The network for 'hematopoietic or lymphoid organ development' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

hematopoietic or lymphoid organ development

The process whose specific outcome is the progression of any organ involved in hematopoiesis (also known as hemopoiesis) or lymphoid cell activation over time, from its formation to the mature structure. Such development includes differentiation of resident cell types (stromal cells) and of migratory cell types dependent on the unique microenvironment afforded by the organ for their proper differentiation.

Danio rerio
Name Description Probability Func Analog Organism
cmyb transcription factor cmyb 1.000
osr1 odd-skipped related 1 (Drosophila) 1.000
runx1 runt-related transcription factor 1 1.000
hhex hematopoietically expressed homeobox 0.997
ikzf1 IKAROS family zinc finger 1 (Ikaros) 0.995
plcg1 phospholipase C, gamma 1 0.994
mafba v-maf musculoaponeurotic fibrosarcoma oncogene family, protein B (avian) 0.993
gata1a GATA binding protein 1a 0.985
hbbe1.1 hemoglobin beta embryonic-1.1 0.984
spns2 spinster homolog 2 (Drosophila) 0.982
tfr1a transferrin receptor 1a 0.978
LOC566708 FL cytokine receptor-like 0.975
met met proto-oncogene (hepatocyte growth factor receptor) 0.963
smad5 MAD homolog 5 (Drosophila) 0.963
pcna proliferating cell nuclear antigen 0.960
rag1 recombination activating gene 1 0.959
wnt2bb wingless-type MMTV integration site family, member 2Bb 0.954
gata6 GATA-binding protein 6 0.951
tp53 tumor protein p53 0.951
trim33 tripartite motif-containing 33 0.949
alas2 aminolevulinate, delta-, synthetase 2 0.948
kita kit receptor a 0.930
lcp1 lymphocyte cytosolic plastin 1 0.929
hoxd4a homeo box D4a 0.929
lmo2 LIM domain only 2 (rhombotin-like 1) 0.926
fgf8a fibroblast growth factor 8 a 0.919
ephb4b eph receptor B4b 0.911
traf4a tnf receptor-associated factor 4a 0.911
hey2 hairy/enhancer-of-split related with YRPW motif 2 0.902
chd chordin 0.901
notch3 notch homolog 3 0.888
tbx5a T-box 5a 0.882
dnmt4 DNA (cytosine-5-)-methyltransferase 4 0.870
myf5 myogenic factor 5 0.864
wnt4a wingless-type MMTV integration site family, member 4a 0.861
urod uroporphyrinogen decarboxylase 0.855
mmp2 matrix metalloproteinase 2 0.848
hbaa1 hemoglobin alpha adult-1 0.846
tal1 T-cell acute lymphocytic leukemia 1 0.845
mib mind bomb 0.844
dlb deltaB 0.823
si:ch211-235f6.2 si:ch211-235f6.2 0.816
cdh5 cadherin 5 0.807
npm1 nucleophosmin 1 0.806
tbx16 T-box gene 16 0.799
med12 mediator of RNA polymerase II transcription, subunit 12 homolog 0.799
klf4 Kruppel-like factor 4 0.796
sox7 SRY-box containing gene 7 0.796
efnb2a ephrin B2a 0.789
ets1a v-ets erythroblastosis virus E26 oncogene homolog 1a 0.789
epor erythropoietin receptor 0.783
mll myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila) 0.781
hbbe3 hemoglobin beta embryonic-3 0.780
etv2 ets variant gene 2 0.761
epb41 erythrocyte membrane protein band 4.1 (elliptocytosis 1, RH-linked) 0.756
egr1 early growth response 1 0.750
fgf10a fibroblast growth factor 10a 0.748
snrnp70 small nuclear ribonucleoprotein 70 (U1) 0.739
znfl2a zinc finger-like gene 2a 0.739
jag2 jagged 2 0.730
trpv6 transient receptor potential cation channel, subfamily V, member 6 0.730
hand2 heart and neural crest derivatives expressed transcript 2 0.729
bmp2b bone morphogenetic protein 2b 0.728
ndr2 nodal-related 2 0.726
kdrl kinase insert domain receptor like 0.723
dusp6 dual specificity phosphatase 6 0.722
erg v-ets erythroblastosis virus E26 oncogene like (avian) 0.721
bmper BMP binding endothelial regulator 0.710
cebpa CCAAT/enhancer binding protein (C/EBP), alpha 0.702
hhip hedgehog interacting protein 0.698
ppox protoporphyrinogen oxidase 0.696
hnf1ba HNF1 homeobox Ba 0.693
nola1 nucleolar protein family A, member 1 (H/ACA small nucleolar RNPs) 0.681
tpm4 tropomyosin 4 0.680
tbx1 T-box 1 0.679
cdx4 caudal type homeo box transcription factor 4 0.672
csnk1a1 casein kinase 1, alpha 1 0.670
otpa orthopedia homolog a 0.666
kcnh2 potassium voltage-gated channel, subfamily H (eag-related), member 2 0.664
gli2a GLI-Kruppel family member GLI2a 0.662
dlc deltaC 0.661
cebpb CCAAT/enhancer binding protein (C/EBP), beta 0.655
bmp4 bone morphogenetic protein 4 0.649
ddx18 DEAD (Asp-Glu-Ala-Asp) box polypeptide 18 0.644
dld deltaD 0.643
fn1 fibronectin 1 0.642
tie1 endothelium-specific receptor tyrosine kinase 1 0.632
cpox coproporphyrinogen oxidase 0.632
cpsf1 cleavage and polyadenylation specific factor 1 0.626
fzd5 frizzled homolog 5 0.621
rpl11 ribosomal protein L11 0.619
eomesa eomesodermin homolog a 0.614
rarab retinoic acid receptor, alpha b 0.614
wnt9b wingless-type MMTV integration site family, member 9B 0.607
hbae1 hemoglobin alpha embryonic-1 0.599
dll4 delta-like 4 (Drosophila) 0.593
haus3 HAUS augmin-like complex, subunit 3 0.592
wu:fv91b12 wu:fv91b12 0.583
tcf7l2 transcription factor 7-like 2 (T-cell specific, HMG-box) 0.578
fgfr4 fibroblast growth factor receptor 4 0.577
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
Rac1 CG2248 gene product from transcript CG2248-RA 0.959
bsk basket 0.930
put punt 0.890
tsr twinstar 0.821
Gug Grunge 0.816
rap retina aberrant in pattern 0.792
Pten CG5671 gene product from transcript CG5671-RB 0.729
tkv thickveins 0.716
twi twist 0.703
shn schnurri 0.700
Pvr PDGF- and VEGF-receptor related 0.665
Rel Relish 0.654
drk downstream of receptor kinase 0.621
hth homothorax 0.590
da daughterless 0.570
nmo nemo 0.548
cta concertina 0.534
Egfr Epidermal growth factor receptor 0.527
Dad Daughters against dpp 0.521
fu fused 0.516
dom domino 0.507
robo roundabout 0.503
numb CG3779 gene product from transcript CG3779-RB 0.477
os outstretched 0.477
gbb glass bottom boat 0.473
Rala Ras-related protein 0.465
E(spl) Enhancer of split 0.463
rl rolled 0.425
hep hemipterous 0.410
wg wingless 0.390
rho rhomboid 0.384
mbc myoblast city 0.373
dome domeless 0.363
Atg1 Autophagy-specific gene 1 0.362
sns sticks and stones 0.342
scb scab 0.337
ena enabled 0.326
hipk homeodomain interacting protein kinase 0.316
Ubx Ultrabithorax 0.307
zfh1 Zn finger homeodomain 1 0.302
Dcr-2 Dicer-2 0.293
if inflated 0.292
ci cubitus interruptus 0.281
sbb scribbler 0.280
Pi3K92E CG4141 gene product from transcript CG4141-RB 0.273
oho23B overgrown hematopoietic organs at 23B 0.273
N Notch 0.273
Pp2B-14D Protein phosphatase 2B at 14D 0.273
ap apterous 0.269
rin rasputin 0.262
mnb minibrain 0.256
Mhc Myosin heavy chain 0.254
Rab7 Rab-protein 7 0.246
kuz kuzbanian 0.238
Mad Mothers against dpp 0.236
Akt1 CG4006 gene product from transcript CG4006-RA 0.230
Hem HEM-protein 0.227
krz kurtz 0.225
Adf1 Adh transcription factor 1 0.223
tin tinman 0.214
ush u-shaped 0.208
klu klumpfuss 0.206
E(bx) Enhancer of bithorax 0.203
Lis-1 Lissencephaly-1 0.197
ik2 IkappaB kinase-like 2 0.191
Mrtf Myocardin-related transcription factor 0.188
srp serpent 0.185
G-oalpha47A G protein oalpha 47A 0.183
dpp decapentaplegic 0.180
insc inscuteable 0.178
CycA Cyclin A 0.168
Thor CG8846 gene product from transcript CG8846-RA 0.161
Tom Twin of m4 0.161
Tl Toll 0.160
