The network for 'ventricular cardiac muscle cell differentiation' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

ventricular cardiac muscle cell differentiation

The process in which a relatively unspecialized cell acquires specialized features of a ventricular cardiac muscle cell. Cardiac muscle cells are striated muscle cells that are responsible for heart contraction. The ventricle is the part of the heart that pumps blood out of the organ.

Danio rerio
Name Description Probability Func Analog Organism
bmp2b bone morphogenetic protein 2b 0.997
bmp4 bone morphogenetic protein 4 0.994
ttna titin a 0.946
nkx2.5 NK2 transcription factor related 5 0.930
vmhc ventricular myosin heavy chain 0.881
hey2 hairy/enhancer-of-split related with YRPW motif 2 0.617
actc1b actin, alpha, cardiac muscle 1b 0.556
desma desmin a 0.553
myl1 myosin, light chain 1, alkali; skeletal, fast 0.475
myl7 myosin, light polypeptide 7, regulatory 0.409
lft2 lefty2 0.404
tnnc2 troponin C type 2 (fast) 0.357
mylz2 myosin, light polypeptide 2, skeletal muscle 0.336
atp2a2a ATPase, Ca++ transporting, cardiac muscle, slow twitch 2a 0.258
actc1a actin, alpha, cardiac muscle 1a 0.256
gpr126 G protein-coupled receptor 126 0.225
myh6 myosin, heavy polypeptide 6, cardiac muscle, alpha 0.224
mef2ca myocyte enhancer factor 2ca 0.194
sema3aa semaphorin 3aa 0.183
fgf8a fibroblast growth factor 8 a 0.182
ttnb titin b 0.178
tnnc1b troponin C type 1b (slow) 0.175
rarab retinoic acid receptor, alpha b 0.147
tbx5a T-box 5a 0.136
slc8a1a solute carrier family 8 (sodium/calcium exchanger), member 1a 0.115
casq2 calsequestrin 2 0.098
smyd1b SET and MYND domain containing 1b 0.098
fgf3 fibroblast growth factor 3 0.090
tbx20 T-box 20 0.088
wnt11r wingless-type MMTV integration site family, member 11, related 0.088
ldb3b LIM domain binding 3b 0.086
spaw southpaw 0.086
tnnc1a troponin C type 1a (slow) 0.082
nexn nexilin (F actin binding protein) 0.072
rbfox1l RNA binding protein, fox-1 homolog (C. elegans) 1-like 0.066
rxrga retinoid x receptor, gamma a 0.065
myod1 myogenic differentiation 1 0.062
cx43 connexin 43 0.056
aldh1a2 aldehyde dehydrogenase 1 family, member A2 0.052
tmem38a transmembrane protein 38A 0.051
aldoab aldolase a, fructose-bisphosphate, b 0.051
cmlc1 cardiac myosin light chain-1 0.047
atp2a1 ATPase, Ca++ transporting, cardiac muscle, fast twitch 1 0.047
tnni1b troponin I, skeletal, slow b 0.047
tbx1 T-box 1 0.044
synpo2lb synaptopodin 2-like b 0.041
mylz3 myosin, light polypeptide 3, skeletal muscle 0.041
brd2a bromodomain-containing 2a 0.040
egr1 early growth response 1 0.038
dlx2a distal-less homeobox gene 2a 0.037
tnni2a.4 troponin I, skeletal, fast 2a.4 0.037
pvalb2 parvalbumin 2 0.036
tpma alpha-tropomyosin 0.034
tbx18 T-box 18 0.033
pcdh10b protocadherin 10b 0.033
gata6 GATA-binding protein 6 0.031
ckmb creatine kinase, muscle b 0.030
alcama activated leukocyte cell adhesion molecule a 0.030
tnnt3b troponin T3b, skeletal, fast 0.030
pvalb4 parvalbumin 4 0.030
ckma creatine kinase, muscle a 0.030
tnnt2a troponin T2a, cardiac 0.029
foxh1 forkhead box H1 0.029
actn3b actinin alpha 3b 0.028
egr2b early growth response 2b 0.025
tbx5b T-box 5b 0.024
hand2 heart and neural crest derivatives expressed transcript 2 0.023
nanos3 nanos homolog 3 0.022
tpm2 tropomyosin 2 (beta) 0.022
zgc:91930 zgc:91930 0.021
tbx2a T-box gene 2a 0.021
ogg1 8-oxoguanine DNA glycosylase 0.020
efnb2a ephrin B2a 0.019
scn4ba sodium channel, voltage-gated, type IV, beta a 0.019
aldh1a3 aldehyde dehydrogenase 1 family, member A3 0.019
lama4 laminin, alpha 4 0.019
smyhc1 slow myosin heavy chain 1 0.018
scn12ab sodium channel, voltage gated, type XII, alpha b 0.018
vdra vitamin D receptor a 0.017
fsta follistatin a 0.017
cpox coproporphyrinogen oxidase 0.017
hhex hematopoietically expressed homeobox 0.017
klf4 Kruppel-like factor 4 0.017
etv5b ets variant 5b 0.016
cav3 caveolin 3 0.015
bmp2a bone morphogenetic protein 2a 0.014
vmhcl ventricular myosin heavy chain-like 0.014
jph2 junctophilin 2 0.014
ccna2 cyclin A2 0.014
mef2d myocyte enhancer factor 2d 0.014
atp1b3b ATPase, Na+/K+ transporting, beta 3b polypeptide 0.014
acta1b actin, alpha 1b, skeletal muscle 0.013
hsp90a.1 heat shock protein 90-alpha 1 0.013
raraa retinoic acid receptor, alpha a 0.013
tmem2 transmembrane protein 2 0.012
pabpc4 poly(A) binding protein, cytoplasmic 4 (inducible form) 0.012
cmyb transcription factor cmyb 0.012
hspb7 heat shock protein family, alpha-crystallin-related, b7 0.012
hspd1 heat shock 60kD protein 1 (chaperonin) 0.012
fgf18a fibroblast growth factor 18a 0.012
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Homo sapiens
Name Description Probability Func Analog Organism
MED25 mediator complex subunit 25 0.977
CDK2 cyclin-dependent kinase 2 0.877
TBX5 T-box 5 0.726
BMPR1A bone morphogenetic protein receptor, type IA 0.605
HDAC4 histone deacetylase 4 0.583
CKS1B CDC28 protein kinase regulatory subunit 1B 0.361
CDK1 cyclin-dependent kinase 1 0.253
RXRA retinoid X receptor, alpha 0.247
RARA retinoic acid receptor, alpha 0.240
HNF4A hepatocyte nuclear factor 4, alpha 0.212
SPOP speckle-type POZ protein 0.204
FLNA filamin A, alpha 0.192
NCOA1 nuclear receptor coactivator 1 0.183
CCNB2 cyclin B2 0.141
CCNA2 cyclin A2 0.132
CCNE1 cyclin E1 0.121
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) 0.119
ERBB3 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) 0.088
HDAC9 histone deacetylase 9 0.086
WDFY3 WD repeat and FYVE domain containing 3 0.086
SRF serum response factor (c-fos serum response element-binding transcription factor) 0.079
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) 0.078
ITGA7 integrin, alpha 7 0.077
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor 0.075
CCNB1 cyclin B1 0.073
ITGB4 integrin, beta 4 0.071
CKS2 CDC28 protein kinase regulatory subunit 2 0.068
ATG12 ATG12 autophagy related 12 homolog (S. cerevisiae) 0.067
ATG3 ATG3 autophagy related 3 homolog (S. cerevisiae) 0.064
KANK2 KN motif and ankyrin repeat domains 2 0.061
GATA4 GATA binding protein 4 0.055
FSTL1 follistatin-like 1 0.049
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.044
FHL3 four and a half LIM domains 3 0.043
MEF2A myocyte enhancer factor 2A 0.037
ATG16L1 ATG16 autophagy related 16-like 1 (S. cerevisiae) 0.036
NCOA3 nuclear receptor coactivator 3 0.036
FLNB filamin B, beta 0.033
PSEN2 presenilin 2 (Alzheimer disease 4) 0.032
ACTN4 actinin, alpha 4 0.031
CDC27 cell division cycle 27 homolog (S. cerevisiae) 0.024
PBX1 pre-B-cell leukemia homeobox 1 0.023
TUBB6 tubulin, beta 6 0.022
PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha 0.022
NOG noggin 0.021
AR androgen receptor 0.021
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.020
CD151 CD151 molecule (Raph blood group) 0.019
NR5A2 nuclear receptor subfamily 5, group A, member 2 0.019
UBE2K ubiquitin-conjugating enzyme E2K (UBC1 homolog, yeast) 0.018
CTBP2 C-terminal binding protein 2 0.018
HIST2H3C histone cluster 2, H3c 0.018
SPTBN1 spectrin, beta, non-erythrocytic 1 0.016
PRKD2 protein kinase D2 0.016
TRPM7 transient receptor potential cation channel, subfamily M, member 7 0.015
ZNF512B zinc finger protein 512B 0.014
TAGLN2 transgelin 2 0.014
AHNAK AHNAK nucleoprotein 0.014
EEF2K eukaryotic elongation factor-2 kinase 0.014
ITGB1BP2 integrin beta 1 binding protein (melusin) 2 0.014
USP25 ubiquitin specific peptidase 25 0.014
TCF4 transcription factor 4 0.014
SPTAN1 spectrin, alpha, non-erythrocytic 1 (alpha-fodrin) 0.013
PDLIM7 PDZ and LIM domain 7 (enigma) 0.013
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 0.013
ALOX12 arachidonate 12-lipoxygenase 0.013
CREBBP CREB binding protein 0.013
INCENP inner centromere protein antigens 135/155kDa 0.013
RXRG retinoid X receptor, gamma 0.012
ZFYVE9 zinc finger, FYVE domain containing 9 0.012
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) 0.012
VTA1 Vps20-associated 1 homolog (S. cerevisiae) 0.012
TP53BP1 tumor protein p53 binding protein 1 0.012
TOP2A topoisomerase (DNA) II alpha 170kDa 0.012
PBK PDZ binding kinase 0.012
DIP2A DIP2 disco-interacting protein 2 homolog A (Drosophila) 0.012
ECHDC1 enoyl CoA hydratase domain containing 1 0.011
HR hairless homolog (mouse) 0.011
FOXC1 forkhead box C1 0.011
ACACA acetyl-CoA carboxylase alpha 0.010
BMPR1B bone morphogenetic protein receptor, type IB 0.010
PTK6 PTK6 protein tyrosine kinase 6 0.010
ATF3 activating transcription factor 3 0.010
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Mus musculus
Name Description Probability Func Analog Organism
Hand2 heart and neural crest derivatives expressed transcript 2 1.000
Nkx2-5 NK2 transcription factor related, locus 5 (Drosophila) 1.000
Hand1 heart and neural crest derivatives expressed transcript 1 0.999
Fgf8 fibroblast growth factor 8 0.998
Shh sonic hedgehog 0.998
Gata4 GATA binding protein 4 0.995
Bmp7 bone morphogenetic protein 7 0.993
Tbx1 T-box 1 0.992
Rarg retinoic acid receptor, gamma 0.990
Bmp4 bone morphogenetic protein 4 0.984
Foxc1 forkhead box C1 0.983
Sox9 SRY-box containing gene 9 0.982
Tgfb2 transforming growth factor, beta 2 0.980
Fgfr2 fibroblast growth factor receptor 2 0.980
Pitx2 paired-like homeodomain transcription factor 2 0.963
Isl1 ISL1 transcription factor, LIM/homeodomain 0.959
Foxc2 forkhead box C2 0.957
Rxra retinoid X receptor alpha 0.951
Pdgfra platelet derived growth factor receptor, alpha polypeptide 0.949
Chrd chordin 0.943
Ednra endothelin receptor type A 0.924
Fgfr3 fibroblast growth factor receptor 3 0.900
Tcfap2a transcription factor AP-2, alpha 0.896
Prrx1 paired related homeobox 1 0.877
Msx1 homeobox, msh-like 1 0.806
Fgfr1 fibroblast growth factor receptor 1 0.782
Ptpn11 protein tyrosine phosphatase, non-receptor type 11 0.760
Ece1 endothelin converting enzyme 1 0.716
Acvr1 activin A receptor, type 1 0.702
Smo smoothened homolog (Drosophila) 0.683
Hoxa1 homeobox A1 0.657
Vegfa vascular endothelial growth factor A 0.638
Ntf3 neurotrophin 3 0.633
Pax2 paired box gene 2 0.572
Nr2f2 nuclear receptor subfamily 2, group F, member 2 0.560
Mesp1 mesoderm posterior 1 0.528
Gata6 GATA binding protein 6 0.513
Eya1 eyes absent 1 homolog (Drosophila) 0.499
Rspo2 R-spondin 2 homolog (Xenopus laevis) 0.473
Hey2 hairy/enhancer-of-split related with YRPW motif 2 0.465
Ror2 receptor tyrosine kinase-like orphan receptor 2 0.424
Gata5 GATA binding protein 5 0.419
Rarb retinoic acid receptor, beta 0.413
Tbx3 T-box 3 0.361
Gli3 GLI-Kruppel family member GLI3 0.342
Jag1 jagged 1 0.301
Zfpm2 zinc finger protein, multitype 2 0.300
Aldh1a2 aldehyde dehydrogenase family 1, subfamily A2 0.279
Tbx5 T-box 5 0.252
Gsc goosecoid homeobox 0.248
Pax8 paired box gene 8 0.236
Gli2 GLI-Kruppel family member GLI2 0.234
Otx2 orthodenticle homolog 2 (Drosophila) 0.211
Runx2 runt related transcription factor 2 0.205
Dlx5 distal-less homeobox 5 0.201
Birc5 baculoviral IAP repeat-containing 5 0.190
Alx4 aristaless-like homeobox 4 0.187
Pax3 paired box gene 3 0.181
Nrp1 neuropilin 1 0.180
Msx2 homeobox, msh-like 2 0.180
Hdac4 histone deacetylase 4 0.180
Six1 sine oculis-related homeobox 1 homolog (Drosophila) 0.162
Thrb thyroid hormone receptor beta 0.140
Ltbp1 latent transforming growth factor beta binding protein 1 0.137
Tgfbr2 transforming growth factor, beta receptor II 0.136
Thra thyroid hormone receptor alpha 0.136
Myl2 myosin, light polypeptide 2, regulatory, cardiac, slow 0.130
Itgb1 integrin beta 1 (fibronectin receptor beta) 0.125
Nkx6-1 NK6 homeobox 1 0.122
Hdac5 histone deacetylase 5 0.121
Gja1 gap junction protein, alpha 1 0.118
Efnb2 ephrin B2 0.108
Pdx1 pancreatic and duodenal homeobox 1 0.107
Foxh1 forkhead box H1 0.106
Fgfrl1 fibroblast growth factor receptor-like 1 0.105
Pbx1 pre B-cell leukemia transcription factor 1 0.096
Hoxd13 homeobox D13 0.096
Fgf15 fibroblast growth factor 15 0.095
Dbp D site albumin promoter binding protein 0.094
Foxe1 forkhead box E1 0.094
Chd7 chromodomain helicase DNA binding protein 7 0.093
Pthlh parathyroid hormone-like peptide 0.092
Tcf21 transcription factor 21 0.090
Gdf6 growth differentiation factor 6 0.089
Mef2d myocyte enhancer factor 2D 0.088
Gja5 gap junction protein, alpha 5 0.088
Rara retinoic acid receptor, alpha 0.085
Prrx2 paired related homeobox 2 0.081
Nog noggin 0.080
Myl3 myosin, light polypeptide 3 0.079
Nr2f1 nuclear receptor subfamily 2, group F, member 1 0.078
Alx3 aristaless-like homeobox 3 0.078
Hey1 hairy/enhancer-of-split related with YRPW motif 1 0.077
Ccna2 cyclin A2 0.075
Bmpr1a bone morphogenetic protein receptor, type 1A 0.074
Chrm2 cholinergic receptor, muscarinic 2, cardiac 0.073
Cdk1 cyclin-dependent kinase 1 0.071
Prc1 protein regulator of cytokinesis 1 0.070
Kcnj5 potassium inwardly-rectifying channel, subfamily J, member 5 0.068
Erbb3 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) 0.068
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Rattus norvegicus
Name Description Probability Func Analog Organism
Pttg1 pituitary tumor-transforming 1 0.185
Traf4af1 TRAF4 associated factor 1 0.142
Cdk1 cyclin-dependent kinase 1 0.138
Top2a topoisomerase (DNA) II alpha 0.123
Cdkn3 cyclin-dependent kinase inhibitor 3 0.082
Ube2c ubiquitin-conjugating enzyme E2C 0.057
Myl2 myosin, light polypeptide 2, regulatory, cardiac, slow 0.043
Ns5atp9 NS5A (hepatitis C virus) transactivated protein 9 0.037
Cdca3 cell division cycle associated 3 0.028
Rrm2 ribonucleotide reductase M2 0.026
Spc25 SPC25, NDC80 kinetochore complex component, homolog (S. cerevisiae) 0.021
Cks2 CDC28 protein kinase regulatory subunit 2 0.019
Nusap1 nucleolar and spindle associated protein 1 0.018
Cox8b cytochrome c oxidase, subunit VIIIb 0.015
Cdc20 cell division cycle 20 homolog (S. cerevisiae) 0.015
Asf1b ASF1 anti-silencing function 1 homolog B (S. cerevisiae) 0.014
Depdc1 DEP domain containing 1 0.014
Hmmr hyaluronan mediated motility receptor (RHAMM) 0.012
LOC689399 hypothetical protein LOC689399 0.012
Actc1 actin, alpha, cardiac muscle 1 0.012
Epn1 Epsin 1 0.012
Hand2 heart and neural crest derivatives expressed 2 0.011
Myom1 myomesin 1 0.010
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism