IMP

Process View

Homo sapiens

19 genes annotated in human

pancreas development

The process whose specific outcome is the progression of the pancreas over time, from its formation to the mature structure. The pancreas is an endoderm derived structure that produces precursors of digestive enzymes and blood glucose regulating enzymes.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "pancreas development"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "pancreas development" (in gray)

Name	Description	Probability	Func Analog Organism
HNF4A	hepatocyte nuclear factor 4, alpha	0.963
NOTCH3	notch 3	0.939
MAFA	v-maf musculoaponeurotic fibrosarcoma oncogene homolog A (avian)	0.929
POU5F1	POU class 5 homeobox 1	0.760
BMPR1A	bone morphogenetic protein receptor, type IA	0.681
BMPR1B	bone morphogenetic protein receptor, type IB	0.345
FOXA2	forkhead box A2	0.302
SETD8	SET domain containing (lysine methyltransferase) 8	0.270
CDX2	caudal type homeobox 2	0.255
RUNX1	runt-related transcription factor 1	0.235
SOX1	SRY (sex determining region Y)-box 1	0.197
EGFR	epidermal growth factor receptor	0.175
FOXF2	forkhead box F2	0.161	Human
SMAD3	SMAD family member 3	0.157
IGF1R	insulin-like growth factor 1 receptor	0.152	Mouse
ONECUT1	one cut homeobox 1	0.147	Mouse
BAX	BCL2-associated X protein	0.143
TCF3	transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47)	0.139
FGF10	fibroblast growth factor 10	0.132
TAL1	T-cell acute lymphocytic leukemia 1	0.131	Human
INSR	insulin receptor	0.122	Mouse
HNF1B	HNF1 homeobox B	0.114
CD177	CD177 molecule	0.108
NOTCH2	notch 2	0.079
MYOD1	myogenic differentiation 1	0.075
GATA2	GATA binding protein 2	0.075
MNX1	motor neuron and pancreas homeobox 1	0.074	Zebrafish Mouse
CCND1	cyclin D1	0.068
FGF1	fibroblast growth factor 1 (acidic)	0.067
PTCH1	patched 1	0.066
NKX2-5	NK2 transcription factor related, locus 5 (Drosophila)	0.064
NOG	noggin	0.059
CDK6	cyclin-dependent kinase 6	0.058
RBPMS	RNA binding protein with multiple splicing	0.056
NKX6-1	NK6 homeobox 1	0.055	Zebrafish Mouse Rat
IL6R	interleukin 6 receptor	0.054
PITX2	paired-like homeodomain 2	0.054
WFIKKN2	WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2	0.054
COL2A1	collagen, type II, alpha 1	0.053
IGF2R	insulin-like growth factor 2 receptor	0.052
EEF2	eukaryotic translation elongation factor 2	0.051
ITGB1BP3	integrin beta 1 binding protein 3	0.051
RBPJ	recombination signal binding protein for immunoglobulin kappa J region	0.051
FOXF1	forkhead box F1	0.050
MDM2	Mdm2 p53 binding protein homolog (mouse)	0.050
PTF1A	pancreas specific transcription factor, 1a	0.048
HOXD12	homeobox D12	0.047
HNF1A	HNF1 homeobox A	0.046	Human Mouse
NKX2-2	NK2 homeobox 2	0.046	Zebrafish Mouse
CREBBP	CREB binding protein	0.045
LHX5	LIM homeobox 5	0.045
CDT1	chromatin licensing and DNA replication factor 1	0.043
FEV	FEV (ETS oncogene family)	0.043
SIM2	single-minded homolog 2 (Drosophila)	0.042
PDX1	pancreatic and duodenal homeobox 1	0.041
B9D2	B9 protein domain 2	0.040
CARD11	caspase recruitment domain family, member 11	0.040
PROX1	prospero homeobox 1	0.040
HDAC2	histone deacetylase 2	0.038
GATA4	GATA binding protein 4	0.037
SOX2	SRY (sex determining region Y)-box 2	0.036
IL6	interleukin 6 (interferon, beta 2)	0.036	Mouse
HOXD11	homeobox D11	0.036
FOXL1	forkhead box L1	0.036	Human
BOP1	block of proliferation 1	0.035
NR0B2	nuclear receptor subfamily 0, group B, member 2	0.033
ZFYVE9	zinc finger, FYVE domain containing 9	0.033
RPL8	ribosomal protein L8	0.032
FGF3	fibroblast growth factor 3	0.031
HIC1	hypermethylated in cancer 1	0.030
NR5A2	nuclear receptor subfamily 5, group A, member 2	0.030
NKX3-2	NK3 homeobox 2	0.030	Mouse
BMPR2	bone morphogenetic protein receptor, type II (serine/threonine kinase)	0.030
GFI1B	growth factor independent 1B transcription repressor	0.030
NR4A1	nuclear receptor subfamily 4, group A, member 1	0.029
FZD10	frizzled homolog 10 (Drosophila)	0.029
GJD2	gap junction protein, delta 2, 36kDa	0.029
EN2	engrailed homeobox 2	0.028
HOXB9	homeobox B9	0.028
POU4F2	POU class 4 homeobox 2	0.028
ZIC1	Zic family member 1 (odd-paired homolog, Drosophila)	0.028	Human
PPARGC1A	peroxisome proliferator-activated receptor gamma, coactivator 1 alpha	0.027
KLF4	Kruppel-like factor 4 (gut)	0.027
MYT1	myelin transcription factor 1	0.027
FOXB1	forkhead box B1	0.026
HOXD13	homeobox D13	0.026
SMAD6	SMAD family member 6	0.026
HGF	hepatocyte growth factor (hepapoietin A; scatter factor)	0.026
AHR	aryl hydrocarbon receptor	0.026
EN1	engrailed homeobox 1	0.026
ACAN	aggrecan	0.025
PYY	peptide YY	0.025
MARCKSL1	MARCKS-like 1	0.025
PCNA	proliferating cell nuclear antigen	0.025
DNMT3B	DNA (cytosine-5-)-methyltransferase 3 beta	0.024
NOTCH1	notch 1	0.024	Zebrafish
DLX4	distal-less homeobox 4	0.023
VDR	vitamin D (1,25- dihydroxyvitamin D3) receptor	0.022
KDM1A	lysine (K)-specific demethylase 1A	0.022
FOXC2	forkhead box C2 (MFH-1, mesenchyme forkhead 1)	0.022	Human
NEUROG3	neurogenin 3	0.021	Human
BBS1	Bardet-Biedl syndrome 1	0.021
IRS1	insulin receptor substrate 1	0.021
RAX	retina and anterior neural fold homeobox	0.021
PAX6	paired box 6	0.021
VSX1	visual system homeobox 1	0.021
SOX11	SRY (sex determining region Y)-box 11	0.021
ARX	aristaless related homeobox	0.020	Zebrafish
HOXD9	homeobox D9	0.020
SFRP5	secreted frizzled-related protein 5	0.020
NTRK1	neurotrophic tyrosine kinase, receptor, type 1	0.019
SIRT1	sirtuin 1	0.019
FGF8	fibroblast growth factor 8 (androgen-induced)	0.019
HOXD3	homeobox D3	0.019
HOXD10	homeobox D10	0.019
PPIH	peptidylprolyl isomerase H (cyclophilin H)	0.019
SCARF2	scavenger receptor class F, member 2	0.019
LHX2	LIM homeobox 2	0.019
CEBPA	CCAAT/enhancer binding protein (C/EBP), alpha	0.019
ALX4	ALX homeobox 4	0.018
WNT1	wingless-type MMTV integration site family, member 1	0.018
POU3F4	POU class 3 homeobox 4	0.018
DLX2	distal-less homeobox 2	0.018
LOC345643	hypothetical LOC345643	0.018
KRTAP4-12	keratin associated protein 4-12	0.018
FZD8	frizzled homolog 8 (Drosophila)	0.017
ST8SIA2	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2	0.017
SIX3	SIX homeobox 3	0.017
BMP4	bone morphogenetic protein 4	0.017
CACNA1G	calcium channel, voltage-dependent, T type, alpha 1G subunit	0.016
HOXA11	homeobox A11	0.016
HMGA2	high mobility group AT-hook 2	0.016
NPAS2	neuronal PAS domain protein 2	0.016
RPL14	ribosomal protein L14	0.016
SIX6	SIX homeobox 6	0.016
KAT2B	K(lysine) acetyltransferase 2B	0.015
MCM6	minichromosome maintenance complex component 6	0.015
BHLHE23	basic helix-loop-helix family, member e23	0.015
TP73	tumor protein p73	0.015
PAX1	paired box 1	0.015
IL6ST	interleukin 6 signal transducer (gp130, oncostatin M receptor)	0.014
BCL11B	B-cell CLL/lymphoma 11B (zinc finger protein)	0.014
IRS2	insulin receptor substrate 2	0.014
TLX3	T-cell leukemia homeobox 3	0.014
RPL4	ribosomal protein L4	0.014
FZD1	frizzled homolog 1 (Drosophila)	0.014
FOXQ1	forkhead box Q1	0.014	Human
LHX1	LIM homeobox 1	0.014
ARHGEF12	Rho guanine nucleotide exchange factor (GEF) 12	0.014
HAND1	heart and neural crest derivatives expressed 1	0.014	Human
HIF1AN	hypoxia inducible factor 1, alpha subunit inhibitor	0.014
HOXB5	homeobox B5	0.014
FOXG1	forkhead box G1	0.014	Human
RPL5	ribosomal protein L5	0.014
SMAD1	SMAD family member 1	0.014
IGFBP1	insulin-like growth factor binding protein 1	0.013
COL13A1	collagen, type XIII, alpha 1	0.013
FOXA1	forkhead box A1	0.013	Human
FSTL1	follistatin-like 1	0.013
HOXB13	homeobox B13	0.013
HOXA3	homeobox A3	0.013
DBN1	drebrin 1	0.013
FGF7	fibroblast growth factor 7	0.013
INHBB	inhibin, beta B	0.013
TCF4	transcription factor 4	0.013
GHR	growth hormone receptor	0.013
NKX2-1	NK2 homeobox 1	0.013
RANBP9	RAN binding protein 9	0.013
FGFR1	fibroblast growth factor receptor 1	0.013
GBX2	gastrulation brain homeobox 2	0.013
NEUROD1	neurogenic differentiation 1	0.013	Human Zebrafish Mouse
MSX1	msh homeobox 1	0.013
HOXB8	homeobox B8	0.013
FGF4	fibroblast growth factor 4	0.013
HES2	hairy and enhancer of split 2 (Drosophila)	0.013
BARX1	BARX homeobox 1	0.012
UNC119B	unc-119 homolog B (C. elegans)	0.012
IHH	Indian hedgehog	0.012
HOXD1	homeobox D1	0.012
GDF7	growth differentiation factor 7	0.012	Human
ZC3HC1	zinc finger, C3HC-type containing 1	0.012
WFIKKN1	WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 1	0.012
WHSC1L1	Wolf-Hirschhorn syndrome candidate 1-like 1	0.012
WNT2	wingless-type MMTV integration site family member 2	0.012
WNT11	wingless-type MMTV integration site family, member 11	0.012
GATAD2B	GATA zinc finger domain containing 2B	0.012
MEGF11	multiple EGF-like-domains 11	0.012
SHOX2	short stature homeobox 2	0.012
PAPPA	pregnancy-associated plasma protein A, pappalysin 1	0.011
HMX1	H6 family homeobox 1	0.011
SPRY4	sprouty homolog 4 (Drosophila)	0.011
SCGN	secretagogin, EF-hand calcium binding protein	0.011
PRRX2	paired related homeobox 2	0.011
HOXA6	homeobox A6	0.011
RPLP0	ribosomal protein, large, P0	0.011
ZIC3	Zic family member 3 (odd-paired homolog, Drosophila)	0.011
CYR61	cysteine-rich, angiogenic inducer, 61	0.011
PRDM13	PR domain containing 13	0.011
NPAS1	neuronal PAS domain protein 1	0.011
RFX6	regulatory factor X, 6	0.011
GATA6	GATA binding protein 6	0.011	Mouse
SOX9	SRY (sex determining region Y)-box 9	0.011	Mouse
BCAN	brevican	0.011
FOXC1	forkhead box C1	0.011	Human
MAML1	mastermind-like 1 (Drosophila)	0.011
PAX9	paired box 9	0.011
STAT3	signal transducer and activator of transcription 3 (acute-phase response factor)	0.011
OTP	orthopedia homeobox	0.011
FOXJ1	forkhead box J1	0.011
NKX2-4	NK2 homeobox 4	0.011
FOXD2	forkhead box D2	0.011	Human
FOXE3	forkhead box E3	0.011	Human
PHOX2A	paired-like homeobox 2a	0.010
GAB1	GRB2-associated binding protein 1	0.010
VAX2	ventral anterior homeobox 2	0.010
TBR1	T-box, brain, 1	0.010
TBX1	T-box 1	0.010
CDH3	cadherin 3, type 1, P-cadherin (placental)	0.010
BHLHE22	basic helix-loop-helix family, member e22	0.010
NELL2	NEL-like 2 (chicken)	0.010
LMX1B	LIM homeobox transcription factor 1, beta	0.010
DDX47	DEAD (Asp-Glu-Ala-Asp) box polypeptide 47	0.010
PAX7	paired box 7	0.010
TLX1	T-cell leukemia homeobox 1	0.010