RpS6 Ribosomal protein S6 0.159
Socs36E Suppressor of cytokine signaling at 36E 0.159
HLHm7 E(spl) region transcript m7 0.158
ash2 absent, small, or homeotic discs 2 0.156
kis kismet 0.155
pan pangolin 0.155
l(2)gl lethal (2) giant larvae 0.147
fj four-jointed 0.142
BRWD3 CG31132 gene product from transcript CG31132-RA 0.142
ct cut 0.140
pnr pannier 0.137
nau nautilus 0.137
fw furrowed 0.133
Cdk4 Cyclin-dependent kinase 4 0.132
Adgf-A Adenosine deaminase-related growth factor A 0.131
loqs loquacious 0.130
kn knot 0.130
MED19 Mediator complex subunit 19 0.129
Ddc Dopa decarboxylase 0.129
Kap-alpha3 karyopherin alpha3 0.129
Alk CG8250 gene product from transcript CG8250-RA 0.127
Kr-h1 Kruppel homolog 1 0.127
babo baboon 0.126
aop anterior open 0.126
repo reversed polarity 0.125
Cip4 CG15015 gene product from transcript CG15015-RA 0.124
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Homo sapiens
Name Description Probability Func Analog Organism
EGFR epidermal growth factor receptor 1.000
CBL Cas-Br-M (murine) ecotropic retroviral transforming sequence 1.000
ERBB2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) 0.999
CREBBP CREB binding protein 0.999
TAL1 T-cell acute lymphocytic leukemia 1 0.999
SMAD2 SMAD family member 2 0.999
RUNX1 runt-related transcription factor 1 0.998
LCK lymphocyte-specific protein tyrosine kinase 0.997
NCOR2 nuclear receptor corepressor 2 0.996
MDM2 Mdm2 p53 binding protein homolog (mouse) 0.995
RELA v-rel reticuloendotheliosis viral oncogene homolog A (avian) 0.995
SMAD3 SMAD family member 3 0.992
STAT1 signal transducer and activator of transcription 1, 91kDa 0.990
EP300 E1A binding protein p300 0.987
RB1 retinoblastoma 1 0.985
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.980
FGFR1 fibroblast growth factor receptor 1 0.975
NOTCH1 notch 1 0.975
ICAM1 intercellular adhesion molecule 1 0.971
AR androgen receptor 0.960
PML promyelocytic leukemia 0.959
ERBB3 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) 0.955
PTPN6 protein tyrosine phosphatase, non-receptor type 6 0.953
DAXX death-domain associated protein 0.953
CD40 CD40 molecule, TNF receptor superfamily member 5 0.943
IL6ST interleukin 6 signal transducer (gp130, oncostatin M receptor) 0.940
TCF3 transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47) 0.936
FGFR2 fibroblast growth factor receptor 2 0.933
TP53 tumor protein p53 0.930
ATN1 atrophin 1 0.929
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.928
HLA-B major histocompatibility complex, class I, B 0.927
TNFRSF1B tumor necrosis factor receptor superfamily, member 1B 0.926
PDGFRB platelet-derived growth factor receptor, beta polypeptide 0.924
ESR1 estrogen receptor 1 0.922
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha) 0.914
TRAF1 TNF receptor-associated factor 1 0.910
CRK v-crk sarcoma virus CT10 oncogene homolog (avian) 0.908
HIPK2 homeodomain interacting protein kinase 2 0.903
SIN3A SIN3 homolog A, transcription regulator (yeast) 0.899
MYC v-myc myelocytomatosis viral oncogene homolog (avian) 0.898
B2M beta-2-microglobulin 0.893
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.889
RXRA retinoid X receptor, alpha 0.888
FAS Fas (TNF receptor superfamily, member 6) 0.888
TGFB1 transforming growth factor, beta 1 0.887
JUN jun proto-oncogene 0.885
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) 0.879
MLL myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila) 0.874
CCR7 chemokine (C-C motif) receptor 7 0.870
IL4R interleukin 4 receptor 0.860
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta 0.853
SP1 Sp1 transcription factor 0.852
PSEN1 presenilin 1 0.844
LAT linker for activation of T cells 0.844
UBC ubiquitin C 0.842
IL2RB interleukin 2 receptor, beta 0.831
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 0.824
CAV1 caveolin 1, caveolae protein, 22kDa 0.817
BHLHE40 basic helix-loop-helix family, member e40 0.815
KAT2B K(lysine) acetyltransferase 2B 0.814
IRF1 interferon regulatory factor 1 0.812
NR4A1 nuclear receptor subfamily 4, group A, member 1 0.808
TCF12 transcription factor 12 0.806
C1QA complement component 1, q subcomponent, A chain 0.806
SUMO3 SMT3 suppressor of mif two 3 homolog 3 (S. cerevisiae) 0.805
LEO1 Leo1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae) 0.800
CCR5 chemokine (C-C motif) receptor 5 0.794
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.791
BIRC3 baculoviral IAP repeat containing 3 0.790
CXCL9 chemokine (C-X-C motif) ligand 9 0.788
SLAMF1 signaling lymphocytic activation molecule family member 1 0.781
IL6 interleukin 6 (interferon, beta 2) 0.781
VEGFA vascular endothelial growth factor A 0.776
ZNF43 zinc finger protein 43 0.769
JAK2 Janus kinase 2 0.768
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain 0.764
UBE2I ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast) 0.763
PDGFRA platelet-derived growth factor receptor, alpha polypeptide 0.761
FLT1 fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor) 0.758
CSNK2A1 casein kinase 2, alpha 1 polypeptide 0.757
NCOA2 nuclear receptor coactivator 2 0.754
PPP1CC protein phosphatase 1, catalytic subunit, gamma isozyme 0.750
CASP3 caspase 3, apoptosis-related cysteine peptidase 0.749
GATA1 GATA binding protein 1 (globin transcription factor 1) 0.744
IRF4 interferon regulatory factor 4 0.732
SYK spleen tyrosine kinase 0.730
IL2RG interleukin 2 receptor, gamma 0.726
JAG1 jagged 1 0.725
STAT5A signal transducer and activator of transcription 5A 0.719
IL8 interleukin 8 0.718
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 0.709
KLF4 Kruppel-like factor 4 (gut) 0.707
IL10RA interleukin 10 receptor, alpha 0.705
SH3BP2 SH3-domain binding protein 2 0.696
ZFYVE9 zinc finger, FYVE domain containing 9 0.689
HDAC3 histone deacetylase 3 0.687
MCL1 myeloid cell leukemia sequence 1 (BCL2-related) 0.686
JUNB jun B proto-oncogene 0.680
PTPN1 protein tyrosine phosphatase, non-receptor type 1 0.679
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Mus musculus
Name Description Probability Func Analog Organism
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Rattus norvegicus
Name Description Probability Func Analog Organism
Dusp1 dual specificity phosphatase 1 0.540
Zfp36 zinc finger protein 36 0.298
Hbb hemoglobin, beta 0.297
LOC689064 beta-globin 0.280
Alas2 aminolevulinate, delta-, synthase 2 0.269
Mylk2 myosin light chain kinase 2 0.206
LOC287167 globin, alpha 0.202
LOC100134871 beta globin minor gene 0.193
Nek9 NIMA (never in mitosis gene a)- related kinase 9 0.189
Sirpa signal-regulatory protein alpha 0.171
Bcl2 B-cell CLL/lymphoma 2 0.140
Jak1 Janus kinase 1 0.136
Hba-a2 hemoglobin alpha, adult chain 2 0.131
Errfi1 ERBB receptor feedback inhibitor 1 0.125
Ccl5 chemokine (C-C motif) ligand 5 0.124
Itgam integrin, alpha M 0.115
Prkch protein kinase C, eta 0.107
Epor erythropoietin receptor 0.104
Cd247 Cd247 molecule 0.102
Ptger4 prostaglandin E receptor 4 (subtype EP4) 0.100
Acap1 ArfGAP with coiled-coil, ankyrin repeat and PH domains 1 0.098
Atf3 activating transcription factor 3 0.098
Cfp complement factor properdin 0.095
Cd37 CD37 molecule 0.095
Rgs1 regulator of G-protein signaling 1 0.091
Laptm5 lysosomal protein transmembrane 5 0.091
Lifr leukemia inhibitory factor receptor alpha 0.088
Fos FBJ osteosarcoma oncogene 0.087
Prf1 perforin 1 (pore forming protein) 0.087
Tgfbr2 transforming growth factor, beta receptor II 0.086
Fgr Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog 0.083
Hist1h2ba histone cluster 1, H2ba 0.081
Cdkn2b cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4) 0.081
Stat4 signal transducer and activator of transcription 4 0.079
Smad1 SMAD family member 1 0.075
Lyz2 lysozyme 2 0.073
Dusp6 dual specificity phosphatase 6 0.072
Tgfb1 transforming growth factor, beta 1 0.071
Junb jun B proto-oncogene 0.071
Slco2b1 solute carrier organic anion transporter family, member 2b1 0.069
Klf4 Kruppel-like factor 4 (gut) 0.069
RT1-Db1 RT1 class II, locus Db1 0.065
Ptprc protein tyrosine phosphatase, receptor type, C 0.065
Cd5 Cd5 molecule 0.065
Il2rb interleukin 2 receptor, beta 0.061
Hbb-b1 hemoglobin, beta adult major chain 0.058
Itpkb inositol 1,4,5-trisphosphate 3-kinase B 0.055
Shc3 SHC (Src homology 2 domain containing) transforming protein 3 0.054
Oxtr oxytocin receptor 0.054
Bmp6 bone morphogenetic protein 6 0.052
Lyn v-yes-1 Yamaguchi sarcoma viral related oncogene homolog 0.050
Btg2 BTG family, member 2 0.049
Bin2 bridging integrator 2 0.048
Ccl4 chemokine (C-C motif) ligand 4 0.047
Tcrb T-cell receptor beta chain 0.046
Lyl1 lymphoblastic leukemia derived sequence 1 0.046
Map4k1 mitogen activated protein kinase kinase kinase kinase 1 0.044
Tmem176b transmembrane protein 176B 0.044
Myc myelocytomatosis oncogene 0.044
Cd2 Cd2 molecule 0.044
Arhgap4 Rho GTPase activating protein 4 0.043
Prl prolactin 0.042
Calcr calcitonin receptor 0.042
Lypd3 Ly6/Plaur domain containing 3 0.041
RT1-Da RT1 class II, locus Da 0.041
Fgfr1 Fibroblast growth factor receptor 1 0.041
Fosl2 fos-like antigen 2 0.040
Il1b interleukin 1 beta 0.039
Ciita class II, major histocompatibility complex, transactivator 0.039
Sema3a sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.038
Trpv1 transient receptor potential cation channel, subfamily V, member 1 0.038
Cd68 Cd68 molecule 0.038
Rassf5 Ras association (RalGDS/AF-6) domain family member 5 0.037
Nfya nuclear transcription factor-Y alpha 0.037
Rara retinoic acid receptor, alpha 0.036
Ccl3 chemokine (C-C motif) ligand 3 0.036
LOC687711 similar to small nuclear ribonucleoprotein D3 0.034
Spta1 spectrin, alpha, erythrocytic 1 (elliptocytosis 2) 0.034
Sp1 Sp1 transcription factor 0.034
Cd86 CD86 molecule 0.034
Cyp27b1 cytochrome P450, family 27, subfamily b, polypeptide 1 0.034
Slfn2 schlafen 2 0.034
Ccr5 chemokine (C-C motif) receptor 5 0.034
Hbe1 hemoglobin, epsilon 1 0.033
Gpr176 G protein-coupled receptor 176 0.033
Actn4 actinin alpha 4 0.033
Cebpa CCAAT/enhancer binding protein (C/EBP), alpha 0.033
Olr837 olfactory receptor 837 0.033
Flt4 fms-related tyrosine kinase 4 0.033
Gzmk granzyme K 0.033
LOC100363671 hypothetical protein LOC100363671 0.033
Ntn1 netrin 1 0.033
Marcks myristoylated alanine rich protein kinase C substrate 0.032
Cyfip1 cytoplasmic FMR1 interacting protein 1 0.032
Ece1 endothelin converting enzyme 1 0.032
Man2b1 mannosidase, alpha, class 2B, member 1 0.031
Il8rb interleukin 8 receptor, beta 0.031
Galr3 galanin receptor 3 0.031
Faslg Fas ligand (TNF superfamily, member 6) 0.031
Dnase1l3 deoxyribonuclease 1-like 3 0.031
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism