IMP

Process View

Homo sapiens

15 genes annotated in human

alpha beta t cell activation

The change in morphology and behavior of an alpha-beta T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific.

Loading network...

In addition to gene-name show these genes:

Known genes in the process in human Include functional analogs

Network Filters

Minimum relationship confidence:

Maximum number of genes:

Highlight known relationships in gold.

Graphical Options

Adjust edge length:

Adjust node size:

Fixed layout

Black background

Low confidence color:

Med confidence color:

High confidence color:

Hide the legend in the network

Save Options

Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "alpha beta t cell activation"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "alpha beta t cell activation" (in gray)

Name	Description	Probability	Func Analog Organism
NFKB1	nuclear factor of kappa light polypeptide gene enhancer in B-cells 1	0.675
PTPN6	protein tyrosine phosphatase, non-receptor type 6	0.403
LCK	lymphocyte-specific protein tyrosine kinase	0.241
BIRC3	baculoviral IAP repeat containing 3	0.238
LCP2	lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)	0.180
TRAF1	TNF receptor-associated factor 1	0.177
IL12B	interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40)	0.175
CCL4	chemokine (C-C motif) ligand 4	0.150	Human
IL4R	interleukin 4 receptor	0.150	Mouse
CCR7	chemokine (C-C motif) receptor 7	0.147
NCOR2	nuclear receptor corepressor 2	0.136
IL2RG	interleukin 2 receptor, gamma	0.121	Mouse
CD2	CD2 molecule	0.097
CBL	Cas-Br-M (murine) ecotropic retroviral transforming sequence	0.087
GRAP2	GRB2-related adaptor protein 2	0.080
CCR5	chemokine (C-C motif) receptor 5	0.076
CASP4	caspase 4, apoptosis-related cysteine peptidase	0.076
LILRA6	leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 6	0.072
CXCL10	chemokine (C-X-C motif) ligand 10	0.071
SIN3A	SIN3 homolog A, transcription regulator (yeast)	0.067
ERBB3	v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)	0.065
CD247	CD247 molecule	0.062
CXCL9	chemokine (C-X-C motif) ligand 9	0.058
ICAM1	intercellular adhesion molecule 1	0.056
CD3E	CD3e molecule, epsilon (CD3-TCR complex)	0.055	Mouse
NFKB2	nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)	0.049
CCL5	chemokine (C-C motif) ligand 5	0.047	Human
IL1B	interleukin 1, beta	0.046
NFKBIE	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon	0.045
TNFRSF9	tumor necrosis factor receptor superfamily, member 9	0.044
IL15RA	interleukin 15 receptor, alpha	0.041
CXCL11	chemokine (C-X-C motif) ligand 11	0.036
HLA-DQA1	major histocompatibility complex, class II, DQ alpha 1	0.036
CTLA4	cytotoxic T-lymphocyte-associated protein 4	0.035
CD40	CD40 molecule, TNF receptor superfamily member 5	0.033
NKX2-5	NK2 transcription factor related, locus 5 (Drosophila)	0.033
IL2RB	interleukin 2 receptor, beta	0.032
IFNG	interferon, gamma	0.031
NR0B1	nuclear receptor subfamily 0, group B, member 1	0.030
LAT	linker for activation of T cells	0.030
SH2D1A	SH2 domain containing 1A	0.029
CCL2	chemokine (C-C motif) ligand 2	0.028	Human
PIK3R1	phosphoinositide-3-kinase, regulatory subunit 1 (alpha)	0.027
IL8	interleukin 8	0.026
IL4	interleukin 4	0.026	Mouse
ABL1	c-abl oncogene 1, non-receptor tyrosine kinase	0.025	Mouse
SIGLEC7	sialic acid binding Ig-like lectin 7	0.025
ZAP70	zeta-chain (TCR) associated protein kinase 70kDa	0.025	Mouse
TRAF3	TNF receptor-associated factor 3	0.024
IL7R	interleukin 7 receptor	0.024
CRKL	v-crk sarcoma virus CT10 oncogene homolog (avian)-like	0.023
CCL8	chemokine (C-C motif) ligand 8	0.023	Human
PTPN22	protein tyrosine phosphatase, non-receptor type 22 (lymphoid)	0.022
CCL22	chemokine (C-C motif) ligand 22	0.021	Human
CREBBP	CREB binding protein	0.021
RUNX1	runt-related transcription factor 1	0.021
LIN9	lin-9 homolog (C. elegans)	0.020
CD86	CD86 molecule	0.020
ZMYND11	zinc finger, MYND-type containing 11	0.020
LILRA1	leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 1	0.019	Human
LILRB1	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1	0.018
NFKBIA	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha	0.018
IL23A	interleukin 23, alpha subunit p19	0.018
LILRB2	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2	0.018	Human
TNFAIP3	tumor necrosis factor, alpha-induced protein 3	0.018
RXRA	retinoid X receptor, alpha	0.018
ITGB1BP3	integrin beta 1 binding protein 3	0.018
PDZD11	PDZ domain containing 11	0.017
CCR1	chemokine (C-C motif) receptor 1	0.017
CD3G	CD3g molecule, gamma (CD3-TCR complex)	0.017
IL10	interleukin 10	0.017
CD80	CD80 molecule	0.017	Mouse
RIPK1	receptor (TNFRSF)-interacting serine-threonine kinase 1	0.016
MED25	mediator complex subunit 25	0.015
SOD2	superoxide dismutase 2, mitochondrial	0.015
SYK	spleen tyrosine kinase	0.014	Mouse
IRF4	interferon regulatory factor 4	0.014	Mouse
TGFB3	transforming growth factor, beta 3	0.013
CSNK1G1	casein kinase 1, gamma 1	0.013
CXCL13	chemokine (C-X-C motif) ligand 13	0.013
CTBP1	C-terminal binding protein 1	0.012
VCAM1	vascular cell adhesion molecule 1	0.012
BCL2A1	BCL2-related protein A1	0.011
CXCR6	chemokine (C-X-C motif) receptor 6	0.011
TRAF3IP3	TRAF3 interacting protein 3	0.011
TBX21	T-box 21	0.011	Human
RUNX3	runt-related transcription factor 3	0.011
IL6	interleukin 6 (interferon, beta 2)	0.011	Mouse
IRF8	interferon regulatory factor 8	0.011
IL6R	interleukin 6 receptor	0.011
DPP4	dipeptidyl-peptidase 4	0.011
TRAF5	TNF receptor-associated factor 5	0.011
PILRA	paired immunoglobin-like type 2 receptor alpha	0.010
GZMB	granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)	0.010
PIK3CA	phosphoinositide-3-kinase, catalytic, alpha polypeptide	0.010
CCL20	chemokine (C-C motif) ligand 20	0.010	Human
CCL13	chemokine (C-C motif) ligand 13	0.010	Human
STAT4	signal transducer and activator of transcription 4	0.010
PDGFRA	platelet-derived growth factor receptor, alpha polypeptide	0.010