Glt25d1 glycosyltransferase 25 domain containing 1 0.047
Nfya nuclear transcription factor-Y alpha 0.047
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism