IMP

Process View

Homo sapiens

4 genes annotated in human

Multi-species View

negative regulation of gastrulation

GO:2000542

Any process that stops, prevents or reduces the frequency, rate or extent of gastrulation.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "negative regulation of gastrulation"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "negative regulation of gastrulation" (in gray)

Name	Description	Probability	Func Analog Organism
COL1A2	collagen, type I, alpha 2	1.000	Human
COL3A1	collagen, type III, alpha 1	1.000	Human
COL1A1	collagen, type I, alpha 1	1.000	Human
COL4A1	collagen, type IV, alpha 1	0.999
COL5A1	collagen, type V, alpha 1	0.999
PDGFB	platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)	0.998
SPARC	secreted protein, acidic, cysteine-rich (osteonectin)	0.995
COL5A2	collagen, type V, alpha 2	0.992
COL4A2	collagen, type IV, alpha 2	0.967
BMPR1A	bone morphogenetic protein receptor, type IA	0.958
COL6A1	collagen, type VI, alpha 1	0.904
MXRA5	matrix-remodelling associated 5	0.850
FSTL1	follistatin-like 1	0.847
DDR2	discoidin domain receptor tyrosine kinase 2	0.802
PDGFRB	platelet-derived growth factor receptor, beta polypeptide	0.800
POSTN	periostin, osteoblast specific factor	0.793
PDGFRA	platelet-derived growth factor receptor, alpha polypeptide	0.783
NOG	noggin	0.705	Zebrafish
LOX	lysyl oxidase	0.621
CDH11	cadherin 11, type 2, OB-cadherin (osteoblast)	0.597
NID2	nidogen 2 (osteonidogen)	0.584
IGFBP3	insulin-like growth factor binding protein 3	0.577
PXDN	peroxidasin homolog (Drosophila)	0.525
COL6A3	collagen, type VI, alpha 3	0.519
ADAM12	ADAM metallopeptidase domain 12	0.436
BBS10	Bardet-Biedl syndrome 10	0.415
LRP6	low density lipoprotein receptor-related protein 6	0.405
FNDC1	fibronectin type III domain containing 1	0.342
COL11A1	collagen, type XI, alpha 1	0.321	Human
ELN	elastin	0.298
FBN1	fibrillin 1	0.295
BGN	biglycan	0.287
LAMB1	laminin, beta 1	0.264
WNT5A	wingless-type MMTV integration site family, member 5A	0.264
COL16A1	collagen, type XVI, alpha 1	0.256
WNT3A	wingless-type MMTV integration site family, member 3A	0.240
BMP7	bone morphogenetic protein 7	0.227	Zebrafish
FRS2	fibroblast growth factor receptor substrate 2	0.222
MMP2	matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)	0.212
PLXDC1	plexin domain containing 1	0.208
BMP2	bone morphogenetic protein 2	0.205	Zebrafish
SULF1	sulfatase 1	0.204
COL18A1	collagen, type XVIII, alpha 1	0.193
SFRP2	secreted frizzled-related protein 2	0.173	Mouse
FBLN2	fibulin 2	0.170
ANGPTL2	angiopoietin-like 2	0.168
COL6A2	collagen, type VI, alpha 2	0.166
THY1	Thy-1 cell surface antigen	0.152
PDGFA	platelet-derived growth factor alpha polypeptide	0.151
NEDD4	neural precursor cell expressed, developmentally down-regulated 4	0.145
FGF2	fibroblast growth factor 2 (basic)	0.135
LAMC1	laminin, gamma 1 (formerly LAMB2)	0.131
COL5A3	collagen, type V, alpha 3	0.130	Human
CTHRC1	collagen triple helix repeat containing 1	0.121
SMAD1	SMAD family member 1	0.118
SMURF1	SMAD specific E3 ubiquitin protein ligase 1	0.116
LRRC17	leucine rich repeat containing 17	0.116
THBS1	thrombospondin 1	0.115
RPS6KA6	ribosomal protein S6 kinase, 90kDa, polypeptide 6	0.114
NID1	nidogen 1	0.113
COL10A1	collagen, type X, alpha 1	0.110
TNC	tenascin C	0.107
ELF5	E74-like factor 5 (ets domain transcription factor)	0.103
COL12A1	collagen, type XII, alpha 1	0.102
WISP1	WNT1 inducible signaling pathway protein 1	0.101
MDFI	MyoD family inhibitor	0.099
GLT8D2	glycosyltransferase 8 domain containing 2	0.094
ZFYVE9	zinc finger, FYVE domain containing 9	0.093
GPR124	G protein-coupled receptor 124	0.091
NDP	Norrie disease (pseudoglioma)	0.091
FOXF2	forkhead box F2	0.090
ADAMTS2	ADAM metallopeptidase with thrombospondin type 1 motif, 2	0.086
OLFML2B	olfactomedin-like 2B	0.085
MFAP2	microfibrillar-associated protein 2	0.084
COL14A1	collagen, type XIV, alpha 1	0.083
ITGBL1	integrin, beta-like 1 (with EGF-like repeat domains)	0.082
MSX1	msh homeobox 1	0.081
TGFB1I1	transforming growth factor beta 1 induced transcript 1	0.081
MGP	matrix Gla protein	0.079
OLFML3	olfactomedin-like 3	0.079
SFRP4	secreted frizzled-related protein 4	0.072	Human
PLCG1	phospholipase C, gamma 1	0.072
TWIST1	twist homolog 1 (Drosophila)	0.069
ASPN	asporin	0.067
WFIKKN2	WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2	0.063
FKBP10	FK506 binding protein 10, 65 kDa	0.062
DACT1	dapper, antagonist of beta-catenin, homolog 1 (Xenopus laevis)	0.060
COL2A1	collagen, type II, alpha 1	0.059	Human
TGFB3	transforming growth factor, beta 3	0.056
TGFB2	transforming growth factor, beta 2	0.056
COMP	cartilage oligomeric matrix protein	0.056
PCOLCE	procollagen C-endopeptidase enhancer	0.056
FZD7	frizzled homolog 7 (Drosophila)	0.052
CD248	CD248 molecule, endosialin	0.051
MXRA8	matrix-remodelling associated 8	0.051
THBS2	thrombospondin 2	0.048
SNAI2	snail homolog 2 (Drosophila)	0.048
SFRP1	secreted frizzled-related protein 1	0.046
LTBP2	latent transforming growth factor beta binding protein 2	0.045
EDNRA	endothelin receptor type A	0.043
LRRC15	leucine rich repeat containing 15	0.041
TCF7L1	transcription factor 7-like 1 (T-cell specific, HMG-box)	0.039
CD34	CD34 molecule	0.038
PRKCDBP	protein kinase C, delta binding protein	0.038
CTGF	connective tissue growth factor	0.038
PDGFRL	platelet-derived growth factor receptor-like	0.037
NR4A1	nuclear receptor subfamily 4, group A, member 1	0.037
INHBB	inhibin, beta B	0.036
EHF	ets homologous factor	0.035
KDELR3	KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3	0.035
LUM	lumican	0.035
BMP4	bone morphogenetic protein 4	0.034	Zebrafish
MRC2	mannose receptor, C type 2	0.033
HSPG2	heparan sulfate proteoglycan 2	0.033
CXCL12	chemokine (C-X-C motif) ligand 12	0.033
COL8A2	collagen, type VIII, alpha 2	0.032
EGFL6	EGF-like-domain, multiple 6	0.032
IGF1	insulin-like growth factor 1 (somatomedin C)	0.032
TMEM119	transmembrane protein 119	0.032
UNC5B	unc-5 homolog B (C. elegans)	0.031
CNN1	calponin 1, basic, smooth muscle	0.030
SDC2	syndecan 2	0.030
LOXL1	lysyl oxidase-like 1	0.029
GAS1	growth arrest-specific 1	0.029
PPIC	peptidylprolyl isomerase C (cyclophilin C)	0.029
COL7A1	collagen, type VII, alpha 1	0.028
MCAM	melanoma cell adhesion molecule	0.028
FBLN1	fibulin 1	0.028
SOX11	SRY (sex determining region Y)-box 11	0.027
FZD1	frizzled homolog 1 (Drosophila)	0.027	Human
SPON2	spondin 2, extracellular matrix protein	0.026
GPX8	glutathione peroxidase 8 (putative)	0.026
HMCN1	hemicentin 1	0.026
IGFBP5	insulin-like growth factor binding protein 5	0.026
NOSTRIN	nitric oxide synthase trafficker	0.025
FZD8	frizzled homolog 8 (Drosophila)	0.025	Human
ZCCHC24	zinc finger, CCHC domain containing 24	0.025
ADAMTS5	ADAM metallopeptidase with thrombospondin type 1 motif, 5	0.024
COCH	coagulation factor C homolog, cochlin (Limulus polyphemus)	0.023
AEBP1	AE binding protein 1	0.023
FBXL7	F-box and leucine-rich repeat protein 7	0.023
AXL	AXL receptor tyrosine kinase	0.023
ISLR	immunoglobulin superfamily containing leucine-rich repeat	0.023
MN1	meningioma (disrupted in balanced translocation) 1	0.023
LAMA2	laminin, alpha 2	0.023
HYAL1	hyaluronoglucosaminidase 1	0.023
CILP	cartilage intermediate layer protein, nucleotide pyrophosphohydrolase	0.022
