IMP
Process View
positive regulation of transforming growth factor beta receptor signaling pathway
Any process that activates or increases the frequency, rate or extent of TGF-beta receptor signaling pathway activity.
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Click on a gene's description to view its network relationships with genes known to be involved in "positive regulation of transforming growth factor beta receptor signaling pathway"
| Name | Description | Probability | Func Analog Organism | |
|---|---|---|---|---|
| SMAD2 | SMAD family member 2 | 0.980 | Human | |
| SMAD3 | SMAD family member 3 | 0.977 | Human | |
| SMAD7 | SMAD family member 7 | 0.960 | Human | |
| SMAD4 | SMAD family member 4 | 0.900 | ||
| SMAD1 | SMAD family member 1 | 0.821 | Human | |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | 0.776 | ||
| EP300 | E1A binding protein p300 | 0.545 | ||
| SMAD5 | SMAD family member 5 | 0.441 | Human | |
| PIAS4 | protein inhibitor of activated STAT, 4 | 0.379 | ||
| FN1 | fibronectin 1 | 0.359 | ||
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.314 | ||
| PTK2 | PTK2 protein tyrosine kinase 2 | 0.285 | ||
| BCAR1 | breast cancer anti-estrogen resistance 1 | 0.272 | ||
| NCK2 | NCK adaptor protein 2 | 0.205 | ||
| FHL2 | four and a half LIM domains 2 | 0.197 | ||
| SKIL | SKI-like oncogene | 0.180 | ||
| TGFB1 | transforming growth factor, beta 1 | 0.173 | ||
| FBXL12 | F-box and leucine-rich repeat protein 12 | 0.155 | ||
| SMURF1 | SMAD specific E3 ubiquitin protein ligase 1 | 0.128 | ||
| TPBG | trophoblast glycoprotein | 0.126 | ||
| UBE2I | ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast) | 0.109 | ||
| STRADA | STE20-related kinase adaptor alpha | 0.104 | ||
| TGFBR2 | transforming growth factor, beta receptor II (70/80kDa) | 0.095 | ||
| SNIP1 | Smad nuclear interacting protein 1 | 0.086 | ||
| ITGA5 | integrin, alpha 5 (fibronectin receptor, alpha polypeptide) | 0.069 | ||
| CREBBP | CREB binding protein | 0.064 | ||
| TGFBR1 | transforming growth factor, beta receptor 1 | 0.060 | ||
| TOX4 | TOX high mobility group box family member 4 | 0.052 | ||
| DLG1 | discs, large homolog 1 (Drosophila) | 0.051 | ||
| CXXC5 | CXXC finger protein 5 | 0.046 | ||
| PIAS1 | protein inhibitor of activated STAT, 1 | 0.045 | ||
| TGM2 | transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase) | 0.042 | ||
| SKI | v-ski sarcoma viral oncogene homolog (avian) | 0.042 | ||
| TGFB1I1 | transforming growth factor beta 1 induced transcript 1 | 0.042 | ||
| RASSF5 | Ras association (RalGDS/AF-6) domain family member 5 | 0.040 | ||
| MMP2 | matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) | 0.039 | ||
| LPXN | leupaxin | 0.039 | Human | |
| VCL | vinculin | 0.038 | ||
| SIN3A | SIN3 homolog A, transcription regulator (yeast) | 0.036 | ||
| LIMS1 | LIM and senescent cell antigen-like domains 1 | 0.036 | Human | |
| MTMR4 | myotubularin related protein 4 | 0.031 | ||
| ITGB3 | integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) | 0.031 | ||
| PML | promyelocytic leukemia | 0.030 | ||
| ENG | endoglin | 0.028 | ||
| PHC2 | polyhomeotic homolog 2 (Drosophila) | 0.027 | ||
| HOXA1 | homeobox A1 | 0.027 | ||
| LIMD1 | LIM domains containing 1 | 0.027 | ||
| SRF | serum response factor (c-fos serum response element-binding transcription factor) | 0.026 | ||
| COL1A1 | collagen, type I, alpha 1 | 0.026 | ||
| AR | androgen receptor | 0.026 | ||
| RUNX1 | runt-related transcription factor 1 | 0.025 | ||
| CDKN2A | cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4) | 0.023 | ||
| SP1 | Sp1 transcription factor | 0.023 | ||
| ITGAV | integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51) | 0.021 | ||
| TLN1 | talin 1 | 0.020 | ||
| CDK6 | cyclin-dependent kinase 6 | 0.018 | ||
| FBXL15 | F-box and leucine-rich repeat protein 15 | 0.018 | ||
| SIAH1 | seven in absentia homolog 1 (Drosophila) | 0.018 | ||
| DVL2 | dishevelled, dsh homolog 2 (Drosophila) | 0.017 | ||
| BBS10 | Bardet-Biedl syndrome 10 | 0.017 | ||
| MKRN1 | makorin ring finger protein 1 | 0.017 | ||
| YY1 | YY1 transcription factor | 0.017 | ||
| DAXX | death-domain associated protein | 0.017 | ||
| CREB1 | cAMP responsive element binding protein 1 | 0.017 | ||
| FSTL1 | follistatin-like 1 | 0.016 | ||
| VDR | vitamin D (1,25- dihydroxyvitamin D3) receptor | 0.016 | ||
| TRAF4 | TNF receptor-associated factor 4 | 0.015 | ||
| HIPK3 | homeodomain interacting protein kinase 3 | 0.015 | Human | |
| MEST | mesoderm specific transcript homolog (mouse) | 0.014 | ||
| TFAP2A | transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha) | 0.014 | ||
| STRADB | STE20-related kinase adaptor beta | 0.014 | ||
| UBE2V1 | ubiquitin-conjugating enzyme E2 variant 1 | 0.014 | ||
| ITGA7 | integrin, alpha 7 | 0.014 | ||
| SIRT1 | sirtuin 1 | 0.013 | ||
| MYO1C | myosin IC | 0.013 | ||
| RAP1B | RAP1B, member of RAS oncogene family | 0.012 | ||
| IP6K2 | inositol hexakisphosphate kinase 2 | 0.012 | ||
| PHF21A | PHD finger protein 21A | 0.012 | ||
| DCAF7 | DDB1 and CUL4 associated factor 7 | 0.012 | ||
| COPS2 | COP9 constitutive photomorphogenic homolog subunit 2 (Arabidopsis) | 0.012 | ||
| HSPB1 | heat shock 27kDa protein 1 | 0.011 | ||
| TFAP2C | transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma) | 0.011 | ||
| GLUL | glutamate-ammonia ligase | 0.011 | ||
| TGFB3 | transforming growth factor, beta 3 | 0.011 | ||
| CSNK1E | casein kinase 1, epsilon | 0.011 | ||
| TRIM33 | tripartite motif containing 33 | 0.010 | ||
| GSK3B | glycogen synthase kinase 3 beta | 0.010 | ||
| SMAD6 | SMAD family member 6 | 0.010 | Human | |
| LIMK2 | LIM domain kinase 2 | 0.010 | ||
| TFPI2 | tissue factor pathway inhibitor 2 | 0.010 | ||
| YWHAE | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide | 0.010 | ||
| MYST1 | MYST histone acetyltransferase 1 | 0.010 | ||
| CDC42EP1 | CDC42 effector protein (Rho GTPase binding) 1 | 0.010 | ||
| NR2F2 | nuclear receptor subfamily 2, group F, member 2 | 0.010 |