IMP

Process View

Homo sapiens

12 genes annotated in human

Multi-species View

axis specification

GO:0009798

The establishment, maintenance and elaboration of a pattern along a line or around a point.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "axis specification"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "axis specification" (in gray)

Name	Description	Probability	Func Analog Organism
RAC1	ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)	0.987	Fly
YWHAZ	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide	0.961	Worm Fly
CTNNB1	catenin (cadherin-associated protein), beta 1, 88kDa	0.727	Zebrafish Mouse Worm
SMAD2	SMAD family member 2	0.715
YWHAB	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide	0.580	Worm Fly
CDC42	cell division cycle 42 (GTP binding protein, 25kDa)	0.487
SMURF2	SMAD specific E3 ubiquitin protein ligase 2	0.412
HNRNPD	heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa)	0.402	Fly
ARHGDIA	Rho GDP dissociation inhibitor (GDI) alpha	0.329
SMAD4	SMAD family member 4	0.302	Human Mouse Fly
HNRNPC	heterogeneous nuclear ribonucleoprotein C (C1/C2)	0.262
EGFR	epidermal growth factor receptor	0.251	Fly
ELAVL1	ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R)	0.234
DDX3X	DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, X-linked	0.205
YWHAQ	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide	0.175	Worm Fly
RELA	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	0.133	Zebrafish
MAGOH	mago-nashi homolog, proliferation-associated (Drosophila)	0.125	Fly
YWHAE	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide	0.117	Fly
CDC27	cell division cycle 27 homolog (S. cerevisiae)	0.087
BMPR1A	bone morphogenetic protein receptor, type IA	0.079	Mouse
HNRNPK	heterogeneous nuclear ribonucleoprotein K	0.078
NFKB1	nuclear factor of kappa light polypeptide gene enhancer in B-cells 1	0.070
SMAD1	SMAD family member 1	0.069	Human
MAFG	v-maf musculoaponeurotic fibrosarcoma oncogene homolog G (avian)	0.066
JAG1	jagged 1	0.062
SYNCRIP	synaptotagmin binding, cytoplasmic RNA interacting protein	0.062	Fly
USP7	ubiquitin specific peptidase 7 (herpes virus-associated)	0.060
HNRNPU	heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A)	0.058
ERBB2	v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)	0.055	Fly
YBX1	Y box binding protein 1	0.048
EIF4A3	eukaryotic translation initiation factor 4A3	0.048	Fly
SMAD3	SMAD family member 3	0.045	Human
OCRL	oculocerebrorenal syndrome of Lowe	0.044
FBLN1	fibulin 1	0.042
RAF1	v-raf-1 murine leukemia viral oncogene homolog 1	0.042	Fly
YWHAG	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide	0.041	Worm Fly
APC	adenomatous polyposis coli	0.040	Mouse
PAK2	p21 protein (Cdc42/Rac)-activated kinase 2	0.039
RHOA	ras homolog gene family, member A	0.039
BRAF	v-raf murine sarcoma viral oncogene homolog B1	0.038	Fly
DHX9	DEAH (Asp-Glu-Ala-His) box polypeptide 9	0.037
HNRNPH3	heterogeneous nuclear ribonucleoprotein H3 (2H9)	0.036
IQGAP1	IQ motif containing GTPase activating protein 1	0.035
GDA	guanine deaminase	0.034
PARD6A	par-6 partitioning defective 6 homolog alpha (C. elegans)	0.031
PABPC1	poly(A) binding protein, cytoplasmic 1	0.031
GNB1	guanine nucleotide binding protein (G protein), beta polypeptide 1	0.030
ANAPC5	anaphase promoting complex subunit 5	0.029
REL	v-rel reticuloendotheliosis viral oncogene homolog (avian)	0.027
SMAD7	SMAD family member 7	0.027	Human
SMURF1	SMAD specific E3 ubiquitin protein ligase 1	0.026
GSK3B	glycogen synthase kinase 3 beta	0.026
QKI	quaking homolog, KH domain RNA binding (mouse)	0.026
SNAP25	synaptosomal-associated protein, 25kDa	0.026
STIP1	stress-induced-phosphoprotein 1	0.026
PRKCZ	protein kinase C, zeta	0.025
CTNNA1	catenin (cadherin-associated protein), alpha 1, 102kDa	0.023
ZMYND11	zinc finger, MYND-type containing 11	0.023
AXIN1	axin 1	0.023	Zebrafish Mouse
CHRD	chordin	0.021	Zebrafish Fly
HNRNPF	heterogeneous nuclear ribonucleoprotein F	0.020
FN1	fibronectin 1	0.020
UBC	ubiquitin C	0.018
STRADA	STE20-related kinase adaptor alpha	0.018
RASA1	RAS p21 protein activator (GTPase activating protein) 1	0.017
PTPN11	protein tyrosine phosphatase, non-receptor type 11	0.017	Fly
NFKBIA	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha	0.017	Fly
MAPK1	mitogen-activated protein kinase 1	0.017
PTBP1	polypyrimidine tract binding protein 1	0.017	Fly
UBE2I	ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)	0.017	Fly
BTRC	beta-transducin repeat containing	0.016
C19orf39	chromosome 19 open reading frame 39	0.016
SRSF9	serine/arginine-rich splicing factor 9	0.016
ABL1	c-abl oncogene 1, non-receptor tyrosine kinase	0.016
SKP1	S-phase kinase-associated protein 1	0.016
BMP2	bone morphogenetic protein 2	0.016	Zebrafish Fly
BMI1	BMI1 polycomb ring finger oncogene	0.016
SCHIP1	schwannomin interacting protein 1	0.016
CBL	Cas-Br-M (murine) ecotropic retroviral transforming sequence	0.016	Fly
ARHGDIB	Rho GDP dissociation inhibitor (GDI) beta	0.015
NCKAP1	NCK-associated protein 1	0.015	Mouse
EIF4G1	eukaryotic translation initiation factor 4 gamma, 1	0.015
CDC37	cell division cycle 37 homolog (S. cerevisiae)	0.015
ZYX	zyxin	0.015
SKIL	SKI-like oncogene	0.015
PALB2	partner and localizer of BRCA2	0.014
ARAF	v-raf murine sarcoma 3611 viral oncogene homolog	0.014	Fly
CRKL	v-crk sarcoma virus CT10 oncogene homolog (avian)-like	0.014
YWHAH	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide	0.014	Worm Fly
CLNS1A	chloride channel, nucleotide-sensitive, 1A	0.014
NFKB2	nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)	0.014
PBK	PDZ binding kinase	0.014
MSN	moesin	0.013	Fly
AMMECR1	Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1	0.013
WNT3A	wingless-type MMTV integration site family, member 3A	0.013
FGFR1	fibroblast growth factor receptor 1	0.013
HNRNPA3	heterogeneous nuclear ribonucleoprotein A3	0.013
BCL3	B-cell CLL/lymphoma 3	0.013	Fly
CDH5	cadherin 5, type 2 (vascular endothelium)	0.013
CALM1	calmodulin 1 (phosphorylase kinase, delta)	0.012
CXXC5	CXXC finger protein 5	0.012
ERBB4	v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)	0.012	Fly
DCP1A	DCP1 decapping enzyme homolog A (S. cerevisiae)	0.012
HNRPDL	heterogeneous nuclear ribonucleoprotein D-like	0.012	Fly
PAK1	p21 protein (Cdc42/Rac)-activated kinase 1	0.012
PXN	paxillin	0.011
RFWD2	ring finger and WD repeat domain 2	0.011
KIF5B	kinesin family member 5B	0.011	Fly
NLK	nemo-like kinase	0.011	Worm
EIF4B	eukaryotic translation initiation factor 4B	0.011
GNAI2	guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2	0.011	Worm
SLC9A3R1	solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1	0.011
PRKCI	protein kinase C, iota	0.011
RANBP2	RAN binding protein 2	0.011
MAPRE1	microtubule-associated protein, RP/EB family, member 1	0.011
WDYHV1	WDYHV motif containing 1	0.011
TIRAP	toll-interleukin 1 receptor (TIR) domain containing adaptor protein	0.010
ZFX	zinc finger protein, X-linked	0.010
MKL1	megakaryoblastic leukemia (translocation) 1	0.010
CD2AP	CD2-associated protein	0.010
MOBKL1B	MOB1, Mps One Binder kinase activator-like 1B (yeast)	0.010
FBXW11	F-box and WD repeat domain containing 11	0.010