LAMB2	laminin, beta 2 (laminin S)	0.022
PRELP	proline/arginine-rich end leucine-rich repeat protein	0.022
ACAN	aggrecan	0.022
CCDC80	coiled-coil domain containing 80	0.022
LTBP1	latent transforming growth factor beta binding protein 1	0.022
CDH5	cadherin 5, type 2 (vascular endothelium)	0.021
COL8A1	collagen, type VIII, alpha 1	0.021
BNC2	basonuclin 2	0.021
VWF	von Willebrand factor	0.021
ROR1	receptor tyrosine kinase-like orphan receptor 1	0.021
PMEPA1	prostate transmembrane protein, androgen induced 1	0.020
OLFML2A	olfactomedin-like 2A	0.020
DUSP1	dual specificity phosphatase 1	0.020
RHOB	ras homolog gene family, member B	0.020
CALD1	caldesmon 1	0.020
GREM1	gremlin 1	0.020
LHFP	lipoma HMGIC fusion partner	0.019
MFAP5	microfibrillar associated protein 5	0.019
FOXF1	forkhead box F1	0.019
TBX2	T-box 2	0.019
CYR61	cysteine-rich, angiogenic inducer, 61	0.019
PRRX1	paired related homeobox 1	0.019
RCN3	reticulocalbin 3, EF-hand calcium binding domain	0.018
EHD2	EH-domain containing 2	0.018
KCNE4	potassium voltage-gated channel, Isk-related family, member 4	0.018
PARVA	parvin, alpha	0.018
GJA1	gap junction protein, alpha 1, 43kDa	0.018
GPC4	glypican 4	0.018
IGDCC4	immunoglobulin superfamily, DCC subclass, member 4	0.018
LEPREL4	leprecan-like 4	0.018
FZD4	frizzled homolog 4 (Drosophila)	0.017	Human
BMPR1B	bone morphogenetic protein receptor, type IB	0.017
ST8SIA2	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2	0.017
FGF18	fibroblast growth factor 18	0.017
NOTCH3	notch 3	0.017
ADRA2A	adrenergic, alpha-2A-, receptor	0.016
LAMA4	laminin, alpha 4	0.016
FZD2	frizzled homolog 2 (Drosophila)	0.016	Human
TRIL	TLR4 interactor with leucine-rich repeats	0.016
RAMP2	receptor (G protein-coupled) activity modifying protein 2	0.016
FAP	fibroblast activation protein, alpha	0.016
ITGA2	integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)	0.016
GNG11	guanine nucleotide binding protein (G protein), gamma 11	0.016
NTM	neurotrimin	0.016
APLNR	apelin receptor	0.016
SLC2A10	solute carrier family 2 (facilitated glucose transporter), member 10	0.015
SCUBE2	signal peptide, CUB domain, EGF-like 2	0.015
HTRA3	HtrA serine peptidase 3	0.015
HIC1	hypermethylated in cancer 1	0.015
COL4A6	collagen, type IV, alpha 6	0.015
SOSTDC1	sclerostin domain containing 1	0.015
PCDH17	protocadherin 17	0.015
CXCL14	chemokine (C-X-C motif) ligand 14	0.015
COL15A1	collagen, type XV, alpha 1	0.015
FOXC1	forkhead box C1	0.015
CRX	cone-rod homeobox	0.015
DIO2	deiodinase, iodothyronine, type II	0.015
SRPX	sushi-repeat containing protein, X-linked	0.015
COL9A2	collagen, type IX, alpha 2	0.015
SEMA3G	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3G	0.015
PRSS23	protease, serine, 23	0.015
RUNX1T1	runt-related transcription factor 1; translocated to, 1 (cyclin D-related)	0.015
SMAD9	SMAD family member 9	0.014
SOX9	SRY (sex determining region Y)-box 9	0.014
WIF1	WNT inhibitory factor 1	0.014
BMPR2	bone morphogenetic protein receptor, type II (serine/threonine kinase)	0.014
INHBA	inhibin, beta A	0.014
NRP1	neuropilin 1	0.014
HOXC6	homeobox C6	0.014
EDN1	endothelin 1	0.014
JAM2	junctional adhesion molecule 2	0.014
CRLF1	cytokine receptor-like factor 1	0.014
S1PR1	sphingosine-1-phosphate receptor 1	0.013
NOS3	nitric oxide synthase 3 (endothelial cell)	0.013
EPHB3	EPH receptor B3	0.013
SIX1	SIX homeobox 1	0.013
NUAK1	NUAK family, SNF1-like kinase, 1	0.013
NFATC4	nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4	0.013
SOX7	SRY (sex determining region Y)-box 7	0.013
FZD10	frizzled homolog 10 (Drosophila)	0.013	Human
LAT	linker for activation of T cells	0.013
ZNF423	zinc finger protein 423	0.013
VEGFC	vascular endothelial growth factor C	0.013
TMEM45A	transmembrane protein 45A	0.013
COLEC12	collectin sub-family member 12	0.013
MATN2	matrilin 2	0.013
LAMA5	laminin, alpha 5	0.013
OGN	osteoglycin	0.013
MYO1B	myosin IB	0.013
GPC3	glypican 3	0.013
KCNJ8	potassium inwardly-rectifying channel, subfamily J, member 8	0.013
FST	follistatin	0.013
COL9A1	collagen, type IX, alpha 1	0.013
ID4	inhibitor of DNA binding 4, dominant negative helix-loop-helix protein	0.012
BAMBI	BMP and activin membrane-bound inhibitor homolog (Xenopus laevis)	0.012
PTHLH	parathyroid hormone-like hormone	0.012
ANGPT1	angiopoietin 1	0.012
FKBP9	FK506 binding protein 9, 63 kDa	0.012
KAL1	Kallmann syndrome 1 sequence	0.012
ROBO1	roundabout, axon guidance receptor, homolog 1 (Drosophila)	0.012
GLI3	GLI family zinc finger 3	0.012
ODZ4	odz, odd Oz/ten-m homolog 4 (Drosophila)	0.012
VASN	vasorin	0.012
ITIH5	inter-alpha (globulin) inhibitor H5	0.012
NXN	nucleoredoxin	0.012
GATA5	GATA binding protein 5	0.012
ING2	inhibitor of growth family, member 2	0.012
RASL12	RAS-like, family 12	0.012
DCHS1	dachsous 1 (Drosophila)	0.012
PTK7	PTK7 protein tyrosine kinase 7	0.012
FOXD1	forkhead box D1	0.012
COL13A1	collagen, type XIII, alpha 1	0.012
WNT2	wingless-type MMTV integration site family member 2	0.012
SHROOM2	shroom family member 2	0.012
HEY1	hairy/enhancer-of-split related with YRPW motif 1	0.011
COL21A1	collagen, type XXI, alpha 1	0.011
CDKN2B	cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)	0.011
MOXD1	monooxygenase, DBH-like 1	0.011
FAT1	FAT tumor suppressor homolog 1 (Drosophila)	0.011
AMOTL2	angiomotin like 2	0.011
VCAN	versican	0.011
PAMR1	peptidase domain containing associated with muscle regeneration 1	0.011
DKK3	dickkopf homolog 3 (Xenopus laevis)	0.011
LOXL2	lysyl oxidase-like 2	0.011
MYLK	myosin light chain kinase	0.011
TRPC6	transient receptor potential cation channel, subfamily C, member 6	0.011
CFHR1	complement factor H-related 1	0.011
MFAP4	microfibrillar-associated protein 4	0.011
NPTX2	neuronal pentraxin II	0.011
CAPN6	calpain 6	0.011
C5orf13	chromosome 5 open reading frame 13	0.011
FLRT2	fibronectin leucine rich transmembrane protein 2	0.011
TNFSF11	tumor necrosis factor (ligand) superfamily, member 11	0.011
FN1	fibronectin 1	0.011
SULF2	sulfatase 2	0.011
OLFML1	olfactomedin-like 1	0.011
SOX17	SRY (sex determining region Y)-box 17	0.011	Mouse
PDGFC	platelet derived growth factor C	0.011
PRRX2	paired related homeobox 2	0.011
GXYLT2	glucoside xylosyltransferase 2	0.011
ITGA8	integrin, alpha 8	0.011
FGFR3	fibroblast growth factor receptor 3	0.011
SIM2	single-minded homolog 2 (Drosophila)	0.011
PTGIS	prostaglandin I2 (prostacyclin) synthase	0.011
HOXD1	homeobox D1	0.011
FBXL15	F-box and leucine-rich repeat protein 15	0.011
MMRN2	multimerin 2	0.011
SHOX2	short stature homeobox 2	0.011
CSPG4	chondroitin sulfate proteoglycan 4	0.011
PERP	PERP, TP53 apoptosis effector	0.011
GRB7	growth factor receptor-bound protein 7	0.011
GATA6	GATA binding protein 6	0.011
WNT11	wingless-type MMTV integration site family, member 11	0.011
FMO1	flavin containing monooxygenase 1	0.011
GLI2	GLI family zinc finger 2	0.010
FOXO1	forkhead box O1	0.010
RARRES2	retinoic acid receptor responder (tazarotene induced) 2	0.010
NES	nestin	0.010
ID3	inhibitor of DNA binding 3, dominant negative helix-loop-helix protein	0.010
SIX2	SIX homeobox 2	0.010
HTRA1	HtrA serine peptidase 1	0.010
DCN	decorin	0.010
EFNB2	ephrin-B2	0.010
PLOD2	procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2	0.010
AR	androgen receptor	0.010
CXCR7	chemokine (C-X-C motif) receptor 7	0.010
BICC1	bicaudal C homolog 1 (Drosophila)	0.010