The network for 'aorta development' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

aorta development

The progression of the aorta over time, from its initial formation to the mature structure. An aorta is an artery that carries blood from the heart to other parts of the body.

Danio rerio
Name Description Probability Func Analog Organism
tal1 T-cell acute lymphocytic leukemia 1 0.995
tbx1 T-box 1 0.967
pax2a paired box gene 2a 0.949
cxcr4a chemokine (C-X-C motif) receptor 4a 0.894
kdrl kinase insert domain receptor like 0.890
dlc deltaC 0.837
nkx2.5 NK2 transcription factor related 5 0.794
hey2 hairy/enhancer-of-split related with YRPW motif 2 0.784
mib mind bomb 0.723
lmx1b.1 LIM homeobox transcription factor 1, beta 1 0.715
jag1b jagged 1b 0.697
dld deltaD 0.641
fgf8a fibroblast growth factor 8 a 0.557
eya1 eyes absent homolog 1 0.511
ascl1a achaete-scute complex-like 1a (Drosophila) 0.503
gli2a GLI-Kruppel family member GLI2a 0.488
foxi1 forkhead box I1 0.485
irx3a iroquois homeobox protein 3a 0.459
fgf3 fibroblast growth factor 3 0.455
eng2b engrailed 2b 0.450
hhex hematopoietically expressed homeobox 0.436
sox3 SRY-box containing gene 3 0.428
hand2 heart and neural crest derivatives expressed transcript 2 0.425
foxj1a forkhead box J1a 0.418
tfap2a transcription factor AP-2 alpha 0.418
hnf1ba HNF1 homeobox Ba 0.407
gata5 GATA-binding protein 5 0.396
six2a sine oculis-related homeobox 2a 0.381
tbx16 T-box gene 16 0.379
notch1a notch homolog 1a 0.364
dla deltaA 0.363
isl1 islet1 0.355
pou5f1 POU domain, class 5, transcription factor 1 0.352
gata2a GATA-binding protein 2a 0.344
gbx2 gastrulation brain homeo box 2 0.327
dlb deltaB 0.320
lmo2 LIM domain only 2 (rhombotin-like 1) 0.309
aplnrb apelin receptor b 0.300
pcdh8 protocadherin 8 0.300
otpb orthopedia homolog b 0.300
cdh2 cadherin 2, neuronal 0.274
etv2 ets variant gene 2 0.274
shha sonic hedgehog a 0.272
gata6 GATA-binding protein 6 0.267
ccm2 cerebral cavernous malformation 2 0.262
jag2 jagged 2 0.262
wnt11 wingless-type MMTV integration site family, member 11 0.257
hey1 hairy/enhancer-of-split related with YRPW motif 1 0.256
wnt2bb wingless-type MMTV integration site family, member 2Bb 0.252
notch1b notch homolog 1b 0.247
mef2d myocyte enhancer factor 2d 0.240
gata3 GATA-binding protein 3 0.239
edn1 endothelin 1 0.235
nr2f2 nuclear receptor subfamily 2, group F, member 2 0.232
pax8 paired box gene 8 0.228
med12 mediator of RNA polymerase II transcription, subunit 12 homolog 0.223
supt5h suppressor of Ty 5 homolog (S. cerevisiae) 0.216
hoxb1b homeo box B1b 0.215
hmgcrb 3-hydroxy-3-methylglutaryl-Coenzyme A reductase b 0.214
tp53 tumor protein p53 0.205
cdx4 caudal type homeo box transcription factor 4 0.199
sox32 SRY-box containing gene 32 0.193
otx2 orthodenticle homolog 2 0.192
crabp2a cellular retinoic acid binding protein 2, a 0.192
foxd3 forkhead box D3 0.189
myod1 myogenic differentiation 1 0.169
cobl cordon-bleu homolog (mouse) 0.157
arhgef7b Rho guanine nucleotide exchange factor (GEF) 7b 0.153
sox10 SRY-box containing gene 10 0.150
ndr2 nodal-related 2 0.149
tbx5a T-box 5a 0.145
trpv4 transient receptor potential cation channel, subfamily V, member 4 0.139
ptch1 patched 1 0.136
sox11a SRY-box containing gene 11a 0.136
rerea arginine-glutamic acid dipeptide (RE) repeats a 0.134
eng2a engrailed 2a 0.134
jag1a jagged 1a 0.128
dmrt3a doublesex and mab-3 related transcription factor 3a 0.125
cxcl12b chemokine (C-X-C motif) ligand 12b (stromal cell-derived factor 1) 0.122
