IMP

Process View

Homo sapiens

4 genes annotated in human

negative regulation of myotube differentiation

Any process that decreases the frequency, rate or extent of myotube differentiation. Myotube differentiation is the process in which a relatively unspecialized cell acquires specialized features of a myotube cell. Myotubes are multinucleated cells that are formed when proliferating myoblasts exit the cell cycle, differentiate and fuse.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "negative regulation of myotube differentiation"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "negative regulation of myotube differentiation" (in gray)

Name	Description	Probability	Func Analog Organism
CEACAM6	carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)	1.000	Human
CEACAM1	carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)	1.000	Human
CEACAM5	carcinoembryonic antigen-related cell adhesion molecule 5	1.000
CEACAM7	carcinoembryonic antigen-related cell adhesion molecule 7	0.992	Human
HDAC4	histone deacetylase 4	0.891
TBX5	T-box 5	0.888
PSG4	pregnancy specific beta-1-glycoprotein 4	0.888
MEF2C	myocyte enhancer factor 2C	0.835
CEACAM8	carcinoembryonic antigen-related cell adhesion molecule 8	0.756	Human
PRKD2	protein kinase D2	0.648
MEF2A	myocyte enhancer factor 2A	0.510
PSG5	pregnancy specific beta-1-glycoprotein 5	0.473	Human
NCOR2	nuclear receptor corepressor 2	0.456
YWHAH	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide	0.443
JAG1	jagged 1	0.425
YWHAE	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide	0.366
PSG1	pregnancy specific beta-1-glycoprotein 1	0.358
UBE2I	ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)	0.358
BCL6	B-cell CLL/lymphoma 6	0.349
SRF	serum response factor (c-fos serum response element-binding transcription factor)	0.346
SIN3A	SIN3 homolog A, transcription regulator (yeast)	0.334
CXCL11	chemokine (C-X-C motif) ligand 11	0.251
NCOR1	nuclear receptor corepressor 1	0.225
HIPK2	homeodomain interacting protein kinase 2	0.193
PSG3	pregnancy specific beta-1-glycoprotein 3	0.187
NOTCH3	notch 3	0.166
CASP10	caspase 10, apoptosis-related cysteine peptidase	0.157
RAF1	v-raf-1 murine leukemia viral oncogene homolog 1	0.142
PML	promyelocytic leukemia	0.139
RBPJ	recombination signal binding protein for immunoglobulin kappa J region	0.138
HDAC3	histone deacetylase 3	0.125
RASSF1	Ras association (RalGDS/AF-6) domain family member 1	0.114
PSG9	pregnancy specific beta-1-glycoprotein 9	0.111	Human
FAS	Fas (TNF receptor superfamily, member 6)	0.110
PPARA	peroxisome proliferator-activated receptor alpha	0.104
PAX8	paired box 8	0.104
FOXP3	forkhead box P3	0.102
MDM4	Mdm4 p53 binding protein homolog (mouse)	0.101
TNFRSF10A	tumor necrosis factor receptor superfamily, member 10a	0.101
XIAP	X-linked inhibitor of apoptosis	0.087
TNFSF10	tumor necrosis factor (ligand) superfamily, member 10	0.085
GATA4	GATA binding protein 4	0.079
PSG6	pregnancy specific beta-1-glycoprotein 6	0.072	Human
AR	androgen receptor	0.070
MAML1	mastermind-like 1 (Drosophila)	0.070
PSG2	pregnancy specific beta-1-glycoprotein 2	0.057
YWHAG	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide	0.051
ELK1	ELK1, member of ETS oncogene family	0.049
CXCL9	chemokine (C-X-C motif) ligand 9	0.044
PSG7	pregnancy specific beta-1-glycoprotein 7 (gene/pseudogene)	0.041
HDAC9	histone deacetylase 9	0.040	Human
MDM2	Mdm2 p53 binding protein homolog (mouse)	0.039
GABARAP	GABA(A) receptor-associated protein	0.037
MUL1	mitochondrial E3 ubiquitin protein ligase 1	0.037
KIF1C	kinesin family member 1C	0.037
CDKN2A	cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)	0.036
CLEC4M	C-type lectin domain family 4, member M	0.032
MIF4GD	MIF4G domain containing	0.031
IKZF3	IKAROS family zinc finger 3 (Aiolos)	0.028
NFKB1	nuclear factor of kappa light polypeptide gene enhancer in B-cells 1	0.028
TNFRSF10B	tumor necrosis factor receptor superfamily, member 10b	0.026
CARTPT	CART prepropeptide	0.026
ETV6	ets variant 6	0.025
TP53	tumor protein p53	0.025
CASP3	caspase 3, apoptosis-related cysteine peptidase	0.025
PAX5	paired box 5	0.025
JUB	jub, ajuba homolog (Xenopus laevis)	0.024
WHSC1L1	Wolf-Hirschhorn syndrome candidate 1-like 1	0.023
TCN1	transcobalamin I (vitamin B12 binding protein, R binder family)	0.023
ATXN1	ataxin 1	0.022
GPR97	G protein-coupled receptor 97	0.022
TIE1	tyrosine kinase with immunoglobulin-like and EGF-like domains 1	0.022
RIPK1	receptor (TNFRSF)-interacting serine-threonine kinase 1	0.021
TBL1X	transducin (beta)-like 1X-linked	0.021
SSPN	sarcospan (Kras oncogene-associated gene)	0.020
TSC2	tuberous sclerosis 2	0.020
SFN	stratifin	0.020
MAP3K5	mitogen-activated protein kinase kinase kinase 5	0.020
S100P	S100 calcium binding protein P	0.020
JAG2	jagged 2	0.019
MPRIP	myosin phosphatase Rho interacting protein	0.018
LILRA5	leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 5	0.018
CBLB	Cas-Br-M (murine) ecotropic retroviral transforming sequence b	0.018
CALCOCO1	calcium binding and coiled-coil domain 1	0.018
DLL1	delta-like 1 (Drosophila)	0.018
NOTCH2	notch 2	0.018
ARHGEF7	Rho guanine nucleotide exchange factor (GEF) 7	0.017
L3MBTL2	l(3)mbt-like 2 (Drosophila)	0.017
CGN	cingulin	0.017
SKIL	SKI-like oncogene	0.017
ARHGEF2	Rho/Rac guanine nucleotide exchange factor (GEF) 2	0.017
BAD	BCL2-associated agonist of cell death	0.017
CASP8	caspase 8, apoptosis-related cysteine peptidase	0.017
MYOD1	myogenic differentiation 1	0.017
NEUROG3	neurogenin 3	0.016
IPO13	importin 13	0.016
MAP3K2	mitogen-activated protein kinase kinase kinase 2	0.016
RASSF5	Ras association (RalGDS/AF-6) domain family member 5	0.016
CAMTA2	calmodulin binding transcription activator 2	0.016
BRAF	v-raf murine sarcoma viral oncogene homolog B1	0.016
MKL1	megakaryoblastic leukemia (translocation) 1	0.016
FOLR3	folate receptor 3 (gamma)	0.015
MARK2	MAP/microtubule affinity-regulating kinase 2	0.015
KRT34	keratin 34	0.015
HDAC5	histone deacetylase 5	0.015
FADD	Fas (TNFRSF6)-associated via death domain	0.015
BANP	BTG3 associated nuclear protein	0.015
DNMT3B	DNA (cytosine-5-)-methyltransferase 3 beta	0.015
FOXA1	forkhead box A1	0.015
CYP4F3	cytochrome P450, family 4, subfamily F, polypeptide 3	0.015
PSG11	pregnancy specific beta-1-glycoprotein 11	0.014
C1QL1	complement component 1, q subcomponent-like 1	0.014
ARAF	v-raf murine sarcoma 3611 viral oncogene homolog	0.013
GPRC5A	G protein-coupled receptor, family C, group 5, member A	0.013
LBX1	ladybird homeobox 1	0.013
KRT23	keratin 23 (histone deacetylase inducible)	0.013
KCNE3	potassium voltage-gated channel, Isk-related family, member 3	0.013
KLC2	kinesin light chain 2	0.013
RALGPS2	Ral GEF with PH domain and SH3 binding motif 2	0.013
TMPRSS2	transmembrane protease, serine 2	0.013
NADK	NAD kinase	0.013
EMR3	egf-like module containing, mucin-like, hormone receptor-like 3	0.013
TCAP	titin-cap (telethonin)	0.013
MAGEA2	melanoma antigen family A, 2	0.013
ZBTB16	zinc finger and BTB domain containing 16	0.013
SPOP	speckle-type POZ protein	0.012
MYOG	myogenin (myogenic factor 4)	0.012
FGF5	fibroblast growth factor 5	0.012
SIX2	SIX homeobox 2	0.012
S100A12	S100 calcium binding protein A12	0.012
MYH6	myosin, heavy chain 6, cardiac muscle, alpha	0.011
PI3	peptidase inhibitor 3, skin-derived	0.011
MARK3	MAP/microtubule affinity-regulating kinase 3	0.011
TRAF3	TNF receptor-associated factor 3	0.011
ABP1	amiloride binding protein 1 (amine oxidase (copper-containing))	0.011
S100B	S100 calcium binding protein B	0.011
DIABLO	diablo, IAP-binding mitochondrial protein	0.011
ULK1	unc-51-like kinase 1 (C. elegans)	0.011
SYVN1	synovial apoptosis inhibitor 1, synoviolin	0.011
MYBPC3	myosin binding protein C, cardiac	0.011
SLC2A4	solute carrier family 2 (facilitated glucose transporter), member 4	0.011
HDAC7	histone deacetylase 7	0.011	Human
CXCR1	chemokine (C-X-C motif) receptor 1	0.011
VDR	vitamin D (1,25- dihydroxyvitamin D3) receptor	0.011
RNASE3	ribonuclease, RNase A family, 3	0.011
HBQ1	hemoglobin, theta 1	0.011
PARD3B	par-3 partitioning defective 3 homolog B (C. elegans)	0.010
DPP4	dipeptidyl-peptidase 4	0.010
TJP2	tight junction protein 2 (zona occludens 2)	0.010
PIAS2	protein inhibitor of activated STAT, 2	0.010
IL1RN	interleukin 1 receptor antagonist	0.010
RGS3	regulator of G-protein signaling 3	0.010
CASP9	caspase 9, apoptosis-related cysteine peptidase	0.010
PGR	progesterone receptor	0.010
TFF1	trefoil factor 1	0.010
RPS27L	ribosomal protein S27-like	0.010
FOXO1	forkhead box O1	0.010
TACSTD2	tumor-associated calcium signal transducer 2	0.010
MNX1	motor neuron and pancreas homeobox 1	0.010
TBX1	T-box 1	0.010
GFI1B	growth factor independent 1B transcription repressor	0.010
MAPK7	mitogen-activated protein kinase 7	0.010
SH3BP4	SH3-domain binding protein 4	0.010