IMP

Process View

Homo sapiens

17 genes annotated in human

positive regulation of mitochondrial membrane permeability

Any process that increases the frequency, rate or extent of the passage or uptake of molecules by the mitochondrial membrane.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "positive regulation of mitochondrial membrane permeability"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "positive regulation of mitochondrial membrane permeability" (in gray)

Name	Description	Probability	Func Analog Organism
BCL2	B-cell CLL/lymphoma 2	0.985
BCL2L11	BCL2-like 11 (apoptosis facilitator)	0.980	Mouse
MCL1	myeloid cell leukemia sequence 1 (BCL2-related)	0.957
JUN	jun proto-oncogene	0.923	Human
BNIP3	BCL2/adenovirus E1B 19kDa interacting protein 3	0.859
BAK1	BCL2-antagonist/killer 1	0.843
BAX	BCL2-associated X protein	0.826	Mouse
BCL2L1	BCL2-like 1	0.815
FOS	FBJ murine osteosarcoma viral oncogene homolog	0.712
BAD	BCL2-associated agonist of cell death	0.572
BNIP3L	BCL2/adenovirus E1B 19kDa interacting protein 3-like	0.413	Human
PMAIP1	phorbol-12-myristate-13-acetate-induced protein 1	0.300	Mouse
BECN1	beclin 1, autophagy related	0.184
GADD45A	growth arrest and DNA-damage-inducible, alpha	0.182
ATF3	activating transcription factor 3	0.163
JUNB	jun B proto-oncogene	0.158	Human
PPP2R5B	protein phosphatase 2, regulatory subunit B', beta	0.149
IER2	immediate early response 2	0.143
BIK	BCL2-interacting killer (apoptosis-inducing)	0.134
BID	BH3 interacting domain death agonist	0.130	Mouse
MAPK8	mitogen-activated protein kinase 8	0.097
TP53BP2	tumor protein p53 binding protein, 2	0.093
BBC3	BCL2 binding component 3	0.092
DTNBP1	dystrobrevin binding protein 1	0.092
FKBP8	FK506 binding protein 8, 38kDa	0.090
JUND	jun D proto-oncogene	0.078	Human
SLC25A3	solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 3	0.064
JDP2	Jun dimerization protein 2	0.054
AMBRA1	autophagy/beclin-1 regulator 1	0.053
BLOC1S3	biogenesis of lysosomal organelles complex-1, subunit 3	0.052
PLDN	pallidin homolog (mouse)	0.051
ZFP36	zinc finger protein 36, C3H type, homolog (mouse)	0.049
MUTED	muted homolog (mouse)	0.042
OCIAD1	OCIA domain containing 1	0.040
PPP1R15A	protein phosphatase 1, regulatory (inhibitor) subunit 15A	0.037
SNAPIN	SNAP-associated protein	0.036
MDM4	Mdm4 p53 binding protein homolog (mouse)	0.034
HUWE1	HECT, UBA and WWE domain containing 1	0.034
TMEM11	transmembrane protein 11	0.032
FOSL1	FOS-like antigen 1	0.030
ACAT1	acetyl-CoA acetyltransferase 1	0.030
RDH11	retinol dehydrogenase 11 (all-trans/9-cis/11-cis)	0.029
RELA	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	0.025
ZHX1	zinc fingers and homeoboxes 1	0.024
DEAF1	deformed epidermal autoregulatory factor 1 (Drosophila)	0.024
MS4A7	membrane-spanning 4-domains, subfamily A, member 7	0.022
AXIN1	axin 1	0.022
DUSP1	dual specificity phosphatase 1	0.021
ING2	inhibitor of growth family, member 2	0.021
GNB5	guanine nucleotide binding protein (G protein), beta 5	0.021
NBR1	neighbor of BRCA1 gene 1	0.020
PPIA	peptidylprolyl isomerase A (cyclophilin A)	0.020
ALDH2	aldehyde dehydrogenase 2 family (mitochondrial)	0.020
VDAC2	voltage-dependent anion channel 2	0.019
PDCD6	programmed cell death 6	0.018
BLOC1S1	biogenesis of lysosomal organelles complex-1, subunit 1	0.018
FOSB	FBJ murine osteosarcoma viral oncogene homolog B	0.018
ETS2	v-ets erythroblastosis virus E26 oncogene homolog 2 (avian)	0.018
GBP2	guanylate binding protein 2, interferon-inducible	0.018
BCL3	B-cell CLL/lymphoma 3	0.017
MAPK14	mitogen-activated protein kinase 14	0.017
BHLHE40	basic helix-loop-helix family, member e40	0.017
ATG4B	ATG4 autophagy related 4 homolog B (S. cerevisiae)	0.016
RNF144B	ring finger protein 144B	0.016
OXA1L	oxidase (cytochrome c) assembly 1-like	0.016
ROBO2	roundabout, axon guidance receptor, homolog 2 (Drosophila)	0.015
CLU	clusterin	0.015
ZFYVE1	zinc finger, FYVE domain containing 1	0.015
BCL2L2	BCL2-like 2	0.014
WT1	Wilms tumor 1	0.014
PPP2CA	protein phosphatase 2, catalytic subunit, alpha isozyme	0.014
PSEN2	presenilin 2 (Alzheimer disease 4)	0.014
TELO2	TEL2, telomere maintenance 2, homolog (S. cerevisiae)	0.014
QARS	glutaminyl-tRNA synthetase	0.014
E4F1	E4F transcription factor 1	0.014
HADHA	hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit	0.014
CDK10	cyclin-dependent kinase 10	0.014
UBE2I	ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)	0.014
GAPDH	glyceraldehyde-3-phosphate dehydrogenase	0.013
IRF3	interferon regulatory factor 3	0.013
SIX1	SIX homeobox 1	0.013
DDIT3	DNA-damage-inducible transcript 3	0.013
SPNS1	spinster homolog 1 (Drosophila)	0.012
RNR2	l-rRNA	0.012
NDUFA4L2	NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2	0.012
ATF4	activating transcription factor 4 (tax-responsive enhancer element B67)	0.012
IRF2BP1	interferon regulatory factor 2 binding protein 1	0.012
MAFF	v-maf musculoaponeurotic fibrosarcoma oncogene homolog F (avian)	0.012
ATP5A1	ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle	0.012
RHOA	ras homolog gene family, member A	0.011
SDHB	succinate dehydrogenase complex, subunit B, iron sulfur (Ip)	0.011
IER5	immediate early response 5	0.011
HDAC6	histone deacetylase 6	0.011
NAF1	nuclear assembly factor 1 homolog (S. cerevisiae)	0.010