IMP

Process View

Homo sapiens

27 genes annotated in human

regulation of epidermal growth factor receptor signaling pathway

GO:0042058

Any process that modulates the frequency, rate or extent of epidermal growth factor receptor signaling pathway activity.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "regulation of epidermal growth factor receptor signaling pathway"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "regulation of epidermal growth factor receptor signaling pathway" (in gray)

Name	Description	Probability	Func Analog Organism
PIK3R1	phosphoinositide-3-kinase, regulatory subunit 1 (alpha)	0.845
EGFR	epidermal growth factor receptor	0.637
PTPN1	protein tyrosine phosphatase, non-receptor type 1	0.592	Human
GRB2	growth factor receptor-bound protein 2	0.564	Fly
ERBB2	v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)	0.461
LCP2	lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)	0.261
GHR	growth hormone receptor	0.261
ESR1	estrogen receptor 1	0.113	Rat
NCK1	NCK adaptor protein 1	0.085
DLG1	discs, large homolog 1 (Drosophila)	0.069	Fly
SHC1	SHC (Src homology 2 domain containing) transforming protein 1	0.064
APBB1	amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65)	0.058
SRC	v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)	0.055
UCHL1	ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)	0.054
ERBB3	v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)	0.052
STAMBP	STAM binding protein	0.049
DLG4	discs, large homolog 4 (Drosophila)	0.046	Fly
PLCG1	phospholipase C, gamma 1	0.043	Fly
MPDZ	multiple PDZ domain protein	0.040
ERBB4	v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)	0.036
ASAP1	ArfGAP with SH3 domain, ankyrin repeat and PH domain 1	0.035
PTK2	PTK2 protein tyrosine kinase 2	0.033	Fly
GDA	guanine deaminase	0.033
LCK	lymphocyte-specific protein tyrosine kinase	0.032
APBB2	amyloid beta (A4) precursor protein-binding, family B, member 2	0.032
PTPN11	protein tyrosine phosphatase, non-receptor type 11	0.031
ABL1	c-abl oncogene 1, non-receptor tyrosine kinase	0.030
CBL	Cas-Br-M (murine) ecotropic retroviral transforming sequence	0.029	Human Fly
MAGI2	membrane associated guanylate kinase, WW and PDZ domain containing 2	0.029
GAB1	GRB2-associated binding protein 1	0.028
SNX9	sorting nexin 9	0.028
MAP3K5	mitogen-activated protein kinase kinase kinase 5	0.027
MET	met proto-oncogene (hepatocyte growth factor receptor)	0.025
CTNND1	catenin (cadherin-associated protein), delta 1	0.024
LAT	linker for activation of T cells	0.024
ABI2	abl-interactor 2	0.023
PSEN1	presenilin 1	0.023	Mouse
ITCH	itchy E3 ubiquitin protein ligase homolog (mouse)	0.022
CDH1	cadherin 1, type 1, E-cadherin (epithelial)	0.020	Human
MUC1	mucin 1, cell surface associated	0.020
SLC9A3R1	solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1	0.020
PTEN	phosphatase and tensin homolog	0.019
SHC2	SHC (Src homology 2 domain containing) transforming protein 2	0.018
ARHGAP5	Rho GTPase activating protein 5	0.018
STAT3	signal transducer and activator of transcription 3 (acute-phase response factor)	0.018
MAGI3	membrane associated guanylate kinase, WW and PDZ domain containing 3	0.018
VAV1	vav 1 guanine nucleotide exchange factor	0.018
SNF8	SNF8, ESCRT-II complex subunit, homolog (S. cerevisiae)	0.018
SH2D3A	SH2 domain containing 3A	0.017
CCDC6	coiled-coil domain containing 6	0.017
PBRM1	polybromo 1	0.017
ZAP70	zeta-chain (TCR) associated protein kinase 70kDa	0.017
SPRR2A	small proline-rich protein 2A	0.016
EIF1B	eukaryotic translation initiation factor 1B	0.016
EPOR	erythropoietin receptor	0.016
UBQLN1	ubiquilin 1	0.016
PTPN6	protein tyrosine phosphatase, non-receptor type 6	0.016
ADAM17	ADAM metallopeptidase domain 17	0.016
DSG2	desmoglein 2	0.016
PTPRA	protein tyrosine phosphatase, receptor type, A	0.016
CDH5	cadherin 5, type 2 (vascular endothelium)	0.016
GRAP2	GRB2-related adaptor protein 2	0.015	Fly
SH3GL2	SH3-domain GRB2-like 2	0.015
LRRK2	leucine-rich repeat kinase 2	0.015
XPO6	exportin 6	0.015
MAD2L2	MAD2 mitotic arrest deficient-like 2 (yeast)	0.015
PDCD6IP	programmed cell death 6 interacting protein	0.015
MAP3K11	mitogen-activated protein kinase kinase kinase 11	0.015
ARID1B	AT rich interactive domain 1B (SWI1-like)	0.015
JUP	junction plakoglobin	0.015
UBE3A	ubiquitin protein ligase E3A	0.015
ANKS1B	ankyrin repeat and sterile alpha motif domain containing 1B	0.014
ZNF746	zinc finger protein 746	0.014
PIK3R2	phosphoinositide-3-kinase, regulatory subunit 2 (beta)	0.014
SOCS1	suppressor of cytokine signaling 1	0.014	Human
PACSIN3	protein kinase C and casein kinase substrate in neurons 3	0.014
ADNP	activity-dependent neuroprotector homeobox	0.014
APP	amyloid beta (A4) precursor protein	0.014	Mouse
PPP5C	protein phosphatase 5, catalytic subunit	0.013
ARRDC3	arrestin domain containing 3	0.013
DHX30	DEAH (Asp-Glu-Ala-His) box polypeptide 30	0.013
CDKN1B	cyclin-dependent kinase inhibitor 1B (p27, Kip1)	0.013
SNX33	sorting nexin 33	0.013
GRIN2B	glutamate receptor, ionotropic, N-methyl D-aspartate 2B	0.013
NCOR1	nuclear receptor corepressor 1	0.013
MAPK8IP1	mitogen-activated protein kinase 8 interacting protein 1	0.013
PAG1	phosphoprotein associated with glycosphingolipid microdomains 1	0.013
TOM1L1	target of myb1 (chicken)-like 1	0.013
MAPK8IP2	mitogen-activated protein kinase 8 interacting protein 2	0.012
GRB7	growth factor receptor-bound protein 7	0.012
CHMP4B	chromatin modifying protein 4B	0.012
PRKCA	protein kinase C, alpha	0.012
ARID1A	AT rich interactive domain 1A (SWI-like)	0.012
VAV3	vav 3 guanine nucleotide exchange factor	0.012
PTPN23	protein tyrosine phosphatase, non-receptor type 23	0.012	Fly
ADRM1	adhesion regulating molecule 1	0.012
CTNNB1	catenin (cadherin-associated protein), beta 1, 88kDa	0.012
MYLK2	myosin light chain kinase 2	0.011
AR	androgen receptor	0.011
MATK	megakaryocyte-associated tyrosine kinase	0.011
PTPRJ	protein tyrosine phosphatase, receptor type, J	0.011
GRB10	growth factor receptor-bound protein 10	0.011
UHRF2	ubiquitin-like with PHD and ring finger domains 2	0.011
FLNB	filamin B, beta	0.011
EGF	epidermal growth factor	0.011
SRCIN1	SRC kinase signaling inhibitor 1	0.010
ADRBK1	adrenergic, beta, receptor kinase 1	0.010
VAV2	vav 2 guanine nucleotide exchange factor	0.010
SH3D19	SH3 domain containing 19	0.010
GRIN2A	glutamate receptor, ionotropic, N-methyl D-aspartate 2A	0.010
TNS4	tensin 4	0.010
TCF7L2	transcription factor 7-like 2 (T-cell specific, HMG-box)	0.010
SFN	stratifin	0.010
BLNK	B-cell linker	0.010
CRKL	v-crk sarcoma virus CT10 oncogene homolog (avian)-like	0.010
AXIN1	axin 1	0.010