phox2a paired-like homeobox 2a 0.120
pitx3 paired-like homeodomain transcription factor 3 0.118
tbx20 T-box 20 0.115
foxn4 forkhead box N4 0.113
apc adenomatosis polyposis coli 0.111
myl7 myosin, light polypeptide 7, regulatory 0.110
myh6 myosin, heavy polypeptide 6, cardiac muscle, alpha 0.110
alcama activated leukocyte cell adhesion molecule a 0.108
vasp vasodilator-stimulated phosphoprotein 0.104
nr2f1a nuclear receptor subfamily 2, group F, member 1a 0.101
sulf2 sulfatase 2 0.101
her5 hairy-related 5 0.100
sox19a SRY-box containing gene 19a 0.099
aldh1a2 aldehyde dehydrogenase 1 family, member A2 0.098
pax6a paired box gene 6a 0.098
hmgb1a high-mobility group box 1a 0.097
hs3st1l2 heparan sulfate (glucosamine) 3-O-sulfotransferase 1-like 2 0.096
irx5a iroquois homeobox protein 5a 0.096
fli1a friend leukemia integration 1a 0.096
notch3 notch homolog 3 0.095
zgc:112257 zgc:112257 0.091
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Homo sapiens
Name Description Probability Func Analog Organism
NOTCH3 notch 3 0.652
NOTCH1 notch 1 0.337
APBB1 amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65) 0.266
MLL myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila) 0.187
PBX1 pre-B-cell leukemia homeobox 1 0.177
PDGFRA platelet-derived growth factor receptor, alpha polypeptide 0.148
PDGFB platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog) 0.093
PKD1 polycystic kidney disease 1 (autosomal dominant) 0.070
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 0.060
TAL1 T-cell acute lymphocytic leukemia 1 0.054
NR4A1 nuclear receptor subfamily 4, group A, member 1 0.054
MKL1 megakaryoblastic leukemia (translocation) 1 0.049
NCOR2 nuclear receptor corepressor 2 0.047
PTCH1 patched 1 0.033
SMAD3 SMAD family member 3 0.029
HNF4A hepatocyte nuclear factor 4, alpha 0.029
ATXN1L ataxin 1-like 0.029
SPDEF SAM pointed domain containing ets transcription factor 0.029
MEIS2 Meis homeobox 2 0.028
SPEN spen homolog, transcriptional regulator (Drosophila) 0.028
SEC24A SEC24 family, member A (S. cerevisiae) 0.026
MYOCD myocardin 0.026
RBBP5 retinoblastoma binding protein 5 0.025
COL1A2 collagen, type I, alpha 2 0.025
SMAD9 SMAD family member 9 0.025
NOTCH2 notch 2 0.023
BCAR1 breast cancer anti-estrogen resistance 1 0.022
FBLN5 fibulin 5 0.022
CTTN cortactin 0.022
PIK3CA phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.022
MYOG myogenin (myogenic factor 4) 0.021
TRPC1 transient receptor potential cation channel, subfamily C, member 1 0.020
SEC23A Sec23 homolog A (S. cerevisiae) 0.019
PDGFA platelet-derived growth factor alpha polypeptide 0.019
MAML1 mastermind-like 1 (Drosophila) 0.019
CAV1 caveolin 1, caveolae protein, 22kDa 0.017
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.017
MKL2 MKL/myocardin-like 2 0.017
COL1A1 collagen, type I, alpha 1 0.016
AFF1 AF4/FMR2 family, member 1 0.016
SKIL SKI-like oncogene 0.015
MARCKSL1 MARCKS-like 1 0.015
PUM1 pumilio homolog 1 (Drosophila) 0.014
HOXA9 homeobox A9 0.014
MDFI MyoD family inhibitor 0.014
PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha 0.014
CXXC5 CXXC finger protein 5 0.014
HCFC2 host cell factor C2 0.013
PAM peptidylglycine alpha-amidating monooxygenase 0.013
ASH2L ash2 (absent, small, or homeotic)-like (Drosophila) 0.013
HIVEP1 human immunodeficiency virus type I enhancer binding protein 1 0.013
FCN2 ficolin (collagen/fibrinogen domain containing lectin) 2 (hucolin) 0.012
NR5A2 nuclear receptor subfamily 5, group A, member 2 0.012
RUNX1 runt-related transcription factor 1 0.012
BBS10 Bardet-Biedl syndrome 10 0.012
PTK2 PTK2 protein tyrosine kinase 2 0.012
PDGFRB platelet-derived growth factor receptor, beta polypeptide 0.012
MYST1 MYST histone acetyltransferase 1 0.012
PAPPA pregnancy-associated plasma protein A, pappalysin 1 0.011
HIST1H3B histone cluster 1, H3b 0.011
LTBP1 latent transforming growth factor beta binding protein 1 0.011
SOCS5 suppressor of cytokine signaling 5 0.011
SMAD4 SMAD family member 4 0.011
EFNB2 ephrin-B2 0.011
CALD1 caldesmon 1 0.011
TPM2 tropomyosin 2 (beta) 0.010
PDGFC platelet derived growth factor C 0.010
KIAA0174 KIAA0174 0.010
TCF3 transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47) 0.010
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Mus musculus
Name Description Probability Func Analog Organism
Fgfr2 fibroblast growth factor receptor 2 1.000
Fgf8 fibroblast growth factor 8 0.974
Tbx3 T-box 3 0.967
Eya1 eyes absent 1 homolog (Drosophila) 0.957
Tcfap2a transcription factor AP-2, alpha 0.947
Hand2 heart and neural crest derivatives expressed transcript 2 0.899
Col1a1 collagen, type I, alpha 1 0.879
Pitx2 paired-like homeodomain transcription factor 2 0.876
Notch1 Notch gene homolog 1 (Drosophila) 0.866
Hand1 heart and neural crest derivatives expressed transcript 1 0.863
Sox2 SRY-box containing gene 2 0.862
Fgfr1 fibroblast growth factor receptor 1 0.837
Pax3 paired box gene 3 0.836
Meox2 mesenchyme homeobox 2 0.824
Six1 sine oculis-related homeobox 1 homolog (Drosophila) 0.787
Foxg1 forkhead box G1 0.780
Jag1 jagged 1 0.780
Prrx1 paired related homeobox 1 0.765
Msx1 homeobox, msh-like 1 0.720
Gli3 GLI-Kruppel family member GLI3 0.697
Pbx1 pre B-cell leukemia transcription factor 1 0.665
Nkx2-5 NK2 transcription factor related, locus 5 (Drosophila) 0.657
Chd7 chromodomain helicase DNA binding protein 7 0.635
Foxc2 forkhead box C2 0.594
Zeb1 zinc finger E-box binding homeobox 1 0.529
Efnb2 ephrin B2 0.516
Dll4 delta-like 4 (Drosophila) 0.505
Hes1 hairy and enhancer of split 1 (Drosophila) 0.487
Foxc1 forkhead box C1 0.474
Dll1 delta-like 1 (Drosophila) 0.472
Smad6 MAD homolog 6 (Drosophila) 0.448
Pkd1 polycystic kidney disease 1 homolog 0.428
Nog noggin 0.428
Otx2 orthodenticle homolog 2 (Drosophila) 0.410
Tlx3 T-cell leukemia, homeobox 3 0.409
Notch2 Notch gene homolog 2 (Drosophila) 0.387
Hes5 hairy and enhancer of split 5 (Drosophila) 0.376
Gsc goosecoid homeobox 0.352
Shh sonic hedgehog 0.335
Ascl1 achaete-scute complex homolog 1 (Drosophila) 0.327
Col1a2 collagen, type I, alpha 2 0.321
Tgfb2 transforming growth factor, beta 2 0.310
Six4 sine oculis-related homeobox 4 homolog (Drosophila) 0.306
Nos3 nitric oxide synthase 3, endothelial cell 0.304
Prrx2 paired related homeobox 2 0.279
Hoxa1 homeobox A1 0.247
Rbpj recombination signal binding protein for immunoglobulin kappa J region 0.242
Col5a2 collagen, type V, alpha 2 0.235
Tbx2 T-box 2 0.226
Notch3 Notch gene homolog 3 (Drosophila) 0.222
Hspg2 perlecan (heparan sulfate proteoglycan 2) 0.209
Alx4 aristaless-like homeobox 4 0.193
Dlx1 distal-less homeobox 1 0.187
Col3a1 collagen, type III, alpha 1 0.183
Hey1 hairy/enhancer-of-split related with YRPW motif 1 0.182
Ror2 receptor tyrosine kinase-like orphan receptor 2 0.181
Pitx1 paired-like homeodomain transcription factor 1 0.181
Six5 sine oculis-related homeobox 5 homolog (Drosophila) 0.179
Fgfr3 fibroblast growth factor receptor 3 0.175
Nodal nodal 0.170
Runx2 runt related transcription factor 2 0.155
Col6a1 collagen, type VI, alpha 1 0.149
Col5a1 collagen, type V, alpha 1 0.148
Sox11 SRY-box containing gene 11 0.139
Six2 sine oculis-related homeobox 2 homolog (Drosophila) 0.137
Gbx2 gastrulation brain homeobox 2 0.135
Vegfa vascular endothelial growth factor A 0.130
Lrp6 low density lipoprotein receptor-related protein 6 0.129
Hoxa13 homeobox A13 0.128
Pdgfrb platelet derived growth factor receptor, beta polypeptide 0.128
Col6a2 collagen, type VI, alpha 2 0.127
Tbx15 T-box 15 0.123
Dlx5 distal-less homeobox 5 0.116
Ptk7 PTK7 protein tyrosine kinase 7 0.112
Myl2 myosin, light polypeptide 2, regulatory, cardiac, slow 0.111
Vangl2 vang-like 2 (van gogh, Drosophila) 0.108
Gata4 GATA binding protein 4 0.107
Col15a1 collagen, type XV, alpha 1 0.106
She src homology 2 domain-containing transforming protein E 0.106
Bmp4 bone morphogenetic protein 4 0.103
Foxi3 forkhead box I3 0.102
Efna2 ephrin A2 0.101
Dlx2 distal-less homeobox 2 0.095
Fbn1 fibrillin 1 0.095
Ednra endothelin receptor type A 0.089
Nr2f2 nuclear receptor subfamily 2, group F, member 2 0.083
Snai1 snail homolog 1 (Drosophila) 0.081
Wnt3a wingless-related MMTV integration site 3A 0.080
Hey2 hairy/enhancer-of-split related with YRPW motif 2 0.076
Bicc1 bicaudal C homolog 1 (Drosophila) 0.076
Hoxa3 homeobox A3 0.075
Zic3 zinc finger protein of the cerebellum 3 0.072
Irx3 Iroquois related homeobox 3 (Drosophila) 0.068
Hoxa9 homeobox A9 0.068
Bmp7 bone morphogenetic protein 7 0.068
Isl1 ISL1 transcription factor, LIM/homeodomain 0.067
Gata3 GATA binding protein 3 0.067
Col11a1 collagen, type XI, alpha 1 0.067
Sox17 SRY-box containing gene 17 0.065
Eln elastin 0.061
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Rattus norvegicus
Name Description Probability Func Analog Organism
Col1a1 collagen, type I, alpha 1 0.968
Col1a2 collagen, type I, alpha 2 0.900
Col5a2 collagen, type V, alpha 2 0.899
Col5a1 collagen, type V, alpha 1 0.632
Bgn biglycan 0.578
Postn periostin, osteoblast specific factor 0.248
Col3a1 collagen, type III, alpha 1 0.192
Fbn1 fibrillin 1 0.158
Col12a1 collagen, type XII, alpha 1 0.151
Fstl1 follistatin-like 1 0.150
Ogn osteoglycin 0.130
Lum lumican 0.126
Pxdn peroxidasin homolog (Drosophila) 0.106
Loxl1 lysyl oxidase-like 1 0.101
Fn1 fibronectin 1 0.084
Mmp23 matrix metallopeptidase 23 0.060
Nid2 nidogen 2 0.058
Vim vimentin 0.045
Rcn3 reticulocalbin 3, EF-hand calcium binding domain 0.039
Ctsk cathepsin K 0.035
Dcn decorin 0.031
Rhoj ras homolog gene family, member J 0.028
Aspn asporin 0.028
Col4a1 collagen, type IV, alpha 1 0.026
Ccdc80 coiled-coil domain containing 80 0.025
Srpx2 sushi-repeat-containing protein, X-linked 2 0.024
Sparc secreted protein, acidic, cysteine-rich (osteonectin) 0.023
Pmepa1 prostate transmembrane protein, androgen induced 1 0.020
Boc biregional cell adhesion molecule-related/down-regulated by oncogenes (Cdon) binding protein 0.020
Col14a1 collagen, type XIV, alpha 1 0.019
Col4a5 collagen, type IV, alpha 5 0.019
Efemp2 EGF-containing fibulin-like extracellular matrix protein 2 0.017
Aebp1 AE binding protein 1 0.015
Col5a3 collagen, type V, alpha 3 0.015
Lamc1 laminin, gamma 1 0.015
Eln elastin 0.015
Dab2 disabled homolog 2 (Drosophila) 0.014
Col15a1 collagen, type XV, alpha 1 0.014
Mfap4 microfibrillar-associated protein 4 0.014
Serpinh1 serine (or cysteine) peptidase inhibitor, clade H, member 1 0.012
Asam adipocyte-specific adhesion molecule 0.012
Lox lysyl oxidase 0.011
Mfap5 microfibrillar associated protein 5 0.011
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism