IMP

Process View

Homo sapiens

22 genes annotated in human

negative regulation of cell projection organization

Any process that stops, prevents, or reduces the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell projections.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "negative regulation of cell projection organization"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "negative regulation of cell projection organization" (in gray)

Name	Description	Probability	Func Analog Organism
HDAC2	histone deacetylase 2	0.901	Mouse Fly
HDAC1	histone deacetylase 1	0.541	Fly
FGFR1	fibroblast growth factor receptor 1	0.460	Fly
FGF1	fibroblast growth factor 1 (acidic)	0.354	Worm
NEDD4	neural precursor cell expressed, developmentally down-regulated 4	0.285
PSEN2	presenilin 2 (Alzheimer disease 4)	0.247
ARHGDIB	Rho GDP dissociation inhibitor (GDI) beta	0.195
ATG13	ATG13 autophagy related 13 homolog (S. cerevisiae)	0.185
GABARAPL1	GABA(A) receptor-associated protein like 1	0.180
CDC42	cell division cycle 42 (GTP binding protein, 25kDa)	0.139
FYN	FYN oncogene related to SRC, FGR, YES	0.123
PRKAR1A	protein kinase, cAMP-dependent, regulatory, type I, alpha (tissue specific extinguisher 1)	0.116
CHDH	choline dehydrogenase	0.113
A2M	alpha-2-macroglobulin	0.102
FLNB	filamin B, beta	0.102
PTPN13	protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase)	0.093
GOLGB1	golgin B1	0.081
LRP6	low density lipoprotein receptor-related protein 6	0.076
SPG21	spastic paraplegia 21 (autosomal recessive, Mast syndrome)	0.075
GOLGA2	golgin A2	0.071
SQSTM1	sequestosome 1	0.069
TGFBR2	transforming growth factor, beta receptor II (70/80kDa)	0.067
ERBB3	v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)	0.067
NCF1	neutrophil cytosolic factor 1	0.064
SETDB1	SET domain, bifurcated 1	0.062
GRB7	growth factor receptor-bound protein 7	0.062
APOC1	apolipoprotein C-I	0.059
TMSB4X	thymosin beta 4, X-linked	0.054
NCOA1	nuclear receptor coactivator 1	0.050
ATN1	atrophin 1	0.050
HP	haptoglobin	0.049
CPE	carboxypeptidase E	0.049
BAIAP2	BAI1-associated protein 2	0.049
C17orf28	chromosome 17 open reading frame 28	0.047
RB1CC1	RB1-inducible coiled-coil 1	0.047
SIN3A	SIN3 homolog A, transcription regulator (yeast)	0.046
CREBBP	CREB binding protein	0.046
NDEL1	nudE nuclear distribution gene E homolog (A. nidulans)-like 1	0.044
PXN	paxillin	0.044
EPOR	erythropoietin receptor	0.044
FGFR3	fibroblast growth factor receptor 3	0.043	Fly
BCAR1	breast cancer anti-estrogen resistance 1	0.043
FGF10	fibroblast growth factor 10	0.042
VEGFA	vascular endothelial growth factor A	0.040
KDR	kinase insert domain receptor (a type III receptor tyrosine kinase)	0.039
APPL1	adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1	0.039
CHD3	chromodomain helicase DNA binding protein 3	0.039
FGFR2	fibroblast growth factor receptor 2	0.037	Fly
ZYX	zyxin	0.036
EGFR	epidermal growth factor receptor	0.035
TEX11	testis expressed 11	0.033
MMP14	matrix metallopeptidase 14 (membrane-inserted)	0.033
RAB2A	RAB2A, member RAS oncogene family	0.032
ALK	anaplastic lymphoma receptor tyrosine kinase	0.032
ST13	suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein)	0.032
CAV1	caveolin 1, caveolae protein, 22kDa	0.030
FAM118B	family with sequence similarity 118, member B	0.030
CYFIP2	cytoplasmic FMR1 interacting protein 2	0.030
GNAI2	guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2	0.030
CALR	calreticulin	0.029
TWF2	twinfilin, actin-binding protein, homolog 2 (Drosophila)	0.029
LAPTM4A	lysosomal protein transmembrane 4 alpha	0.029
FAT1	FAT tumor suppressor homolog 1 (Drosophila)	0.029
CTGF	connective tissue growth factor	0.028
RAP1A	RAP1A, member of RAS oncogene family	0.027
NPTN	neuroplastin	0.026
FAM20C	family with sequence similarity 20, member C	0.026
CDH5	cadherin 5, type 2 (vascular endothelium)	0.026
JAM2	junctional adhesion molecule 2	0.026
CCDC85A	coiled-coil domain containing 85A	0.026
UBR5	ubiquitin protein ligase E3 component n-recognin 5	0.026
WASL	Wiskott-Aldrich syndrome-like	0.025
NGFR	nerve growth factor receptor	0.025	Rat
PLEKHF2	pleckstrin homology domain containing, family F (with FYVE domain) member 2	0.025
RNF11	ring finger protein 11	0.025
JAM3	junctional adhesion molecule 3	0.023
CDK5	cyclin-dependent kinase 5	0.023	Mouse
SORBS1	sorbin and SH3 domain containing 1	0.023
APOC3	apolipoprotein C-III	0.023
DLG5	discs, large homolog 5 (Drosophila)	0.023
INPP5D	inositol polyphosphate-5-phosphatase, 145kDa	0.023
MAGI2	membrane associated guanylate kinase, WW and PDZ domain containing 2	0.023
CUL7	cullin 7	0.023
PKN2	protein kinase N2	0.023
SORBS3	sorbin and SH3 domain containing 3	0.022
GANAB	glucosidase, alpha; neutral AB	0.022
ITGA5	integrin, alpha 5 (fibronectin receptor, alpha polypeptide)	0.022
FN1	fibronectin 1	0.021
STBD1	starch binding domain 1	0.021
PTK2B	PTK2B protein tyrosine kinase 2 beta	0.021
CDC27	cell division cycle 27 homolog (S. cerevisiae)	0.021
COL4A3BP	collagen, type IV, alpha 3 (Goodpasture antigen) binding protein	0.021
APP	amyloid beta (A4) precursor protein	0.021
FZD1	frizzled homolog 1 (Drosophila)	0.021
TSC22D4	TSC22 domain family, member 4	0.020
FGA	fibrinogen alpha chain	0.020
TGFB1	transforming growth factor, beta 1	0.020
RABGAP1	RAB GTPase activating protein 1	0.020	Human
STMN2	stathmin-like 2	0.020
RXRA	retinoid X receptor, alpha	0.020
F11R	F11 receptor	0.019
MAPK6	mitogen-activated protein kinase 6	0.019
CDK5R1	cyclin-dependent kinase 5, regulatory subunit 1 (p35)	0.019	Mouse
HLA-DPA1	major histocompatibility complex, class II, DP alpha 1	0.019
ARPC2	actin related protein 2/3 complex, subunit 2, 34kDa	0.019
TGFB3	transforming growth factor, beta 3	0.018
SPOP	speckle-type POZ protein	0.018
UBE2D1	ubiquitin-conjugating enzyme E2D 1 (UBC4/5 homolog, yeast)	0.018
RABGAP1L	RAB GTPase activating protein 1-like	0.018	Human
CDCP1	CUB domain containing protein 1	0.018
KIAA0408	KIAA0408	0.017
WASF1	WAS protein family, member 1	0.017
CDH1	cadherin 1, type 1, E-cadherin (epithelial)	0.017
PRKD2	protein kinase D2	0.017
TNK2	tyrosine kinase, non-receptor, 2	0.017
CXCR4	chemokine (C-X-C motif) receptor 4	0.017
GNB1	guanine nucleotide binding protein (G protein), beta polypeptide 1	0.017
MAP1S	microtubule-associated protein 1S	0.016
PLCB3	phospholipase C, beta 3 (phosphatidylinositol-specific)	0.016
SMAD2	SMAD family member 2	0.016
TJP1	tight junction protein 1 (zona occludens 1)	0.016
DDX3X	DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, X-linked	0.016
CYFIP1	cytoplasmic FMR1 interacting protein 1	0.016
FAM160A2	family with sequence similarity 160, member A2	0.015
CTNNA1	catenin (cadherin-associated protein), alpha 1, 102kDa	0.015
JAG2	jagged 2	0.015
RDH11	retinol dehydrogenase 11 (all-trans/9-cis/11-cis)	0.015
CLIP1	CAP-GLY domain containing linker protein 1	0.015
RTN4	reticulon 4	0.015
ING5	inhibitor of growth family, member 5	0.015
NELL2	NEL-like 2 (chicken)	0.015
RPS6KA1	ribosomal protein S6 kinase, 90kDa, polypeptide 1	0.015
RTN3	reticulon 3	0.014	Human
LCMT1	leucine carboxyl methyltransferase 1	0.014
JAK3	Janus kinase 3	0.014
PDGFRA	platelet-derived growth factor receptor, alpha polypeptide	0.014
PKP4	plakophilin 4	0.014
ATP6AP2	ATPase, H+ transporting, lysosomal accessory protein 2	0.014
TTC19	tetratricopeptide repeat domain 19	0.014
SRGAP2	SLIT-ROBO Rho GTPase activating protein 2	0.014
TBL1XR1	transducin (beta)-like 1 X-linked receptor 1	0.014
DCTN1	dynactin 1	0.013
CRMP1	collapsin response mediator protein 1	0.013
TTR	transthyretin	0.013
PRKCI	protein kinase C, iota	0.013
PRKCZ	protein kinase C, zeta	0.013
CDK6	cyclin-dependent kinase 6	0.013
TSC22D1	TSC22 domain family, member 1	0.013
CDH11	cadherin 11, type 2, OB-cadherin (osteoblast)	0.013
NR4A1	nuclear receptor subfamily 4, group A, member 1	0.013
BCL2L1	BCL2-like 1	0.013
APOA2	apolipoprotein A-II	0.013
AGRN	agrin	0.013
RUNDC3A	RUN domain containing 3A	0.013
FHL2	four and a half LIM domains 2	0.012
MYO6	myosin VI	0.012
TAF1D	TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa	0.012
CEP70	centrosomal protein 70kDa	0.012
PLAU	plasminogen activator, urokinase	0.012
ARL4D	ADP-ribosylation factor-like 4D	0.012
FBLN1	fibulin 1	0.012
PPP1CB	protein phosphatase 1, catalytic subunit, beta isozyme	0.012
GATAD2B	GATA zinc finger domain containing 2B	0.012
ECSIT	ECSIT homolog (Drosophila)	0.012
KCTD4	potassium channel tetramerisation domain containing 4	0.012
NUDT18	nudix (nucleoside diphosphate linked moiety X)-type motif 18	0.012
KIAA1217	KIAA1217	0.012
CALCOCO2	calcium binding and coiled-coil domain 2	0.012
WBP2	WW domain binding protein 2	0.012
GPRASP2	G protein-coupled receptor associated sorting protein 2	0.012
MBD1	methyl-CpG binding domain protein 1	0.012
ATG4B	ATG4 autophagy related 4 homolog B (S. cerevisiae)	0.012
FRS2	fibroblast growth factor receptor substrate 2	0.012
SALL2	sal-like 2 (Drosophila)	0.011
CCND2	cyclin D2	0.011
NOSTRIN	nitric oxide synthase trafficker	0.011
COL5A1	collagen, type V, alpha 1	0.011
LTBP2	latent transforming growth factor beta binding protein 2	0.011
PDLIM5	PDZ and LIM domain 5	0.011
LCAT	lecithin-cholesterol acyltransferase	0.011
TNFRSF10C	tumor necrosis factor receptor superfamily, member 10c, decoy without an intracellular domain	0.011
MSN	moesin	0.011
KCNRG	potassium channel regulator	0.011
CHRD	chordin	0.011
POM121	POM121 membrane glycoprotein	0.011
TGFBR1	transforming growth factor, beta receptor 1	0.011
CTNNB1	catenin (cadherin-associated protein), beta 1, 88kDa	0.011
BEGAIN	brain-enriched guanylate kinase-associated homolog (rat)	0.011
DEF6	differentially expressed in FDCP 6 homolog (mouse)	0.011
KDELR1	KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1	0.011
NEDD4L	neural precursor cell expressed, developmentally down-regulated 4-like	0.011
FGF7	fibroblast growth factor 7	0.011
NCSTN	nicastrin	0.011
FGF2	fibroblast growth factor 2 (basic)	0.010	Worm
TCF4	transcription factor 4	0.010
FLRT2	fibronectin leucine rich transmembrane protein 2	0.010
HSPG2	heparan sulfate proteoglycan 2	0.010
EFNB2	ephrin-B2	0.010
RBBP4	retinoblastoma binding protein 4	0.010
PTPN5	protein tyrosine phosphatase, non-receptor type 5 (striatum-enriched)	0.010
RAB14	RAB14, member RAS oncogene family	0.010
GJA1	gap junction protein, alpha 1, 43kDa	0.010
JUB	jub, ajuba homolog (Xenopus laevis)	0.010
PFN1	profilin 1	0.010	Human
TMED2	transmembrane emp24 domain trafficking protein 2	0.010
TIAM1	T-cell lymphoma invasion and metastasis 1	0.010
PTEN	phosphatase and tensin homolog	0.010	Mouse Fly
BCL11B	B-cell CLL/lymphoma 11B (zinc finger protein)	0.010	Human
TGFB2	transforming growth factor, beta 2	0.010
VPS26A	vacuolar protein sorting 26 homolog A (S. pombe)	0.010
RAB5A	RAB5A, member RAS oncogene family	0.010
MAGI3	membrane associated guanylate kinase, WW and PDZ domain containing 3	0.010
TES	testis derived transcript (3 LIM domains)	0.010
NGF	nerve growth factor (beta polypeptide)	0.010