IMP

Process View

Homo sapiens

14 genes annotated in human

negative regulation of erk1 and erk2 cascade

Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "negative regulation of erk1 and erk2 cascade"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "negative regulation of erk1 and erk2 cascade" (in gray)

Name	Description	Probability	Func Analog Organism
MAPK1	mitogen-activated protein kinase 1	1.000
MAPK14	mitogen-activated protein kinase 14	1.000
DUSP1	dual specificity phosphatase 1	0.999	Human Rat
C1QA	complement component 1, q subcomponent, A chain	0.997	Human
PIK3R1	phosphoinositide-3-kinase, regulatory subunit 1 (alpha)	0.988
CRKL	v-crk sarcoma virus CT10 oncogene homolog (avian)-like	0.947
MAPK3	mitogen-activated protein kinase 3	0.921
CBL	Cas-Br-M (murine) ecotropic retroviral transforming sequence	0.920
CFTR	cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)	0.912
DUSP5	dual specificity phosphatase 5	0.824	Human
MAP2K1	mitogen-activated protein kinase kinase 1	0.782
DUSP3	dual specificity phosphatase 3	0.761
GHR	growth hormone receptor	0.743
DUSP7	dual specificity phosphatase 7	0.610	Human
FYN	FYN oncogene related to SRC, FGR, YES	0.546
KLF6	Kruppel-like factor 6	0.479
PTPRR	protein tyrosine phosphatase, receptor type, R	0.455
TICAM2	toll-like receptor adaptor molecule 2	0.303
RPS6KA3	ribosomal protein S6 kinase, 90kDa, polypeptide 3	0.257
DUSP6	dual specificity phosphatase 6	0.242
IGF1R	insulin-like growth factor 1 receptor	0.236
PEA15	phosphoprotein enriched in astrocytes 15	0.221
PTPRJ	protein tyrosine phosphatase, receptor type, J	0.220
KLHL3	kelch-like 3 (Drosophila)	0.218
BCR	breakpoint cluster region	0.213
C1QC	complement component 1, q subcomponent, C chain	0.198	Human
MAP2K4	mitogen-activated protein kinase kinase 4	0.171
C1QB	complement component 1, q subcomponent, B chain	0.168	Human
CRK	v-crk sarcoma virus CT10 oncogene homolog (avian)	0.150
SLC9A3R1	solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1	0.135
ABL1	c-abl oncogene 1, non-receptor tyrosine kinase	0.126	Mouse
ZFP36L1	zinc finger protein 36, C3H type-like 1	0.126
ARHGAP9	Rho GTPase activating protein 9	0.118
PTPN7	protein tyrosine phosphatase, non-receptor type 7	0.099	Human Fly
GRB10	growth factor receptor-bound protein 10	0.098
MAPK8	mitogen-activated protein kinase 8	0.095
PPP2R5C	protein phosphatase 2, regulatory subunit B', gamma	0.083
ZFP36	zinc finger protein 36, C3H type, homolog (mouse)	0.081
RANBP3	RAN binding protein 3	0.077
IER2	immediate early response 2	0.076
ATF2	activating transcription factor 2	0.073
BCAR1	breast cancer anti-estrogen resistance 1	0.060
NR4A2	nuclear receptor subfamily 4, group A, member 2	0.058
PXN	paxillin	0.058
PAG1	phosphoprotein associated with glycosphingolipid microdomains 1	0.057
MBP	myelin basic protein	0.056
MAFF	v-maf musculoaponeurotic fibrosarcoma oncogene homolog F (avian)	0.050
INSR	insulin receptor	0.049
PTPN11	protein tyrosine phosphatase, non-receptor type 11	0.045
ATF3	activating transcription factor 3	0.044
MAP2K3	mitogen-activated protein kinase kinase 3	0.043
FAF1	Fas (TNFRSF6) associated factor 1	0.040
NEDD4L	neural precursor cell expressed, developmentally down-regulated 4-like	0.039
JUN	jun proto-oncogene	0.039
ITGB1	integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)	0.039
PDGFRA	platelet-derived growth factor receptor, alpha polypeptide	0.039
MTPN	myotrophin	0.039
OXSR1	oxidative-stress responsive 1	0.038
LY96	lymphocyte antigen 96	0.038
IRS2	insulin receptor substrate 2	0.037
STAT5A	signal transducer and activator of transcription 5A	0.036
PPP1R15A	protein phosphatase 1, regulatory (inhibitor) subunit 15A	0.036
FOS	FBJ murine osteosarcoma viral oncogene homolog	0.036
SLC9A3R2	solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 2	0.035	Human
WAS	Wiskott-Aldrich syndrome (eczema-thrombocytopenia)	0.035
PTPRB	protein tyrosine phosphatase, receptor type, B	0.035
CSNK2B	casein kinase 2, beta polypeptide	0.034
IER3	immediate early response 3	0.034
C19orf46	chromosome 19 open reading frame 46	0.032
MAPKAPK2	mitogen-activated protein kinase-activated protein kinase 2	0.032
MKNK1	MAP kinase interacting serine/threonine kinase 1	0.031
MAP2K6	mitogen-activated protein kinase kinase 6	0.030
JUND	jun D proto-oncogene	0.029
MLLT4	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4	0.028
SEC24D	SEC24 family, member D (S. cerevisiae)	0.027
SHC1	SHC (Src homology 2 domain containing) transforming protein 1	0.027
MKNK2	MAP kinase interacting serine/threonine kinase 2	0.025
GADD45A	growth arrest and DNA-damage-inducible, alpha	0.024
NFKBIZ	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta	0.023
RPS6KA4	ribosomal protein S6 kinase, 90kDa, polypeptide 4	0.022
GSK3B	glycogen synthase kinase 3 beta	0.022
IRS1	insulin receptor substrate 1	0.022
SIGLEC1	sialic acid binding Ig-like lectin 1, sialoadhesin	0.021
LCK	lymphocyte-specific protein tyrosine kinase	0.020
GLIS2	GLIS family zinc finger 2	0.020
TIRAP	toll-interleukin 1 receptor (TIR) domain containing adaptor protein	0.020
FZD5	frizzled homolog 5 (Drosophila)	0.019
EGR1	early growth response 1	0.018
MYO6	myosin VI	0.018
DUSP9	dual specificity phosphatase 9	0.017	Human
MARCO	macrophage receptor with collagenous structure	0.017
FOSB	FBJ murine osteosarcoma viral oncogene homolog B	0.017
ZNF746	zinc finger protein 746	0.017
ARHGEF12	Rho guanine nucleotide exchange factor (GEF) 12	0.016
TAB1	TGF-beta activated kinase 1/MAP3K7 binding protein 1	0.016
LDB2	LIM domain binding 2	0.016
SLC26A3	solute carrier family 26, member 3	0.016
TRIB1	tribbles homolog 1 (Drosophila)	0.015
PTPN3	protein tyrosine phosphatase, non-receptor type 3	0.015
CSDA	cold shock domain protein A	0.015
WDR1	WD repeat domain 1	0.015
ZNF71	zinc finger protein 71	0.015
FHL2	four and a half LIM domains 2	0.015
C10orf116	chromosome 10 open reading frame 116	0.015
DUSP4	dual specificity phosphatase 4	0.015	Human
PHLDA1	pleckstrin homology-like domain, family A, member 1	0.015
CSRNP1	cysteine-serine-rich nuclear protein 1	0.015
IER5	immediate early response 5	0.015
MASP1	mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor)	0.015
ASAP1	ArfGAP with SH3 domain, ankyrin repeat and PH domain 1	0.015
EGR2	early growth response 2	0.014
FAM48A	family with sequence similarity 48, member A	0.014
SH3BP2	SH3-domain binding protein 2	0.014
CMTM6	CKLF-like MARVEL transmembrane domain containing 6	0.014
DUSP16	dual specificity phosphatase 16	0.014	Human
SPTBN4	spectrin, beta, non-erythrocytic 4	0.014
TGFB3	transforming growth factor, beta 3	0.014
CBLB	Cas-Br-M (murine) ecotropic retroviral transforming sequence b	0.013
CTBP1	C-terminal binding protein 1	0.013
GAB2	GRB2-associated binding protein 2	0.013
ITGA1	integrin, alpha 1	0.013
APOA1	apolipoprotein A-I	0.013
LYN	v-yes-1 Yamaguchi sarcoma viral related oncogene homolog	0.013
MSH5	mutS homolog 5 (E. coli)	0.013
RALYL	RALY RNA binding protein-like	0.013
ARRB1	arrestin, beta 1	0.012
DGCR14	DiGeorge syndrome critical region gene 14	0.012
SOS2	son of sevenless homolog 2 (Drosophila)	0.012
JUNB	jun B proto-oncogene	0.012
CSNK2A2	casein kinase 2, alpha prime polypeptide	0.012
MAP4K1	mitogen-activated protein kinase kinase kinase kinase 1	0.011
EGFR	epidermal growth factor receptor	0.011
BTN2A2	butyrophilin, subfamily 2, member A2	0.011	Mouse
MAPK11	mitogen-activated protein kinase 11	0.011
SPRY4	sprouty homolog 4 (Drosophila)	0.011
IL6ST	interleukin 6 signal transducer (gp130, oncostatin M receptor)	0.011
BTN2A1	butyrophilin, subfamily 2, member A1	0.011	Mouse
STAT3	signal transducer and activator of transcription 3 (acute-phase response factor)	0.011
ELK1	ELK1, member of ETS oncogene family	0.011
MAGI3	membrane associated guanylate kinase, WW and PDZ domain containing 3	0.011
SOS1	son of sevenless homolog 1 (Drosophila)	0.011
VSIG4	V-set and immunoglobulin domain containing 4	0.011
KLHL2	kelch-like 2, Mayven (Drosophila)	0.011
C1S	complement component 1, s subcomponent	0.011
POLR2L	polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa	0.010
LMO4	LIM domain only 4	0.010	Human
LRP6	low density lipoprotein receptor-related protein 6	0.010