IMP

Process View

Homo sapiens

4 genes annotated in human

protein autoprocessing

Processing which a protein carries out itself. This involves actions such as the autolytic removal of residues to generate the mature form of the protein.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "protein autoprocessing"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "protein autoprocessing" (in gray)

Name	Description	Probability	Func Analog Organism
SERPINE1	serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1	0.988
NLRC4	NLR family, CARD domain containing 4	0.902
PTPN1	protein tyrosine phosphatase, non-receptor type 1	0.780
XRCC5	X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)	0.699
CAPNS1	calpain, small subunit 1	0.579
CRADD	CASP2 and RIPK1 domain containing adaptor with death domain	0.532
MET	met proto-oncogene (hepatocyte growth factor receptor)	0.404
PRKDC	protein kinase, DNA-activated, catalytic polypeptide	0.369
STAT3	signal transducer and activator of transcription 3 (acute-phase response factor)	0.245
PLAUR	plasminogen activator, urokinase receptor	0.209
WRN	Werner syndrome, RecQ helicase-like	0.158
PLAT	plasminogen activator, tissue	0.154	Human
CARD16	caspase recruitment domain family, member 16	0.128
PIAS4	protein inhibitor of activated STAT, 4	0.117
RIPK2	receptor-interacting serine-threonine kinase 2	0.116
PLAU	plasminogen activator, urokinase	0.112	Human
IFI16	interferon, gamma-inducible protein 16	0.108
APOH	apolipoprotein H (beta-2-glycoprotein I)	0.106
LRDD	leucine-rich repeats and death domain containing	0.099
TADA3	transcriptional adaptor 3	0.079
APLF	aprataxin and PNKP like factor	0.060
CASP8	caspase 8, apoptosis-related cysteine peptidase	0.058
GBP2	guanylate binding protein 2, interferon-inducible	0.058
SP100	SP100 nuclear antigen	0.041
APTX	aprataxin	0.041
LDLR	low density lipoprotein receptor	0.040
ELF4	E74-like factor 4 (ets domain transcription factor)	0.040
IL18	interleukin 18 (interferon-gamma-inducing factor)	0.039
MTHFD1L	methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like	0.036
XRCC6	X-ray repair complementing defective repair in Chinese hamster cells 6	0.034
UBE2I	ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)	0.034
ELF3	E74-like factor 3 (ets domain transcription factor, epithelial-specific )	0.033
RAI1	retinoic acid induced 1	0.032
HDAC1	histone deacetylase 1	0.032
NMT1	N-myristoyltransferase 1	0.031
CASP10	caspase 10, apoptosis-related cysteine peptidase	0.029
TLR1	toll-like receptor 1	0.028
HNRNPL	heterogeneous nuclear ribonucleoprotein L	0.027
KNG1	kininogen 1	0.027
UNG	uracil-DNA glycosylase	0.026
VTN	vitronectin	0.025
KYNU	kynureninase	0.025
ORM1	orosomucoid 1	0.024
BCL2A1	BCL2-related protein A1	0.024
FUT6	fucosyltransferase 6 (alpha (1,3) fucosyltransferase)	0.023
AMT	aminomethyltransferase	0.022
CD44	CD44 molecule (Indian blood group)	0.022
PYCARD	PYD and CARD domain containing	0.022
CAST	calpastatin	0.021
ANXA2	annexin A2	0.021
SERPINF2	serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2	0.020
PICK1	protein interacting with PRKCA 1	0.020
HDGF	hepatoma-derived growth factor	0.020
WFDC2	WAP four-disulfide core domain 2	0.019
PIAS2	protein inhibitor of activated STAT, 2	0.019
TNFSF13B	tumor necrosis factor (ligand) superfamily, member 13b	0.019
IL1A	interleukin 1, alpha	0.018
CLEC2B	C-type lectin domain family 2, member B	0.018
NOD2	nucleotide-binding oligomerization domain containing 2	0.018
MUC4	mucin 4, cell surface associated	0.018
BIRC3	baculoviral IAP repeat containing 3	0.018
HIPK2	homeodomain interacting protein kinase 2	0.018
CARD6	caspase recruitment domain family, member 6	0.017
FAS	Fas (TNF receptor superfamily, member 6)	0.017
GOT2	glutamic-oxaloacetic transaminase 2, mitochondrial (aspartate aminotransferase 2)	0.017
ITGA5	integrin, alpha 5 (fibronectin receptor, alpha polypeptide)	0.017
TRIM22	tripartite motif containing 22	0.017
SERPINC1	serpin peptidase inhibitor, clade C (antithrombin), member 1	0.017
LIG3	ligase III, DNA, ATP-dependent	0.017
SQRDL	sulfide quinone reductase-like (yeast)	0.016
APAF1	apoptotic peptidase activating factor 1	0.016
GCGR	glucagon receptor	0.016
TFR2	transferrin receptor 2	0.016
TMPRSS11D	transmembrane protease, serine 11D	0.015
PIGR	polymeric immunoglobulin receptor	0.015
EMP1	epithelial membrane protein 1	0.015
IL1B	interleukin 1, beta	0.015
C4BPB	complement component 4 binding protein, beta	0.015
CHD1L	chromodomain helicase DNA binding protein 1-like	0.015
GBP1	guanylate binding protein 1, interferon-inducible	0.015
MLKL	mixed lineage kinase domain-like	0.014
CRP	C-reactive protein, pentraxin-related	0.014
GJB1	gap junction protein, beta 1, 32kDa	0.014
SAMD9L	sterile alpha motif domain containing 9-like	0.014
USF1	upstream transcription factor 1	0.014
ERG	v-ets erythroblastosis virus E26 oncogene homolog (avian)	0.014
PLG	plasminogen	0.013	Human
CTSS	cathepsin S	0.013
CTSC	cathepsin C	0.013
RSAD2	radical S-adenosyl methionine domain containing 2	0.013
PRR15L	proline rich 15-like	0.013
RDH16	retinol dehydrogenase 16 (all-trans)	0.013
TNS1	tensin 1	0.013
HABP2	hyaluronan binding protein 2	0.013	Human
SKP2	S-phase kinase-associated protein 2 (p45)	0.012
PROZ	protein Z, vitamin K-dependent plasma glycoprotein	0.012
CPN1	carboxypeptidase N, polypeptide 1	0.012
VIL1	villin 1	0.012
APOB	apolipoprotein B (including Ag(x) antigen)	0.012
GNA15	guanine nucleotide binding protein (G protein), alpha 15 (Gq class)	0.012
GLP1R	glucagon-like peptide 1 receptor	0.012
SERPINB2	serpin peptidase inhibitor, clade B (ovalbumin), member 2	0.012
SAA4	serum amyloid A4, constitutive	0.012
AMBP	alpha-1-microglobulin/bikunin precursor	0.012
AXL	AXL receptor tyrosine kinase	0.012
CAPN2	calpain 2, (m/II) large subunit	0.012	Rat
RAB17	RAB17, member RAS oncogene family	0.012
TFF3	trefoil factor 3 (intestinal)	0.012
XDH	xanthine dehydrogenase	0.012
SERPINA10	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10	0.012
DAXX	death-domain associated protein	0.012
SUMO4	SMT3 suppressor of mif two 3 homolog 4 (S. cerevisiae)	0.011
XIAP	X-linked inhibitor of apoptosis	0.011
IL15	interleukin 15	0.011
APOL6	apolipoprotein L, 6	0.011
GBA3	glucosidase, beta, acid 3 (cytosolic)	0.011
MCPH1	microcephalin 1	0.011
SORD	sorbitol dehydrogenase	0.011
EVI2A	ecotropic viral integration site 2A	0.011
METTL13	methyltransferase like 13	0.011
FGB	fibrinogen beta chain	0.011
SMAD7	SMAD family member 7	0.011
GLRX	glutaredoxin (thioltransferase)	0.011
APEX1	APEX nuclease (multifunctional DNA repair enzyme) 1	0.011
GLIPR1	GLI pathogenesis-related 1	0.011
MYST1	MYST histone acetyltransferase 1	0.011
NLRP2	NLR family, pyrin domain containing 2	0.011
TRIM38	tripartite motif containing 38	0.011
S100A10	S100 calcium binding protein A10	0.011
LY96	lymphocyte antigen 96	0.011
TM4SF4	transmembrane 4 L six family member 4	0.010
MYOF	myoferlin	0.010
SPP2	secreted phosphoprotein 2, 24kDa	0.010
TNFSF10	tumor necrosis factor (ligand) superfamily, member 10	0.010
CASP9	caspase 9, apoptosis-related cysteine peptidase	0.010
CDHR2	cadherin-related family member 2	0.010
SLC4A1	solute carrier family 4, anion exchanger, member 1 (erythrocyte membrane protein band 3, Diego blood group)	0.010
HPN	hepsin	0.010	Human
SERPINA6	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6	0.010
SERPINA5	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5	0.010
PDGFC	platelet derived growth factor C	0.010
OSMR	oncostatin M receptor	0.010
SLC25A15	solute carrier family 25 (mitochondrial carrier; ornithine transporter) member 15	0.010
APOL3	apolipoprotein L, 3	0.010
PLAC8	placenta-specific 8	0.010
IGFALS	insulin-like growth factor binding protein, acid labile subunit	0.010
SRPX	sushi-repeat containing protein, X-linked	0.010
GCKR	glucokinase (hexokinase 4) regulator	0.010
CASP3	caspase 3, apoptosis-related cysteine peptidase	0.010
SERPINE2	serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2	0.010
C8G	complement component 8, gamma polypeptide	0.010
CYP4A11	cytochrome P450, family 4, subfamily A, polypeptide 11	0.010