IMP

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Homo sapiens

28 genes annotated in human

lipid storage disease

DOID:9455

A lysosomal storage disease that involves the accumulation of harmful amounts of lipids (fats) in some of the body's cells and tissues.

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "lipid storage disease"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "lipid storage disease" (in gray)

Name	Description	Probability
CTSA	cathepsin A	1.000
LAMP1	lysosomal-associated membrane protein 1	1.000
GRN	granulin	0.998
PSAP	prosaposin	0.994
NEU1	sialidase 1 (lysosomal sialidase)	0.991
TPP1	tripeptidyl peptidase I	0.968
CTSD	cathepsin D	0.961
GNS	glucosamine (N-acetyl)-6-sulfatase	0.941
CTSB	cathepsin B	0.838
HEXB	hexosaminidase B (beta polypeptide)	0.818
GM2A	GM2 ganglioside activator	0.723
LAMP2	lysosomal-associated membrane protein 2	0.606
ATP6AP1	ATPase, H+ transporting, lysosomal accessory protein 1	0.575
NPC2	Niemann-Pick disease, type C2	0.430
PLD3	phospholipase D family, member 3	0.429
GAA	glucosidase, alpha; acid	0.416
GLB1	galactosidase, beta 1	0.413
MAN2B1	mannosidase, alpha, class 2B, member 1	0.376
OS9	osteosarcoma amplified 9, endoplasmic reticulum lectin	0.318
APLP2	amyloid beta (A4) precursor-like protein 2	0.211
A2M	alpha-2-macroglobulin	0.194
CST3	cystatin C	0.164
MFSD1	major facilitator superfamily domain containing 1	0.150
APOC1	apolipoprotein C-I	0.144
C1orf85	chromosome 1 open reading frame 85	0.144
ANXA4	annexin A4	0.127
GABARAP	GABA(A) receptor-associated protein	0.126
TIMP2	TIMP metallopeptidase inhibitor 2	0.108
HLA-C	major histocompatibility complex, class I, C	0.100
TNFRSF1A	tumor necrosis factor receptor superfamily, member 1A	0.098
FCGRT	Fc fragment of IgG, receptor, transporter, alpha	0.096
HLA-G	major histocompatibility complex, class I, G	0.093
FUCA1	fucosidase, alpha-L- 1, tissue	0.088
GNPTG	N-acetylglucosamine-1-phosphate transferase, gamma subunit	0.088
HEXA	hexosaminidase A (alpha polypeptide)	0.082
USP22	ubiquitin specific peptidase 22	0.076
MANBA	mannosidase, beta A, lysosomal	0.074
PRCP	prolylcarboxypeptidase (angiotensinase C)	0.073
CTSL1	cathepsin L1	0.069
FTL	ferritin, light polypeptide	0.066
NUCB1	nucleobindin 1	0.062
ATP6V0D1	ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d1	0.059
CSTB	cystatin B (stefin B)	0.054
SCPEP1	serine carboxypeptidase 1	0.052
PBXIP1	pre-B-cell leukemia homeobox interacting protein 1	0.050
CTSH	cathepsin H	0.048
NCSTN	nicastrin	0.044
RNF13	ring finger protein 13	0.042
SH3BGRL	SH3 domain binding glutamic acid-rich protein like	0.038
MR1	major histocompatibility complex, class I-related	0.038
DNASE2	deoxyribonuclease II, lysosomal	0.038
HP	haptoglobin	0.037
NAGPA	N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase	0.037
NAGA	N-acetylgalactosaminidase, alpha-	0.036
ASAH1	N-acylsphingosine amidohydrolase (acid ceramidase) 1	0.035
FTH1	ferritin, heavy polypeptide 1	0.034
CREG1	cellular repressor of E1A-stimulated genes 1	0.034
TSC22D1	TSC22 domain family, member 1	0.034
ATP6V0C	ATPase, H+ transporting, lysosomal 16kDa, V0 subunit c	0.033
CD63	CD63 molecule	0.033
NAGK	N-acetylglucosamine kinase	0.032
LRP1	low density lipoprotein receptor-related protein 1	0.031
NR1H2	nuclear receptor subfamily 1, group H, member 2	0.030
PGCP	plasma glutamate carboxypeptidase	0.028
GUSB	glucuronidase, beta	0.027
HSPG2	heparan sulfate proteoglycan 2	0.027
P2RX4	purinergic receptor P2X, ligand-gated ion channel, 4	0.026
PTTG1IP	pituitary tumor-transforming 1 interacting protein	0.026
ATP6V0E1	ATPase, H+ transporting, lysosomal 9kDa, V0 subunit e1	0.025
EPHX1	epoxide hydrolase 1, microsomal (xenobiotic)	0.025
FBXO6	F-box protein 6	0.025
MVP	major vault protein	0.024
SGSH	N-sulfoglucosamine sulfohydrolase	0.023
GBA	glucosidase, beta, acid	0.023
IFI30	interferon, gamma-inducible protein 30	0.023
LTA4H	leukotriene A4 hydrolase	0.023
LRP10	low density lipoprotein receptor-related protein 10	0.022
PEPD	peptidase D	0.022
PLTP	phospholipid transfer protein	0.022
ZBED1	zinc finger, BED-type containing 1	0.021
PPT1	palmitoyl-protein thioesterase 1	0.021
GPNMB	glycoprotein (transmembrane) nmb	0.021
MAN2B2	mannosidase, alpha, class 2B, member 2	0.020
MCOLN1	mucolipin 1	0.018
TMEM127	transmembrane protein 127	0.018
LIPA	lipase A, lysosomal acid, cholesterol esterase	0.018
BRI3	brain protein I3	0.017
EDEM2	ER degradation enhancer, mannosidase alpha-like 2	0.017
TOM1	target of myb1 (chicken)	0.017
GNPDA1	glucosamine-6-phosphate deaminase 1	0.016
CTNS	cystinosis, nephropathic	0.016
LGMN	legumain	0.016
SUMF1	sulfatase modifying factor 1	0.016
SLC25A11	solute carrier family 25 (mitochondrial carrier; oxoglutarate carrier), member 11	0.015
SLC22A18	solute carrier family 22, member 18	0.015
GANAB	glucosidase, alpha; neutral AB	0.015
GPR137B	G protein-coupled receptor 137B	0.015
CD68	CD68 molecule	0.015
HMOX1	heme oxygenase (decycling) 1	0.014
CLCN7	chloride channel 7	0.014
CASP7	caspase 7, apoptosis-related cysteine peptidase	0.014
LGALS3BP	lectin, galactoside-binding, soluble, 3 binding protein	0.014
SLC38A7	solute carrier family 38, member 7	0.013
ATP6V0A1	ATPase, H+ transporting, lysosomal V0 subunit a1	0.013
IGF2R	insulin-like growth factor 2 receptor	0.013
LRPAP1	low density lipoprotein receptor-related protein associated protein 1	0.013
SIGMAR1	sigma non-opioid intracellular receptor 1	0.013
RPS6KA1	ribosomal protein S6 kinase, 90kDa, polypeptide 1	0.013
RPN2	ribophorin II	0.013
TMEM179B	transmembrane protein 179B	0.013
ARSA	arylsulfatase A	0.012
EXT2	exostosin 2	0.012
UNC45A	unc-45 homolog A (C. elegans)	0.012
SLC17A5	solute carrier family 17 (anion/sugar transporter), member 5	0.012
SIDT2	SID1 transmembrane family, member 2	0.012
RNASET2	ribonuclease T2	0.011
ATP6V1B2	ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B2	0.011
ACP5	acid phosphatase 5, tartrate resistant	0.011
TMBIM4	transmembrane BAX inhibitor motif containing 4	0.011
TMEM9B	TMEM9 domain family, member B	0.010
CTSO	cathepsin O	0.010
GALC	galactosylceramidase	0.010
CLN3	ceroid-lipofuscinosis, neuronal 3	0.008
GLA	galactosidase, alpha	0.007
CYP27A1	cytochrome P450, family 27, subfamily A, polypeptide 1	0.006
ABHD5	abhydrolase domain containing 5	0.005
CTSF	cathepsin F	0.004
NPC1	Niemann-Pick disease, type C1	0.004
CLN8	ceroid-lipofuscinosis, neuronal 8 (epilepsy, progressive with mental retardation)	0.004
CLN6	ceroid-lipofuscinosis, neuronal 6, late infantile, variant	0.003
DNAJC5	DnaJ (Hsp40) homolog, subfamily C, member 5	0.003
APOE	apolipoprotein E	0.003
SMPD1	sphingomyelin phosphodiesterase 1, acid lysosomal	0.002
CLN5	ceroid-lipofuscinosis, neuronal 5	0.002
MFSD8	major facilitator superfamily domain containing 8	0.001