IMP

Process View

Homo sapiens

27 genes annotated in human

tumor necrosis factor mediated signaling pathway

A series of molecular signals initiated by the binding of a tumor necrosis factor to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "tumor necrosis factor mediated signaling pathway"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "tumor necrosis factor mediated signaling pathway" (in gray)

Name	Description	Probability	Func Analog Organism
BCAR1	breast cancer anti-estrogen resistance 1	0.898
PTPN1	protein tyrosine phosphatase, non-receptor type 1	0.808
TRADD	TNFRSF1A-associated via death domain	0.744
C1QA	complement component 1, q subcomponent, A chain	0.488	Human
CFLAR	CASP8 and FADD-like apoptosis regulator	0.463
ZNF43	zinc finger protein 43	0.457
TRAF1	TNF receptor-associated factor 1	0.302	Human
TRAF2	TNF receptor-associated factor 2	0.294
CASP8	caspase 8, apoptosis-related cysteine peptidase	0.159
ZNF253	zinc finger protein 253	0.149
TRAF5	TNF receptor-associated factor 5	0.134	Human
INADL	InaD-like (Drosophila)	0.131
STAT1	signal transducer and activator of transcription 1, 91kDa	0.124
STAT3	signal transducer and activator of transcription 3 (acute-phase response factor)	0.122	Human
IL4R	interleukin 4 receptor	0.115
TNFRSF14	tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator)	0.112	Human
TRAF3	TNF receptor-associated factor 3	0.111
TRAF6	TNF receptor-associated factor 6	0.110	Human
JAK2	Janus kinase 2	0.094
CAV1	caveolin 1, caveolae protein, 22kDa	0.094
RIPK1	receptor (TNFRSF)-interacting serine-threonine kinase 1	0.087
IFNAR2	interferon (alpha, beta and omega) receptor 2	0.075
ZNF273	zinc finger protein 273	0.072	Human
CD40	CD40 molecule, TNF receptor superfamily member 5	0.071	Human
ZNF85	zinc finger protein 85	0.071	Human
IRAK1	interleukin-1 receptor-associated kinase 1	0.068
C1QC	complement component 1, q subcomponent, C chain	0.064	Human
SRC	v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)	0.064
ZNF675	zinc finger protein 675	0.064
HP	haptoglobin	0.063
SOCS3	suppressor of cytokine signaling 3	0.061
IKBKG	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma	0.060
ZNF708	zinc finger protein 708	0.053	Human
KRT8	keratin 8	0.052
CASP10	caspase 10, apoptosis-related cysteine peptidase	0.049
TNFRSF10B	tumor necrosis factor receptor superfamily, member 10b	0.046
MAP3K14	mitogen-activated protein kinase kinase kinase 14	0.044
IFNAR1	interferon (alpha, beta and omega) receptor 1	0.043
STAT6	signal transducer and activator of transcription 6, interleukin-4 induced	0.040	Human
IRAK2	interleukin-1 receptor-associated kinase 2	0.038
ZNF91	zinc finger protein 91	0.037
RNF31	ring finger protein 31	0.037
INSR	insulin receptor	0.035
ZNF680	zinc finger protein 680	0.035	Human
TNFRSF10A	tumor necrosis factor receptor superfamily, member 10a	0.034
ZNF254	zinc finger protein 254	0.033	Human
A2M	alpha-2-macroglobulin	0.033
ZNF93	zinc finger protein 93	0.029
GHR	growth hormone receptor	0.026
ZNF746	zinc finger protein 746	0.026
APOC1	apolipoprotein C-I	0.026
CDKN1A	cyclin-dependent kinase inhibitor 1A (p21, Cip1)	0.026
IL12RB2	interleukin 12 receptor, beta 2	0.025
NLRC4	NLR family, CARD domain containing 4	0.025
C1QB	complement component 1, q subcomponent, B chain	0.025	Human
TMEM173	transmembrane protein 173	0.025
FADD	Fas (TNFRSF6)-associated via death domain	0.025
IFNGR1	interferon gamma receptor 1	0.024
FYN	FYN oncogene related to SRC, FGR, YES	0.024
CREBBP	CREB binding protein	0.024
LCAT	lecithin-cholesterol acyltransferase	0.024
IL2RB	interleukin 2 receptor, beta	0.023
FAS	Fas (TNF receptor superfamily, member 6)	0.022	Rat
IKBKB	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta	0.022
NMI	N-myc (and STAT) interactor	0.021
ZNF107	zinc finger protein 107	0.021
PML	promyelocytic leukemia	0.020
STAT5A	signal transducer and activator of transcription 5A	0.020	Human
IL6ST	interleukin 6 signal transducer (gp130, oncostatin M receptor)	0.018
MEFV	Mediterranean fever	0.018
BIRC3	baculoviral IAP repeat containing 3	0.018
ZNF430	zinc finger protein 430	0.017	Human
SOCS1	suppressor of cytokine signaling 1	0.016
UBE2I	ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)	0.016
ZNF117	zinc finger protein 117	0.016	Human
TOX4	TOX high mobility group box family member 4	0.015
ZMYND11	zinc finger, MYND-type containing 11	0.015
IRF9	interferon regulatory factor 9	0.015
EPOR	erythropoietin receptor	0.015
STAT2	signal transducer and activator of transcription 2, 113kDa	0.015	Human
SFN	stratifin	0.014
SH2B1	SH2B adaptor protein 1	0.014
CASP1	caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)	0.014
NUMBL	numb homolog (Drosophila)-like	0.014
ZNF92	zinc finger protein 92	0.014	Human
LIMD1	LIM domains containing 1	0.013
DAXX	death-domain associated protein	0.013
TNFRSF9	tumor necrosis factor receptor superfamily, member 9	0.013
CAPN1	calpain 1, (mu/I) large subunit	0.013
GRB10	growth factor receptor-bound protein 10	0.012
TNFSF14	tumor necrosis factor (ligand) superfamily, member 14	0.012	Human
PDCD6IP	programmed cell death 6 interacting protein	0.012
MATK	megakaryocyte-associated tyrosine kinase	0.012
CLTC	clathrin, heavy chain (Hc)	0.011
TRAF3IP2	TRAF3 interacting protein 2	0.011
IL2RG	interleukin 2 receptor, gamma	0.011
TNFRSF10C	tumor necrosis factor receptor superfamily, member 10c, decoy without an intracellular domain	0.011
ITK	IL2-inducible T-cell kinase	0.011
STAP2	signal transducing adaptor family member 2	0.010
TNFAIP3	tumor necrosis factor, alpha-induced protein 3	0.010
TRIP10	thyroid hormone receptor interactor 10	0.010
JAK3	Janus kinase 3	0.010	Human
GIT2	G protein-coupled receptor kinase interacting ArfGAP 2	0.010